1. Multifunctional osthole liposomes and brain targeting functionality with potential applications in a mouse model of Alzheimer's disease.
- Author
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Ni, Ying-Nan, Kong, Liang, Li, Xue-Tao, Xiao, Hong-He, Wu, Yu-Tong, Liang, Xi-Cai, Lin, Ying, Li, Wan-Yi, Deng, Yan, Li, Yan, Shi, Yue, Cheng, Lan, Li, Hong-Yan, Ju, Rui-Jun, and Yang, Jing-Xian
- Subjects
LABORATORY mice ,LIPOSOMES ,ALZHEIMER'S disease ,BIOAVAILABILITY ,ANIMAL disease models ,BLOOD-brain barrier ,DOSAGE forms of drugs - Abstract
Osthole (Ost) is a coumarin compound and a potential drug for Alzheimer's disease (AD). However, the effectiveness of Ost is limited by solubility, bioavailability, and low permeability of the blood-brain barrier. In this study, we constructed Ost liposomes with modified CXCR4 on the surface (CXCR4-Ost-Lips), and investigated the intracellular distribution of liposomes in APP-SH-SY5Y cells. In addition, the neuroprotective effect of CXCR4-Ost-Lips was examined in vitro and in vivo. The results showed that CXCR4-Ost-Lips increased intracellular uptake by APP-SH-SY5Y cells and exerted a cytoprotective effect in vitro. The results of Ost brain distribution showed that CXCR4-Ost-Lips prolonged the cycle time of mice and increased the accumulation of Ost in the brain. In addition, CXCR4-Ost-Lips enhanced the effect of Ost in relieving AD-related pathologies. These results indicate that CXCR4-modified liposomes are a potential Ost carrier to treat AD. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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