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A variety of terms, such as "antiepileptic," "anticonvulsant," and "antiseizure" have been historically applied to medications for the treatment of seizure disorders. Terminology is important because using terms that do not accurately reflect the action of specific treatments may result in a misunderstanding of their effects and inappropriate use. The present International League Against Epilepsy (ILAE) position paper used a Delphi approach to develop recommendations on English‐language terminology applicable to pharmacological agents currently approved for treating seizure disorders. There was consensus that these medications should be collectively named "antiseizure medications". This term accurately reflects their primarily symptomatic effect against seizures and reduces the possibility of health care practitioners, patients, or caregivers having undue expectations or an incorrect understanding of the real action of these medications. The term "antiseizure" to describe these agents does not exclude the possibility of beneficial effects on the course of the disease and comorbidities that result from the downstream effects of seizures, whenever these beneficial effects can be explained solely by the suppression of seizure activity. It is acknowledged that other treatments, mostly under development, can exert direct favorable actions on the underlying disease or its progression, by having "antiepileptogenic" or "disease‐modifying" effects. A more‐refined terminology to describe precisely these actions needs to be developed. [ABSTRACT FROM AUTHOR]

The gig economy and gig work have grown quickly in recent years and have drawn much attention from researchers in different fields. Because the platform mediated gig economy is a relatively new phenomenon, studies have produced a range of interesting findings; of interest here are the socio‐technical issues that this work has surfaced. This systematic literature review (SLR) provides a snapshot of a range of socio‐technical issues raised in the last 12 years of literature focused on the platform mediated gig economy. Based on a sample of 515 papers gathered from nine databases in multiple disciplines, 132 were coded that specifically studied the gig economy, gig work, and gig workers. Three main socio‐technical themes were identified: (1) the digital workplace, which includes information infrastructure and digital labor that are related to the nature of gig work and the user agency; (2) algorithmic management, which includes platform governance, performance management, information asymmetry, power asymmetry, and system manipulation, relying on a diverse set of technological tools including algorithms and big data analytics; (3) ethical design, as a relevant value set that gig workers expect from the platform, which includes trust, fairness, equality, privacy, and transparency. A social informatics perspective is used to rethink the relationship between gig workers and platforms, extract the socio‐technical issues noted in prior research, and discuss the underexplored aspects of the platform mediated gig economy. The results draw attention to understudied yet critically important socio‐technical issues in the gig economy that suggest short‐ and long‐term opportunities for future research directions. [ABSTRACT FROM AUTHOR]

While bibliographic classifications are traditionally based on disciplines, the logical alternative is phenomenon‐based classification. Although not prevalent, this approach has been explored in the 20th century by J.D. Brown, the Classification Research Group, and others. Its principles have been stated in the León Manifesto (2007) and are currently represented by such general schemes as the Basic Concepts Classification and the Integrative Levels Classification. A phenomenon‐based classification lists classes of phenomena, including things and processes irrespective of the discipline studying them (which can optionally be specified as an additional facet). Facets can work in a phenomenon‐based system much as in a disciplinary one. This kind of system will promote the identification of potential relationships between research in different disciplines, and will especially benefit interdisciplinary work. The paper reviews the theory, history, structure, advantages, applications, and evaluation of phenomenon‐based classification systems. [ABSTRACT FROM AUTHOR]

Self‐charging power systems (SCPSs) are envisioned as promising solutions for emerging electronics to mitigate the increasing global concern about battery waste. However, present SCPSs suffer from large form factors, unscalable fabrication, and material complexity. Herein, a type of highly stable, eco‐friendly conductive inks based on poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS) are developed for direct ink writing of multiple components in the SCPSs, including electrodes for miniaturized spacer‐free triboelectric nanogenerators (TENGs) and microsupercapacitors (MSCs), and interconnects. The principle of “one ink, multiple functions” enables to almost fully print the entire SCPSs on the same paper substrate in a monolithic manner without post‐integration. The monolithic fabrication significantly improves the upscaling capability for manufacturing and reduces the form factor of the entire SCPSs (a small footprint area of ≈2 cm × 3 cm and thickness of ≈1 mm). After pressing/releasing the TENGs for ≈79000 cycles, the 3‐cell series‐connected MSC array can be charged to 1.6 V while the 6‐cell array to 3.0 V. On‐paper SCPSs are promising to serve as lightweight, thin, sustainable, and low‐cost power supplies. [ABSTRACT FROM AUTHOR]

In order to achieve rapid, non‐destructive, efficient, and accurate classification of paper cup samples, we propose a classification model that integrates shifted‐excitation Raman difference spectroscopy (SERDS) with self‐organizing map (SOM) and Bayesian optimization–support vector machine (BO‐SVM). We collected differential Raman data from 52 paper cup samples using SERDS, with an excitation wavelength range of 784–785 nm, a laser power of 440 mW, an integration time of 10 s, and a spectral range spanning from 280 to 2700 cm−1. Subsequently, principal component analysis (PCA) was applied to reduce the dimensionality of the data. The SOM clustering outcomes were utilized as the foundation for constructing the discriminant analysis (FDA) and BO‐SVM classification models. The primary constituent of the paper cup samples was identified as cellulose, while additional fillers such as talc, calcium carbonate, and kaolin were also present. The SOM clustering categorized the samples into seven distinct groups. The FDA model achieved a classification accuracy of 92.3%, and the BO‐SVM model reached a classification accuracy of 96.2%. The SOM clustering effectively discerned samples with different fillers, as evidenced by distinct peak numbers and shapes in the differential Raman spectra, thereby underscoring the practical significance of SOM clustering. In comparison with FDA, BO‐SVM exhibited enhanced classification accuracy and exceptional performance in handling outliers and linearly inseparable data, indicating its superior generalization capabilities. [ABSTRACT FROM AUTHOR]

