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Your search keyword '"McColgan, Peter"' showing total 3 results
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3 results on '"McColgan, Peter"'

1. NfL concentration in CSF is a quantitative marker of the rate of neurodegeneration in aging and Huntington's disease: a semi-mechanistic model-based analysis.

Author

Machacek, Matthias, Garcia-Montoya, Elena, McColgan, Peter, Sanwald-Ducray, Patricia, and Mazer, Norman Alan

Subjects
HUNTINGTON disease, NEURODEGENERATION, PRESBYCUSIS, CEREBROSPINAL fluid shunts, AGING, ALZHEIMER'S disease, SPINAL muscular atrophy
Abstract

The article discusses the development of a semi-mechanistic model that relates the concentration of neurofilament light chain (NfL) in cerebrospinal fluid (CSF) to neurodegeneration in aging and Huntington's disease (HD). The model successfully predicts NfL concentration in CSF and suggests that it reflects the rate of neurodegeneration. The text also discusses the potential application of the model to other neurodegenerative diseases. The document is a list of references that cover various studies and papers related to NfL and its role in neurological disorders, providing a comprehensive source for further research. [Extracted from the article]

Published
2024
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