81 results on '"Mowat, A P"'
Search Results
2. Impact of introducing a faecal immunochemical test (FIT) for haemoglobin into primary care on the outcome of patients with new bowel symptoms: a prospective cohort study
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Callum G Fraser, Robert J C Steele, Craig Mowat, Jayne Digby, Judith A Strachan, Rebecca McCann, Christopher Hall, Duncan Heather, and Francis Carey
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Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
ObjectiveTo determine whether a faecal immunochemical test (FIT) for faecal haemoglobin concentration (f-Hb) can be safely implemented in primary care as a rule-out test for significant bowel disease (SBD) (colorectal cancer (CRC), higher risk adenoma (HRA) and inflammatory bowel disease (IBD)) when used as an adjunct to the clinical assessment of new bowel symptoms.DesignSingle-centre prospective cohort study of all patients who attended primary care and submitted a FIT in the first calendar year of the service beginning December 2015. f-Hb was estimated using HM-JACKarc (Kyowa Medex) with a clinical cut-off of ≥10 µg Hb/g faeces. Incident cases of CRC were verified via anonymised record linkage to the Scottish Cancer Registry.Results5422 patients submitted 5660 FIT specimens, of which 5372 were analysed (positivity: 21.9%). 2848 patients were referred immediately to secondary care and three with f-Hb
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- 2019
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3. Hepatic haemangiomata: diagnosis and management.
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LARCHER, V. F., HOWARD, E. R., MOWAT, ALEX P., and Mowat, A P
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HEPATIC artery surgery ,HEART failure ,HEMANGIOMAS ,HEPATIC artery ,LIVER ,LIVER tumors ,RADIOGRAPHY ,RADIONUCLIDE imaging ,DISEASE complications - Abstract
Five cases of hepatic haemangioma are described, and a sixth (previously reported) is reviewed. Clinical features, investigation, and management are described to show the great variability of the complications and prognosis. Five children presented in the first 10 weeks of life with hepatomegaly; 4 developed congestive cardiac failure; 3 had cutaneous haemangiomata. One child presented at age 4 years with hepatomegaly and anaemia, and on investigation had features of chronic disseminated intravascular coagulation. Focal decrease or patchiness in hepatic uptake of technetium-99m colloid, and abnormal intrahepatic circulation was shown in all cases. In 3 children liver biopsy was performed to exclude malignant disease. In one patient there was spontaneous regression of the tumour by age 3 years. In 3 cases hepatic artery ligation was necessary to control congestive cardiac failure which had persisted despite treatment with digoxin, diuretics, and oral corticosteroids, a procedure which was without complications after up to 8 years. One infant with intractable portal hypertension, hepatic vein obstruction, and severe cholestasis died with persisting alimentary haemorrhage and intra-abdominal sepsis. One child aged 4 years showed no immediate response to hepatic artery ligation but the size of her tumour got smaller and the clinical features diminished after irradiation. These tumours cause considerable morbidity and have a high reported mortality. If congestive cardiac failure is not rapidly controlled, hepatic artery ligation should be performed. [ABSTRACT FROM AUTHOR]
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- 1981
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4. Immune responses to liver membrane antigens in patients with cystic fibrosis and liver disease.
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MIELI-VERGANI, GIORGINA, PSACHAROPOULOS, HELEN T., NICHOLSON, ANDREA M., EDDLESTON, A. L. W. F., MOWAT, ALEX P., WILLIAMS, ROGER, Mieli-Vergani, G, Psacharopoulos, H T, Nicholson, A M, Eddleston, A L, Mowat, A P, and Williams, R
- Abstract
Biliary obstruction by viscid mucus, although important, may not be the only factor for the development of liver disease in some patients with cystic fibrosis. In the present study the relationship between immune responses to liver antigens and the presence of liver damage was investigated using the leucocyte migration test and lymphocyte cytotoxicity to isolated rabbit hepatocytes. Inhibition of leucocyte migration by purified liver-specific lipoprotein, derived from hepatocyte plasma membrane, was found in 9 of 11 children with liver disease, but in only 5 of 14 with cystic fibrosis and no overt liver disease (P < 0.025). Lymphocyte toxicity to isolated rabbit hepatocytes was significantly increased in 10 of 13 children with liver disease, but in only 6 of 29 children without liver disease (P < 0.001). Experiments using lymphocyte subpopulations showed that the cytotoxicity was mediated by a non-T-cell population and could be blocked with liver-specific lipoprotein in 7 out of 10 cases, suggesting that the reaction in these patients was specifically directed against liver-specific lipoprotein. The study suggests that sensitisation against liver membrane antigens, whether arising primarily or secondarily in some way to other hepatic lesions, may contribute to the progression of liver damage in cystic fibrosis. [ABSTRACT FROM AUTHOR]
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- 1980
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5. Hepatic scintigraphy in management of infants and children with liver disease.
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SMITH, ARNOLD L., MOWAT, ALEX P., WILLIAMS, ROGER, Smith, A L, Mowat, A P, and Williams, R
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Scintiscans of liver and spleen using technetium 99m sulphur colloid in 15 infants with extrahepatic biliary atresia and 11 infants with severe obstructive jaundice (7 with genetic deficiency of alpha 1-antitrypsin) showed similar hepatic size, pattern of isotope uptake, and splenic abnormality with no distinguishing features. In 37 older children with a variety of liver disorders, the scan was invaluable in showing filling defects in five instances. Selenomethionine was taken up not only by the two filling defects due to hepatoblastoma but also in a haemangioendothelioma. In the remaining patiens liver scanning confirmed hepatic abnormality and the necessity for more specific invasive diagnostic investigations. [ABSTRACT FROM AUTHOR]
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- 1977
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6. Extrahepatic biliary atresia versus neonatal hepatitis. Review of 137 prospectively investigated infants.
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MOWAT, ALEX P., PSACHAROPOULOS, H. T., WILLIAMS, ROGER, Mowat, A P, and Williams, R
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BILE duct abnormalities ,BILE duct surgery ,JEJUNUM surgery ,LIVER surgery ,HUMAN abnormalities ,ALPHA 1-antitrypsin deficiency ,BIOPSY ,NEONATAL jaundice ,LIVER ,LIVER function tests ,LONGITUDINAL method ,FLUORESCENT dyes - Abstract
In a prospective regional survey of neonatal hepatitis syndrome 32 infants had extrahepatic biliary atresia (EHBA) and 103 had hepatitis. No cause for the lesion was found in infants with extrahepatic biliary atresia, but in 32 with hepatitis a specific cause was identified, 24 having genetic deficiency of the serum protein alpha1-antitrypsin. No differences were observed in parental age, mother's health in pregnancy, month of birth, birth order, or sex of the infants. Familial idiopathic hepatitis occurred in 3 of 67 sibs of patients with idiopathic hepatitis, but the 33 sibs of EHBA patients had no liver disease. Of the infants with hepatitis, 36 were of low birthweight, less than 2.5 kg, and 23 were born prematurely. Infants with biliary atresia were all of normal birthweight and only one was born prematurely. Consideration of clinical and biochemical abnormalities in the first 2 months of life showed no differences between the two groups except that infants with EHBA were more commonly jaundiced from birth (80%) and had more frequently acholic stools (83%). The frequency of these features in patients with hepatitis being 68% and 52%. Standard tests of liver function were not discriminatory. Percutaneous liver biopsies were diagnostic in 75% of those with EHBA and in 92% of those with hepatitis. The I131 Rose Bengal faecal excretion was less than 10% in 26 of 28 infants with EHBA and in only 5 of 18 with hepatitis. These latter two investigations together allowed a correct preoperativer diagnosis of EHBA in all instances. Bile drainage was achieved surgically in only 3 cases. A major reason for these poor results may have been the late referral of cases for diagnosis and laparotomy, which should be performed as soon as the diagnosis is suspected and always by 70 days of age. [ABSTRACT FROM AUTHOR]
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- 1976
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7. Failure of laboratory and radiological studies to predict jejunal mucosal atrophy.
