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Background and objective: In light of the importance of mental health in today life, attending to mental health of theyouth to pave the way for a better future is of paramount importance. Various factors can influence mental health, one of which is the quality of attachment to and trust in God. The aim of this paper was to examine the capability of this quality so as to predict the mental health of Tehran University students. Methods: This research was of correlation type which utilized analysis of regression and the multiple correlation factor to analyze data. The participants were 300 students studying at University of Tehran (207 males and 93 females) who were stratified into theology 34, biology 38, art 21, literature 54, economics 21, technical 68, English Language 38, and Psychology 26. Data collection was done on the basis of the revised list of mental symptoms, Kirkpatrictest of attachment to God method and Rahyaft questionnaire in life events. Results: in this study, it was demonstrated that 29% of the variance of students' mental health was represented by factors of attachment to God, and the value of F (found in the analysis of regression) showed that only the aspects of attributive and action were meaningful at the significance level of below 0.5% among other variances and the other predictors of students' metal health all were meaningful at the significance level of below 0.01%. Conclusion: The findings of the study demonstrate the relation between spirituality and mental health in such a way that mental health can be helped by strengthening and reinforcing the students' sources of spirituality including trust in God. [ABSTRACT FROM AUTHOR]