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Your search keyword '"Wu, Xiaowen"' showing total 177 results
Start Over Author "Wu, Xiaowen" Language english Publisher elsevier b.v.
177 results on '"Wu, Xiaowen"'

50. Apatinib combined with camrelizumab in advanced acral melanoma patients: An open-label, single-arm phase 2 trial.

Author

Wang, Xuan, Wu, Xiaowen, Yang, Yue, Xu, Weiran, Tian, Hui, Lian, Bin, Chi, Zhihong, Si, Lu, Sheng, Xinan, Kong, Yan, Zhou, Li, Mao, Lili, Li, Siming, Tang, Bixia, Yan, Xieqiao, Bai, Xue, Guo, Jun, and Cui, ChuanLiang

Subjects
*THERAPEUTIC use of antineoplastic agents, *FOOT diseases, *IMMUNE checkpoint inhibitors, *CLINICAL trials, *MELANOMA, *SKIN tumors, *PROTEIN-tyrosine kinase inhibitors, *TREATMENT effectiveness, *DESCRIPTIVE statistics, *PROTEINURIA, *PATIENT safety, *IMMUNOTHERAPY, *EVALUATION
Abstract

At present, immune monotherapy and combination therapy has not shown satisfactory effects on acral melanoma, and still no standard treatment is available for advanced acral melanoma. Here, a phase II trial was performed to explore the safety and efficacy of apatinib combined with camrelizumab in advanced acral melanoma patients as first-line therapy (NCT03955354). Patients with pathologically confirmed, locally unresectable or metastatic treatment native acral melanoma received 250 mg apatinib once daily and camrelizumab 200 mg once every two weeks intravenously every 28-day cycle. The primary end-point was objective response rate and the secondary end-points were disease control rate, overall survival, progression-free survival and safety. Thirty patients were recruited between January 2015 and January 2022. Among them, 21 (70.0%) had stage IV, and a median tumour burden was 50 mm (range: 11–187). Objective response rate was 24.1%, and 7 of 29 patients had an anti-tumour response, including partial response (n = 5) and complete response (n = 2). Disease control rate was 82.8%, median progression-free survival was 7.39 months (confidence interval: 3.65-9.92), and median overall survival was 13.4 months (confidence interval: 1.9–25.0). Grade 3–4 treatment-related toxicity (grade 3 50.5%; grade 4 3.3%) included transaminase elevations, proteinuria, leukocytopenia, vomiting, diarrhea and drug-induced liver injury. No treatment-related mortality occurred. The mutations of TTN, MUC16, VPS13D, ALPK2 and SCUBE1 showed significant alterations with survival outcome. Apatinib combined with camrelizumab showed manageable safety profile and reasonable anti-tumour activity in advanced acral melanoma patients as first-line therapy. • Acral melanoma. • Safety and efficacy of apatinib combined with camrelizumab as first-line therapy. • The first trial of immunotherapy combi anti-angiogenesis inhibitor in acral melanoma. [ABSTRACT FROM AUTHOR]

Published
2023
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