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SANDERSON, MARY C., DAVIS, L. R., MOWAT, ALEX P., Sanderson, M C, and Mowat, A P
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Of 58 children with suspected malabsorption, 27 were shown to have subtotal or partial atrophy, and 31 had normal mucosal histology. Oral glucose tolerance tests, faecal fat excretion, D-xylose excretion tests, Prosparol absorption studies, haematological investigations, and radiological examination of the small bowel failed to distinguish these two groups and frequently gave misleading results. It is concluded that in suspected coeliac disease small intestinal biopsy should be performed as a primary investigation. [ABSTRACT FROM AUTHOR]
- Published
- 1975
8. Immunohistochemical features of the portal tract mononuclear cell infiltrate in chronic aggressive hepatitis.
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Senaldi, Giorgio, Portmann, Bernard, Mowat, Alex P., Mieli-Vergani, Giorgina, Vergani, Diego, Senaldi, G, Portmann, B, Mowat, A P, Mieli-Vergani, G, and Vergani, D
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The portal tract mononuclear cell infiltrate has been characterised in 28 liver biopsy samples showing features of chronic aggressive hepatitis from 12 patients with autoimmune chronic active hepatitis, 12 with primary sclerosing cholangitis, and four with other chronic liver diseases (two with alpha 1-antitrypsin deficiency, one with Wilson's disease, and one with chronic hepatitis B infection). In all patients liver disease had started in childhood. The mononuclear cell infiltrate was investigated by a two step immunoperoxidase technique using monoclonal antibodies to: total, alpha/beta T cell receptor positive, helper/inducer, suppressor/cytotoxic T lymphocytes; B lymphocytes; killer/natural killer cells; monocyte/macrophages; and to the activation markers HLA-DR antigens, interleukin 2 receptor (IL-2R), transferrin receptor, and 4F2Ag. In all samples the infiltrate consisted of mainly alpha/beta T cell receptor T lymphocytes. Although T helper/inducer cells predominated in patients with autoimmune chronic active hepatitis, T suppressor/cytotoxic lymphocytes were preponderant in patients with primary sclerosing cholangitis and the other chronic liver diseases. Killer/natural killer cells accounted for up to 25% of the mononuclear cell infiltrate in patients with autoimmune chronic active hepatitis, being rare or absent in the other diseases. Monocytes/macrophages were always found, but they were more numerous in primary sclerosing cholangitis than in the other chronic liver diseases. B lymphocytes were rare or absent in all subjects. Activated mononuclear cells were present in all subjects, but although in patients with autoimmune chronic active hepatitis and primary sclerosing cholangitis most cells of the infiltrate expressed HLA-DR antigens and up to 75% IL-2R, in other forms of chronic liver diseases HLA-DR positive cells were less common and IL-2R positive cells ere rare or absent. These results show that the cells responsible for the histological characteristics of chronic aggressive hepatitis vary in their functional phenotype and state of activation according to the type of underlying liver disorder, confirming the involvement of different pathogenetic mechanisms. [ABSTRACT FROM AUTHOR]
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- 1992
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9. Liver transplantation.
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Chiyende, Judith, Mowat, Alex P., Chiyende, J, and Mowat, A P
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- 1992
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10. Earlier identification of biliary atresia and hepatobiliary disease: selective screening in the third week of life.
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Mowat, Alex P., Davidson, L. L., Dick, M. C., and Mowat, A P
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- 1995
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11. Jaundice at 14 days of age: exclude biliary atresia.
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HUSSEIN, M., HOWARD, E. R., MIELI-VERGANI, G., MOWAT, ALEX P., and Mowat, A P
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- 1991
12. Endoscopic retrograde cholangiopancreatography in infantile cholestasis.
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Wilkinson, Mark L., Mieli-Vergani, Giorgina, Ball, Colin, Portmann, Bernard, Mowat, Alex P., Wilkinson, M L, Mieli-Vergani, G, Ball, C, Portmann, B, and Mowat, A P
- Abstract
The difficulty of distinguishing surgically correctable causes of conjugated hyperbilirubinaemia in infants from other causes means that some infants may undergo laparotomy and intraoperative cholangiography unnecessarily, and others may be referred for surgery too late. In an attempt to improve the diagnostic accuracy in infants with conjugated hyperbilirubinaemia when standard methods produced equivocal results, we have been using prototype paediatric duodenoscopes (PJF 7.5 and XPJF 8.0; Olympus) to perform endoscopic retrograde cholangiopancreatography (ERCP). From 159 infants with conjugated hyperbilirubinaemia, 11 were referred for ERCP, which was performed in nine. In four in whom bile ducts were definitely visualised laparotomy was avoided. Operative cholangiography confirmed patent bile ducts in one in whom visualisation had been uncertain. Three of four in whom bile ducts were not seen had extrahepatic biliary atresia. Visible bile drainage in the fourth excluded atresia. No major complications ensued but there was radiological evidence of gall bladder perforation in one (common hepatic duct block) and overinflation with air was a problem until finer cannulae (Wilson-Cook) were introduced. In appropriately selected patients with conjugated hyperbilirubinaemia, ERCP with paediatric duodenoscopes in experienced hands may provide useful diagnostic information. [ABSTRACT FROM AUTHOR]
- Published
- 1991
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13. CORRESPONDENCE.
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Dykes, Evelyn H., Freeth, S.J., Marteau, Theresa M., Seedhouse, David, Sheppard, M., Fraser, C.G., Fogarty, Yvonne, Mowat, Alex P., Mielli-Vergani, Giorgina, Howard, Edward R., Dawood, Richard M., Porter, Alison W., Kishen, Roop, Bowles, Brenda J.M., Davies, Robert J.O., Hopkin, Julian M., Carson, Peter, and Chew, C.A.
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LETTERS to the editor ,PROFESSIONAL ethics of surgeons - Abstract
Presents several letters to the editor published in the 'British Medical Journal' as of August 1989. Inquiries related to selection of surgeon as leader for the trauma team; Interrelations between the death at Lake Nyos and carbon dioxide emission; Scrutiny on the ethical practices involved in clinical research.
