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The aim of this study was to investigate the therapeutic effect of cryoablation treatment in advanced NSCLC patients who had failed first-line chemotherapy. Eighty-seven patients from ten hospitals in China were enrolled into the study, forty-four patients received cryoablation treatment plus basic treatment (experimental group), and forty-three patients had basic treatment alone (control group). Follow-up was performed once every three months until the end of the study or the death of the patient. The primary endpoints were overall and post-intervention survival; secondary endpoints included tumor markers, solid tumor efficacy, and symptom changes before and after treatment. There was no significant difference in median OS between the two groups of patients (9.0 months vs 11.2 months, P = 0.583). The disease control rate (DCR) and living quality of the experimental group was higher than that of the control group. In terms of OS, indiscriminate use of cryoablation for such patients was not beneficial, though it could improve symptoms of patients. Cryoablation had a significant effect on selected advanced NSCLC patients after the failure of first-line chemotherapy. [ABSTRACT FROM AUTHOR]

Global climate has undergone dramatic changes over the past 200 years, accurately identifying the climate transition (from LIA to 20th century warming) and its controlling factors will help to address the risks posed by global warming. Detailed analyses of chronology, grain size, color reflectance (L*, a*) and carbon content (TOC, TIC) were conducted on a 200-year sedimentary record from lake Ebinur in Xinjiang, northwest China. The results show that lake sediments are mainly transported by wind, and there are two kinds of different sources and transport processes. Comparative analysis of multi-proxies reveals that the climate transition took place in 1920 AD. In the early period (1816–1920 AD), the high C values indicate strong transport dynamics; the high proportion of ultrafine component indicates strong pedogenesis, combined with high TOC and a* values, it is inferred that the climate is cold and wet. In the later period (1920–2019 AD), the proxies show opposite changes, which may reveal a warm and dry climate. Based on a comprehensive analysis of multi-drivers, we propose that the increase of solar irradiance played a dominant role in 1920 AD climate transition, and the gradual rise in the concentrations of greenhouse gases may have a positive feedback effect. • Lake Ebinur sediments are mainly transported by wind. • A climate transition occurred in 1920 AD: from cold LIA to 20th century warming. • The increase of solar irradiance is the main driver of the 1920 AD climate transition. [ABSTRACT FROM AUTHOR]

Poncirus polyandra , a plant species with extremely small populations in China, has become extinct in the wild. This study aimed to identify functional genes that improve tolerance to abiotic and biotic stresses. Here, we present a high-quality chromosome-scale reference genome of P. polyandra. The reference genome is 315.78 Mb in size, with an N50 scaffold size of 32.07 Mb, and contains nine chromosomes with 20,815 protein-coding genes, covering 97.82% of the estimated gene space. We identified 17 rapidly evolving nucleotide-binding-site (NBS) genes, three C-repeat-binding factors (CBF) genes, 19 citrus greening disease (Huanglongbing, HLB) tolerance genes, 11 citrus tristeza virus (CTV) genes, and one citrus nematode resistance gene. A divergence time of 1.96 million years ago was estimated between P. polyandra and P. trifoliata. This is the first genome-scale assembly and annotation of P. polyandra , which will be useful for genetic, genomic, and molecular research and provide guidance for the development of conservation strategies. • The whole-genome sequence of Poncirus polyandra is 315.78 Mb with scaffold N50 of 32.07 Mb. • 17 rapidly evolving NBS genes, three CBF genes, 19 HLB tolerance genes, 11 CTV genes, and one citrus nematode resistance gene were identified. • A divergence time of 1.96 million years ago between P. polyandra and P. trifoliata was estimated. [ABSTRACT FROM AUTHOR]

• Authoritative parenting style is significantly and positively associated with preschool-aged child cognitive development. • Authoritarian parenting style is significantly and negatively associated with preschool-aged child cognitive development. • Mothers, more educated, and higher SES caregivers are more likely to use authoritative parenting style. • Authoritative parenting style has greater benefits in terms of cognitive development for girls than boys. The correlation between parenting style and child cognitive development has been widely documented in Western societies. There has been far less research, however, in non-Western societies and none at all in rural China. This study aimed to investigate the association between parenting style and child cognitive development in rural China. Participants were 1272 preschool-aged children and their primary caregivers. Children were 49 to 65 months old (51% male), and all were ethnically Han. Primary caregivers reported their parenting style, and children were assessed on their cognitive skills. Two alternative approaches (two dimensions and four categories) were used to examine the correlation between parenting style and child cognitive development. The results show a positive correlation between an authoritative parenting style and child cognitive development and show a negative correlation between an authoritarian parenting style and development. When the mother is the primary caregiver, more educated, or from a wealthier family, she is more likely to use an authoritative parenting style and less likely to use an authoritarian one. In addition, the authoritative style has a stronger correlation with the cognitive developmental outcomes of girls than of boys. The findings encourage researchers to conduct future work on how to implement parenting training interventions that are able to ascertain whether parents in rural China can be taught to adopt an authoritative parenting style. Future research should also seek to identify whether an authoritative parenting style produces (in a causal manner) any significant long-term benefits to the cognitive development of children in rural China. [ABSTRACT FROM AUTHOR]