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2. Global burden and strength of evidence for 88 risk factors in 204 countries and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Brauer, Michael, Roth, Gregory A, Aravkin, Aleksandr Y, Zheng, Peng, Abate, Kalkidan Hassen, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasi, Madineh Akram, Abbasian, Mohammadreza, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abd ElHafeez, Samar, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abedi, Aidin, Abedi, Armita, Abegaz, Tadesse M, Abeldaño Zuñiga, Roberto Ariel, Abiodun, Olumide, Abiso, Temesgen Lera, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abukhadijah, Hana Jihad Jihad, Aburuz, Salahdein, Abu-Zaid, Ahmed, Adane, Mesafint Molla, Addo, Isaac Yeboah, Addolorato, Giovanni, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Aden, Bashir, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adibi, Amin, Adnani, Qorinah Estiningtyas 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Roland Dominic G, Jatau, Abubakar Ibrahim, Javadov, Sabzali, Javaheri, Tahereh, Jayaram, Shubha, Jeganathan, Jayakumar, Jeswani, Bijay Mukesh, Jiang, Heng, Johnson, Catherine O, Jokar, Mohammad, Jomehzadeh, Nabi, Jonas, Jost B, Joo, Tamas, Joseph, Abel, Joseph, Nitin, Joshi, Vivek, Joshua, Charity Ehimwenma, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kaambwa, Billingsley, Kabir, Ali, Kabir, Zubair, Kadashetti, Vidya, Kahn, Ethan M, Kalani, Rizwan, Kaliyadan, Feroze, Kalra, Sanjay, Kamath, Rajesh, Kanagasabai, Thanigaivelan, Kanchan, Tanuj, Kandel, Himal, Kanmiki, Edmund Wedam, Kanmodi, Kehinde Kazeem, Kansal, Sushil Kumar, Kapner, Daniel John, Kapoor, Neeti, Karagiannidis, Efstratios, Karajizadeh, Mehrdad, Karakasis, Paschalis, Karanth, Shama D, Karaye, Ibraheem M, Karch, André, Karim, Asima, Karimi, Hanie, Karmakar, Shilpi, Kashoo, Faizan Zaffar, Kasraei, Hengameh, Kassahun, Woldeteklehaymanot Dagne, Kassebaum, Nicholas J, Kassel, Molly B, Katikireddi, Srinivasa Vittal, Kauppila, Joonas H, Kawakami, Norito, Kaydi, Neda, Kayode, Gbenga A, Kazemi, Foad, Keiyoro, Peter Njenga, Kemmer, Laura, Kempen, John H, Kerr, Jessica A, Kesse-Guyot, Emmanuelle, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khajuria, Himanshu, Khalaji, Amirmohammad, Khalil, Mariam, Khalilian, Alireza, Khamesipour, Faham, Khan, Asaduzzaman, Khan, M Nuruzzaman, Khan, Maseer, Khan, Mohammad Jobair, Khan, Moien AB, Khanmohammadi, Shaghayegh, Khatab, Khaled, Khatatbeh, Haitham, Khatatbeh, Moawiah Mohammad, Khatib, Mahalaqua Nazli, Khavandegar, Armin, Khayat Kashani, Hamid Reza, Khidri, Feriha Fatima, Khodadoust, Elaheh, Khormali, Moein, Khorrami, Zahra, Khosla, Atulya Aman, Khosrowjerdi, Mahmood, Khreis, Haneen, Khusun, Helda, Kifle, Zemene Demelash, Kim, Kwanghyun, Kim, Min Seo, Kim, Yun Jin, Kimokoti, Ruth W, Kisa, Adnan, Kisa, Sezer, Knibbs, Luke D, Knudsen, Ann Kristin Skrindo, Koh, David S Q, Kolahi, Ali-Asghar, Kompani, Farzad, Kong, Jianqiu, Koren, Gerbrand, Korja, Miikka, Korshunov, Vladimir Andreevich, Korzh, Oleksii, Kosen, Soewarta, Kothari, Nikhil, Koul, Parvaiz A, Koulmane Laxminarayana, Sindhura Lakshmi, Krishan, Kewal, Krishnamoorthy, Vijay, Krishnamoorthy, Yuvaraj, Krishnan, Bindu, Krohn, Kris J, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kuddus, Md Abdul, Kuddus, Mohammed, Kugbey, Nuworza, Kuitunen, Ilari, Kulimbet, Mukhtar, Kulkarni, Vishnutheertha, Kumar, Ashish, Kumar, Nithin, Kumar, Vijay, Kundu, Satyajit, Kurmi, Om P, Kusnali, Asep, Kusuma, Dian, Kutluk, Tezer, La Vecchia, Carlo, Ladan, Muhammad Awwal, Laflamme, Lucie, Lahariya, Chandrakant, Lai, Daphne Teck Ching, Lal, Dharmesh Kumar, Lallukka, Tea, Lám, Judit, Lan, Qing, Lan, Tuo, Landires, Iván, Lanfranchi, Francesco, Langguth, Berthold, Lansingh, Van Charles, Laplante-Lévesque, Ariane, Larijani, Bagher, Larsson, Anders O, Lasrado, Savita, Lauriola, Paolo, Le, Huu-Hoai, Le, Long Khanh Dao, Le, Nhi Huu Hanh, Le, Thao Thi Thu, Leasher, Janet L, Ledda, Caterina, Lee, Munjae, Lee, Paul H, Lee, Seung Won, Lee, 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Samer H, Murray, Christopher J L, and Gakidou, Emmanuela
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3. Burden of disease scenarios for 204 countries and territories, 2022–2050: a forecasting analysis for the Global Burden of Disease Study 2021
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Vollset, Stein Emil, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbastabar, Hedayat, Abd Al Magied, Abdallah H A, Abd ElHafeez, Samar, Abdelkader, Atef, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdi, Parsa, Abdollahi, Mohammad, Abdoun, Meriem, Abdullahi, Auwal, Abebe, Mesfin, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Absalan, Abdorrahim, Abualruz, Hasan, Abubakar, Bilyaminu, Abukhadijah, Hana Jihad Jihad, Addolorato, Giovanni, Adekanmbi, Victor, Adetunji, Charles Oluwaseun, Adetunji, Juliana Bunmi, Adeyeoluwa, Temitayo Esther, Adha, Rishan, Adhikary, Ripon Kumar, Adnani, Qorinah Estiningtyas Sakilah, Adzigbli, Leticia Akua, Afrashteh, Fatemeh, Afzal, Muhammad Sohail, Afzal, Saira, Agbozo, Faith, Agodi, Antonella, Agrawal, Anurag, Agyemang-Duah, Williams, Ahinkorah, Bright Opoku, Ahlstrom, Austin J, Ahmad, Aqeel, Ahmad, 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4. Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021
