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The article presents guidelines for the management of cold urticaria, a rare condition characterized by skin lesions and potentially life-threatening systemic reactions to cold exposure. The guidelines recommend limited paraclinical examinations, such as blood count and C-reactive protein tests, to rule out other diseases. The guidelines also propose a severity classification for cold urticaria and recommend the use of an ice cube test for diagnosis. Treatment options include antihistamines and, in severe cases, autoinjectable adrenaline kits and omalizumab. The guidelines were developed by a multidisciplinary working group and are available on a dedicated website. [Extracted from the article]

Of the seven patients in this subset, six had further injections and only one relapsed, although less severely, and two patients presented with different cutaneous reactions following the next injection. Only two patients had a classical Sweet syndrome histology showing a diffuse dermal neutrophilic infiltrate, while two had a dermal infiltrate of histiocyte-like immature myeloid cells compatible with histiocytoid Sweet syndrome (Figure 1c, d). Sweet-like syndrome and multiple COVID arm syndrome following COVID-19 vaccines: "specific" patterns in a series of 192 patients. [Extracted from the article]