Microfluidic fuel cells (MFCs) are potential micro power sources for portable electronics. MFCs utilize the co‐laminar flowing of the solutions in the microchannel and remove the membranes in the traditional fuel cells. Flow‐through electrodes exploit the internal electrode surfaces and improve the MFC performance. Carbon paper (CP) has been widely used as a flow‐through electrode with a limited specific surface area. We have also used graphite felt (GF) with a high specific surface area as the electrode and then compared the performance of the MFCs with the CP and GF as the electrodes, respectively. Firstly, we showed the SEM surface morphologies of the two electrodes with or without the Pd catalysts. Secondly, we compared the electrochemical activities of the two electrodes in the solutions, respectively. The GF electrode always showed higher electrochemical activities than the CP electrode, since the GF electrode owned its larger accessible electrochemical surface area and less electrode resistance than the CP electrode. Thirdly, we compared the performance of the MFCs with the two electrodes. The results showed that the performance of the MFC with the GF electrodes electrodes was optimum, with the peak power density of 175.60 mW cm−2 and limiting current density of 616.53 mA cm−2. Finally, we conducted the discharge performance of the MFCs with the two electrodes. There existed a minor variation in the discharge current densities of the MFCs with the CP cathodes. [ABSTRACT FROM AUTHOR]

Background and purpose: Despite the growing awareness of academic fraud, its prevalence in the field of neurology has not been fully assessed. This review aims to analyze the characteristics of the retracted papers in the field of neurology and the reasons for the retraction to better understand the trends in this area and to assist to avoid retraction incidents. Methods: A total of 79 papers were included, which pertained to 22 countries and 64 journals. The marking methods for retracting original papers included watermarks (89.04%), retracted signs in the text (5.48%) and no prompt (5.48%). The median M (interquartile range [IQR]) of citations in retractions in neurology was 7 (41). Studies continued to be cited after retraction with an M (IQR) of 3 (16). The journal impact factor was between 0 and 157.335, with an M (IQR) of 5.127 (3.668). 45.21% and 31.51% papers were mainly published in the first and second quartile journals, respectively. The M (IQR) time elapsed between publication and retraction was 32 (44) months. The reasons for retraction included two major categories, academic misconduct (79.75%) and academic unintentional mistakes (20.25%). Results and conclusions: The number of retractions in neurology has been on the rise over the past decade, with fabricated academic misconduct being the main cause of the retractions. Due to the long time lag between publication and retraction, a number of unreliable findings continue to be cited following retraction. In addition to the requisite standards of academic ethics, augmenting research training and fostering interdisciplinary collaboration are crucial in enhancing research integrity. [ABSTRACT FROM AUTHOR]

Air pollution caused by particulate matter (PM) poses an imminent threat to the global environment and public health. However, balancing the removal efficiency and pressure drop of most filter materials is difficult. Moreover, filter materials are non‐degradable and non‐recyclable, causing serious harm to the environment. Herein, a strategy to create fully degradable branched poly (lactic acid) (PLA) nanofibers based on electrospinning by adjusting the spinning solution properties was reported and branched PLA nanofibers were applied as nanofiber filter paper for air filtration materials. When the PLA and tetrabutylammonium chloride concentrations were 8 and 5 wt%, respectively, PLA nanofibers with branched structures were obtained. The obtained nanofibers possessed a small pore size (0.70 μm), high porosity (92.3%), appropriate mechanical properties, resulting in high PM0.3 removal efficiency (99.95%), low air resistance (79.67 Pa), and promising long‐term PM2.5 purification. Notably, branched T‐PLA‐5 nanofibers exhibited excellent filtration performance when applied to cellulose wood pulp paper. The filtration efficiency of the nanofiber filter paper remained stable above 85% for PM0.3 (32 L min−1) after 5000 backflushings. Thus, the preparation of such nanomaterials may provide new insights into the design and development of high‐performance degradable filtration materials for various applications. [ABSTRACT FROM AUTHOR]

Over the past years, eosinophils have become a focus of scientific interest, especially in the context of their recently uncovered functions (e.g. antiviral, anti-inflammatory, regulatory). These versatile cells display both beneficial and detrimental activities under various physiological and pathological conditions. Eosinophils are involved in the pathogenesis of many diseases which can be classified into primary (clonal) and secondary (reactive) disorders and idiopathic (hyper)eosinophilic syndromes. Depending on the biological specimen, the eosinophil count in different body compartments may serve as a biomarker reflecting the underlying pathophysiology and/or activity of distinct diseases and as a therapy-driving (predictive) and monitoring tool. Personalized selection of an appropriate therapeutic strategy directly or indirectly targeting the increased number and/or activity of eosinophils should be based on the understanding of eosinophil homeostasis including their interactions with other immune and non-immune cells within different body compartments. Hence, restoring as well as maintaining homeostasis within an individual's eosinophil pool is a goal of both specific and non-specific eosinophil-targeting therapies. Despite the overall favourable safety profile of the currently available anti-eosinophil biologics, the effect of eosinophil depletion should be monitored from the perspective of possible unwanted consequences., (© 2023 European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