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Naghavi, Mohsen, Ong, Kanyin Liane, Aali, Amirali, Ababneh, Hazim S, Abate, Yohannes Habtegiorgis, Abbafati, Cristiana, Abbasgholizadeh, Rouzbeh, Abbasian, Mohammadreza, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd ElHafeez, Samar, Abdelmasseh, Michael, Abd-Elsalam, Sherief, Abdelwahab, Ahmed, Abdollahi, Mohammad, Abdollahifar, Mohammad-Amin, Abdoun, Meriem, Abdulah, Deldar Morad, Abdullahi, Auwal, Abebe, Mesfin, Abebe, Samrawit Shawel, Abedi, Aidin, Abegaz, Kedir Hussein, Abhilash, E S, Abidi, Hassan, Abiodun, Olumide, Aboagye, Richard Gyan, Abolhassani, Hassan, Abolmaali, Meysam, Abouzid, Mohamed, Aboye, Girma Beressa, Abreu, Lucas Guimarães, Abrha, Woldu Aberhe, Abtahi, Dariush, Abu Rumeileh, Samir, Abualruz, Hasan, Abubakar, Bilyaminu, Abu-Gharbieh, Eman, Abu-Rmeileh, Niveen ME, Aburuz, Salahdein, Abu-Zaid, Ahmed, Accrombessi, Manfred Mario Kokou, Adal, Tadele Girum, Adamu, Abdu A, Addo, Isaac Yeboah, Addolorato, Giovanni, Adebiyi, Akindele Olupelumi, Adekanmbi, Victor, 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Maureene Auma, Ong, Sokking, Onwujekwe, Obinna E, Onyedibe, Kenneth Ikenna, Ordak, Michal, Orisakwe, Orish Ebere, Orish, Verner N, Ortega-Altamirano, Doris V, Ortiz, Alberto, Osman, Wael M S, Ostroff, Samuel M, Osuagwu, Uchechukwu Levi, Otoiu, Adrian, Otstavnov, Nikita, Otstavnov, Stanislav S, Ouyahia, Amel, Ouyang, Guoqing, Owolabi, Mayowa O, Ozten, Yaz, P A, Mahesh Padukudru, Padron-Monedero, Alicia, Padubidri, Jagadish Rao, Pal, Pramod Kumar, Palicz, Tamás, Palladino, Claudia, Palladino, Raffaele, Palma-Alvarez, Raul Felipe, Pan, Feng, Pan, Hai-Feng, Pana, Adrian, Panda, Paramjot, Panda-Jonas, Songhomitra, Pandi-Perumal, Seithikurippu R, Pangaribuan, Helena Ullyartha, Panos, Georgios D, Panos, Leonidas D, Pantazopoulos, Ioannis, Pantea Stoian, Anca Mihaela, Papadopoulou, Paraskevi, Parikh, Romil R, Park, Seoyeon, Parthasarathi, Ashwaghosha, Pashaei, Ava, Pasovic, Maja, Passera, Roberto, Pasupula, Deepak Kumar, Patel, Hemal M, Patel, Jay, Patel, Sangram Kishor, Patil, Shankargouda, 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PRISCILLA, TINA, Pritchett, Natalie, Purohit, Bharathi M, Puvvula, Jagadeesh, Qasim, Nameer Hashim, Qattea, Ibrahim, Qazi, Asma Saleem, Qian, Gangzhen, Qiu, Suli, Qureshi, Maryam Faiz, Rabiee Rad, Mehrdad, Radfar, Amir, Radhakrishnan, Raghu Anekal, Radhakrishnan, Venkatraman, Raeisi Shahraki, Hadi, Rafferty, Quinn, Raggi, Alberto, Raghav, Pankaja Raghav, Raheem, Nasiru, Rahim, Fakher, Rahim, Md Jillur, Rahimi-Movaghar, Vafa, Rahman, Md Mosfequr, Rahman, Mohammad Hifz Ur, Rahman, Mosiur, Rahman, Muhammad Aziz, Rahmani, Amir Masoud, Rahmani, Shayan, Rahmanian, Vahid, Rajaa, Sathish, Rajput, Prashant, Rakovac, Ivo, Ramasamy, Shakthi Kumaran, Ramazanu, Sheena, Rana, Kritika, Ranabhat, Chhabi Lal, Rancic, Nemanja, Rane, Amey, Rao, Chythra R, Rao, Indu Ramachandra, Rao, Mithun, Rao, Sowmya J, Rasali, Drona Prakash, Rasella, Davide, Rashedi, Sina, Rashedi, Vahid, Rashidi, Mohammad-Mahdi, Rasouli-Saravani, Ashkan, Rasul, Azad, Rathnaiah Babu, Giridhara, Rauniyar, Santosh Kumar, Ravangard, Ramin, Ravikumar, Nakul, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawlley, Bharat, Raza, Rabail Zehra, Razo, Christian, Redwan, Elrashdy Moustafa Mohamed, Rehman, Faizan Ur, Reifels, Lennart, Reiner Jr, Robert C, Remuzzi, Giuseppe, Reyes, Luis Felipe, Rezaei, Maryam, Rezaei, Nazila, Rezaei, Negar, Rezaeian, Mohsen, Rhee, Taeho Gregory, Riaz, Mavra A, Ribeiro, Antonio Luiz P, Rickard, Jennifer, Riva, Hannah R, Robinson-Oden, Hannah Elizabeth, Rodrigues, Célia Fortuna, Rodrigues, Mónica, Roever, Leonardo, Rogowski, Emma Lynn Best, Rohloff, Peter, Romadlon, Debby Syahru, Romero-Rodríguez, Esperanza, Romoli, Michele, Ronfani, Luca, Roshandel, Gholamreza, Roth, Gregory A, Rout, Himanshu Sekhar, Roy, Nitai, Roy, Priyanka, Rubagotti, Enrico, Ruela, Guilherme de Andrade, Rumisha, Susan Fred, Runghien, Tilleye, Rwegerera, Godfrey M, Rynkiewicz, Andrzej, S N, Chandan, Saad, Aly M A, Saadatian, Zahra, Saber, Korosh, Saber-Ayad, Maha Mohamed, SaberiKamarposhti, Morteza, Sabour, Siamak, Sacco, Simona, Sachdev, Perminder S, Sachdeva, Rajesh, Saddik, Basema, Saddler, Adam, Sadee, Bashdar Abuzed, Sadeghi, Ehsan, Sadeghi, Erfan, Sadeghian, Farideh, Saeb, Mohammad Reza, Saeed, Umar, Safaeinejad, Fahimeh, Safi, Sher Zaman, Sagar, Rajesh, Saghazadeh, Amene, Sagoe, Dominic, Saheb Sharif-Askari, Fatemeh, Saheb Sharif-Askari, Narjes, Sahebkar, Amirhossein, Sahoo, Soumya Swaroop, Sahoo, Umakanta, Sahu, Monalisha, Saif, Zahra, Sajid, Mirza Rizwan, Sakshaug, Joseph W, Salam, Nasir, Salamati, Payman, Salami, Afeez Abolarinwa, Salaroli, Luciane B, Saleh, Mohamed A, Salehi, Sana, Salem, Marwa Rashad, Salem, Mohammed Z Y, Salimi, Sohrab, Samadi Kafil, Hossein, Samadzadeh, Sara, Samargandy, Saad, Samodra, Yoseph Leonardo, Samy, Abdallah M, Sanabria, Juan, Sanna, Francesca, Santomauro, Damian Francesco, Santos, Itamar S, Santric-Milicevic, Milena M, Sao Jose, Bruno Piassi, Sarasmita, Made Ary, Saraswathy, Sivan Yegnanarayana Iyer, Saravanan, Aswini, Saravi, Babak, Sarikhani, Yaser, Sarkar, Tanmay, Sarmiento-Suárez, Rodrigo, Sarode, Gargi Sachin, Sarode, Sachin C, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Satpathy, Maheswar, Sayeed, Abu, Sayeed, Md Abu, Saylan, Mete, Sayyah, Mehdi, Scarmeas, Nikolaos, Schaarschmidt, Benedikt Michael, Schlaich, Markus P, Schlee, Winfried, Schmidt, Maria Inês, Schneider, Ione Jayce Ceola, Schuermans, Art, Schumacher, Austin E, Schutte, Aletta Elisabeth, Schwarzinger, Michaël, Schwebel, David C, Schwendicke, Falk, Šekerija, Mario, Selvaraj, Siddharthan, Senapati, Sabyasachi, Senthilkumaran, Subramanian, Sepanlou, Sadaf G, Serban, Dragos, Sethi, Yashendra, Sha, Feng, Shabany, Maryam, Shafaat, Amir, Shafie, Mahan, Shah, Nilay S, Shah, Pritik A, Shah, Syed Mahboob, Shahabi, Saeed, Shahbandi, Ataollah, Shahid, Izza, Shahid, Samiah, Shahid, Wajeehah, Shahsavari, Hamid R, Shahwan, Moyad Jamal, Shaikh, Ahmed, Shaikh, Masood Ali, Shakeri, Alireza, Shalash, Ali S, Sham, Sunder, Shamim, Muhammad Aaqib, Shams-Beyranvand, Mehran, Shamshad, Hina, Shamsi, Mohammad Anas, Shanawaz, Mohd, Shankar, Abhishek, Sharfaei, Sadaf, Sharifan, Amin, Sharifi-Rad, Javad, Sharma, Rajesh, Sharma, Saurab, Sharma, Ujjawal, Sharma, Vishal, Shastry, Rajesh P, Shavandi, Amin, Shayan, Maryam, Shehabeldine, Amr Mohamed Elsayed, Sheikh, Aziz, Sheikhi, Rahim Ali, Shen, Jiabin, Shetty, Adithi, Shetty, B Suresh Kumar, Shetty, Pavanchand H, Shi, Peilin, Shibuya, Kenji, Shiferaw, Desalegn, Shigematsu, Mika, Shin, Min-Jeong, Shin, Youn Ho, Shiri, Rahman, Shirkoohi, Reza, Shitaye, Nebiyu Aniley, Shittu, Aminu, Shiue, Ivy, Shivakumar, K M, Shivarov, Velizar, Shokraneh, Farhad, Shokri, Azad, Shool, Sina, Shorofi, Seyed Afshin, Shrestha, Sunil, Shuval, Kerem, Siddig, Emmanuel Edwar, Silva, João Pedro, Silva, Luís Manuel Lopes Rodrigues, Silva, Soraia, Simpson, Colin R, Singal, Anjali, Singh, Abhinav, Singh, Balbir Bagicha, Singh, Garima, Singh, Jasbir, Singh, Narinder Pal, Singh, Paramdeep, Singh, Surjit, Sinha, Dhirendra Narain, Sinto, Robert, Siraj, Md Shahjahan, Sirota, Sarah