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Your search keyword '"Kaplan, Robert C"' showing total 17 results
Start Over Author "Kaplan, Robert C" Language english Publisher biomed central
17 results on '"Kaplan, Robert C"'

1. Characterizing longitudinal change in accelerometry-based moderate-to-vigorous physical activity in the Hispanic Community Health Study/Study of Latinos and the Framingham Heart Study

Author

Mossavar-Rahmani, Yasmin, Lin, Juan, Pan, Stephanie, Song, Rebecca J., Xue, Xiaonan, Spartano, Nicole L., Xanthakis, Vanessa, Sotres-Alvarez, Daniela, Marquez, David X., Daviglus, Martha, Carlson, Jordan A., Parada, Jr, Humberto, Evenson, Kelly R., Talavera, Ana C., Gellman, Marc, Perreira, Krista M., Gallo, Linda C., Vasan, Ramachandran S., and Kaplan, Robert C.

Published
2023
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2. Gut microbiota, circulating inflammatory markers and metabolites, and carotid artery atherosclerosis in HIV infection

Author

Wang, Zheng, Peters, Brandilyn A., Bryant, MacKenzie, Hanna, David B., Schwartz, Tara, Wang, Tao, Sollecito, Christopher C., Usyk, Mykhaylo, Grassi, Evan, Wiek, Fanua, Peter, Lauren St., Post, Wendy S., Landay, Alan L., Hodis, Howard N., Weber, Kathleen M., French, Audrey, Golub, Elizabeth T., Lazar, Jason, Gustafson, Deborah, Sharma, Anjali, Anastos, Kathryn, Clish, Clary B., Burk, Robert D., Kaplan, Robert C., Knight, Rob, and Qi, Qibin

Published
2023
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5. Metabolic and inflammatory perturbation of diabetes associated gut dysbiosis in people living with and without HIV infection

Author

Luo, Kai, Peters, Brandilyn A., Moon, Jee-Young, Xue, Xiaonan, Wang, Zheng, Usyk, Mykhaylo, Hanna, David B., Landay, Alan L., Schneider, Michael F., Gustafson, Deborah, Weber, Kathleen M., French, Audrey, Sharma, Anjali, Anastos, Kathryn, Wang, Tao, Brown, Todd, Clish, Clary B., Kaplan, Robert C., Knight, Rob, Burk, Robert D., and Qi, Qibin

Published
2024
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6. Predictors of incident diabetes in two populations: framingham heart study and hispanic community health study / study of latinos

Author

Kaplan, Robert C., Song, Rebecca J., Lin, Juan, Xanthakis, Vanessa, Hua, Simin, Chernofsky, Ariel, Evenson, Kelly R., Walker, Maura E., Cuthbertson, Carmen, Murabito, Joanne M., Cordero, Christina, Daviglus, Martha, Perreira, Krista M., Gellman, Marc, Sotres-Alvarez, Daniela, Vasan, Ramachandran S., Xue, Xiaonan, Spartano, Nicole L., and Mossavar-Rahmani, Yasmin

Published
2022
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7. Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells

Author

Vallejo, Jenifer, Saigusa, Ryosuke, Gulati, Rishab, Armstrong Suthahar, Sujit Silas, Suryawanshi, Vasantika, Alimadadi, Ahmad, Durant, Christopher P., Ghosheh, Yanal, Roy, Payel, Ehinger, Erik, Pattarabanjird, Tanyaporn, Hanna, David B., Landay, Alan L., Tracy, Russell P., Lazar, Jason M., Mack, Wendy J., Weber, Kathleen M., Adimora, Adaora A., Hodis, Howard N., Tien, Phyllis C., Ofotokun, Igho, Heath, Sonya L., Shemesh, Avishai, McNamara, Coleen A., Lanier, Lewis L., Hedrick, Catherine C., Kaplan, Robert C., and Ley, Klaus

Published
2022
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8. Rare coding variants in RCN3 are associated with blood pressure

