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Your search keyword '"Timothy S. C. Hinks"' showing total 9 results
Start Over "Timothy S. C. Hinks" Language english Publisher american thoracic society
9 results on '"Timothy S. C. Hinks"'

1. Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma

Author

Adel H. Mansur, Peter Bradding, Simon Couillard, Liam G Heaney, Lorcan McGarvey, Rahul Shrimanker, Timothy S. C. Hinks, Stephen J. Fowler, Ian D. Pavord, and Rekha Chaudhuri

Subjects
Pulmonary and Respiratory Medicine, Adult, Male, 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Anti-Asthmatic Agents/therapeutic use, medicine.drug_class, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Severe asthma, Drug Resistance, Adrenal Cortex Hormones/therapeutic use, Asthma/diagnosis, Critical Care and Intensive Care Medicine, Nitric Oxide, Biomarkers/analysis, Severity of Illness Index, Adrenal Cortex Hormones, Correspondence, Administration, Inhalation, medicine, Humans, Nitric Oxide/analysis, Anti-Asthmatic Agents, Aged, business.industry, Eosinophils/metabolism, Exhalation, Middle Aged, Asthma, Eosinophils, Cross-Sectional Studies, Breath Tests, Case-Control Studies, Exhaled nitric oxide, Immunology, Corticosteroid, Female, business, Biomarkers
Published
2021

2. Fractional Exhaled Nitric Oxide Nonsuppression Identifies Corticosteroid-Resistant Type 2 Signaling in Severe Asthma.

Author

Couillard, Simon, Shrimanker, Rahul, Chaudhuri, Rekha, Mansur, Adel H., McGarvey, Lorcan P., Heaney, Liam G., Fowler, Stephen J., Bradding, Peter, Pavord, Ian D., Hinks, Timothy S. C., and MRC UK Refractory Asthma Stratification programme (RASP-UK)

Subjects
NITRIC oxide, EOSINOPHILS, SPUTUM, INFLAMMATION, ASTHMA, DRUG therapy for asthma, ASTHMA diagnosis, RESEARCH, ADRENOCORTICAL hormones, CROSS-sectional method, RESEARCH methodology, DRUG resistance, CASE-control method, MEDICAL cooperation, EVALUATION research, BRONCHODILATOR agents, SEVERITY of illness index, COMPARATIVE studies, RESEARCH funding, BREATH tests, INHALATION administration, RESPIRATION
Abstract

The article presents a study on the association of fractional exhaled nitric oxide and blood eosinophils with inflammation observed in the sputum and blood compartments in severe asthma. Topics discussed include the prognostic information on the occurrence of severe asthma attacks being provided by fractional exhaled nitric oxide and the blood eosinophil, the methods used in the study, and limitations of the study.

Published
2021
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5. Blood Eosinophil Depletion with Mepolizumab, Benralizumab, and Prednisolone in Eosinophilic Asthma.

Author

Moran, Angela M., Ramakrishnan, Sanjay, Borg, Catherine A., Connolly, Clare M., Couillard, Simon, Mwasuku, Christine M., Pavord, Ian D., Hinks, Timothy S. C., Lehtimӓki, Lauri, and Lehtimäki, Lauri

Subjects
PATIENTS, ASTHMA, INTERLEUKIN-5, IMMUNOGLOBULINS, DRUGS, THERAPEUTIC use of glucocorticoids, THERAPEUTIC use of monoclonal antibodies, DRUG therapy for asthma, BRONCHODILATOR agents, COMPARATIVE studies, EOSINOPHILS, GLUCOCORTICOIDS, RESEARCH methodology, MEDICAL cooperation, MONOCLONAL antibodies, RESEARCH, EVALUATION research, PREDNISOLONE
Abstract

The article informs that eosinophilic airway inflammation is present in approximately half of patients with asthma, and it is particularly associated with asthma attacks. Topics include the two anti– Interleukin 5 (IL5) monoclonal antibodies are licensed for use in asthma and can be administered subcutaneously are mepolizumab, and benralizumab; and both anti–IL-5 monoclonal antibodies have proven efficacy in decreasing the frequency of asthma exacerbations.

Published
2020
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8. Reply to Lipworth : Don't Forget about Facilitatory Effects of Corticosteroids on β2-Adrenoceptors in Acute Asthma.

Author

Moran, Angela M., Ramakrishnan, Sanjay, Borg, Catherine A., Connolly, Clare M., Couillard, Simon, Mwasuku, Christine M., Pavord, Ian D., Hinks, Timothy S. C., and Lehtimӓki, Lauri

Subjects
ASTHMA, EOSINOPHILS, CORTICOSTEROIDS
Abstract

The article presents the reply to Lipworth for the biology of asthma attacks being more complex than blood eosinophils alone and corticosteroids having a wide range of potentially relevant antiinflammatory effects.

Published
2020
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9. In-Parallel Ventilator Sharing during an Acute Shortage: Too Much Risk for a Wider Uptake.

Author

Chase, J. Geoffrey, Yeong-Shiong Chiew, Lambermont, Bernard, Morimont, Philippe, Shaw, Geoffrey M., Desaive, Thomas, and Chiew, Yeong-Shiong

Subjects
COVID-19, PATIENTS
Abstract

The article highlights the ventilator sharing protocol for COVID-19 disease. Topics include patient compatibility criteria are crucial and require time; patient selection and management require considerable expertise to ensure safety; and lung damage from divergent patient courses does not occur.

Published
2020
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