Brooke, Sitas, Freddy, Sivakumar, Shravan, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Sleet, David A, Socea, Bogdan, Sokhan, Anton, Solanki, Ranjan, Solanki, Shipra, Soleimani, Hamidreza, Soliman, Sameh S M, Song, Suhang, Song, Yimeng, Sorensen, Reed J D, Soriano, Joan B, Soyiri, Ireneous N, Spartalis, Michael, Spearman, Sandra, Sreeramareddy, Chandrashekhar T, Srivastava, Vijay Kumar, Stanaway, Jeffrey D, Stanikzai, Muhammad Haroon, Stark, Benjamin A, Starnes, Joseph R, Starodubova, Antonina V, Stein, Caroline, Stein, Dan J, Steinbeis, Fridolin, Steiner, Caitlyn, Steinmetz, Jaimie D, Steiropoulos, Paschalis, Stevanović, Aleksandar, Stockfelt, Leo, Stokes, Mark A, Stortecky, Stefan, Subramaniyan, Vetriselvan, Suleman, Muhammad, Suliankatchi Abdulkader, Rizwan, Sultana, Abida, Sun, Haitong Zhe, Sun, Jing, Sundström, Johan, Sunkersing, David, Sunnerhagen, Katharina S, Swain, Chandan Kumar, Szarpak, Lukasz, Szeto, Mindy D, Szócska, Miklós, Tabaee Damavandi, Payam, Tabarés-Seisdedos, Rafael, Tabatabaei, Seyyed Mohammad, Tabatabaei Malazy, Ozra, Tabatabaeizadeh, Seyed-Amir, Tabatabai, Shima, Tabish, Mohammad, TADAKAMADLA, JYOTHI, Tadakamadla, Santosh Kumar, Taheri Abkenar, Yasaman, Taheri Soodejani, Moslem, Taiba, Jabeen, Takahashi, Ken, Talaat, Iman M, Talukder, Ashis, Tampa, Mircea, Tamuzi, Jacques Lukenze, Tan, Ker-Kan, Tandukar, Sarmila, Tang, Haosu, Tang, Hong K, Tarigan, Ingan Ukur, Tariku, Mengistie Kassahun, Tariqujjaman, Md, Tarkang, Elvis Enowbeyang, Tavakoli Oliaee, Razieh, Tavangar, Seyed Mohammad, Taveira, Nuno, Tefera, Yibekal Manaye, Temsah, Mohamad-Hani, Temsah, Reem Mohamad Hani, Teramoto, Masayuki, Tesler, Riki, Teye-Kwadjo, Enoch, Thakur, Rishu, Thangaraju, Pugazhenthan, Thankappan, Kavumpurathu Raman, Tharwat, Samar, Thayakaran, Rasiah, Thomas, Nihal, Thomas, Nikhil Kenny, Thomson, Azalea M, Thrift, Amanda G, Thum, Chern Choong Chern, Thygesen, Lau Caspar, Tian, Jing, Tichopad, Ales, Ticoalu, Jansje Henny Vera, Tillawi, Tala, Tiruye, Tenaw Yimer, Titova, Mariya Vladimirovna, Tonelli, Marcello, Topor-Madry, Roman, Toriola, Adetunji T, Torre, Anna E, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Tran, Jasmine T, Tran, Nghia Minh, Trico, Domenico, Tromans, Samuel Joseph, Truyen, Thien Tan Tri Tai, Tsatsakis, Aristidis, Tsegay, Guesh Mebrahtom, Tsermpini, Evangelia Eirini, Tumurkhuu, Munkhtuya, Tung, Kang, Tyrovolas, Stefanos, Uddin, Sayed Mohammad Nazim, Udoakang, Aniefiok John, Udoh, Arit, Ullah, Atta, Ullah, Irfan, Ullah, Saeed, Ullah, Sana, Umakanthan, Srikanth, Umeokonkwo, Chukwuma David, Unim, Brigid, Unnikrishnan, Bhaskaran, Unsworth, Carolyn Anne, Upadhyay, Era, Urso, Daniele, Usman, Jibrin Sammani, Vahabi, Seyed Mohammad, Vaithinathan, Asokan Govindaraj, Valizadeh, Rohollah, Van de Velde, Sarah M, Van den Eynde, Jef, Varga, Orsolya, Vart, Priya, Varthya, Shoban Babu, Vasankari, Tommi Juhani, Vasic, Milena, Vaziri, Siavash, Vellingiri, Balachandar, Venketasubramanian, Narayanaswamy, Verghese, Nicholas Alexander, Verma, Madhur, Veroux, Massimiliano, Verras, Georgios-Ioannis, Vervoort, Dominique, Villafañe, Jorge Hugo, Villanueva, Gabriela Ines, Vinayak, Manish, Violante, Francesco S, Viskadourou, Maria, Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vo, Bay, Vollset, Stein Emil, Vongpradith, Avina, Vos, Theo, Vujcic, Isidora S, Vukovic, Rade, Wafa, Hatem A, Waheed, Yasir, Wamai, Richard G, Wang, Cong, Wang, Ning, Wang, Shu, Wang, Song, Wang, Yanzhong, Wang, Yuan-Pang, Waqas, Muhammad, Ward, Paul, Wassie, Emebet Gashaw, Watson, Stefanie, Watson, Stephanie Louise Watson, Weerakoon, Kosala Gayan, Wei, Melissa Y, Weintraub, Robert G, Weiss, Daniel J, Westerman, Ronny, Whisnant, Joanna L, Wiangkham, Taweewat, Wickramasinghe, Dakshitha Praneeth, Wickramasinghe, Nuwan Darshana, Wilandika, Angga, Wilkerson, Caroline, Willeit, Peter, Wilson, Shadrach, Wojewodzic, Marcin W, Woldegebreal, Demewoz H, Wolf, Axel Walter, Wolfe, Charles D A, Wondimagegene, Yohannes Addisu, Wong, Yen Jun, Wongsin, Utoomporn, Wu, Ai-Min, Wu, Chenkai, Wu, Felicia, Wu, Xinsheng, Wu, Zenghong, Xia, Juan, Xiao, Hong, Xie, Yang, Xu, Suowen, Xu, Wang-Dong, Xu, Xiaoyue, Xu, Yvonne Yiru, Yadollahpour, Ali, Yamagishi, Kazumasa, Yang, Danting, Yang, Lin, Yano, Yuichiro, Yao, Yao, Yaribeygi, Habib, Ye, Pengpeng, Yehualashet, Sisay Shewasinad, Yesiltepe, Metin, Yesuf, Subah Abderehim, Yezli, Saber, Yi, Siyan, Yigezu, Amanuel, Yiğit, Arzu, Yiğit, Vahit, Yip, Paul, Yismaw, Malede Berihun, Yismaw, Yazachew, Yon, Dong Keon, Yonemoto, Naohiro, Yoon, Seok-Jun, You, Yuyi, Younis, Mustafa Z, Yousefi, Zabihollah, Yu, Chuanhua, Yu, Yong, Yuh, Faith H, Zadey, Siddhesh, Zadnik, Vesna, Zafari, Nima, Zakham, Fathiah, Zaki, Nazar, Zaman, Sojib Bin, Zamora, Nelson, Zand, Ramin, Zangiabadian, Moein, Zar, Heather J, Zare, Iman, Zarrintan, Armin, Zeariya, Mohammed G M, Zeinali, Zahra, Zhang, Haijun, Zhang, Jianrong, Zhang, Jingya, Zhang, Liqun, Zhang, Yunquan, Zhang, Zhi-Jiang, Zhao, Hanqing, Zhong, Chenwen, Zhou, Juexiao, Zhu, Bin, Zhu, Lei, Ziafati, Makan, Zielińska, Magdalena, Zitoun, Osama A, Zoladl, Mohammad, Zou, Zhiyong, Zuhlke, Liesl J, Zumla, Alimuddin, Zweck, Elric, Zyoud, Samer H, Wool, Eve E, and Murray, Christopher J L
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- 2024
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5. Gastrointestinal Variant of Lemierre's Syndrome: A Systematic Review and Comprehensive Analysis of 36 Case Reports
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Jaber, Fouad, Alsakarneh, Saqr, Alsharaeh, Tala, Salahat, Ahmed-Jordan, Elfert, Khaled, Beran, Azizullah, Gangwani, Manesh K., Abboud, Yazan, Al-sayyed, Leen, Madi, Mahmoud Y., Jaber, Mohammad, Dahiya, Dushyant S., Numan, Laith, and Duong, Nikki
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- 2024
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6. Prevalence and sex differences in endoscopy-related injuries: comprehensive systematic review and meta-analysis
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Beran, Azizullah, Mohamed, Mouhand F., Guardiola, John J., Aboursheid, Tarek, Vargas, Alejandra, Nayfeh, Tarek, Elfert, Khaled, Shaear, Mohammad, Fatima, Hala, Easler, Jeffrey J., Al-Haddad, Mohammad, Fayad, Nabil, Young, Patrick, Shah, Samir A., and Rex, Douglas K.
