1. Low-level HIV viremia is associated with low antiretroviral prescription refill rates and social deprivation.
- Author
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Goupil de Bouillé, Jeanne, Collignon, Marion, Capsec, Jean, Guillon, Leslie, Le Moal, Gwenael, Barin, Francis, Roncato, Mariam, Hocqueloux, Laurent, Stefic, Karl, Bernard, Louis, and Gras, Guillaume
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HIV infections , *HIV-positive persons , *ACADEMIC medical centers , *CONFIDENCE intervals , *VIRAL load , *MULTIVARIATE analysis , *ANTIRETROVIRAL agents , *CASE-control method , *FISHER exact test , *MANN Whitney U Test , *SOCIOECONOMIC factors , *T-test (Statistics) , *DRUGS , *VIREMIA , *DESCRIPTIVE statistics , *CHI-squared test , *PATIENT compliance , *POLYMERASE chain reaction , *ODDS ratio , *DATA analysis software - Abstract
Optimal management of patients experiencing persistent low-level viremia (LLV) remains challenging and poorly understood. This study aimed to assess the association between poor antiretroviral treatment (ARV) adherence and persistent LLV. ADHELOW is a sub-study of the ECHEC cohort comprising HIV-infected adults with virological failure (viral load>50 copies/mL). Patients were recruited in 2013–2015 from 4 French university hospitals. Those with LLV (i.e., ≥2 viral load measurements between 50 and 500 copies/mL) were selected and matched on age and sex to 3 controls with virological suppression. The adherence rate was estimated using pharmacy-delivered prescription refills over one year. Overall, 60 patients were included (15 LLV and 45 controls). Mean age was 50.20 years, M/F sex ratio was 14 and mean EPICES (social deprivation) score was 42.90. In univariable analyses, LLV patients had significantly lower adherence (<80%: 53.30% vs. 6.67%, p < 0.01) and were more likely to have an EPICES score >40.2 (60.00% vs. 24.44%, p < 0.01). In multivariable analysis, these two variables remained significantly associated with LLV (OR 31.49, CI 95% [4.54–218.70]) and OR 11.00 (CI 95% [1.87–218.70], respectively). Poor long-term treatment adherence, estimated by prescription refills, was strongly associated with LLV. This reinforces the message that adherence counseling should be the primary intervention to overcome LLV. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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