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- 1989
14. Alpha 1-antitrypsin deficiency, complement activation, and chronic liver disease.
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Littleton, E T, Bevis, L, Hansen, L J, Peakman, M, Mowat, A P, Mieli-Vergani, G, and Vergani, D
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Activation of the complement system, the main humoral mediator of inflammation, is restrained by the action of enzyme inhibitors including alpha 1-antitrypsin. Deficiency leads to chronic liver disease in about one in five children with this genetic defect. Complement activation was investigated in 34 children with alpha 1 AT deficiency (12 with minimal, 10 with moderate, and 12 with severe liver disease) and in 38 sex and age matched normal children by measuring the complement parent molecules C3, C4, the C3d fragment and by calculating the C3d:C3 ratio. C3 and C4 were lower in children with severe liver disease compared with controls, indicating impairment of hepatic protein synthesis or complement consumption. The C3d activation fragment was higher in all the patient groups when compared with controls while the C3d:C3 ratio, a measure of activation independent of the concentrations of the parent molecule, was higher in patients than in controls and increased with the degree of disease severity. These results suggest that complement may have a role in the pathogenesis of the chronic liver disease associated with alpha 1AT deficiency. [ABSTRACT FROM PUBLISHER]
- Published
- 1991
15. Class I and class II major histocompatibility complex antigens on hepatocytes: importance of the method of detection and expression in histologically normal and diseased livers.
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Senaldi, G, Lobo-Yeo, A, Mowat, A P, Mieli-Vergani, G, and Vergani, D
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Methodological differences in major histocompatibility complex (MHC) antigen detection were investigated on isolated, viable hepatocytes and cryostat hepatic sections from 27 children with liver disorders, six of whom had normal histology. Class I antigens were constantly found on sections using a three step immunoperoxidase technique after acetone/chloroform fixation, other techniques being less sensitive, or on isolated hepatocytes by indirect immunofluorescence alone. With mechanical isolation the percentage of positivity ranged from 85 to 100%, while with collagenase isolation it ranged from 22 to 49% on immediate testing, and from 53 to 80% after 24 hour incubation. Class II antigens were only detected in one patient with autoimmune chronic active hepatitis and two with primary sclerosing cholangitis. Flow cytofluorimetric analysis in 11 cases confirmed class II or class I positivity, or both, on isolated hepatocytes, allowing MHC antigen expression on hepatocytes to be measured. Class I and II antigen detection on hepatocytes is influenced by the technique used. Although class I antigens are invariably expressed on hepatocytes, class II antigens are only found on hepatocytes from patients with immune mediated liver disorders. [ABSTRACT FROM PUBLISHER]
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- 1991
16. Ten minute radiopharmaceutical test in biliary atresia.
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EL TUMI, M. A., CLARKE, M. B., BARRETT, J. J., and MOWAT, A. P.
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To provide an objective rapid means of excluding extrahepatic biliary atresia (atresia), a hepatic index was devised from the ratio of the net hepatic to cardiac distribution of 99mTc diisopropyl iminodiacetic acid or methylbrom iminodiacetic acid between 2.5 and 10 minutes after injection. The hepatic index was compared with subjective assessment of abdominal scintigraphy performed repeatedly over 24 hours. In 22 infants with hepatitis the hepatic index ranged from 5.03 to 14.9, one having no excretion on scintiscan. In 26 infants with atresia the index ranged from 0.49 to 4.26 and in two with paucity of intralobular bile ducts it was 1.85 and 3.69. None of these infants had excretion apparent on scintiscans. Similarly, low hepatic indices occurred in four infants with liver dysfunction but pigmented stools, three of whom had no excretion apparent on scintiscans. These preliminary studies suggest that a hepatic index of greater than 5 is much more rapid and as specific in excluding atresia as repeated abdominal scintigraphy. [ABSTRACT FROM AUTHOR]
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- 1987
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17. 12 articles of 1926.
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Forfar, J O, Mowat, A P, Clarke, C A, Chiswick, M L, Gordon, N, McNeish, A S, Booth, I W, Bower, B D, Arneil, G C, Walker-Smith, J A, Smithells, R W, Wigglesworth, J S, and Robinson, R J
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- 1986
18. Hepatitis syndrome in infancy--an epidemiological survey with 10 year follow up.
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DICK, M. C. and MOWAT, A. P.
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BILE duct abnormalities ,ALPHA 1-antitrypsin deficiency ,HEPATITIS ,HYPERBILIRUBINEMIA ,LIVER ,LONGITUDINAL method ,NECROSIS ,SYNDROMES - Abstract
Fifty four infants with hepatobiliary disease and conjugated hyperbilirubinaemia of more than two weeks' duration were identified in a defined area of south east England in a prospective study between January 1971 and December 1973. The overall incidence was one case per 2500 live births. The cases were regularly reviewed and all survivors except one were assessed at age 10 years. Nine of 11 with extrahepatic biliary atresia died from liver disease by 2 years of age, one died at 5 years, and the survivor has cirrhosis with portal hypertension. Four out of seven with alpha 1 antitrypsin deficiency died aged 1 to 3 years from liver disease and one of the survivors has cirrhosis. All three infants with intrauterine infection and one with chromosomal abnormality died in infancy. Three children with other associated factors, choledochal cyst, galactosaemia, and rhesus isoimmunisation, recovered completely with no persisting liver disease. Two of 29 with cryptogenic hepatitis died, but only a further two have signs of persisting liver disease. Perinatal complications were more common in this group. Four of the 27 children surviving to the age of 10 years are educationally subnormal. Prognosis for infants with intrahepatic liver disease in the absence of known associated factors is good and every effort should be made to minimise the short term effects of cholestasis. [ABSTRACT FROM AUTHOR]
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- 1985
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19. Duration of chronic active hepatitis and the development of cirrhosis.
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VEGNENTE, A., LARCHER, V. F., MOWAT, A. P., PORTMANN, B., and WILLIAMS, R.
