1. The hypertriglyceridemic waist phenotype is associated with fatty liver and glycometabolic profiles in overweight and obese adults: a cross-sectional study.
- Author
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Zhou M, Li F, Tang H, Wu S, Meng L, Dong Y, Wang F, Quach B, Yang Y, Ma J, and Baker JS
- Subjects
- Adult, Blood Glucose metabolism, Blood Pressure, Body Mass Index, China, Cholesterol, HDL blood, Cross-Sectional Studies, Fatty Liver metabolism, Female, Glycated Hemoglobin metabolism, Humans, Hypertriglyceridemic Waist, Insulin blood, Insulin Resistance, Male, Middle Aged, Obesity metabolism, Obesity physiopathology, Overweight metabolism, Overweight physiopathology, Phenotype, Risk Factors, Waist Circumference, Young Adult, Fatty Liver etiology, Obesity complications, Overweight complications, Triglycerides blood
- Abstract
The present study aimed to distinguish different hypertriglyceridemic waist phenotypes and relevant risks of developing fatty liver and abnormal glycometabolic profiles in overweight/obese adults. A total of 1221 Chinese adults with mean (standard deviation [SD]) age of 37 (9) years, 37.3% males and 62.7% females, body mass index (BMI) of 29.0 (4.0) kg/m
2 , triglyceride (TG) 2.04 (1.45) mmol/L, and waist circumference (WC) 95.8 (10.7) cm were included and classified into four phenotypes: normal TG & normal WC (N-N); normal TG & high WC (N-WC); high TG & normal WC (TG-N); high TG & high WC (TG-WC). Participants in TG-WC group had the highest BMI, WC, blood pressure (BP), insulin, Homeostatic Model Assessment of Insulin Resistance (HOMA-IR), glycosylated hemoglobin (HbA1c), low-density lipoprotein cholesterol (LDL), and fatty liver. Participants within N-WC group had a significantly higher risk of fatty liver (adjusted OR 3.50 [95% CI 2.05-5.97]), as well as TG-N (adjusted OR 2.59 [95% CI 1.61-4.16]) and TG-WC (adjusted OR 4.12 [95% CI 2.28-7.46]). The risk of elevated HOMA-IR was significantly higher in TG-N (adjusted OR 2.16 [95% CI 1.33-3.50]) and TG-WC (adjusted OR 2.04 [95% CI 1.22-3.40]). The risk of elevated HbA1c was significantly higher in the TG-WC (adjusted OR 2.79 [95% CI 1.47-5.31]). Hypertriglyceridemic waist phenotype can be a potential and cost-effective method to identify individuals with a high risk of fatty liver and glycometabolic disorders., (© 2022. The Author(s).)- Published
- 2022
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