1. Specific Hypothalamic Neurons Required for Sensing Conspecific Male Cues Relevant to Inter-male Aggression.
- Author
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Chen AX, Yan JJ, Zhang W, Wang L, Yu ZX, Ding XJ, Wang DY, Zhang M, Zhang YL, Song N, Jiao ZL, Xu C, Zhu SJ, and Xu XH
- Subjects
- Aggression physiology, Animals, Clozapine analogs & derivatives, Clozapine pharmacology, Female, Male, Mice, Rats, Septal Nuclei physiology, Vomeronasal Organ physiology, Aggression psychology, Cues, Hypothalamus, Posterior physiology, Neurons physiology, Urine physiology
- Abstract
The hypothalamus regulates innate social interactions, but how hypothalamic neurons transduce sex-related sensory signals emitted by conspecifics to trigger appropriate behaviors remains unclear. Here, we addressed this issue by identifying specific hypothalamic neurons required for sensing conspecific male cues relevant to inter-male aggression. By in vivo recording of neuronal activities in behaving mice, we showed that neurons expressing dopamine transporter (DAT
+ ) in the ventral premammillary nucleus (PMv) of the hypothalamus responded to male urine cues in a vomeronasal organ (VNO)-dependent manner in naive males. Retrograde trans-synaptic tracing further revealed a specific group of neurons in the bed nucleus of the stria terminalis (BNST) that convey male-relevant signals from VNO to PMv. Inhibition of PMvDAT+ neurons abolished the preference for male urine cues and reduced inter-male attacks, while activation of these neurons promoted urine marking and aggression. Thus, PMvDAT+ neurons exemplify a hypothalamic node that transforms sex-related chemo-signals into recognition and behaviors., Competing Interests: Declaration of Interests The authors declare no competing interests., (Copyright © 2020 Elsevier Inc. All rights reserved.)- Published
- 2020
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