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AUTOANTIBODY analysis ,IMMUNOGLOBULIN analysis ,ASPARTATE aminotransferase ,BILIRUBIN ,CHRONIC diseases ,HEPATITIS ,CIRRHOSIS of the liver ,SERUM albumin ,TIME ,RETROSPECTIVE studies ,AZATHIOPRINE ,PREDNISOLONE ,PROTHROMBIN time ,DISEASE complications - Abstract
Chronic hepatitis implies that clinical and biochemical features of hepatitis have been present for at least 6 months; but irreversible liver damage may occur with subclinical disease suggesting that pathological features should also define chronicity. We examined 28 children with hepatitis B negative chronic active hepatitis to determine whether the severity of abnormal biochemical tests of liver function, raised serum immunoglobulin concentrations, and positive serum autoantibodies, which are characteristic features in immunosuppressant responsive disease, varied with the duration of symptoms. The pattern of abnormality in these patients was similar whether the disease had been present for less than three months, from three to 6 months, or for more than 6 months, and apart from lack of hyperbilirubinaemia was similar in patients presenting with complications of cirrhosis without previous symptoms of liver disease. Two children died of liver disease. The remainder showed a clinical, biochemical, and immunological response to prednisolone or azathioprine, or both. These drugs have now been withdrawn in 8 patients without relapse, and disease activity is completely suppressed in 13. Unfortunately, 15 survivors have definite cirrhosis and a further five have possible cirrhosis. Eight of 10 survivors with symptoms of more than 6 months duration before treatment have cirrhosis compared with two of 12 with symptoms of less than 6 months. It is suggested that consideration of this diagnosis at onset of symptoms and immediate immunosuppressant treatment after appropriate confirmatory investigations may reduce the incidence of cirrhosis in hepatitis B negative chronic active hepatitis in children. [ABSTRACT FROM AUTHOR]
- Published
- 1984
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20. Outcome of liver disease associated with alpha 1 antitrypsin deficiency (PiZ). Implications for genetic counselling and antenatal diagnosis.
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Psacharopoulos, H T, Mowat, A P, Cook, P J, Carlile, P A, Portmann, B, and Rodeck, C H
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LIVER disease diagnosis ,ALPHA 1-antitrypsin deficiency ,GENETIC counseling ,LIVER diseases ,LONGITUDINAL method ,PRENATAL diagnosis ,PHENOTYPES - Abstract
We reviewed the hepatic features in 136 children with alpha 1 antitrypsin deficiency (PiZ). Eighty two were studied prospectively, 74 of whom had chronic liver disease. Sixty seven children with liver disease presented in the first four months of life, four were older infants and children with chronic liver disease, 10 (three with liver disease) were identified in studies of the family of these propositi, and one was identified when she had liver disease associated with infectious mononucleosis. By 17 years of age 20 of these 74 children with chronic liver disease had died, 20 had established cirrhosis, 19 had persisting liver disease, and only 15 had made a complete, clinical and biochemical recovery. The outcome of liver disease was similar in a further 39 previously unreported PiZ infants and children with liver disease who were not prospectively studied. Because liver disease affects only a proportion of infants with PiZ phenotype and because the severity of their liver disease is so variable, we have analysed the outcome of liver disease in 27 observed families and in 20 previously reported families with more than one child with PiZ. In 34 families the outcome of liver disease was similar in the two children. From an analysis of the families with a severely affected child, we conclude that if the first PiZ child of PiZ heterozygote parents has unresolved liver disease, there is a 78% chance that a second PiZ child will have similar liver disease. After careful counselling, fetoscopy, fetal blood sampling, and protease inhibitor phenotyping, possible termination of pregnancy should be carefully considered in these families. [ABSTRACT FROM AUTHOR]
- Published
- 1983
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21. Outcome of liver disease associated with α1 antitrypsin deficiency (PiZ).
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PSACHAROPOULOS, H. T., MOWAT, A. P., COOK, P. J. L., CARLILE, P. A., PORTMANN, B., and RODECK, C. H.
- Published
- 1983
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22. The prelaparotomy diagnosis of extrahepatic biliary atresia.
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MANOLAKI, A. G., LARCHER, V. F., MOWAT, A. P., BARRETT, J. J., PORTMANN, B., and HOWARD, E. R.
- Abstract
The diagnostic accuracy of laboratory investigations in the prelaparotomy differentiation between extrahepatic biliary atresia (EHBA) and intrahepatic disease (IHD) was assessed in 86 consecutive infants presenting with conjugated hyperbilirubinaemia. Forty five infants had EHBA and 41 IHD. The mean serum bilirubin concentration, gamma-glutamyltranspeptidase (GGT) activity, and the GGT/aspartate transaminase (AST) ratio were appreciably higher in infants with EHBA than in those with IHD. In infants with IHD, however, serum bilirubin concentrations were in the EHBA range in 19 (47%), as were GGT values in 29 (71%), and GGT/AST ratios in 33 (80%). In individual patients neither increasing nor decreasing GGT values were of diagnostic importance. Failure of biliary excretion of 99Tcm-p-Butyl-ida occurred in 29 of 30 (97%) patients with EHBA but also in 22 of 23 (67%) with IHD. In all 5 patients with IHD associated with alpha 1 antitrypsin deficiency these 4 investigations gave results in the EHBA range. Liver biopsy specimen interpretation, correct in 38 of 42 infants with EHBA, gave an overall accuracy of diagnosis of 86%: the results of 3 further biopsies were equivocal. In 33 of 40 infants with IHD bile duct obstruction was excluded; the remaining 7, including 4 with alpha 1 antitrypsin deficiency, showed equivocal changes. Faecal excretion of 131I rose bengal faecal excretion was less than 10% in 36 of 37 patients with EHBA and in 9 of 26 with IHD, giving an overall accuracy of diagnosis of 84%. In patients in whom genetic disorders, such as alpha 1 antitrypsin deficiency had been excluded, interpretation of liver biopsy specimens together with 131I rose bengal faecal excretion remain the most accurate means of identifying those who need surgery for EHBA and of avoiding unnecessary laparotomy in infants with IHD. [ABSTRACT FROM AUTHOR]
- Published
- 1983
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23. Hepatic portoenterostomy for biliary atresia. A comparative study of histology and prognosis after surgery.
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Lawrence, D, Howard, E R, Tzannatos, C, and Mowat, A P
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BILE duct abnormalities ,BILE duct surgery ,LIVER surgery ,AGE distribution ,BILE ducts ,LIVER ,RESEARCH methodology ,META-analysis ,PROGNOSIS - Abstract
Specimens of excised tissue from the porta hepatis in 26 infants with extrahepatic biliary atresia undergoing hepatic portoenterostomy were analysed histologically for the presence and size of biliary ductules. No correlation could be found between the establishment of effective biliary drainage and the number or size of biliary ductules. it is suggested that prognosis after surgery may be related to the intrahepatic lesion and age of the child at operation rather than to the histology of the extrahepatic bile duct remnants. [ABSTRACT FROM AUTHOR]
- Published
- 1981
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24. Extrahepatic biliary atresia: preoperative assessment and surgical results in 47 consecutive cases.
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PSACHAROPOULOS, H. T., HOWARD, E. R., PORTMANN, B., and MOWAT, A. P.