The research presented in this paper introduces a novel environmental energy‐harvesting technology that harnesses electricity from the evaporation of water using porous structural materials. Specifically, a strategy employing paper‐based hydroelectric generators (p‐HEGs) is proposed to capture the energy produced during water evaporation and convert it into usable electricity. The p‐HEGs offer several advantages, including simplicity in fabrication, low cost, and reusability. To evaluate their effectiveness, the water evaporation‐induced electrical output performance of four different p‐HEGs are compared. Among the variants tested, the p‐HEG combining wood pulp and polyester fiber exhibits the best output performance. At room temperature, this particular p‐HEG generates a short‐circuit current and open‐circuit voltage of ≈0.4 µA and 0.3 V, respectively, thereby demonstrating excellent electrical stability. Furthermore, the electrical current and voltage generated by the p‐HEG through water evaporation are able to power an LED light, both individually and in series and parallel connections. This study delves into the potential of electricity harvesting from water evaporation and establishes it as a viable method for renewable energy applications. [ABSTRACT FROM AUTHOR]

Metal–organic frameworks (MOFs) derived nanostructures receive immense research focus due to its high porosity, conductivity, and structural tailrolability features. In this work, porous Zeolitic Imidazole Framework‐67 (ZIF‐67) to synthesize cobalt phosphide/carbon composite (ZCoPC) that serves as a positive electrode is utilized. Furthermore, porous and conductive office paper derived carbon (OPC) are utilized as a negative electrode to make a hybrid system. The metalloid characteristics, high conductivity, and good porosity of ZCoPC material makes it a high‐performance battery like electrode. ZCoPC electrode achieves maximum specific capacity of 192.6 mAh g−1 at 1 A g−1 using 1 m potassium hydroxide (KOH) electrolyte. Furthermore, surface and diffusion charge participation investigation are also undergone for ZCoPC electrode that helps in determining the actual charge dynamics occurring in the electrode. In addition, a supercapattery device is assembled using ZCoPC as battery electrode and OPC as supercapacitor electrode. The as fabricated OPC//ZCoPC hybrid supercapattery device delivers extraordinary energy density of 31.6 Wh kg−1 with a power density of 700 W kg−1 and also a long cycle life of 92.3% even after 10,000 charge–discharge cycles. Hence, these outcomes demonstrate that the synergy of porous MOF derived metal phosphide and OPC electrodes are beneficial for supercapattery devices. [ABSTRACT FROM AUTHOR]

Objectives: To elucidate whether occupational exposure to soft paper dust increases the incidence of cancer. Methods: We studied 7988 workers in Swedish soft paper mills from 1960 to 2008, of whom 3233 (2 187 men and 1046 women) had more than 10 years of employment. They were divided into high exposure (>5 mg/m3 for >1 year) or lower exposure to soft paper dust based on a validated job‐exposure matrix. They were followed from 1960 to 2019, and person‐years at risk were stratified according to gender, age, and calendar‐year. The expected numbers of incident tumors were calculated using the Swedish population as the reference, and standardized incidence ratios (SIR) with 95% confidence intervals (95% CI) were assessed. Results: Among high‐exposure workers with more than 10 years of employment, there was an increased incidence of colon cancer (SIR 1.66, 95% CI 1.20−2.31), small intestine cancer (SIR 3.27, 95% CI 1.36−7.86), and thyroid gland cancer (SIR 2.68, 95% CI 1.11−6.43), as well as lung cancer (SIR 1.56, 95% CI 1.12−2.19). Among the lower‐exposed workers there was an increased incidence of connective tissue tumors (sarcomas) (SIR 2.26, 95% CI 1.13−4.51) and pleural mesothelioma (SIR 3.29, 95% CI 1.37−7.91). Conclusion: Workers in soft paper mills with high exposure to soft paper dust have an increased incidence of large and small intestine tumors. Whether the increased risk is caused by paper dust exposure or some unknown associated factors is unclear. The increased incidence of pleural mesothelioma is probably linked to asbestos exposure. The reason for increased incidence of sarcomas is unknown. [ABSTRACT FROM AUTHOR]

Summary: The short shelf life of fresh strawberries limits its marketing potential, despite its valuable economic and nutritional benefits. An environmentally friendly fresh‐keeping paper was prepared with oregano essential oil (OEO) and tea polyphenols (TP) and used in the storage of strawberries. Results showed that, during the late storage period, the TP and OEO fresh‐keeping paper treatments reduced malondialdehyde (MDA) content by 29.04% and 34.47%, respectively, compared with the control samples. The treatments also reduced decay incidence, weight loss, epidermal microorganisms and total anthocyanins content (TAC). Furthermore, the treatments reduce polyphenol oxidase (PPO) activity, delay the colour development and maintain better sensory attributes. Notably, OEO fresh‐keeping paper treatment not only increased the titratable acidity (TA) and total soluble solids (TSS) content but also improved the scavenging ability of reactive oxygen species by maintaining high levels of superoxide dismutase (SOD) and catalase (CAT) activity. These results demonstrated that fresh‐keeping paper treatment has the potential to extend the post‐harvest life of strawberries and improve their quality. [ABSTRACT FROM AUTHOR]

DNA is a promising material for high density and long‐term archival data storage. In addition to algorithms for encoding digital information into DNA sequences, the DNA writing (chemical synthesis) and reading (DNA sequencing), the preservation of DNA mixtures with high sequence diversity is another critical issue for sustainable, long‐term, and large‐scale DNA data storage. Here, this work demonstrates a method for low‐cost, convenient and sustainable DNA data storage on cellulose paper. A DNA pool comprising thousands of sequences, in which archival data are encoded, is conveniently stored on a cellulose paper with a calculated density as high as 15 TB per mm3 through electrostatic adsorption. This work demonstrates that these digitally encoded DNA pools can be stable for years on the cellulose paper after drying even when directly exposed to air. Furthermore, the reversible electrostatic adsorption enables repeated loading/retrieval of DNA on/off cellulose paper. Therefore, this sustainable DNA preservation on cellulose paper through the convenient electrostatic adsorption exhibits a great advantage in terms of storage capacity and cost that is crucial for practical systems to achieve large‐scale and long‐time data storage. [ABSTRACT FROM AUTHOR]