Author

He, Karen Y., Kelly, Tanika N., Wang, Heming, Liang, Jingjing, Zhu, Luke, Cade, Brian E., Assimes, Themistocles L., Becker, Lewis C., Beitelshees, Amber L., Bielak, Lawrence F., Bress, Adam P., Brody, Jennifer A., Chang, Yen-Pei Christy, Chang, Yi-Cheng, de Vries, Paul S., Duggirala, Ravindranath, Fox, Ervin R., Franceschini, Nora, Furniss, Anna L., Gao, Yan, Guo, Xiuqing, Haessler, Jeffrey, Hung, Yi-Jen, Hwang, Shih-Jen, Irvin, Marguerite Ryan, Kalyani, Rita R., Liu, Ching-Ti, Liu, Chunyu, Martin, Lisa Warsinger, Montasser, May E., Muntner, Paul M., Mwasongwe, Stanford, Naseri, Take, Palmas, Walter, Reupena, Muagututi’a Sefuiva, Rice, Kenneth M., Sheu, Wayne H.-H., Shimbo, Daichi, Smith, Jennifer A., Snively, Beverly M., Yanek, Lisa R., Zhao, Wei, Blangero, John, Boerwinkle, Eric, Chen, Yii-Der Ida, Correa, Adolfo, Cupples, L. Adrienne, Curran, Joanne E., Fornage, Myriam, He, Jiang, Hou, Lifang, Kaplan, Robert C., Kardia, Sharon L. R., Kenny, Eimear E., Kooperberg, Charles, Lloyd-Jones, Donald, Loos, Ruth J. F., Mathias, Rasika A., McGarvey, Stephen T., Mitchell, Braxton D., North, Kari E., Peyser, Patricia A., Psaty, Bruce M., Raffield, Laura M., Rao, D. C., Redline, Susan, Reiner, Alex P., Rich, Stephen S., Rotter, Jerome I., Taylor, Kent D., Tracy, Russell, Vasan, Ramachandran S., Morrison, Alanna C., Levy, Daniel, Chakravarti, Aravinda, Arnett, Donna K., and Zhu, Xiaofeng

Published
2022
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9. Author Correction: Combined protein and transcript single-cell RNA sequencing in human peripheral blood mononuclear cells

Author

Vallejo, Jenifer, Saigusa, Ryosuke, Gulati, Rishab, Suthahar, Sujit Silas Armstrong, Suryawanshi, Vasantika, Alimadadi, Ahmad, Durant, Christopher P., Ghosheh, Yanal, Roy, Payel, Ehinger, Erik, Pattarabanjird, Tanyaporn, Hanna, David B., Landay, Alan L., Tracy, Russell P., Lazar, Jason M., Mack, Wendy J., Weber, Kathleen M., Adimora, Adaora A., Hodis, Howard N., Tien, Phyllis C., Ofotokun, Igho, Heath, Sonya L., Shemesh, Avishai, McNamara, Coleen A., Lanier, Lewis L., Hedrick, Catherine C., Kaplan, Robert C., and Ley, Klaus

Published
2022
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13. Author Correction: Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Author

Kaplan, Robert C., Wang, Zheng, Usyk, Mykhaylo, Sotres-Alvarez, Daniela, Daviglus, Martha L., Schneiderman, Neil, Talavera, Gregory A., Gellman, Marc D., Thyagarajan, Bharat, Moon, Jee-Young, Vázquez-Baeza, Yoshiki, McDonald, Daniel, Williams-Nguyen, Jessica S., Wu, Michael C., North, Kari E., Shaffer, Justin, Sollecito, Christopher C., Qi, Qibin, Isasi, Carmen R., Wang, Tao, Knight, Rob, and Burk, Robert D.

Published
2020
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14. Gut microbiome composition in the Hispanic Community Health Study/Study of Latinos is shaped by geographic relocation, environmental factors, and obesity

Author

Kaplan, Robert C., Wang, Zheng, Usyk, Mykhaylo, Sotres-Alvarez, Daniela, Daviglus, Martha L., Schneiderman, Neil, Talavera, Gregory A., Gellman, Marc D., Thyagarajan, Bharat, Moon, Jee-Young, Vázquez-Baeza, Yoshiki, McDonald, Daniel, Williams-Nguyen, Jessica S., Wu, Michael C., North, Kari E., Shaffer, Justin, Sollecito, Christopher C., Qi, Qibin, Isasi, Carmen R., Wang, Tao, Knight, Rob, and Burk, Robert D.

Published
2019
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15. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos

Author

Fernández-Rhodes, Lindsay, Howard, Annie Green, Graff, Mariaelisa, Isasi, Carmen R., Highland, Heather M., Young, Kristin L., Parra, Esteban, Below, Jennifer E., Qi, Qibin, Kaplan, Robert C., Justice, Anne E., Papanicolaou, George, Laurie, Cathy C., Grant, Struan F. A., Haiman, Christopher, Loos, Ruth J. F., and North, Kari E.

Published
2018
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16. Complex patterns of direct and indirect association between the transcription Factor-7 like 2 gene, body mass index and type 2 diabetes diagnosis in adulthood in the Hispanic Community Health Study/Study of Latinos

Author

North, Kari E, Haiman, Christopher, Qi, Qibin, Justice, Anne E, Laurie, Cathy C, Howard, Annie G, Grant, Struan F A, Graff, Mariaelisa, Below, Jennifer E, Loos, Ruth J F, Parra, Esteban, Isasi, Carmen R, Kaplan, Robert C, Fernández-Rhodes, Lindsay, Young, Kristin L, Highland, Heather M, and Papanicolaou, George