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- 2024
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7. Midodrine for Recurrent Vasovagal Syncope: A Systematic Review and Meta-analysis of Randomized Control Trials
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Mhanna, Mohammed, Beran, Azizullah, Mhanna, Asmaa S., Al-Abdouh, Ahmad, Jabri, Ahmad, Numan, Mahmoud J., Alsaiqali, Mahmoud, Musallam, Rami, Zerihun, Kirubel, and Mahmood, Asif
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- 2024
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8. Clinically Significant Gastrointestinal Bleeding Using Proton Pump Inhibitors or Histamine Type-2 Receptor Antagonists in Patients Intubated for over 48 Hours: A Systematic Review and Meta-Analysis
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Khokher, Waleed, Kesireddy, Nithin, Iftikhar, Saffa, Beran, Azizullah, Abuhelwa, Ziad, Malhas, Saif-Eddin, Saif, Talha, Rashid, Rakin, Ali, Hyder, Malik, Ahmad, and Assaly, Ragheb
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- 2024
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9. Molnupiravir for the Treatment of Coronavirus Disease 2019: A Systematic Review With Meta-Analysis of 12,451 Patients
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Beran, Azizullah, Mhanna, Asmaa, Mhanna, Mohammed, Farrow, David, Sidiki, Sabeen, Khader, Yasmin, Srour, Omar, and Kayyali, Ammar
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- 2024
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10. G-EYE Improves Polyp, Adenoma, and Serrated Polyp Detection Rates in Colonoscopy: A Systematic Review and Meta-analysis.
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Haghbin, Hossein, Zakirkhodjaev, Nurruddinkhodja, Beran, Azizullah, Smith, Wade Lee, and Aziz, Muhammad
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- 2024
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11. Intravenous iron therapy for patients with iron deficiency and heart failure: a systematic review and meta-analysis of randomized controlled trials.
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Mhanna, Mohammed, Sauer, Michael C., Al-Abdouh, Ahmad, Jabri, Ahmad, Beran, Azizullah, Barbarawi, Mahmoud, Mansour, Shareef, and Hanna, Elias B.
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Heart failure (HF) presents a significant health challenge, with intravenous (IV) iron therapy considered a potential treatment avenue. We assessed IV iron therapy's efficacy in HF patients with concurrent iron deficiency versus standard of care. Primary outcomes included the composite of HF hospitalizations or cardiovascular-related mortality, HF hospitalizations, and all-cause, HF, and cardiovascular mortality rates. Secondary measures encompassed improvements in New York Heart Association functional classification, quality of life, 6-minute walk test, left ventricular ejection fraction, and adverse events. We used a random-effects model to compute relative risk (RR) or mean difference (MD) with 95% confidence intervals (CIs). Based on an analysis of 14 randomized controlled trials involving 6614 patients, IV iron therapy significantly reduced composite outcome (RR: 0.84, 95% CI: 0.73, 0.96; P = 0.01) and HF hospitalizations (RR: 0.74, 95% CI: 0.61, 0.89; P = 0.002) compared to standard of care. Mortality rates showed no significant difference. IV iron therapy improved New York Heart Association functional classification, quality of life, and 6-minute walk test, with no major impact on left ventricular ejection fraction. Adverse events remained stable. IV iron therapy holds promise for diminishing HF hospitalizations and enhancing quality of life and 6-minute walk test in HF patients. Yet, its effect on all-cause or cardiovascular mortalities appears limited. [ABSTRACT FROM AUTHOR]
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- 2024
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12. Dye Chromoendoscopy Outperforms High-Definition White Light Endoscopy in Dysplasia Detection for Patients With Inflammatory Bowel Disease: An Updated Meta-Analysis of Randomized Controlled Trials.
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Mohamed, Mouhand F. H., Marino, Daniel, Elfert, Khaled, Beran, Azizullah, Nayfeh, Tarek, Abdallah, Mohamed A., Sultan, Shahnaz, and Shah, Samir A.
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- 2024
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13. Glucagon for Esophageal Foreign Body Impaction: A Systematic Review and Meta-analysis of Randomized Controlled Trials.
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Ismail, AbdiGhani, Beran, Azizullah, Saadat, Saad, Veraza, Diego Izquierdo, and Guardiola, John J.
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- 2024
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14. Balanced crystalloids versus isotonic saline in pediatric sepsis: a comprehensive systematic review and meta-analysis.
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Mhanna, Asmaa, Beran, Azizullah, Srour, Omar, Mhanna, Mohammed, Assaly, Ahmad, Elsayed, Abdelrahman, Horen, Nicholas G., and Assaly, Ragheb
- Abstract
We conducted a comprehensive meta-analysis to compare the effects of balanced crystalloids (BC) and isotonic saline (IS) in pediatric sepsis. A systematic search was performed for studies comparing BC and IS in pediatric sepsis. Outcomes included mortality, acute kidney injury (AKI), need for renal replacement therapy (RRT), hospital length of stay (LOS), and pediatric intensive care unit (PICU) LOS. A random-effect models was used to calculated pooled odds ratios (OR) and mean differences (MD) with 95% confidence intervals (CIs). The analysis included six studies with 8753 children. BC demonstrated significant reductions in overall mortality (OR 0.84, 95% CI 0.71 to 0.98, P = 0.03, I
2 = 0%) and AKI (OR 0.74, 95% CI 0.57 to 0.96, P = 0.03, I2 = 37%) compared to IS. RRT need was similar between the BC and IS groups (OR 0.79, 95% CI 0.60 to 1.02, P = 0.07, I2 = 0%). Hospital and PICU LOS did not differ significantly. However, subgroup analysis of randomized controlled trials revealed significantly shorter hospital LOS in the BC group (mean difference −0.66 days, 95% CI −1.10 to −0.23, P = 0.003, I2 = 0%). Our meta-analysis demonstrates that using BC in pediatric sepsis is associated with reduced mortality, AKI, and hyperchloremia rates compared to IS, while maintaining similar hospital and PICU LOS. Large-scale randomized controlled trials are needed to validate these findings. [ABSTRACT FROM AUTHOR]- Published
- 2024
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15. Plasma exchange for acute and acute-on-chronic liver failure: A systematic review and meta-analysis.
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Beran, Azizullah, Mohamed, Mouhand F. H., Shaear, Mohammad, Nayfeh, Tarek, Mhanna, Mohammed, Srour, Omar, Nawras, Mohamad, Mentrose, Jonathan A., Assaly, Ragheb, Kubal, Chandrashekhar A., Ghabril, Marwan S., Hernaez, Ruben, and Patidar, Kavish R.
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- 2024
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16. A comparison of career plans of gastroenterology fellows compared to fellows in other internal medicine subspecialties.
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Alsakarneh, Saqr, Almeqdadi, Mohammad, Jaber, Fouad, Beran, Azizullah, Aldiabat, Mohammd, Kilani, Yassine, Reid, Adam Muhammad, Zulqarnain, Mir, Abughazaleh, Saeed, Duong, Nikki, and Clarkston, Wendell
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The career trajectory of medical professionals, particularly in specialized fields like gastroenterology, can significantly impact healthcare and research. This study aimed to analyze career choices among gastroenterology fellows in the US and investigate the factors influencing these choices. We utilized data from the American Medical Association on internal medicine subspecialty fellows. The study examined career plans of gastroenterology fellows and compared them with those of other subspecialties. A chi-square test was performed to assess differences in career choices and practice settings. Among gastroenterology fellows, 46% opted for private practice, 28% pursued further training, and 26% chose academia. Notably, gastroenterology fellows were more inclined toward private practice than their counterparts in other subspecialties (46.3% vs 38.4%) and were less likely to pursue academic careers (25.6% vs 30.7%). This study highlights a concerning trend among recent gastroenterology fellowship graduates favoring private practice over academic careers or additional training. To sustain and strengthen academic medicine in gastroenterology, interventions such as scholarships, mentorship programs, and loan repayment initiatives tailored to academic pursuits could play a crucial role. [ABSTRACT FROM AUTHOR]
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- 2024
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17. Impact of COVID-19 infection on patients admitted with nonvariceal upper gastrointestinal bleeding: an analysis from the National Inpatient Sample.
