1. Low Serum Vitamin D Levels May Contribute to Gastric Dysmotility in de novo Parkinson's Disease.
- Author
-
Kwon, Ki Young, Jo, Kwang Deog, Lee, Moon Kyu, Oh, Minyoung, Kim, Eyu Nyong, Park, Jinse, Kim, Ji Sun, Youn, Jinyoung, Oh, Engseok, Kim, Hee-Tae, Oh, Mi Young, and Jang, Wooyoung
- Subjects
VITAMIN D ,GASTRIC emptying ,PARKINSON'S disease ,GASTROPARESIS ,SERUM - Abstract
Background and Objectives: Gastrointestinal dysfunction is a common non motor symptom in Parkinson's disease (PD). However, the potential association between vitamin D and gastroparesis in PD has not been previously investigated. The aim of this study was to compare vitamin D levels between drug-naive de novo PD patients with normal gastric emptying and those with delayed gastric emptying. Methods: Fifty-one patients with drug-naive de novo PD and 20 age-matched healthy controls were enrolled in this study. Gastric emptying time (GET) was assessed by scintigraphy, and gastric emptying half-time (T
1/2 ) was determined. The PD patients were divided into a delayed-GET group and a normal-GET group. Results: The serum 25-hydroxyvitamin D 3 levels were decreased in the delayed-GET group compared with the normal-GET and control groups (11.59 ± 4.90 vs. 19.43 ± 6.91 and 32.69 ± 4.93, respectively, p < 0.01). In the multivariate model, the serum 25-hydroxyvitamin D3 level was independently associated with delayed gastric emptying in PD patients. Conclusions: Vitamin D status may be an independent factor for gastric dysmotility in PD. Although the underlying mechanism remains to be characterized, vitamin D status may play a role in the pathogenesis of delayed gastric emptying in drug-naive PD. [ABSTRACT FROM AUTHOR]- Published
- 2016
- Full Text
- View/download PDF