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BILE duct abnormalities ,BILE duct surgery ,LIVER ,RESEARCH methodology ,META-analysis ,PROGNOSIS ,SURGICAL complications ,FLUORESCENT dyes - Abstract
Of 47 consecutive infants with extrahepatic biliary atresia, effective bile drainage with the return of the serum bilirubin concentration to normal, was achieved in 17 (38%). Direct bile duct-to-bowl anastomosis, attempted in 15 infants, produced bile drainage in only those 4 (9%) in whom bile could be seen within the bile duct remnants at laparotomy. 13 (45%) of 29 infants subjected to portoenterostomy (direct liver-to-bowel anastomosis) had satisfactory prolonged bile drainage with normal serum bilirubin values. Although a correct preoperative diagnosis was made in each case, in 3 (6%) the 72-hour faecal rose bengal 131I excretion was greater than 10% of the injected dose, and in 5 (11%) the hepatic histology did not indicate bile duct obstruction, showing that both investigations are necessary for preoperative diagnosis. Preoperative clinical, laboratory, and hepatic histological features in the 16 jaundice-free survivors showed no significant difference when compared with the 31 infants in whom surgery was successful. Cholangitis occurred in only 7 (43%) of 16 infants with satisfactory bile drainage and was easily controlled with antibiotic treatment. No cutaneous enterostomies were performed. In most survivors liver function tests remain abnormal, but the patients are symptom-free. While it is too early to predict a long-term prognosis for these children, our eldest survivors are healthy and show normal development. [ABSTRACT FROM AUTHOR]
- Published
- 1980
25. Fulminant hepatic failure in childhood.
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PSACHAROPOULOS, H. T., MOWAT, ALEX P., DAVIES, M., PORTMANN, B., SILK, D. B. A., and WILLIAMS, ROGER
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- 1980
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26. Spontaneous perforation of common bile duct in infants.
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Howard, E R, Johnston, D I, and Mowat, A P
- Abstract
Two infants with spontaneous perforation of the common bile duct are described. One presented with mild jaundice, dark urine, acholic stools, and hydroceles, the other with bilateral inguinal hernia. In both the diagnosis was unsuspected until bile-stained ascites was discovered. Both eventually developed bile-staining of the scrotum. Neither was acutely ill. The 131I-Rose Bengal faecal excretion test showed reduced faecal excretion at 8% and 12% of the injected dose with 16-5 and 17%/dl of the dose being recovered in the ascitic fluid 48 hours after intravenous injection. The ascitic:plasma ratio of isotope at that time was 32:1 and 28:1. Operative cholangiography in both showed a perforation at the junction of the cystic duct and common bile duct with no contrast entering the duodenum. Cholecystenterostomy using a Roux-en-Y loop of jejunum produced a rapid sustained recovery and is suggested as the treatment of choice. This condition should be considered in the differential diagnosis of obstructive jaundice in infancy since early surgical correction is necessary. [ABSTRACT FROM AUTHOR]
- Published
- 1976
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27. Spontaneous perforation of commonbile duct in infants.
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HOWARD, E. R., JOHNSTON, D. I., and MOWAT, A. P.
- Published
- 1976
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28. Radioimmunoassay of serum glycocholic acid, standard laboratory tests of liver function and liver biopsy findings: comparative study of children with liver disease.
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Matsui, A, Psacharopoulos, H T, Mowat, A P, Portmann, B, and Murphy, G M
- Abstract
Serum glycocholic acid (SGC) was measured by radioimmunoassay in 277 samples from 122 children with hepatobiliary disorders and from 23 healthy age-matched controls. In patients with hepatobiliary disease the SGC was more frequently abnormal (83%) than values for serum albumin (7%), prothrombin time (17%), bilirubin (22%), alkaline phosphatase (45%), aspartate transaminase (57%) and gammaglutamyl transpeptidase (63%). The cumulative frequency of abnormality of these six tests was equal to that of SGC alone. Serum glycocholic acid concentrations were raised in 13 patients in whom all other tests of liver function were normal. Two of these had clinical and histological evidence of liver disease, while four had biopsy-proven hepatic fibrosis or cirrhosis, and two of three with chronic active hepatitis in remission subsequently relapsed. Four patients have as yet, no other clinical or biochemical evidence of continuing liver disease. Serum glycocholic acid was normal in seven children with abnormal aspartate transaminase or gammaglutamyl transpeptidase in whom there is strong suspicion of significant hepatic disease. A wide range of values of SGC was found with marked overlap between the values found in the different disease entities studied. The SGC value was related to the serum concentration of aspartate transaminase and gammaglutamyl transpeptidase but not to other tests of liver function. Serum glycocholic acid concentration was considered in relation to the severity of histological abnormality in 25 percutaneous liver biopsies. The extent of the rise in SGC was related to the presence or degree of histological severity of oedema in the portal tracts, disruption of the limiting plate, parenchymal fibrosis and hepatocellular necrosis but not to other histological features. The very high incidence of abnormal SGC values found in this study does suggest that in an ordinary inpatient and outpatient service SGC determination is a practical and sensitive indicator of the presence of significant liver disease but for its comprehensive identification aspartate transaminase and gammaglutamyl transpeptidase must also be determined. [ABSTRACT FROM PUBLISHER]
- Published
- 1982
29. Liver disease in infancy: histological features and relationship to alpha-antitrypsin phenotype.
- Author
-
Talbot, I C and Mowat, A P
- Abstract
Sixty-nine specimens of liver tissue from 53 infants with neonatal hepatitis or its sequelae were examined without knowledge of the alpha1-antitrypsin phenotype. Distinctive, diastase-resistant, PAS-positive, pure magenta-coloured, sharply defined globules, 2-20 microns in diameter were found in periportal and paraseptal hepatocytes in all liver biopsies from eight alpha1-antitrypsin deficient (PiZZ) infants biopsied after the age of 12 weeks. Such globules were not seen in biopsies from PiZZ individuals aged less than 12 weeks nor in individuals of normal alpha1-antitrypsin phenotype (PiMM). No other specific histological abnormality was found in PiZZ individuals, but in them giant-cell transformation was infrequent and liver damage was more severe, three of 14 cases developing cirrhosis in contrast to four of 27 PiMM subjects. The pathogenesis of liver disease in PiZZ individuals is discussed. [ABSTRACT FROM PUBLISHER]
- Published
- 1975
30. CORRESPONDENCE.
- Author
-
Peckham, Catherine S., Marshall, W.C., Dudgeon, J.A., Marshall, Andrew, Barritt, D.W., Allison, D.J., Mowat, Alex P., Howard, Edward R., Foster, K.J., Karran, S.J., Halnan, Keith, Birley, J.L.T., Clarke, A.K., Lauste, L.W., Haxton, A.R., Grant, Andrew, Warren, Roderic, and Sandler, R.M.
- Subjects
MEDICAL literature ,RUBELLA vaccines ,HYPERTENSION ,PATIENTS - Abstract
Comments on various topics related to medicine in Great Britain. Aspects of rubella vaccination; Details on drug compliance in hypertensive patients; Lists of radiological techniques for controlling gastrointestinal bleeding.