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Elfert, Khaled, Malik, Mushrin, Aboursheid, Tarek, Mohamed, Mouhand, Elfert, Yomna, Beran, Azizullah, Jaber, Fouad, Elromisy, Esraa, Al-Taee, Ahmad, and Kahaleh, Michel
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Nonvariceal upper gastrointestinal bleeding (NVUGIB) is a medical emergency that has significant morbidity and mortality. The available data about the impact of COVID-19 infection on mortality in patients with NVUGIB is limited. We identified all hospitalizations with a principal diagnosis of NVUGIB in 2020. The baseline characteristics and clinical outcomes of patients with COVID-19 infection were compared to those without COVID-19 infection. NVUGIB patients with COVID-19 infection had higher mortality (5% vs 2%, P < 0.0001), a longer mean length of stay (6.85 vs 4.48 days, P < 0.0001), and a lower rate of esophagogastroduodenoscopy utilization (40% vs 51%, P < 0.0001) than those without COVID-19 infection. Multivariate logistic regression analysis showed that COVID-19 infection was associated with a higher mortality rate (odds ratio 2.2, 95% confidence interval, 1.4–3.4). COVID-19 infection is an independent predictor of mortality in adults hospitalized with NVUGIB. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Increasing trend of endoscopic drainage utilization for the management of pancreatic pseudocyst: insights from a nationwide database.
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Elfert, Khaled, Chamay, Salomon, Dos Santos, Lamin, Mohamed, Mouhand, Beran, Azizullah, Jaber, Fouad, Abosheaishaa, Hazem, Nayudu, Suresh, and Ho, Sammy
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DATABASES ,DRAINAGE ,LENGTH of stay in hospitals - Abstract
Background/Aims: The pancreatic pseudocyst (PP) is a type of fluid collection that typically develops as a delayed complication of acute pancreatitis. Drainage is indicated for symptomatic patients and/or associated complications, such as infection and bleeding. Drainage modalities include percutaneous, endoscopic, laparoscopic, and open drainage. This study aimed to assess trends in the utilization of different drainage modalities for treating PP from 2016 to 2020. The trends in mortality, mean length of hospital stay, and mean hospitalization costs were also assessed. Methods: The National Inpatient Sample database was used to obtain data. The variables were generated using International Classification of Diseases-10 diagnostic and procedural codes. Results: Endoscopic drainage was the most commonly used drainage modality in 2018-2020, with an increasing trend over time (385 procedures in 2018 to 515 in 2020; p=0.003). This is associated with a decrease in the use of other drainage modalities. A decrease in the hospitalization cost for PP requiring drainage was also noted (29,318 United States dollar [USD] in 2016 to 18,087 USD in 2020, p<0.001). Conclusions: Endoscopic drainage is becoming the most commonly used modality for the treatment of PP in hospitals located in the US. This new trend is associated with decreasing hospitalization costs. [ABSTRACT FROM AUTHOR]
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- 2024
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19. The National Burden of Colorectal Cancer in the United States from 1990 to 2019.
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Alsakarneh, Saqr, Jaber, Fouad, Beran, Azizullah, Aldiabat, Mohammad, Abboud, Yazan, Hassan, Noor, Abdallah, Mohamed, Abdelfattah, Thaer, Numan, Laith, Clarkston, Wendell, Bilal, Mohammad, and Shaukat, Aasma
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HEALTH policy ,CANCER patient psychology ,TIME ,AGE distribution ,DISEASE incidence ,POPULATION geography ,COLORECTAL cancer ,SEX distribution ,DISEASE prevalence ,ECONOMIC aspects of diseases ,HEALTH equity ,HEALTH care rationing ,DISEASE risk factors - Abstract
Simple Summary: Colorectal cancer (CRC) is a significant global health concern, ranking as the second leading cause of cancer-related deaths. Despite an overall decline in CRC rates in the United States, there is a concerning rise in early-onset cases (diagnosed before age 50). This study, utilizing comprehensive data from the Global Burden of Disease 2019, delves into the state-specific trends in CRC incidence, prevalence, and mortality over three decades (1990–2019). Notably, the research reveals varying patterns across geographic regions, gender, and age groups. Understanding these nuanced trends is crucial for targeted resource allocation and policy decisions to effectively combat CRC, a disease with an increasing impact on younger adults in the United States. CRC accounts for approximately a tenth of all cancer cases and deaths in the US. Due to large differences in demographics among the different states, we aim to determine trends in the CRC epidemiology and across different states, age groups, and genders. CRC rates, age-adjusted to the standard US population, were obtained from the GBD 2019 database. Time trends were estimated as annual percentage change (APC). A pairwise comparison was conducted between age- and gender-specific trends using the tests of parallelism and coincidence. Age-specific trends were also assessed in two age subgroups: younger adults aged 15–49 years and older adults aged 50–74 years. We also analyzed the prevalence, incidence, mortality, and DALYs in the US between 1990 and 2019. A total of 5.53 million patients were diagnosed with CRC in the US between 1990 and 2019. Overall, CRC incidence rates have significantly increased in younger adults (11.1 per 100,000 persons) and decreased in older adults (136.8 per 100,000 persons) (AAPC = 1.2 vs. −0.6; AAPC difference = 1.8, p < 0.001). Age-specific trends were neither identical (p < 0.001) nor parallel (p < 0.001), suggesting that CRC incidence rates are different and increasing at a greater rate in younger adults compared to older adults. However, for both men and women (49.4 and 35.2 per 100,000 persons), incidence rates have decreased over the past three decades at the same rate (AAPC = −0.5 vs. −0.5; AAPC difference = 0, p = 0.1). Geographically, the southern states had the highest mortality rates with Mississippi having the highest rate of 20.1 cases per 100,000 population in 2019. Massachusetts, New York, and the District of Colombia had the greatest decreases in mortality over the study period (−42.1%, −41.4%, and −40.9%). Decreased mortality was found in all states except Mississippi, where the mortality of CRC increased over the study period (+1.5%). This research provides crucial insights for policymakers to tailor resource allocation, emphasizing the dynamic nature of CRC burden across states and age groups, ultimately informing targeted strategies for prevention and intervention. [ABSTRACT FROM AUTHOR]
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- 2024
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20. Mo2009 EFFICACY OF TC-325 HEMOSTATIC POWDER FOR MANAGING PATIENTS PRESENTING WITH MALIGNANT GASTROINTESTINAL BLEEDING: A META-ANALYSIS OF RANDMOZIED CONTROLLED TRIALS
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Jaber, Fouad, Alsakarneh, Saqr, Mohamed, Islam, Gangwani, Manesh Kumar, Wilson, Natalie J., Abboud, Yazan, Elfert, Khaled, Dahiya, Dushyant Singh, Jaber, Mohammad, Alsharaeh, Tala S., and Beran, Azizullah
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- 2024
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21. Mo1411 PREDICTORS OF POST-ERCP PANCREATITIS: A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS OF 229 STUDIES WITH OVER 3.3 MILLION PATIENTS
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Beran, Azizullah, Aboursheid, Tarek, Albunni, Hashem, Ali, Adel Hajj, Mohamed, Mouhand F., Vargas, Alejandra, Salame, Marita, Karkash, Ahmad, Obaitan, Itegbemie, Saleem, Nasir, Gutta, Aditya, Gromski, Mark A., Al-Haddad, Mohammad A., Fogel, Evan L., and Easler, Jeffrey J.
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- 2024
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22. Tu2026 COMPARISON OF COLONOSCOPY QUALITY METRICS USING ARTIFICIAL INTELLIGENCE ASSISTED COLONOSCOPY VERSUS STANDARD COLONOSCOPY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS
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Jaber, Fouad, Alsakarneh, Saqr, Madi, Mahmoud Y., Numan, Laith, Beran, Azizullah, Abboud, Yazan, Wilson, Natalie J., Jaber, Mohammad, Abdallah, Mohamed, Bilal, Mohammad, and Shaukat, Aasma
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- 2024
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23. Su1431 DOES THE ETIOLOGY OF CHRONIC PANCREATITIS IMPACT THE CLINICAL OUTCOMES: A POPULATION-BASED ANALYSIS FROM THE TRINETX DIAMOND NETWORK
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Elfert, Khaled, Nassar, Mahmoud, Mohamed, Mouhand F., Beran, Azizullah, Abosheaishaa, Hazem, Mohamed, Islam, Alsakarneh, Saqr, Khalifa, Ali, Aloum, Khalid, and Elhanafi, Sherif E.
