1. Antimicrobial metal-based thiophene derived compounds.
- Author
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Yasmeen, Shakeela, Sumrra, Sajjad Hussain, Akram, Muhammad Safwan, and Chohan, Zahid H.
- Subjects
THIOPHENE derivatives ,COPPER compounds ,NICKEL compounds ,ZINC compounds ,ESCHERICHIA coli - Abstract
A novel series of thiophene derived Schiff bases and their transition metal- [Co(II), Cu(II), Zn(II), Ni(II)] based compounds are reported. The Schiff bases act as tridentate ligands toward metal ions via azomethine-N, deprotonated-N of ammine substituents and S-atom of thienyl moiety. The synthesized ligands along with their metal complexes were screened for theirin vitroantibacterial activity against six bacterial pathogens(Escherichia coli,Shigella flexneri,Pseudomonas aeruginosa,Salmonella typhi,Staphylococcus aureusandBacillus subtilis) and for antifungal activity against six fungal pathogens (Trichophytonlongifusus,Candida albicans,Aspergillus flavus,Microsporum canis,Fusarium solaniandCandida glabrata). The results of antimicrobial studies revealed the free ligands to possess potential activity which significantly increased upon chelation. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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