To relief the water shortage crisis in China, the Chinese government has initiated a series of clean production (CP) measures to reduce the freshwater consumption and wastewater discharge from paper industry. In this study, a new CP technology was introduced in the paper industry to reuse tissue paper mill effluent water as intake water of corrugated paper mill. The feasibility and impact of the new CP technology was investigated in three different scales, laboratory experiments, pilot‐scale testing, and long‐term implementation. Results show that the water quality of treated tissue paper mill effluent water is competitive with that of freshwater and some water quality indexes are even better, indicating that treated tissue paper mill effluent water is a suitable alternative to replace the freshwater as intake water for the corrugated paper mill. By reusing tissue paper mill effluent water as intake water of corrugated paper mill, most physical properties of different corrugated paper layers are improved or similar as those by using freshwater as intake water in all different scale experiments. Moreover, the new CP technology significantly reduced the freshwater consumption for the corrugated paper mill, eliminated the wastewater discharged from the tissue paper mill, and at the same time, lowered the operation cost for both paper mills in terms of freshwater consumption and wastewater treatment cost. Total 216,000 RMB will be saved every year with an assumption that tissue paper mill provides annual daily average 2000 cubic meter of effluent water to corrugated paper mill every day. © 2017 American Institute of Chemical Engineers Environ Prog, 37: 934–941, 2018 [ABSTRACT FROM AUTHOR]

Summary: In recent years, many initial coin offerings (ICOs) scams have been reported, attracting attention to this relatively new and unregulated ICO market, which lacks disclosure requirements and therefore suffers from intensifying problems of information asymmetry inherent in crowdfunding. As a prospectus‐type document, an ICO white paper serves as a major means of voluntary disclosure practices adopted by ventures seeking external financing. Given the importance of an ICO white paper and the difficulty of assessing its quality, we propose to benchmark it against white paper content for security token offerings (STOs)—a more regulated ICO subset. Using the similarity of ICO white papers with STO white papers to proxy for disclosure quality, we document that the ICO campaigns that have white papers more similar to STO white papers are more likely to raise funding successfully. Our findings provide implications for policymakers, ICO fundraisers, and investors on the importance of white paper quality. [ABSTRACT FROM AUTHOR]

Miniaturized paper‐based electrochemical sensors were fabricated using kraft paper and CO2 laser, dispensing the need for chemical reagents and controlled atmospheric conditions. This study initially evaluated the paper type and laser processing parameters, enhancing the electrodes′ robustness, electrochemical response, and electrical resistance. The sensors were also treated by applying −1 V for 60 s in 1.0 mol L−1 KCl, which is a simple and rapid procedure. The electrochemical treatment increased the electroactive area and roughness, confirmed by scanning electron microscopy. These aspects helped modulate the sensors′ electrochemical response for nitrite determination, improving selectivity and sensitivity for this compound. The sensors also showed repeatability and batch‐to‐batch reproducibility, with 2.2 and 10 % RSD, respectively. Therefore, this work brings a protocol to fabricating competitive electrochemical sensors through a sustainable strategy, opening possibilities for designing new analytical systems. [ABSTRACT FROM AUTHOR]

In this work, poly‐epoxy‐acrylate (PEA) resin was prepared by modifying polyacrylate resin with epoxy resin through a simple solution polymerization method. The prepared PEA resin was then neutralized by alkaline treatment to obtain excellent water solubility and used as an ecofriendly binder for automotive oil filter paper. The effect of alkaline neutralization degree on the water solubility of the PEA resin was studied. Also, the influence of epoxy content on the grafting degree of PEA resin was tested. The mechanical strength and oil resistance properties of oil filter paper strengthened by the prepared PEA resin were compared to other commercial binders. The microstructure and pore size of the oil filter paper were observed by scanning electron microscope and tested by capillary flow porometer (PMI), respectively. The results show that the prepared PEA resin can greatly enhance the mechanical and oil resistance properties of the oil filter paper while maintaining its filtration properties. The prepared PEA resin has the potential to be used as an ecofriendly water‐based binder for automotive oil filter paper. [ABSTRACT FROM AUTHOR]

Nairobi's land digitisation programme presents continuous challenges to the Kenyan state's aspirations of reforming land administration. By drawing upon insights from archival sciences and digital geographies, this paper argues that digitisation of Kenya's land administration records presents us with an opportunity to pay attention to how information flows from paper to digital systems, and the nature of human condition that makes it possible. Based on research of land digitisation initiatives in Nairobi and its peripheral counties, this paper explores first, how digitisation initiates a large‐scale state exercise of sorting paper in the land records departments that constitutes the archival apparatus of the state; and second, how the archival labour of state officials in this process is at the same time significant, invisible and devalued. Through interviews of state officials in county and state departments, we argue that the digitisation process is far more complex and messier than the rhetoric of seamless transition to automated land administration in Kenya. Digitisation involves a slow embodied labour in sorting paper by state officials who have little power in shaping the design of the platform that they are expected to use. The devaluation of the archival labour of state officials who are not professionally trained in ‘archival practice’ and are seemingly voiceless in the production of national land information platforms leads to subversion and non‐cooperation with the platform itself. The paper concludes that an expansive lens of seeing digital platforms through the tools and technologies of archiving practices enables us to understand why platforms fail, why and how paper increases value within digital systems and how archival labour is central to the politics of digitisation and platformisation in the future. [ABSTRACT FROM AUTHOR]

