1. Influence of Large-Scale Brain State Dynamics on the Evoked Response to Brain Stimulation.
- Author
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Kabir A, Dhami P, Dussault Gomez MA, Blumberger DM, Daskalakis ZJ, Moreno S, and Farzan F
- Subjects
- Humans, Male, Female, Adult, Young Adult, Evoked Potentials physiology, Transcranial Magnetic Stimulation methods, Electroencephalography methods, Prefrontal Cortex physiology, Brain physiology
- Abstract
Understanding how spontaneous brain activity influences the response to neurostimulation is crucial for the development of neurotherapeutics and brain-computer interfaces. Localized brain activity is suggested to influence the response to neurostimulation, but whether fast-fluctuating (i.e., tens of milliseconds) large-scale brain dynamics also have any such influence is unknown. By stimulating the prefrontal cortex using combined transcranial magnetic stimulation (TMS) and electroencephalography, we examined how dynamic global brain state patterns, as defined by microstates, influence the magnitude of the evoked brain response. TMS applied during what resembled the canonical Microstate C was found to induce a greater evoked response for up to 80 ms compared with other microstates. This effect was found in a repeated experimental session, was absent during sham stimulation, and was replicated in an independent dataset. Ultimately, ongoing and fast-fluctuating global brain states, as probed by microstates, may be associated with intrinsic fluctuations in connectivity and excitation-inhibition balance and influence the neurostimulation outcome. We suggest that the fast-fluctuating global brain states be considered when developing any related paradigms., Competing Interests: D.M.B. has received in-kind equipment support for investigator-initiated studies from MagVenture; he has received research support and in-kind equipment support for an investigator-initiated study from BrainsWay and is the site principal investigator for three sponsor-initiated studies for BrainsWay; he has received medication supplies for an investigator-initiated trial from Indivior; and he has participated on an advisory board for Janssen. Z.J.D. has received research and equipment in-kind support for an investigator-initiated study through BrainsWay and MagVenture. A.K., P.D., M.D.G., S.M., and F.F. report no biomedical financial interests or potential competing financial interests., (Copyright © 2024 the authors.)
- Published
- 2024
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