1. The great challenge: bone fragility and environment.
- Author
-
Mazzantini M and De Mattia G
- Subjects
- Humans, Risk Factors, Genetic Predisposition to Disease, Bone and Bones physiopathology, Phenotype, Osteoporosis etiology, Osteoporosis physiopathology, Osteoporosis genetics, Bone Density, Osteoporotic Fractures etiology, Osteoporotic Fractures epidemiology, Gene-Environment Interaction
- Abstract
Osteoporosis is a worldwide common disease characterised by reduced bone mass and increased risk of fractures.Many genetic variants are associated with the disease, but they account for only a small percentage of variance in individual bone mineral density and fragility fracture risk. Only recently have researchers recognised the role of a broad variety of environmental factors in the pathogenesis of osteoporosis, which has led to a further step: how genetic and environmental factors can interact, which is the next frontier in research on bone fragility.
- Published
- 2024
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