Identifying the factors that influence the citation of articles helps authors improve the impact and reach of their research. Analysis of publications in the Journal of Fish Biology between 2008 and 2021 revealed that variables such as the number of keywords, abstract length, number of authors, and page length were associated with higher impact papers. These trends applied to both review and regular papers. These findings suggest that papers that are more informative, have higher numbers of authors, and have more keywords are more likely to be cited. Adoption of some simple "best‐practice" behaviors can improve the likelihood that a paper is cited. [ABSTRACT FROM AUTHOR]

The exponential growth of precision diagnostic tools, including omic technologies, molecular diagnostics, sophisticated genetic and epigenetic editing, imaging and nano‐technologies and patient access to extensive health care, has resulted in vast amounts of unbiased data enabling in‐depth disease characterization. New disease endotypes have been identified for various allergic diseases and triggered the gradual transition from a disease description focused on symptoms to identifying biomarkers and intricate pathogenetic and metabolic pathways. Consequently, the current disease taxonomy has to be revised for better categorization. This European Academy of Allergy and Clinical Immunology Position Paper responds to this challenge and provides a modern nomenclature for allergic diseases, which respects the earlier classifications back to the early 20th century. Hypersensitivity reactions originally described by Gell and Coombs have been extended into nine different types comprising antibody‐ (I‐III), cell‐mediated (IVa‐c), tissue‐driven mechanisms (V‐VI) and direct response to chemicals (VII). Types I‐III are linked to classical and newly described clinical conditions. Type IVa‐c are specified and detailed according to the current understanding of T1, T2 and T3 responses. Types V‐VI involve epithelial barrier defects and metabolic‐induced immune dysregulation, while direct cellular and inflammatory responses to chemicals are covered in type VII. It is notable that several combinations of mixed types may appear in the clinical setting. The clinical relevance of the current approach for allergy practice will be conferred in another article that will follow this year, aiming at showing the relevance in clinical practice where various endotypes can overlap and evolve over the lifetime. [ABSTRACT FROM AUTHOR]

In 2018, the community first observed scientific papers in the biomedical literature that seemed to display systematically fabricated data, pointing to the existence of paper mills: unofficial, potentially illegal organizations selling fake scientific manuscripts. In the present article, we share relevant information specifically about the 'raw data' associated with paper mill manuscripts. If a submitted manuscript displays clear indicators of potential paper mill involvement, we found that the raw data at close inspection often raise doubts about their authenticity. In the absence of real data, paper mills may need to fabricate raw data images when responding to requests from journals. Given the necessity to streamline production of fake manuscripts, the alleged raw data might be created using templates. Some potential methods for generating fake Western blot images are discussed. Paying close attention to image data, including graphs, diagrams, plots and tables, ideally at pre‐publication stage, can clearly help prevent publication of incorrect and fabricated information. [ABSTRACT FROM AUTHOR]

X-ray spectroscopy is a valuable technique for the study of many materials systems. Characterizing reactions in situ and operando can reveal complex reaction kinetics, which is crucial to understanding active site composition and reaction mechanisms. In this project, the design, fabrication and testing of an open-source and easy-to-fabricate electrochemical cell for in situ electrochemistry compatible with X-ray absorption spectroscopy in both transmission and fluorescence modes are accomplished via windows with large opening angles on both the upstream and downstream sides of the cell. Using a hobbyist computer numerical control machine and free 3D CAD software, anyone can make a reliable electrochemical cell using this design. Onion-like carbon nanoparticles, with a 1:3 iron-to-cobalt ratio, were drop-coated onto carbon paper for testing in situ X-ray absorption spectroscopy. Cyclic voltammetry of the carbon paper showed the expected behavior, with no increased ohmic drop, even in sandwiched cells. Chronoamperometry was used to apply 0.4 V versus reversible hydrogen electrode, with and without 15 min of oxygen purging to ensure that the electrochemical cell does not provide any artefacts due to gas purging. The XANES and EXAFS spectra showed no differences with and without oxygen, as expected at 0.4 V, without any artefacts due to gas purging. The development of this open-source electrochemical cell design allows for improved collection of in situ X-ray absorption spectroscopy data and enables researchers to perform both transmission and fluorescence simultaneously. It additionally addresses key practical considerations including gas purging, reduced ionic resistance and leak prevention. [ABSTRACT FROM AUTHOR]

Primary cutaneous B-cell lymphomas (PCBCLs) are lymphoproliferative disorders that appear on the skin without evidence of extracutaneous manifestations at the time of diagnosis. There is a lack of evidence-based guidelines for their clinical management due to the availability of very few large scale studies and controlled clinical trials. Here we present and discuss a series of major unmet clinical needs (UCNs) in the management of PCBCLs by a panel of 16 experts involved in research and clinical practice of PCBCL. The Panel produced recommendations on the appropriateness of the clinical decisions concerning the identified clinical needs and proposed research for improving the knowledge needed to solve them. Recommendations and proposals were achieved by multiple-step formalized procedures to reach a consensus after a comprehensive analysis of the scientific literature. Recommendations and proposals lay in the domain of classification uncertainties of PCBCL, optimization of diagnosis, optimization of prognosis, optimization of staging and critical issues on therapeutic strategies with particular focus on new treatments. These recommendations are intended for use not only by experts but above all by dermatologists and hematologists with limited experience in the field of PCBCLs as well as general practitioners., (© 2023 John Wiley & Sons Ltd.)