Subjects
2. Zero hunger, 3. Good health
Abstract

Background Genome-wide association studies have implicated the transcription factor 7-like 2 (TCF7L2) gene in type 2 diabetes risk, and more recently, in decreased body mass index. Given the contrary direction of genetic effects on these two traits, it has been suggested that the observed association with body mass index may reflect either selection bias or a complex underlying biology at TCF7L2. Methods Using 9031 Hispanic/Latino adults (21–76 years) with complete weight history and genetic data from the community-based Hispanic Community Health Study/Study of Latinos (HCHS/SOL, Baseline 2008–2011), we estimated the multivariable association between the additive number of type 2 diabetes increasing-alleles at TCF7L2 (rs7903146-T) and body mass index. We then used structural equation models to simultaneously model the genetic association on changes in body mass index across the life course and estimate the odds of type 2 diabetes per TCF7L2 risk allele. Results We observed both significant increases in type 2 diabetes prevalence at examination (independent of body mass index) and decreases in mean body mass index and waist circumference across genotypes at rs7903146. We observed a significant multivariable association between the additive number of type 2 diabetes-risk alleles and lower body mass index at examination. In our structured modeling, we observed non-significant inverse direct associations between rs7903146-T and body mass index at ages 21 and 45 years, and a significant positive association between rs7903146-T and type 2 diabetes onset in both middle and late adulthood. Conclusions Herein, we replicated the protective effect of rs7930146-T on body mass index at multiple time points in the life course, and observed that these effects were not explained by past type 2 diabetes status in our structured modeling. The robust replication of the negative effects of TCF7L2 on body mass index in multiple samples, including in our diverse Hispanic/Latino community-based sample, supports a growing body of literature on the complex biologic mechanism underlying the functional consequences of TCF7L2 on obesity and type 2 diabetes across the life course.

17. Whole-genome association analyses of sleep-disordered breathing phenotypes in the NHLBI TOPMed program.

Author

Cade BE, Lee J, Sofer T, Wang H, Zhang M, Chen H, Gharib SA, Gottlieb DJ, Guo X, Lane JM, Liang J, Lin X, Mei H, Patel SR, Purcell SM, Saxena R, Shah NA, Evans DS, Hanis CL, Hillman DR, Mukherjee S, Palmer LJ, Stone KL, Tranah GJ, Abecasis GR, Boerwinkle EA, Correa A, Cupples LA, Kaplan RC, Nickerson DA, North KE, Psaty BM, Rotter JI, Rich SS, Tracy RP, Vasan RS, Wilson JG, Zhu X, and Redline S

Subjects
Alleles, Chromatin Immunoprecipitation Sequencing, Female, Gene Expression Regulation, Genotype, Humans, Male, National Heart, Lung, and Blood Institute (U.S.), Phenotype, Precision Medicine methods, Research, Signal Transduction, Sleep Apnea Syndromes metabolism, United States, Genetic Association Studies, Genetic Predisposition to Disease, Genome-Wide Association Study, Sleep Apnea Syndromes diagnosis, Sleep Apnea Syndromes etiology, Whole Genome Sequencing
Abstract

Background: Sleep-disordered breathing is a common disorder associated with significant morbidity. The genetic architecture of sleep-disordered breathing remains poorly understood. Through the NHLBI Trans-Omics for Precision Medicine (TOPMed) program, we performed the first whole-genome sequence analysis of sleep-disordered breathing., Methods: The study sample was comprised of 7988 individuals of diverse ancestry. Common-variant and pathway analyses included an additional 13,257 individuals. We examined five complementary traits describing different aspects of sleep-disordered breathing: the apnea-hypopnea index, average oxyhemoglobin desaturation per event, average and minimum oxyhemoglobin saturation across the sleep episode, and the percentage of sleep with oxyhemoglobin saturation < 90%. We adjusted for age, sex, BMI, study, and family structure using MMSKAT and EMMAX mixed linear model approaches. Additional bioinformatics analyses were performed with MetaXcan, GIGSEA, and ReMap., Results: We identified a multi-ethnic set-based rare-variant association (p = 3.48 × 10 -8 ) on chromosome X with ARMCX3. Additional rare-variant associations include ARMCX3-AS1, MRPS33, and C16orf90. Novel common-variant loci were identified in the NRG1 and SLC45A2 regions, and previously associated loci in the IL18RAP and ATP2B4 regions were associated with novel phenotypes. Transcription factor binding site enrichment identified associations with genes implicated with respiratory and craniofacial traits. Additional analyses identified significantly associated pathways., Conclusions: We have identified the first gene-based rare-variant associations with objectively measured sleep-disordered breathing traits. Our results increase the understanding of the genetic architecture of sleep-disordered breathing and highlight associations in genes that modulate lung development, inflammation, respiratory rhythmogenesis, and HIF1A-mediated hypoxic response., (© 2021. The Author(s).)

Published
2021
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