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- 2024
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24. 1305 RISK FACTORS FOR BILIARY STRICTURES POST LIVING-DONOR LIVER TRANSPLANTATION: A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS
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Hassouneh, Ramzi, Beran, Azizullah, Rosenheck, Michael S., Olchawa, Nicholas, Kubal, Shekhar, Ghabril, Marwan S., and Gromski, Mark A.
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- 2024
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25. 622 ERCP FOR MANAGEMENT OF POST-CHOLECYSTECTOMY BILE LEAKS IN PATIENTS WITH SUBTOTAL VERSUS TOTAL CHOLECYSTECTOMY: A COMPARATIVE ANALYSIS
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Gao, Ashley, Yadlapati, Sujani, Beran, Azizullah, Bick, Benjamin L., Saleem, Nasir, Gromski, Mark A., Fogel, Evan L., Gutta, Aditya, Obaitan, Itegbemie, Watkins, James L., House, Michael G., Zyromski, Nicholas J., Ellis, Ryan J., Ceppa, Eugene P., and Easler, Jeffrey J.
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- 2024
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26. Su1569 HIGH PREVALENCE OF METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD) IN LEAN AND NON-LEAN PATIENTS WITH INFLAMMATORY BOWEL DISEASE (IBD)
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Mohamed, Mouhand F., Beran, Azizullah, Chu, Jacqueline J., Yang, Wen T., Rajadurai, Suvithan, Ghabril, Marwan S., Shah, Samir A., and Njei, Basile
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- 2024
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27. Su1561 CLINICAL CHARACTERISTICS AND OUTCOMES OF PATIENTS WITH METABOLIC DYSFUNCTION-ASSOCIATED STEATOTIC LIVER DISEASE (MASLD) UNDERGOING PERCUTANEOUS CORONARY INTERVENTION (PCI). INSIGHT FROM THE NATIONAL INPATIENT SAMPLE.
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Aboursheid, Tarek, Hijazi, Mohamad, Albuni, Mhd Kutaiba, Sawaf, Bisher, Khokhlov, Leonid, Elfert, Khaled, Beran, Azizullah, Abdalla, Monzer, and Chaar, Abdelkader
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- 2024
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28. Mo1404 INTRAHEPATIC VERSUS EXTRAHEPATIC BILE DUCT ACCESS DURING ENDOSCOPIC ULTRASOUND GUIDED RENDEZVOUS FOR DIFFICULT BILIARY CANNULATION: A SYSTEMATIC REVIEW AND META-ANALYSIS
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Alsakarneh, Saqr, Jaber, Fouad, Khraisat, Farah A., Madi, Mahmoud Y., Ahmed, Mohamed, Asha, Ahmad Y., Dahiya, Dushyant Singh, Beran, Azizullah, Ghoz, Hassan, and Bilal, Mohammad
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- 2024
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29. Su1113 A SCOPING REVIEW OF COST AND VALUE STATEMENTS OF GENERAL GASTROENTEROLOGY GUIDELINES FROM 2011-2023
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Karna, Rahul, Seid, Amir Sultan, Paladiya, Ruchir, Khataniar, Himsikhar, Ranganatha, Ravishankar, Blomker, Jacquelin, Beran, Azizullah, Dahiya, Dushyant Singh, Roldan, Giovanni A., Lou, Susan, and Bilal, Mohammad
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- 2024
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30. 306 OPTIMIZING ADHERENCE TO QUADRUPLE THERAPY FOR H PYLORI ERADICATION AMONGST ETHNIC MINORITIES: A QUALITY IMPROVEMENT INITIATIVE AT A SAFETY-NET MEDICAL CENTER
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Rahal, Mahmoud A., Patel, Feenalie, Beran, Azizullah, Fayad, Nabil, and Abdeljawad, Khaled
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- 2024
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31. COMBINATION OF SOMATOSTATIN AND NON-STEROIDAL ANTI-INFLAMMATORY DRUGS FOR PREVENTION OF POST-ENDOSCOPIC RETROGRADE CHOLANGIOPANCREATOGRAPHY (ERCP) PANCREATITIS IN HIGH-RISK PATIENTS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.
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Jaber, Fouad, Alsakarneh, Saqr, Alsharaeh, Tala, Alchirazi, Khaled Alsabbagh, Salahat, Ahmed-Jordan, Mohamed, Islam, Jaber, Mohammad, Beran, Azizullah, Abboud, Yazan, Abdu, Manasik, Ahmed, Mohamed, Odah, Tarek, and Ghoz, Hassan
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- 2024
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32. SAFETY AND EFFICACY OF ENDOSCOPIC ULTRASONOGRAPHY-GUIDED HEPATICOGASTROSTOMY AND ANTEROGRADE STENTING: A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS.
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Alsakarneh, Saqr, Madi, Mahmoud, Jaber, Fouad, Kilani, Yassine, Ahmed, Mohamed, Beran, Azizullah, Abdallah, Mohamed, Numan, Laith, Bilal, Mohammad, and Kiwan, Wissam
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- 2024
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33. SAFETY AND ADVERSE EVENTS OF ENDOSCOPIC ULTRASOUND-GUIDED GASTROENTEROSTOMY, SURGICAL GASTROENTEROSTOMY, AND ENTERAL STENTING FOR GASTRIC OUTLET OBSTRUCTION: A SYSTEMATIC REVIEW AND NETWORK META-ANALYSIS.
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Baliss, Michelle, Karna, Rahul, Madi, Mahmoud, Yarra, Pradeep, Beran, Azizullah, Nayfeh, Tarek, Phung, Jenson, Theis-Mahon, Nicole, Rocca, Antonio Cheesman, and Bilal, Mohammad
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- 2024
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34. IN OGILVIE'S SYNDROME: NEOSTIGMINE VS. DECOMPRESSIVE COLONOSCOPY - WHICH COMES FIRST? A SYSTEMATIC REVIEW AND META-ANALYSIS.
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Beran, Azizullah, Shaear, Mohammad, Mohamed, Mouhand, Elkhattib, Ismail, Alsakarneh, Saqr, Alashari, Akram, and Abdeljawad, Khaled
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- 2024
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35. PERFORMANCE OF FECAL IMMUNOCHEMICAL TEST FOR SURVEILLANCE IN PATIENTS WITH HIGH-RISK OF COLORECTAL CANCER: A SYSTEMATIC REVIEW & META-ANALYSIS.
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Karna, Rahul, Bilal, Mohammad, Beran, Azizullah, Paladiya, Ruchir, Khataniar, Himsikhar, Ranganatha, Ravishankar, Theis-Mahon, Nicole, Nayfeh, Tarek, and Shaukat, Aasma
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- 2024
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36. SOFT TIP SNARE COAGULATION OF RESECTION MARGINS IN ENDOSCOPIC MUCOSAL RESECTION OF LARGE NON-PEDUNCULATED COLORECTAL POLYPS: A META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.
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Beran, Azizullah, Alsakarneh, Saqr, Mohamed, Mouhand, Elkhattib, Ismail, Hadaki, Nwal, and Saito, Akira
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- 2024
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37. SOLID ORGAN TRANSPLANT RECIPIENTS HAVE AN INCREASED RISK OF HARBORING COLORECTAL ADENOMAS AND HIGH-RISK ADENOMAS: A SYSTEMATIC REVIEW AND META-ANALYSIS.
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Beran, Azizullah, Mohamed, Mouhand, Elfert, Khaled, Guardiola, John, Rex, Douglas, and Fatima, Hala
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- 2024
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38. BOWEL PERFORATION DUE TO BILIARY STENT MIGRATION AFTER ERCP: A SYSTEMATIC REVIEW.
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Wilson, Natalie, Ezeani, Chukwunonso, Ismail, Abdellatif, Abdalla, Monzer, Mohammed, Shaikhoon, Abdalla, Abubaker, Beran, Azizullah, Jaber, Fouad, Abosheaishaa, Hazem, Loon, Erica, Abdallah, Mohamed, Vargo, John, Bilal, Mohammad, and Chahal, Prabhleen
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- 2024
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39. RISK FACTORS FOR INADEQUATE BOWEL PREPARATION IN COLONOSCOPY: A COMPREHENSIVE SYSTEMATIC REVIEW AND META-ANALYSIS OF 146 STUDIES.