Rewritable photonic crystal (PC) paper has the potential to significantly reduce the consumption of forest resources in the printing industry, while also being environmentally friendly and efficient. However, traditional PC papers based on solvent or photothermal responses can lead to diffusion, which can hinder printing accuracy. In this study, a novel rewritable PC paper compatible with pin‐printing is presented based on a pressure‐responsive shape‐memory PC paper. High‐resolution printing can be realized by both computer‐programmed 3D‐printed seals and pin‐printing techniques. The information written on this PC rewritable paper can be erased by water, enabling the paper to be rewritten and reused at least 8 times without any change in performance. Furthermore, the information stored on the PC paper is stable and can be stored in ordinary environments for at least 6 months without fading. The PC paper has the capability of multicolor printing with a precision finer than 100 μm and has potential in office papers, smart price tags, and anti‐counterfeiting labels. [ABSTRACT FROM AUTHOR]

Rationale: Rapid on‐site detection of persistent organic pollutants (POP) is highly desirable for environmental protection. Methods: Herein, a rapid on‐site analytical workflow was developed for the investigation of polycyclic aromatic hydrocarbons and perfluorinated compounds using multiwalled carbon nanotube–modified paper spray ionization (PSI) coupled with a miniature ion trap mass spectrometer. Critical parameters regarding PSI and miniature mass spectrometry analysis were optimized. Results: The analytical performance of the developed method was evaluated under optimized conditions, obtaining a short analysis duration of less than 1 min, sufficient linearity with correlation coefficients greater than 0.99, acceptable recovery rates of 93.1%–105.8% with relative standard deviations of between 3.5% and 10.3%, and reasonable sensitivity with limits of detection and quantitation of 2–200 and 5–500 μg/L, respectively. Conclusions: Considering these aspects, it was concluded that the present approach demonstrated a promising solution for rapid on‐site detection of emerging POPs. [ABSTRACT FROM AUTHOR]

The International Conference on Cognitive Modelling is dedicated to understanding how the complex processes of the mind can be explained in terms of detailed inner processing. In this issue, we present four representative papers of this field of research from our 20th meeting, ICCM 2022. This meeting was our first hybrid meeting, with a virtual version happening July 11–15, 2022, and an in‐person event from July 23–27, 2022, held in Toronto, Canada. The four papers presented here were the top‐ranked papers across both the virtual and in‐person events. Three of the papers develop novel computational theories about low‐level components within the mind and how those components result in high‐level phenomena such as motivation, anhedonia, and attention. The final paper demonstrates the use of cognitive modeling to develop novel explanations of a paired associate learning task, and uses those insights to develop and explain human performance in a more complex version of that task. [ABSTRACT FROM AUTHOR]

Zanubrutinib has been approved for the treatment of patients with different lymphoproliferative disorders, and now represents a major breakthrough in the treatment of patients resistant or relapsing after the recommended therapies. Because few systematic studies or comparative randomized clinical trials have been conducted, optimal use of the drug in approved indications is challenging, and questions are emerging on its use in earlier stages of the disorders. This article presents the results of group discussion among an ad hoc constituted panel of experts aimed at identifying and addressing unmet clinical needs (UCNs) in the use of zanubrutinib in the lymphomas which have received the approval of use, specifically Waldenström macroglubulinemia, marginal zone lymphoma and mantle cell lymphoma. Key UCNs were selected according to the criterion of clinical relevance using the Delphi process. The panel produced recommendations and proposals for new studies for the management of the identified UCNs. These recommendations are intended for use not only by expert centers but above all by not experienced hematologists as well as general practitioners., (© 2023 The Authors. Hematological Oncology published by John Wiley & Sons Ltd.)

Electrode architectures significantly influence the electrochemical performance, flexibility, and applications of lithium‐ion batteries (LiBs). However, the conventional bar coating for fabricating electrodes limits the addition of customized architecture or patterns. In this study, as a novel approach, patterns are integrated into electrodes through large‐scale roll‐to‐roll (R2R) flexographic printing. Additionally, flexible, recyclable, and biodegradable paper are innovatively used as a printing substrate during printing LiBs manufacturing, which exhibited superior printability. Moreover, the paper is modified with a thin‐layer Al2O3 to function as the separator in the printed LiB. The Al2O3‐coated paper enables an admirable wettability for printing, excellent mechanical properties for high‐speed R2R manufacturing, and outstanding thermal stability for the safe and stable operation of LiBs. The assembled paper cells exhibit nearly 100% discharge capacity retention after 1000 cycles at 3 C and outstanding rate performance. This work inspires future large‐scale microbatteries manufacturing integrated with high‐resolution architecture designs. [ABSTRACT FROM AUTHOR]

Background: Early and accurate diagnosis of Alzheimer's disease (AD) is critical to improve illness management and outcomes, making neuropsychological measures an essential tool for clinicians. Research has demonstrated that proactive semantic interference (PSI) and failure to recover from PSI (frPSI) are sensitive to cognitive changes in early mild cognitive impairment (MCI) and preclinical AD determined by Aβ load using PET (Loewenstein et al., 2018; Matias‐Guiu et al., 2017; Curiel et al., 2019). These novel constructs are assessed by the LASSI‐L (Crocco et al., 2018; Crocco et al., 2020). The aim of the current study was to compare a new computerized version of this measure, the LASSI‐BC, to the standard paper‐and‐pencil version of the test. Method: 110 cognitively unimpaired (CU) older adults and 79 older adults diagnosed with amnestic MCI (aMCI) were administered the paper‐and‐pencil form of the LASSI‐L, whereas 62 CU and 52 aMCI participants were administered the LASSI‐BC. Their performance was compared to assess the validity of the LASSI‐BC to discriminate between different diagnostic groups. Result: To assess the validity of the computerized version, both the aMCI and CU groups were compared using χ2 test for categorical variables and ANOVA for continuous variables, with adjustment for covariates such as degree of initial learning, sex, education, and language of evaluation. The performance of CU and aMCI groups using either form was relatively commensurate. Notably, sensitivity and specificity of measures of PSI and frPSI on both versions were calculated to assess diagnostic validity, yielding the following Results Sensitivity of 86.5%, Specificity of 88.1%, and Overall Classification of 87.4% for the LASSI‐BC relative to a Sensitivity of 65.0%, Specificity of 83.6%, and Overall Classification of 75.8% obtained for the paper‐and‐pencil LASSI‐L. Conclusion: The LASSI‐BC displayed exceptionally high diagnostic validity which was comparable to the well‐established LASSI‐L. Notably, the advantages of the LASSI‐BC include a more standardized administration, suitability for remote assessment, and an automated scoring mechanism that can be verified by a built‐in audio recording of responses. These findings support the LASSI‐BC, a novel computerized assessment, as an exceptional tool for the early identification of individuals at risk of progressing to dementia. [ABSTRACT FROM AUTHOR]

