1. Convergence of 3D printed biomimetic wound dressings and adult stem cell therapy.
- Author
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Shafiee, Abbas, Cavalcanti, Amanda S., Saidy, Navid T., Schneidereit, Dominik, Friedrich, Oliver, Ravichandran, Akhilandeshwari, De-Juan-Pardo, Elena M, and Hutmacher, Dietmar W.
- Subjects
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BIOLOGICAL dressings , *CRYOPRESERVATION of cells , *HYDROCOLLOID surgical dressings , *STEM cell treatment , *SCARS , *SKIN regeneration , *STROMAL cells - Abstract
Biomimetically designed medical-grade polycaprolactone (mPCL) dressings are 3D-printed with pore architecture and anisotropic mechanical characteristics that favor skin wound healing with reduced scarring. Melt electrowritten mPCL dressings are seeded with human gingival tissue multipotent mesenchymal stem/stromal cells and cryopreserved using a clinically approved method. The regenerative potential of fresh or frozen cell-seeded mPCL dressing is compared in a splinted full-thickness excisional wound in a rat model over six weeks. The application of 3D-printed mPCL dressings decreased wound contracture and significantly improved skin regeneration through granulation and re-epithelialization compared to control groups. Combining 3D-printed biomimetic wound dressings and precursor cell delivery enhances physiological wound closure with reduced scar tissue formation. Image 1 [ABSTRACT FROM AUTHOR]
- Published
- 2021
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