- Published
- 1977
31. Fulminant hepatic failure resulting from coexistent Wilson's disease and hepatitis E.
- Author
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Sallie, R, Chiyende, J, Tan, K C, Bradley, D, Portmann, B, Williams, R, Mowat, A P, and Mieli-Vergani, G
- Abstract
Fulminant hepatic failure resulting from hepatitis E and coexistent Wilson's disease was diagnosed in a six year old girl six weeks after returning from a holiday in India. Wilson's disease was diagnosed on the basis of histological evidence of hepatocellular copper deposition, confirmed by biochemical estimation of liver copper concentration. Although severely damaged, the liver was non-cirrhotic. Hepatitis E virus (HEV) was diagnosed by nested polymerase chain reaction, the specificity of which was confirmed by direct sequencing of amplified DNA. Replication of HEV within the liver at the time of diagnosis was confirmed by selective amplification of the antigenomic strand of the virus obtained from total liver RNA. The patient had an orthotopic liver transplantation without recurrence of hepatitis and remains well at 19 months. Viral excretion, recorded by serial amplification of HEV RNA extracted from stool samples, persisted for 30 days after liver grafting. Severe vitiligo, present preoperatively, dramatically improved after liver grafting and institution of immunosuppressive treatment. This case suggests that viral infection may play a part in the acute decompensation seen in some cases of Wilson's disease. [ABSTRACT FROM PUBLISHER]
- Published
- 1994
32. Soluble interleukin 2 receptors in autoimmune chronic active hepatitis.
- Author
-
Lobo-Yeo, A, Mieli-Vergani, G, Mowat, A P, and Vergani, D
- Abstract
Children with uncontrolled autoimmune chronic active hepatitis have increased numbers of activated T lymphocytes expressing interleukin 2 receptors (IL2R). A soluble form of IL2R has recently been described whose proposed role is to downregulate T cell activation by competing for interleukin 2. We investigated whether a deficiency of soluble IL2R could account for the high concentrations of IL2R positive T lymphocytes in autoimmune chronic active hepatitis. Soluble IL2R was measured by enzyme-linked immunosorbent assay in the serum of 16 children with autoimmune chronic active hepatitis, eight with chronic liver disease due to hepatitis B virus infection, seven with Wilson's disease, nine with alpha 1 antitrypsin deficiency, and 15 healthy age matched controls. Soluble IL2R concentration was significantly higher in patients with autoimmune chronic active hepatitis than in healthy controls (mean (SEM) 475 (75) U/ml, 145 (8) U/ml respectively, p less than 0.01). Eleven patients who had active disease had significantly higher soluble IL2R concentrations (590 (89) U/ml) than the five cases with inactive disease (220 (36) U/ml, p less than 0.01). No difference was found between the controls and the patients with chronic liver disease due to hepatitis B infection, Wilson's disease, and alpha 1 antitrypsin deficiency. Percentages and absolute numbers of surface IL2R positive T cells as detected by immunofluorescence were significantly higher in the patients with autoimmune chronic active hepatitis (11.8% (1); 274/microliters (31)) than in controls (0.2% (0.1); 5/microliters (2), p less than 0.001), the highest values being found in those with uncontrolled disease. A significantly positive correlation was observed between concentrations of soluble IL2R and the percentage of T cells expressing IL2 receptors (r=0.67, p<0.001). These results indicate that the high levels of IL2R positive T lymphocytes characteristic of autoimmune chronic active hepatitis are not due to a deficiency of soluble IL2 receptors. [ABSTRACT FROM PUBLISHER]
- Published
- 1990
33. Wilson's disease: clinical presentation and use of prognostic index.
- Author
-
Nazer, H, Ede, R J, Mowat, A P, and Williams, R
- Abstract
As the results of treatment in Wilson's disease are so dependent on the stage at which penicillamine therapy is started, the antecedent history in 34 patients with Wilson's disease was analysed with particular respect to the earliest manifestations of the disease. Lethargy and anorexia (70%) jaundice (56%) and abdominal pain (48%) were the commonest symptoms and less common were intellectual deterioration (22%) and recurrent epistaxes (22%). The duration of symptoms before diagnosis ranged from five days to three years (mean 10.5 months) and in only five of the patients was the diagnosis established before referral. Analysis of the physical signs at presentation showed hepatomegaly (81%) and splenomegaly (70%) to be common and the only signs which were significantly more common in the 13 fatal cases were jaundice and ascites. In three of these and in one other patient who survived the clinical course was exceptionally severe and was indistinguishable from fulminant hepatic failure. Based on the severity of abnormality of serum aspartate aminotransferase, bilirubin, and prothrombin time on admission a prognostic index was derived which enabled complete separation of fatal and nonfatal cases and when subsequently used in a further nine index cases correctly predicted the outcome. Two further cases found to have indices in the fatal category did well after liver transplantation, which needs to be considered as soon as the diagnosis is established in cases with such severe liver damage. [ABSTRACT FROM PUBLISHER]
- Published
- 1986
34. Alagille syndrome: family studies.
- Author
-
Elmslie, F V, Vivian, A J, Gardiner, H, Hall, C, Mowat, A P, and Winter, R M
- Abstract
Alagille syndrome (AGS) is one of the major forms of chronic liver disease in childhood with severe morbidity and a mortality of 10 to 20%. It is characterised by cholestasis of variable severity with paucity of interlobular bile ducts and anomalies of the cardiovascular system, skeleton, eyes, and face. Previous studies suggest a wide variation in the expression of the disease and a high incidence of new mutations. To determine more accurately the rate of new mutations and to develop criteria for detecting the disorder in parents we systematically investigated parents in 14 families with an affected child. Clinical examination was supplemented by liver function tests, echocardiography, radiographic examination of the spine and forearm, ophthalmological assessment, and chromosome analysis. Six parents had typical anomalies in two or more systems pointing to the presence of autosomal dominant inheritance. Systematic screening of parents for the features defined in this study should improve the accuracy of genetic counselling. [ABSTRACT FROM PUBLISHER]
- Published
- 1995
35. Genetic studies on a new deficiency gene (PI*Ztun) at the PI locus.
- Author
-
Whitehouse, D B, Abbott, C M, Lovegrove, J U, McIntosh, I, McMahon, C J, Mieli-Vergani, G, Mowat, A P, and Hopkinson, D A
- Abstract
During a study of the alpha 1 antitrypsin (AAT) protein and its locus (PI) by high resolution isoelectric focusing and direct molecular analysis of 106 PIZ probands and their families, a new allele (Ztun) was identified that resembles Z in many of its properties. Two sibs, both compound heterozygotes for Ztun and Z, showed similar evidence of mild liver involvement that was indistinguishable from that associated with classical ZZ homozygotes. The Ztun protein appeared to be deficient in the plasma to about the same degree as the Z protein. Allele specific oligonucleotide analysis of amplified genomic DNA indicated that the new allele is the result of a mutation in exon V that is identical to the classical G----A transition at codon 342 that results in the Glu----Lys substitution characteristic of the Z allele. An analysis of DNA haplotypes constructed from polymorphic restriction enzyme recognition sites in and around the PI locus confirmed that Ztun probably represents a new mutation at codon 342 that has occurred on an M2-like genetic background. [ABSTRACT FROM PUBLISHER]
- Published
- 1989
36. Cloning of the human alpha 1 antichymotrypsin gene and genetic analysis of the gene in relation to alpha 1 antitrypsin deficiency.