The release of toilet paper (TP) and food waste (FW) in domestic sewage is a common practice in developed countries. Nevertheless, this practice has started to be used in developing countries where anaerobic digestion is applied. Therefore, this work aimed at evaluating the influence of the presence of TP and FW on the anaerobic digestion process in UASB reactors. During the experiment, two UASB reactors (8L) were fed with synthetic domestic sewage with the addition of toilet paper (TPR) and food waste (FWR) residues, respectively. In the first stage of the experiment (S‐I), the reactors operated with an organic load of 0.97 kg COD.m–3.d–1 (TPR) and 0.96 kgCOD.m–3.d–1 (FWR) and, in the second stage (S‐II), the quantities were increased to 1.58 kgCOD.m–3.d–1 (TPR) and 1.35 kgCOD.m–3.d–1 (FWR). In the experimental period of 110 days, the parameters total and filtered COD, series of solids, pH, alkalinity, and VFA were monitored. The mean removal of total COD was of 79±1% (S‐I) and 75±1% (S‐II) for TPR, and of 81±2% (S‐I) and 76±1% (S‐II) for FWR. Regarding VSS, the mean removal was of 94 ± 2% (S‐I) and 97 ± 1% (S‐II) for TPR, and of 95 ± 3% (S‐I) and 96 ± 1% (S‐II) for FWR. The VFA/TA ratio increased from S‐I (0.03 for TPR and FWR) to S‐II (0.17 to TPR and 0.10 to FWR), responding to the organic load increases, but still in the range of process stability. The added toilet paper or food waste were efficiently removed in both stages, reaching removals higher than 75%. In general, both reactors presented a good performance for the anaerobic process even under changes in organic load and influent composition. This experiment showed the feasibility of the combined treatment of TP or FW with domestic sewage in UASB reactors. [ABSTRACT FROM AUTHOR]

Introduction: In allergic asthma patients, one of the more common phenotypes might benefit from allergen immunotherapy (AIT) as add-on intervention to pharmacological treatment. AIT is a treatment with disease-modifying modalities, the evidence for efficacy is based on controlled clinical trials following standardized endpoint measures. However, so far there is a lack of a consensus for asthma endpoints in AIT trials. The aim of a task force (TF) of the European Academy of Allergy and Clinical Immunology (EAACI) is evaluating several outcome measures for AIT in allergic asthma., Methods: The following domains of outcome measures in asthmatic patients have been evaluated for this position paper (PP): (i) exacerbation rate, (ii) lung function, (iii) ICS withdrawal, (iv) symptoms and rescue medication use, (v) questionnaires (PROMS), (vi) bronchial/nasal provocation, (vii) allergen exposure chambers (AEC) and (viii) biomarkers., Results: Exacerbation rate can be used as a reliable objective primary outcome; however, there is limited evidence due to different definitions of exacerbation. The time after ICS withdrawal to first exacerbation is considered a primary outcome measure. Besides, the advantages and disadvantages and clinical implications of further domains of asthma endpoints in AIT trials are elaborated in this PP., Conclusion: This EAACI-PP aims to highlight important aspects of current asthma measures by critically evaluating their applicability for controlled trials of AIT., (© 2023 The Authors. Allergy published by European Academy of Allergy and Clinical Immunology and John Wiley & Sons Ltd.)

A simple approach was developed to fabricate high‐performance MXene/cellulose (MC)‐based electromagnetic interference (EMI) shielding papers. The oriented MXene sheets located on one side of cellulose filter paper construct a continuous conductive layer, endowing the MC paper with high electrical conductivity (240.1 S/m) and excellent EMI shielding effectiveness (29.3 dB for 0.192‐mm thickness) at an MXene content of 0.72 vol%. Moreover, the EMI shielding effectiveness of four stacked MC papers reached 40.5 dB. This result means that 99.9911% of the microwave radiation is attenuated, and 0.0089% is transmitted, through the four‐piece MXene/cellulose filter papers. Therefore, MC paper has promising properties for excellent EMI shielding materials in current electronic devices. [ABSTRACT FROM AUTHOR]

At the shelf, highly bleached (soft and white) toilet papers samples of different brands and one grayish toilet paper sample of another brand have been selected for spectroscopy and X‐ray diffraction analysis, in order to figure out if they can present allergic components in their chemical composition. Traces of Ca, associated with the presence of CaC2O4H2O was found in one of the highly bleached toilet paper samples and in the grayish one. However, no traces of fungi were found in the scanning electronic microscopy images. A trial correlation between the chemical composition and mechanical properties of the tested toilet paper samples, surprisingly shows that the grayish toilet paper sample presents the highest softness. [ABSTRACT FROM AUTHOR]