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Beran, Azizullah, Ali, Adel Hajj, Aboursheid, Tarek, Albunni, Hashem, Hadaki, Nwal, Vargas, Alejandra, Mohamed, Mouhand, Rex, Douglas, and Guardiola, John
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- 2024
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40. RISK OF BLEEDING AFTER PERCUTANEOUS ENDOSCOPIC GASTROSTOMY N PATIENTS ON DUAL ANTIPLATELET THERAPY: A POPULATION-BASED PROPENSITY-MATCHED STUDY.
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Elfert, Khaled, Abosheaishaa, Hazem, Mohamed, Mouhand, Beran, Azizullah, Salem, Ahmed, Elromisy, Esraa, Mohamed, Islam, Nassar, Mahmoud, and Elhanafi, Sherif
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- 2024
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41. LACTULOSE VS POLYETHYLENE GLYCOL FOR BOWEL PREPARATION BEFORE COLONOSCOPY: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRIALS.
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Aboursheid, Tarek, Beran, Azizullah, Hijazi, Mohamad, Albuni, Mhd Kutaiba, Sawaf, Bisher, Rahima, Kenan, Hadaki, Nwal, Elkhattib, Ismail, and Abdeljawad, Khaled
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- 2024
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42. RISK OF PERCUTANEOUS ENDOSCOPIC GASTROSTOMY-RELATED BLEEDING WITH UNINTERRUPTED ANTICOAGULATION: A MULTI-CENTER RETROSPECTIVE COHORT STUDY.
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Elfert, Khaled, Beran, Azizullah, Abosheaishaa, Hazem, Salem, Ahmed, Mohamed, Mouhand, Elromisy, Esraa, Abusuliman, Mohammed, Nassar, Mahmoud, and Elhanafi, Sherif
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- 2024
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43. Risk factors for inadequate bowel preparation in colonoscopy: a comprehensive systematic review and meta-analysis.
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Beran A, Aboursheid T, Ali AH, Albunni H, Mohamed MF, Vargas A, Hadaki N, Alsakarneh S, Rex DK, and Guardiola JJ
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Introduction: Inadequate bowel preparation (IBP) prior to colonoscopy remains a common problem. This meta-analysis aimed to assess the risk factors associated with IBP., Methods: We searched multiple databases for studies that assessed risk factors for IBP after adjustment and reported the data as adjusted odds ratios (OR) with 95% confidence intervals. Meta-analyses were conducted using a random-effects model, and pooled adjusted ORs for risk factors reported in ≥3 studies were constructed., Results: 154 studies with 258,257 participants were included. We analyzed 48 unique risk factors. Sociodemographic predictors of IBP were Medicaid insurance, obesity, current tobacco use, age≥65, Black race, low education level, male gender, and unmarried status. Comorbidity-related predictors of IBP were any psychiatric disease, cirrhosis, ASA class≥3, poor functional status, constipation, diabetes, prior abdominopelvic surgery, and hematochezia. Medication-related predictors of IBP were tricyclic antidepressants (TCA), antidepressants, opioid, non-TCA antidepressants, and calcium channel blockers. Preparation/procedure-related predictors of IBP were brown liquid rectal effluent, any incomplete bowel preparation (BP) intake, lack of split-dose BP, increased BP-to-defecation interval, any non-adherence to dietary instructions, increased BP-to-colonoscopy interval, any BP intolerance, prior IBP, and inpatient status. While afternoon colonoscopy was a predictor of IBP, subgroup analysis of prospective studies revealed no significant association., Conclusions: Our meta-analysis focused on adjusted risk factors to provide precise estimates of the most important risk factors for IBP. Our findings could help develop a validated prediction model to identify high-risk patients for IBP, improve colonoscopy outcomes, reduce the need for repeat colonoscopies, and reduce associated healthcare costs., (Copyright © 2024 by The American College of Gastroenterology.)
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- 2024
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44. Risk factors for biliary strictures and leaks after living-donor liver transplantation: a systematic review and meta-analysis.
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Hassouneh R, Beran A, Rosenheck M, Sosio J, Olchawa N, Kubal C, Ghabril M, and Gromski MA
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Background: Liver transplantation is the only curative treatment of end-stage liver disease. Unfortunately, a significant number of patients on the organ waitlist die waiting for an organ. Living-donor liver transplantation (LDLT) is an approach that has been used to expand organ availability. Although LDLT has excellent outcomes, biliary complications remain a significant drawback. This meta-analysis aimed to precisely assess the predictors of biliary stricture and leak after LDLT., Methods: PubMed, Embase, and Web of Science databases were searched from inception to January 2024. Only studies that used a multivariate model to assess risk factors for post-LDLT biliary stricture or leak in adult participants were included. Studies reporting unadjusted risk factors were excluded. Pooled adjusted odds ratios (ORs) and pooled hazard ratios (HRs) with 95% CIs for risk factors reported in ≥2 studies were obtained within a random-effects model., Results: Overall, 22 studies with 9442 patients who underwent LDLT were included. The post-LDLT biliary stricture rate was 22%, whereas the post-LDLT biliary leak rate was 14%. In addition, 13 unique risk factors were analyzed. Postoperative bile leak (OR, 4.10 [95% CI, 2.88-5.83]; HR, 3.88 [95% CI, 2.15-6.99]) was the most significant predictor of biliary stricture after LDLT. Other significant predictors of biliary stricture after LDLT were right lobe graft (OR, 2.56; 95% CI, 1.23-5.32), multiple ducts for anastomosis (OR, 1.62; 95% CI, 1.08-2.43), ductoplasty (OR, 2.07; 95% CI, 1.36-3.13), ABO incompatibility (OR, 1.45; 95% CI, 1.16-1.81), and acute cellular rejection (OR, 4.10; 95% CI, 2.88-5.83). Donor bile duct size (HR, 0.82; 95% CI, 0.74-0.91; P = .001, I
2 = 0%) was found to be significantly associated with reduced risk of post-LDLT biliary stricture. Donor age, recipient age, recipient male sex, and duct-to-duct anastomosis were not associated with an increased risk of post-LDLT biliary strictures. Multiple ducts for anastomosis (OR, 1.86; 95% CI, 1.43-2.43) was a significant predictor of post-LDLT biliary leak. Recipient age, warm ischemia time, and duct-to-duct anastomosis were not associated with an increased risk of post-LDLT biliary leak., Conclusion: In this meta-analysis, 7 unique risk factors were shown to be predictive of post-LDLT biliary stricture, one of which was associated with both post-LDLT biliary stricture and leak. Donor bile duct size was found to be protective against post-LDLT biliary strictures. Identifying reliable predictors is crucial for recognizing high-risk patients. This approach can facilitate the implementation of preventive measures, surveillance protocols, and targeted interventions to reduce the incidence of biliary strictures after LDLT., Competing Interests: Declaration of competing interest M.A.G. is a consultant of Boston Scientific and Ambu and receives research support from Olympus and Cook Medical. The other authors declare no competing interests., (Copyright © 2024 Society for Surgery of the Alimentary Tract. Published by Elsevier Inc. All rights reserved.)- Published
- 2024
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45. Bowel Perforation Caused by Biliary Stent Migration After ERCP: A Systematic Review.
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Wilson N, Ezeani C, Ismail A, Abdalla M, Mohammed S, Abdalla A, Elawad A, Beran A, Jaber F, Abosheaishaa H, Loon E, Abdallah M, Vargo J, Bilal M, and Chahal P
- Abstract
Goals: This systematic review aims to evaluate the risk factors, clinical features, and outcomes of bowel perforation caused by stent migration after endoscopic retrograde cholangiopancreatography (ERCP)., Background: Distal migration of biliary stents can occur after ERCP. Upon migration, most stents pass through the intestine without adverse events; however, bowel perforation has been reported., Study: A comprehensive literature search of PubMed, EMBASE, and Cochrane databases was conducted through October 2023 for articles that reported bowel perforation because of stent migration. Cases of incomplete stent migration and proximal stent migration were excluded. We followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines to identify full-length articles in English reporting., Results: Of 2041 articles retrieved on the initial search, 92 met the inclusion criteria. A total of 132 cases of bowel perforation occurred due to stent migration after ERCP (56.1% female; average age: 66 y). The median time from initial ERCP to perforation was 44.5 days (IQR 12.5-125.5). Most cases of perforation occurred in the small bowel (64.4%) compared with the colon (34.8%). Stents were mostly plastic (87.1%) with a median diameter of 10 Fr (IQR 8.5-10) and median length of 10.3 cm (IQR 715). Surgical management was pursued in 52.3% and endoscopic management in 42.4%. Bowel resection was required for 25.8% of patients. The overall mortality rate was 17.4%., Conclusion: In summary, this study demonstrates that bowel perforation after ERCP stent migration primarily occurs within 44.5 days and most frequently with a 10 Fr plastic biliary stent. The overall mortality rate was 17.4%. It is important for endoscopists to be mindful of this rare but serious adverse event., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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46. Efficacy and Safety of Endoscopic Through-the-Scope Suture System for Gastrointestinal Defects: A Systematic Review and Meta-analysis.
