1. Immunological Correlates of Prevention of the Onset of Seasonal H3N2 Influenza.
- Author
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Okuda, Moe, Sakai-Tagawa, Yuko, Koga, Michiko, Koibuchi, Tomohiko, Kikuchi, Tadashi, Adachi, Eisuke, Ahyoung Lim, Lay, Yamamoto, Shinya, Yotsuyanagi, Hiroshi, Negishi, Kyota, Jubishi, Daisuke, Yamayoshi, Seiya, and Kawaoka, Yoshihiro
- Subjects
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INFLUENZA , *SEASONAL influenza , *VIRAL shedding , *ANTIBODY-dependent cell cytotoxicity , *INFLUENZA A virus, H3N2 subtype , *VIRUS diseases , *ENZYME-linked immunosorbent assay , *INFLUENZA vaccines , *PROTEINS , *IMMUNOMODULATORS , *SEASONS , *GLYCOSIDASES , *VIRAL antibodies , *INFLUENZA A virus, H1N1 subtype - Abstract
On influenza virus infection or vaccination, immune responses occur, including the production of antibodies with various functions that contribute to protection from seasonal influenza virus infection. In the current study, we attempted to identify the antibody functions that play a central role in preventing the onset of seasonal influenza by comparing the levels of several antibody titers for different antibody functions between 5 subclinically infected individuals and 16 patients infected with seasonal H3N2 virus. For antibody titers before influenza virus exposure, we found that the nAb titers and enzyme-linked immunosorbent assay titers against hemagglutinin and neuraminidase (NA) proteins in the subclinically infected individuals were significantly higher than those in the patients, whereas the NA inhibition titers and antibody-dependent cellular cytotoxicity activities did not significantly differ between subclinically infected individuals and infected patients. These results suggest that nAb and enzyme-linked immunosorbent assay titers against hemagglutinin and NA serve as correlates of symptomatic influenza infection. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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