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Competing Interests: Disclosures Dr Greene has received research support from the Duke University Department of Medicine Chair’s Research Award, the American Heart Association (award 929502), Amgen, AstraZeneca, Bristol Myers Squibb (BMS), Cytokinetics, Merck, Novartis, Pfizer, and Sanofi; has served on advisory boards for Amgen, AstraZeneca, BMS, Boehringer Ingelheim/Lilly, Cytokinetics, Roche Diagnostics, scPharmaceuticals, and Sanofi; has received speaker fees from Boehringer Ingelheim, Cytokinetics, and Roche Diagnostics; and serves as a consultant for Amgen, Bayer, BMS, Corteria Pharmaceuticals, CSL Vifor, Merck, PharmaIN, Roche Diagnostics, Sanofi, Tricog Health, and Urovant Pharmaceuticals. Dr. Spertus discloses providing consultative services on patient-reported outcomes and evidence evaluation to Alnylam, AstraZeneca, Bayer, Merck, Janssen, BMS, Edwards, Kineksia, 4DT Medical, Terumo, Cytokinetics, Imbria, and United Healthcare. He holds research grants from BMS, Abbott Vascular, and Janssen. He owns the copyright to the Seattle Angina Questionnaire, Kansas City Cardiomyopathy Questionnaire, and Peripheral Artery Questionnaire and serves on the Board of Directors for Blue Cross Blue Shield of Kansas City. W. Tang, D.R. Steffen, and M.G. Viola are employees of Analysis Group Inc, which has received consultancy fees from BMS for this study. Drs Zhong, Myers, and Shen and A. Kang, J. Jiang, and X. Liu are employees of BMS. Dr Felker has received research grants from the National Heart, Lung, and Blood Institute, the American Heart Association, Amgen, Bayer, BMS, Merck, Cytokinetics, and CSL-Behring; has acted as a consultant to Novartis, Amgen, BMS, Cytokinetics, Medtronic, Cardionomic, Boehringer Ingelheim, American Regent, Abbott, AstraZeneca, Reprieve, Myovant, Sequana, Windtree Therapeutics, and Whiteswell; and has served on clinical end point committees/data safety monitoring boards for Amgen, Merck, Medtronic, EBR Systems, V-Wave, LivaNova, Siemens, and Rocket Pharma.