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Purpose: The purpose of this study is to describe the mechanism of single-crystal high-temperature creep deformation, predict the creep life more accurately and study the creep constitutive and lifetime models with microstructure evolution. Design/methodology/approach: The mechanical properties of nickel-based single-crystal superalloy are closely related to the γ' phase. Creep tests under four different temperature and stress conditions were carried out. The relationship between creep temperature, stress and life is fitted by numerical method, and the creep activation energy is obtained. The creep fracture surface, morphology and evolution of strengthening phase (γ') and matrix phase (γ) during different creep periods were observed by scanning electron microscope. With the increase of creep temperature, the rafting time is advanced. The detailed morphology and evolution of dislocations were observed by transmission electron microscope (TEM). Findings: With the increase of creep temperature, the rafting time is advanced. The detailed morphology and evolution of dislocations were observed by TEM. Dislocations are mainly concentrated in the γ channel phase, especially at high temperature and low stress. Originality/value: A creep constitutive model based on the evolution of γ' phase size and γ channel width was proposed. Compared with the experimental results, the predicted creep life is within 1.4 times error dispersion band. [ABSTRACT FROM AUTHOR]