1. Cognitive and serotonergic vulnerability to depression: convergent findings.
- Author
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Booij L and Van der Does AJ
- Subjects
- Adult, Cross-Over Studies, Double-Blind Method, Female, Humans, Male, Personality Disorders diagnosis, Personality Disorders epidemiology, Tryptophan deficiency, Cognition Disorders epidemiology, Cognition Disorders metabolism, Depression epidemiology, Depression metabolism, Depression psychology, Serotonin metabolism
- Abstract
Cognitive reactivity (CR) is a psychological vulnerability marker of depression, whereas response to acute tryptophan depletion (ATD; a serotonergic challenge procedure) is a biological vulnerability marker. The aim of this study was to investigate the relationship between these markers. Thirty-nine remitted depressed patients participated in 2 ATD sessions in a double-blind crossover design. CR, assessed prior to the ATD sessions, predicted depressive response to high-dose ATD. CR also diminished the effects of 2 known predictors of ATD response: gender and residual symptoms. Neuroticism and behavioral inhibition were unrelated to ATD response. CR is associated with an increased sensitivity to reductions of serotonin concentrations. These findings present a small step toward unifying cognitive and neurobiological theories of depression., ((c) 2007 APA, all rights reserved.)
- Published
- 2007
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