Flexible optoelectronic devices have attracted enormous attention as an essential component in next‐generation wearable devices. To meet the trend of biocompatibility, flexibility and low cost, paper‐based optoelectronic devices have become compelling candidates. Moreover, 2D organic–inorganic metal halide perovskites have been extensively studied for the application in flexible optoelectronic devices owing to their long‐term moisture stability, optoelectronic tunability, and multiple quantum well (MQW) structures. Herein, the paper‐based flexible optoelectronic devices are designed by spin‐coating PEDOT:PSS and (iso‐BA)2MAn‐1PbnI3n+1 (n ≥ 1) on regular filter paper with responsivity of 2.62 mA W−1 and response time (τrise/τdecay) of 0.81/0.18 s at 35% relative humidity (RH). Furthermore, the responsivity may be increased by 250% within the humidity range from 35% to 90%, and remains above 92% of the initial value after measured for 1800 s at 60% RH. This work can pave the way for further studies about the humidity effect on perovskites for next‐generation green wearable electronics. [ABSTRACT FROM AUTHOR]

We present a method to fabricate handcrafted thermoelectric devices on standard office paper substrates. The devices are based on thin films of WS2, Te, and BP (P‐type semiconductors) and TiS3 and TiS2 (N‐type semiconductors), deposited by simply rubbing powder of these materials against paper. The thermoelectric properties of these semiconducting films revealed maximum Seebeck coefficients of (+1.32 ± 0.27) mV K−1 and (−0.82 ± 0.15) mV K−1 for WS2 and TiS3, respectively. Additionally, Peltier elements were fabricated by interconnecting the P‐ and N‐type films with graphite electrodes. A thermopower value up to 6.11 mV K−1 was obtained when the Peltier element were constructed with three junctions. The findings of this work show proof‐of‐concept devices to illustrate the potential application of semiconducting van der Waals materials in future thermoelectric power generation as well as temperature sensing for low‐cost disposable electronic devices. [ABSTRACT FROM AUTHOR]

The main insulation structure of the valve‐side winding of converter transformer bears the effect of AC and DC superimposed voltage during operation. The electric field intensity in the pressboard is much higher than that in the pressboard in the AC transformer. This condition increases the probability of failure of insulation structure. Therefore, the design and optimization of the main insulation structure of the valve‐side winding are keys to ensure the stable operation of converter transformer. This study establishes a model of the main insulation structure of the valve‐side winding of the ±1100 kV converter transformer. The influence of the insulating oil–paper configuration on the electric field distribution of the main insulation structure of the valve‐side winding is analysed, and then, an optimization idea is proposed. The oil–paper configuration includes two aspects: oil–paper insulation structural design and combination selection, that is, the influence of typical oil–paper structural design parameters and the aging state of different oil–paper combinations on the electric field distribution. Finally, the optimization idea of the oil–paper configuration for valve‐side winding of converter transformer is obtained, and the established model is optimized. [ABSTRACT FROM AUTHOR]

Open data as an integral part of the open science movement enhances the openness and sharing of scientific datasets. Nevertheless, the normative utilization of data journals, data papers, scientific datasets, and data citations necessitates further research. This study aims to investigate the citation practices associated with data papers and to explore the role of data papers in disseminating scientific datasets. Dataset accession numbers from NCBI databases were employed to analyze the prevalence of data citations for data papers from PubMed Central. A dataset citation practice identification rule was subsequently established. The findings indicate a consistent growth in the number of biomedical data journals published in recent years, with data papers gaining attention and recognition as both publications and data sources. Although the use of data papers as citation sources for data remains relatively rare, there has been a steady increase in data paper citations for data utilization through formal data citations. Furthermore, the increasing proportion of datasets reported in data papers that are employed for analytical purposes highlights the distinct value of data papers in facilitating the dissemination and reuse of datasets to support novel research. [ABSTRACT FROM AUTHOR]

Food is necessary for survival, and contamination can shorten humans' lives on Earth in all dimensions. Real‐time screening of food pollutants, such as toxins, infectious agents, and chemical contaminants, is in high demand today. Thus, a cost‐effective and ecologically benign technology must be developed to detect food contamination in a rapid fashion. Nanoparticle (NP)‐based paper sensors are one of the most important alternatives to traditional methods because these are simple, inexpensive, highly selective, and sensitive tools. This article provides an overview of NP‐based paper sensor techniques for detecting toxic food contaminants. [ABSTRACT FROM AUTHOR]

Background: Management of major hemorrhage frequently requires massive transfusion (MT) support, which should be delivered effectively and efficiently. We have previously developed a clinical decision support system (CDS) for MT using a multicenter multidisciplinary user‐centered design study. Here we examine its impact when administering a MT. Study Design and Methods: We conducted a randomized simulation trial to compare a CDS for MT with a paper‐based MT protocol for the management of simulated hemorrhage. A total of 44 specialist physicians, trainees (residents), and nurses were recruited across critical care to participate in two 20‐min simulated bleeding scenarios. The primary outcome was the decision velocity (correct decisions per hour) and overall task completion. Secondary outcomes included cognitive workload and System Usability Scale (SUS). Results: There was a statistically significant increase in decision velocity for CDS‐based management (mean 8.5 decisions per hour) compared to paper based (mean 6.9 decisions per hour; p.003, 95% CI 0.6–2.6). There was no significant difference in the overall task completion using CDS‐based management (mean 13.3) compared to paper‐based (mean 13.2; p.92, 95% CI ‐1.2–1.3). Cognitive workload was statistically significantly lower using the CDS compared to the paper protocol (mean 57.1 vs. mean 64.5, p.005, 95% CI 2.4–12.5). CDS usability was assessed as a SUS score of 82.5 (IQR 75–87.5). Discussion: Compared to paper‐based management, CDS‐based MT supports more time‐efficient decision‐making by users with limited CDS training and achieves similar overall task completion while reducing cognitive load. Clinical implementation will determine whether the benefits demonstrated translate to improved patient outcomes. [ABSTRACT FROM AUTHOR]