- Author
-
Kelsey, G D, Abeliovich, D, McMahon, C J, Whitehouse, D, Corney, G, Povey, S, Hopkinson, D A, Wolfe, J, Mieli-Vergani, G, and Mowat, A P
- Abstract
Deficiency of alpha 1 antitrypsin (Pi) is clinically heterogeneous and the unpredictability of the clinical manifestation in a person of phenotype PiZ, which may vary from severe childhood liver disease to normal health, is a problem in genetic counselling. This problem may increase as couples at risk who have not had an affected child are identified in screening programmes. One possibility is that genetic variation of other protease inhibitors may influence the prognosis. With this in mind we report the isolation of the human gene for alpha 1 antichymotrypsin (AACT) on a series of cosmid clones, with restriction mapping of about 70 kb around the gene. A probe pACE3.4 derived from the 5' end of the gene defines sequences which have been assigned to chromosome 14 using somatic cell hybrids and has been used to show a common TaqI polymorphism with allele frequencies of AACT6 = 0.7 and AACT3 = 0.3 in Europeans. pACE3.4 is closely linked to alpha 1 antitrypsin (maximum lod score in males +2.29 at theta = 0; in females Z = +6.11 at theta = 0.032). Analysis of Pi-AACT haplotypes in 31 families ascertained through PiZ or PiSZ subjects did not show any linkage disequilibrium. The distribution of AACT6 and AACT3 alleles in 16 unrelated PiZ patients presenting with childhood liver disease and five unrelated PiZ patients with adult chest disease did not differ significantly from each other. These results suggest that if genetic variation at the AACT locus does influence the outcome of alpha 1 antitrypsin deficiency, such variation is not in linkage disequilibrium with the AACT polymorphism reported here. [ABSTRACT FROM PUBLISHER]
- Published
- 1988
37. Lymphocyte cytotoxicity to autologous hepatocytes in alpha 1-antitrypsin deficiency.
- Author
-
Mondelli, M, Mieli-Vergani, G, Eddleston, A L, Williams, R, and Mowat, A P
- Abstract
To investigate the possible role of cell mediated cytotoxicity in the pathogenesis or perpetuation of liver damage associated with alpha 1-antitrypsin (AAT) deficiency, peripheral blood lymphocytes (PBL) from 13 children with PiZZ phenotype who had had liver disease in infancy were incubated with autologous hepatocytes in a microcytotoxicity assay. There was a clear trend for cytotoxicity to increase with age and thus significantly increased cytotoxicity was found in four cases older than 2 years, while intermediate values were recorded in three children between 6 months and 2 years and normal values in children younger than 6 months. Fractionation of PBL into T and non-T-enriched subsets showed that both were involved in the cytotoxic reaction. A purified liver membrane lipoprotein preparation (LSP) inhibited both T and non-T-cell cytotoxicity suggesting that LSP is a major target antigen in this system. Control experiments performed in infants with neonatal hepatitis syndrome, but with normal Pi phenotype, showed consistently increased cytotoxicity values. Cell-mediated immune reactions directed against autologous hepatocytes develop late in the course of the liver disease associated with AAT deficiency. While this reaction cannot be involved in the pathogenesis of the initial liver lesion, it may contribute to perpetuation of liver damage. [ABSTRACT FROM PUBLISHER]
- Published
- 1984
38. Bacterial and fungal infection in children with fulminant hepatic failure: possible role of opsonisation and complement deficiency.
- Author
-
Larcher, V F, Wyke, R J, Mowat, A P, and Williams, R
- Abstract
Serious bacterial infection, including eight episodes of bacteraemia, developed in seven of 15 (47%) children with fulminant hepatic failure. Those with infections had a slightly higher leucocyte response than those who did not. Serum immunoglobulin concentrations were normal or raised in all patients. Opsonisation of heat-killed baker's yeast, functionally measured total haemolytic complement, C4, C5, total alternative pathway activity, factor B and D activity, and C3 concentrations were all significantly (p less than 0.005) reduced at presentation but returned to normal in those who survived. The severity of defects in yeast opsonisation, C4, and factor B activity at presentation were significantly correlated with the subsequent development of infection. In five patients bacteraemia occurred at a time when opsonisation and complement components were defective. Plasma infusions in vivo improved opsonisation in vitro and only one bacterial isolate was obtained within four days of such an infusion. Those patients who developed infection had received significantly (p less than 0.05) fewer plasma infusions than those who did not. Our findings suggest that both alternative and classical pathways of complement are defective in children with severe liver disease and may contribute to the susceptibility of such patients to infections. Plasma infusions might be useful in reducing the incidence of bacterial infection in such conditions. [ABSTRACT FROM PUBLISHER]
- Published
- 1982
39. The changing clinical pattern of Reye's syndrome 1982-1990.
- Author
-
Hardie, R. M., Newton, L. H., Bruce, J. C., Glasgow, J. F. T., Mowat, A. P., Stephenson, J. B. P., Hall, S. M., Glasgow, J F, and Stephenson, J B
- Abstract
Objective: To describe trends in the clinical pattern of Reye's syndrome in the British Isles between 1982 and 1990; and to determine the relation between any changes and the June 1986 warnings against the use of aspirin in children.Design: Development, and application to reported cases, of a scoring system designed such that patients showing the typical clinical and pathological features of 'classical' Reye's syndrome scored highly. The relations between 'Reye scores' and a number of explanatory variables were explored using multivariable analysis.Setting: British Isles.Subjects: 445 cases fulfilling the Reye's syndrome case definition reported to the surveillance scheme between January 1982 and December 1990.Main Outcome Measure: Individual 'Reye score'.Results: Cases with high scores were more likely to have occurred in the 4 1/2 year period before June 1986 compared with the subsequent period (p < 0.006). Numbers of cases in the low and intermediate score categories declined by about 50% after June 1986, whereas those in the high category fell by 79%. High scorers were more likely to have received aspirin (p < 0.0001) and were older than intermediate and low scorers (p < 0.008). No relation was identified between score and season of onset.Conclusions: The decline in Reye's syndrome after the aspirin warnings cannot be explained entirely, as has been proposed, by improved diagnosis of 'Reye-like' inherited metabolic and other disorders: this would not account for the greater decline of the high scoring subgroup which also contained those cases most likely to resemble 'classical' Reye's syndrome and to have received aspirin. This study provides further evidence for the role of aspirin in a subset of cases meeting the standard diagnostic criteria for Reye's syndrome and supports the need to consider this disorder as a heterogeneous group of conditions including Reye-like inherited metabolic disorders. [ABSTRACT FROM AUTHOR]- Published
- 1996
- Full Text
- View/download PDF
40. Choledochal cysts: lessons from a 20 year experience.
- Author
-
Stringer, M. D., Dhawan, A., Davenport, M., Mieli-Vergani, G., Mowat, A. P., and Howard, E. R.
