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Limited studies investigated the effects of long-term ozone exposure on cardiometabolic health. We aimed to examine the association of long-term ozone exposure with a range of cardiometabolic diseases, as well as the subclinical indicators in Eastern China. The study included 202,042 adults living in 11 prefecture-level areas in Zhejiang Province between 2014 and 2021. Using a satellite-based model with a 1 × 1 km spatial resolution, we estimated residential 5-year average ozone exposures for each subject. Mixed-effects logistic and linear regression models were applied to explore the associations of ozone exposure with cardiometabolic diseases and subclinical indicators, respectively. We found that a 9% [95% confidence interval (95% CI): 7–12%] higher in odds of cardiometabolic disease per 10 μg/m3 increase in ozone exposure. Specifically, we also found higher prevalence of cardiovascular diseases (15%), stroke (19%), hypertension (7%), dyslipidemia (15%), and hypertriglyceridemia (9%) associated with ozone exposure. However, we did not find significant associations between ozone exposure and coronary heart disease, myocardial infarction, or diabetes mellitus. Long-term ozone exposures were also significantly associated with adverse changes in systolic blood pressure, diastolic blood pressure, total serum cholesterol, triglyceride, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, glucose concentration, and body mass index. Our results showed that people with lower education levels, those over 50 years old, and those who were overweight or obese were more susceptible to the effects of ozone on cardiometabolic diseases. Our findings demonstrated the detrimental effects of long-term ozone exposure on cardiometabolic health, emphasizing the need for ozone control strategies to reduce the burden of cardiometabolic diseases. [Display omitted] • Increase risk of some cardiometabolic diseases associated with O 3 exposure. • Ozone exposures were associated with adverse changes in some subclinical indicators. • More prominent odds of cardiometabolic diseases under higher ozone concentration. • People with characteristics such as aged 50 years and older were more susceptible. [ABSTRACT FROM AUTHOR]

Accurately and quantitatively monitoring the damages in composite structures is very challenging, but important for assessing their integrity. In this paper, an innovative damage location identification and size quantification assessment method based on Lamb wave is proposed for composite laminates. A continuous hidden Markov model (CHMM)-based damage scaling factor together with a weighted average imaging algorithm is adopted in damage location identification. To quantify the degree of structural deviation from the healthy state, the inconspicuous change of guided wave (GW) signal is converted to a CHMM-based damage scaling factor with significant change. Based on the damage scaling factors of all GW sensing paths, a weighted average imaging algorithm is performed to identify the most probable damage location. In addition, a damage quantitative mathematical expression is proposed to approximately estimate the size of circular-shaped damage founded on several different damage-related characterizations. The implementation of the proposed quantitative methodology is comparatively simple and straightforward for damage detection. Experiments on three composite panels with multiple damage cases are conducted to substantiate the proposed method. The sensor layers with embedded piezoelectric transducer (PZT) sensor networks surf-mounted on the structures are employed to excite and receive Lamb wave signals since their superiority of flexibility, electrical stability and apt for complex structures. The results demonstrate that the proposed algorithm is capable of pinpointing both the location and size of the circular-hole damage in composite structures. [ABSTRACT FROM AUTHOR]

• A comprehensive review of disulfide-based polymeric nanomedicines. • A tutorial review on the construction of core and shell crosslinked responsive nanomedicines. • Detail guides on disulfide-based polymer-drug conjugates and dimeric prodrugs. Disulfide bonds (S-S) are widely found in chemistry, biology, and materials science. Polymer nanomaterials containing disulfide bonds with a variety of excellent properties have great potential as drug and gene delivery carriers. The disulfide bond can exist stably in extracellular environment, but upon entering cancer cells, it will undergo a sulfhydryl-disulfide bond exchange reaction with glutathione (GSH) in the cytoplasm, causing the disulfide bond cleavage. Therefore, polymeric nanomaterials containing disulfide bonds are promising in cancer treatment due to the elevated GSH concentration inside cancer cells. This review highlights various synthetic approaches to prepare disulfide containing redox-responsive polymeric nanomedicine, including synthesis of disulfide bonds containing polymers, construction of polymeric nanoparticle with shell or core crosslinked disulfide bonds, preparation of polymer-drug conjugates via disulfide linkers, and disulfide linked responsive payloads. [ABSTRACT FROM AUTHOR]