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Your search keyword '"Androstenedione"' showing total 2 results
2 results on '"Androstenedione"'

1. Glucose action and adrenocortical biosynthesis in women with polycystic ovary syndrome

Author

Farah-Eways, Lisa, Reyna, Rosario, Knochenhauer, Eric S., Bartolucci, Alfred A., and Azziz, Ricardo

Subjects
*INSULIN, *GLUCOSE, *OVARIAN diseases, *SYNDROMES, *GLUCOSE metabolism, *ADRENOCORTICOTROPIC hormone, *ADRENAL cortex, *ADRENOCORTICAL hormones, *COMPARATIVE studies, *DEHYDROEPIANDROSTERONE, *GLUCOSE tolerance tests, *HYDROCORTISONE, *INSULIN resistance, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *PROGESTERONE, *RESEARCH, *POLYCYSTIC ovary syndrome, *STEROIDS, *TESTOSTERONE, *ANDROSTENEDIONE, *EVALUATION research, *CASE-control method
Abstract

: ObjectiveTo determine if insulin or glucose action plays a role in adrenocortical steroidogenesis in the polycystic ovary syndrome (PCOS).: DesignProspective cohort study.: SettingAcademic medical center.: Patient(s)Nine reproductive-aged patients with PCOS and nine age-, race-, and body mass index–matched controls.: Main outcome measure(s)Insulin-modified frequently sampled intravenous glucose tolerance testing and an acute 60-minute ACTH-(1-24) stimulation test. From the glucose tolerance test, glucose and insulin were measured and the insulin sensitivity index, glucose effectiveness, and acute insulin response to glucose were determined. Dehydroepiandrosterone sulfate (DHEAS) basally and 17-hydroxypregnenolone, 17-hydroxyprogesterone, DHEA, androstenedione, and cortisol during ACTH testing at 0 and 60 minute (steroid0 and steroid60) were determined. The net change in steroid during the ACTH test was calculated.: Result(s)The insulin sensitivity index had limited correlation with adrenocortical variables in both groups. In patients with PCOS, glucose effectiveness was positively associated with DHEAS, cortisol0, cortisol60, change in cortisol, DHEA0, DHEA60, change in DHEA, 17-hydroxyprenenolone60, change in 17-hydroxypregnenolone, DHEA0, androstenedione0, 17-hydroxyprenenolone0, 17-hydroxyprogesterone0, 17-hydroxyprenenolone60, and 17-hydroxyprogesterone60.: Conclusion(s)Adrenocortical biosynthesis, basally and in response to ACTH, appears to be closely associated with glucose effectiveness in PCOS. A common factor determining both the effectiveness of glucose to control its own production or uptake and adrenocortical biosynthesis may be aberrant in PCOS. [Copyright &y& Elsevier]

Published
2004
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2. Adrenal response to adrenocorticotropic hormone stimulation in patients with premenstrual syndrome

Author

I Lombardi, M. Palumbo, Patrizia Monteleone, Ar Genazzani, B. Quirici, Elena Casarosa, M. Liut, Stefano Luisi, F Bernardi, and Felice Petraglia

Subjects
Serum, Adult, endocrine system, medicine.medical_specialty, Adolescent, Hydrocortisone, Endocrinology, Diabetes and Metabolism, ACTH, Allopregnanolone, Premenstrual Syndrome, Steroids, Dehydroepiandrosterone, Adrenocorticotropic hormone, Pregnanolone, Luteal phase, Luteal Phase, Dexamethasone, chemistry.chemical_compound, Endocrinology, Adrenocorticotropic Hormone, Internal medicine, Follicular phase, Medicine, Humans, Testosterone, Androstenedione, Progesterone, Estradiol, business.industry, Dehydroepiandrosterone Sulfate, Obstetrics and Gynecology, chemistry, Follicular Phase, Case-Control Studies, Pregnenolone, Adrenal Cortex, Female, Adrenal Cortex Function Tests, business, hormones, hormone substitutes, and hormone antagonists, Hormone, medicine.drug
Abstract

Several studies have been performed during recent years to investigate the existence of a possible endocrine cause for premenstrual syndrome (PMS); the results reported are often discordant. Great interest has been raised around allopregnanolone, which could be involved in the determination of mood disorders reported by PMS patients. During the luteal phase, lower levels of this hormone have been detected in PMS patients. The aim of our study was to evaluate estradiol, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate (DHEAS), androstenedione, total and free testosterone, cortisol, pregnenolone and allopregnanolone levels in 20 patients suffering from PMS and to compare them with those found in 20 fertile healthy women in the follicular and the luteal phases. Adrenocorticotropic hormone (ACTH) tests after dexamethasone suppression were performed in 10 patients of each group during the follicular and the luteal phases. In the PMS group, significantly lower allopregnolone levels were found in the luteal phase, while progesterone was lower in the PMS group in both phases. In the PMS group, higher free testosterone levels were found during the luteal phase and higher DHEA levels in both the follicular and the luteal phases. The present data confirm reduced allopregnanolone levels in the luteal phase in PMS patients, together with higher levels of DHEA and free testosterone. It is possible to conclude that, in addition to the previously described reduced luteal secretion of allopregnanolone, the adrenal gland production of this steroid in PMS sufferers is also impaired in the luteal phase. Considering the specific actions of these hormones on the control of mood and behavior, this specific hormonal milieu may contribute to the cyclic occurrence of anxiety, aggressiveness and irritability reported by PMS patients.

Published
2004

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