- Abstract
Cystic dilatation of the biliary tree is a rare congenital anomaly. To determine mode of presentation, diagnostic pitfalls, and long term outcome after surgery, 78 children (57 girls, 21 boys) with choledochal cyst treated between 1974 and 1994 were reviewed. Anatomical types were: Ic (n = 44), If (n = 28), IVa (n = 4), and V (n = 2); a common pancreaticobiliary channel was identified in 76% patients. Age at presentation ranged from 0-16 (median 2.2) years, six patients being diagnosed by prenatal ultrasonography. Of the 72 patients diagnosed postnatally, 50 (69%) presented with jaundice, associated with abdominal pain in 25 or a palpable mass in three, 13 (18%) presented with pain alone, and two (3%) with a palpable mass. The classic triad of jaundice, pain, and a right hypochondrial mass was present in only four (6%). Four children presented acutely after spontaneous perforation of a choledochal cyst, two presented with ascites and one cyst was discovered incidentally. Plasma and/or biliary amylase values were raised in 30 of 31 patients investigated for abdominal pain; seven had evidence of pancreatitis at operation. In 35 of 67 (52%) patients referred without previous surgery, symptoms had been present for more than one month, and in 14 of them for more than one year, before diagnosis. Delayed referral was due to misdiagnosis as hepatitis (n = 12), incomplete investigation of abdominal pain (n = 6), and failure to note the significance of ultrasonographic findings (n = 10). Two patients referred late died from liver failure. Of the 76 patients with type I or IV cysts, 59 underwent radical cyst excision and hepaticojejunostomy as a primary procedure and 10 as a secondary operation after previously unsuccessful surgery. Sixteen patients have been lost to follow up but most of the remainder are well after a mean period of 4.1 (0.1-13) years. Choledochal cysts are often misdiagnosed, but prognosis is excellent if radical excision is performed. [ABSTRACT FROM AUTHOR]
- Published
- 1995
- Full Text
- View/download PDF
41. Viral hepatitis.
- Author
-
Gregorio, G V, Mieli-Vergani, G, and Mowat, A P
- Published
- 1994
- Full Text
- View/download PDF
42. Severe hypertension after liver transplantation in alpha 1 antitrypsin deficiency.
- Author
-
Noble-Jamieson, G, Barnes, N D, Thiru, S, and Mowat, A P
- Abstract
Five children with alpha 1 antitrypsin deficiency and terminal liver disease received liver grafts; all five became hypertensive and four developed hypertensive encephalopathy. There was evidence of renal disease preoperatively and renal biopsy specimens showed variable glomerulonephritic histology with IgA nephropathy in one, mesangial-proliferative changes in two, and mesangio-capillary glomerulonephritis type I in two. Four hypertensive episodes were preceded by a fall in creatinine clearance. The association of glomerulonephritis with alpha 1 antitrypsin deficiency in children is more common than has been recognised. Affected patients are prone to severe hypertension of probable renal origin after liver transplantation and the renal lesion may affect long term prognosis. [ABSTRACT FROM AUTHOR]
- Published
- 1990
- Full Text
- View/download PDF
43. Severe hypertension after liver transplantation in α1 antitrypsin deficiency.
- Author
-
Noble-Jamieson, G., Barnes, N. D., Thiru, S., and Mowat, A. P.
- Published
- 1990
- Full Text
- View/download PDF
44. α-Antitrypsin Deficiency and Neonatal Hepatitis.
- Author
-
Porter, C. A., Mowat, Alex P., Cook, P. J. L., Haynes, D. W. G., Shilkin, K. B., and Williams, Roger
- Abstract
Five out of 28 infants investigated in a regional survey of neonatal hepatitis were found to have genetically-determined deficiency of α-antitrypsin (ZZ phenotype). The clinical course and pathological changes varied considerably. All five infants had an acute hepatitis-like illness, and although this subsided cirrhosis later developed in three cases. The remaining two infants had minimal abnormalities of the liver function tests at 12 and 18 months of age, and one had increased hepatic fibrosis. Australia antigen was found in the serum of three infants, and Australia antigen or antibody in one or both parents of these and of one further case whose serum was negative. It is suggested that the association of neonatal hepatitis with α-antitrypsin deficiency may be commoner than previously realized and that Australia antigen acts as a trigger factor in these cases. [ABSTRACT FROM PUBLISHER]
- Published
- 1972
- Full Text
- View/download PDF
45. Extrahepatic biliary atresia. Recent developments in management.
- Author
-
Howard, E R and Mowat, A P
- Published
- 1977
46. Extrahepatic biliary atresia.
- Author
-
HOWARD, EDWARD R. and MOWAT, ALEX P.
- Published
- 1977
47. Liver transplantation for neonatal haemochromatosis.
- Author
-
Muiesan, P., Rela, M., Kane, P., Dawan, A., Baker, A., Ball, C., Mowat, A. P., Williams, R., and Heaton, N. D.
- Abstract
Two cases of neonatal haemochromatosis, a rare and often fatal metabolic disorder, presenting with acute liver failure, are reported. Both presented in the first week of life with hypoglycaemia, jaundice, and coagulopathy, with rapid deterioration of liver function. Both received a transplantation using reduced liver grafts. One child was well 18 months later. Few survivors have been reported and despite the difficult perioperative management, liver transplantation is the best treatment for neonatal haemochromatosis. [ABSTRACT FROM AUTHOR]
- Published
- 1995
- Full Text
- View/download PDF
48. Halothane hepatitis in children.
- Author
-
Kenna, J. Gerald, Neuberger, James, Mielli-Vergani, Giorgina, Mowat, Alex P., and Williams, Roger
- Subjects
HEPATITIS in children ,HALOTHANE ,PHYSIOLOGY - Abstract
Examines the occurrence of halothane hepatitis in children. Diagnosis of the disease; Causes of liver diseases; Interval between the final halothane exposure and the onset of jaundice.
- Published
- 1987
- Full Text
- View/download PDF
49. Results of Surgical treatment for extrahepatic biliary atresia in United Kingdom 1980-2.
- Author
-
McClement, J.W., Howard, E.R., and Mowat, Alex P.
- Subjects
BILIARY atresia ,INFANTS ,JAUNDICE - Abstract
Focuses on the surgical treatment for extrahepatic biliary atresia among infants in Great Britain. Identification of jaundice in infants; Symptoms of jaundice; Employment of Kasai's radical surgical approach.
- Published
- 1985
- Full Text
- View/download PDF
50. Focal nodular hyperplasia of the liver: a rational approach to treatment.
- Author
-
Mowat, A P, Gutjahr, P, Portmann, B, Dawson, J L, and Williams, R
- Abstract
Focal nodular hyperplasia of the liver in a 3 year old child has been successfully treated by ligation of the hepatic artery branches supplying the lesion. The prominence of the abnormal vasculature in the lesion and its possible aetiological involvement is stressed. Because of the risks of partial hepatectomy, hepatic artery ligation is suggested as the treatment of choice for focal nodular hyperplasia. [ABSTRACT FROM PUBLISHER]
- Published
- 1976
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