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Aziz M, Haghbin H, Gangwani MK, Beran A, Dahiya DS, Ali H, Sohail AH, Lee-Smith W, Hamdani SU, Kamal F, and Adler DG
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Objective: Recently, a through-the-scope suturing (TTSS) system has received FDA approval and has been evaluated for closing mucosal defects postintervention. We hereby performed a systematic review and pooled meta-analysis of available studies to assess the safety and efficacy of this intervention., Methods: We queried the following databases through April 26, 2023: Embase, MEDLINE, Cochrane Central Register of Controlled Trials, and Web of Science Core Collection. Endoscopists utilizing TTSS for the following reasons were included: endoscopic mucosal resection, endoscopic submucosal dissection, peroral endoscopic myotomy, perforation, fistula closure, and/or stent fixation. The outcomes assessed were technical success, primary clinical success (closure of defect without additional intervention), and overall clinical success (closure of defect with/without additional intervention). Random effects model with the DerSimonian Laird approach was used to report event rates expressed as proportions with a 95% CI., Results: A total of 12 studies with 512 patients (mean age of 61.5 ± 18.4 y, 54.6% females) were included. The technical success rate was 96.0% (CI: 94.3%-97.7%). The primary clinical success rate was 74.8% (CI: 65.5%-84.1%). The overall clinical success rate was 95.4% (CI: 92.6-98.2%). Only 1 mortality case unrelated to intervention was reported., Conclusion: The TTSS appears safe and effective for closing mucosal defects after therapeutic endoscopic interventions. Further cost-effective studies should be performed comparing with endoclips for use in clinical settings., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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47. Is Endoscopic Ultrasound-Guided Hepaticogastrostomy Safe and Effective after Failed Endoscopic Retrograde Cholangiopancreatography?-A Systematic Review and Meta-Analysis.
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Alsakarneh S, Madi MY, Dahiya DS, Jaber F, Kilani Y, Ahmed M, Beran A, Abdallah M, Al Ta'ani O, Mittal A, Numan L, Goyal H, Bilal M, and Kiwan W
- Abstract
Background/Objectives: Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) has emerged as an alternative option for biliary drainage in cases of failed endoscopic retrograde cholangiopancreatography (ERCP). Limited data exist on the safety and efficacy of EUS-HGS. In this comprehensive meta-analysis, we aim to study the safety and efficacy of EUS-HGS in cases of failed conventional ERCP. Methods: Embase, PubMed, and Web of Science databases were searched to include all studies that evaluated the efficacy and safety of EUS-HGS. Using the random effect model, the pooled weight-adjusted event rate estimate for clinical outcomes in each group were calculated with 95% confidence intervals (CIs). The primary outcomes were technical and clinical success rates. Secondary outcomes included overall adverse events (AEs), rates of recurrent biliary obstruction (RBO), and rates or re-intervention. Results: Our analysis included 70 studies, with a total of 3527 patients. The pooled technical and clinical success rates for EUS-HGS were 98.1% ([95% CI, 97.5-98.7]; I
2 = 40%) and 98.1% ([95% CI, 97.5-98.7]; I2 = 40%), respectively. The pooled incidence rate of AEs with EUS-HGS was 14.9% (95% CI, 12.7-17.1), with bile leakage being the most common (2.4% [95% CI, 1.7-3.2]). The pooled incidence of RBO was 15.8% [95% CI, 12.2-19.4], with a high success rate for re-intervention (97.5% [95% CI, 94.7-100]). Conclusions: Our analysis showed high technical and clinical success rates of EUS-HGS, making it a feasible and effective alternative to ERCP. The ongoing development of dedicated devices and techniques is expected to make EUS-HGS more accessible and safer for patients in need of biliary drainage.- Published
- 2024
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48. Early Diagnostic Paracentesis Improves Outcomes of Hospitalized Patients With Cirrhosis and Ascites: A Systematic Review and Meta-Analysis.
- Author
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Beran A, Mohamed MFH, Vargas A, Aboursheid T, Aziz M, Hernaez R, Patidar KR, Nephew LD, Desai AP, Orman E, Chalasani N, and Ghabril MS
- Abstract
Introduction: Diagnostic paracentesis is recommended for patients with cirrhosis admitted to the hospital, but adherence is suboptimal with unclear impact on clinical outcomes. The aim of this meta-analysis was to assess the outcomes of early vs delayed diagnostic paracentesis among hospitalized patients with cirrhosis and ascites., Methods: We searched multiple databases for studies comparing early vs delayed diagnostic paracentesis among hospitalized patients with cirrhosis and ascites. The pooled odds ratio (OR) and mean difference with confidence intervals (CIs) for proportional and continuous variables were calculated using the random-effects model. Early diagnostic paracentesis was defined as receiving diagnostic paracentesis within 12-24 hours of admission. The primary outcome was in-hospital mortality. Secondary outcomes were length of hospital stay, acute kidney injury, and 30-day readmission., Results: Seven studies (n = 78,744) (n = 45,533 early vs n = 33,211 delayed diagnostic paracentesis) were included. Early diagnostic paracentesis was associated with lower in-hospital mortality (OR 0.61, 95% CI 0.46-0.82, P = 0.001), length of hospital stay (mean difference -4.85 days; 95% CI -6.45 to -3.20; P < 0.001), and acute kidney injury (OR 0.62, 95% CI 0.42-0.92, P = 0.02) compared with delayed diagnostic paracentesis, with similar 30-day readmission (OR 1.11, 95% CI 0.52-2.39, P = 0.79). Subgroup analysis revealed consistent results for in-hospital mortality whether early diagnostic paracentesis performed within 12 hours (OR 0.51, 95% CI 0.32-0.79, P = 0.003, I2 = 0%) or within 24 hours of admission (OR 0.67, 95% CI 0.45-0.98, P = 0.04, I2 = 82%). Notably, the mortality OR was numerically lower when diagnostic paracentesis was performed within 12 hours, and the results were precise and homogenous ( I2 = 0%)., Discussion: Findings from this meta-analysis suggest that early diagnostic paracentesis is associated with better patient outcomes. Early diagnostic paracentesis within 12 hours of admission may be associated with the greatest mortality benefit. Data from large-scale randomized trials are needed to validate our findings, especially if there is a greater mortality benefit for early diagnostic paracentesis within 12 hours., (Copyright © 2024 by The American College of Gastroenterology.)
- Published
- 2024
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49. Histological Outcomes of Pharmacological Interventions in Eosinophilic Esophagitis for Adults and Children: A Network Meta-analysis of Randomized Controlled Trials.
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Aziz M, Haghbin H, Gangwani MK, Fatima R, Sohail AH, Ali H, Alyousif ZA, Dahiya DS, Lee-Smith W, Beran A, Kamal F, and Nawras A
- Abstract
Introduction: Multiple pharmacological interventions have been studied for managing eosinophilic esophagitis (EoE). We performed a comprehensive systematic review and network meta-analysis of all available randomized controlled trials (RCT) to assess the efficacy and safety of these interventions in EoE in adults and children., Methods: We performed a comprehensive review of Embase, PubMed, MEDLINE OVID, Cochrane CENTRAL, and Web of Science through May 10, 2023. We performed frequentist approach network meta-analysis using random effects model. We calculated the odds ratio (OR) with 95% CI for dichotomous outcomes., Results: Our search yielded 25 RCTs with 25 discrete interventions and 2067 patients. Compared with placebo, the following interventions improved histology (using study definitions) in decreasing order on ranking: orodispersible budesonide (ODB) low dose, ODB high dose, oral viscous budesonide (OVB) high dose, fluticasone tablet 1.5 mg twice daily, fluticasone 3 mg twice daily, esomeprazole, dupilumab every 2 weeks, dupilumab weekly, OVB medium dose, fluticasone 3 mg daily, cendakimab 180 mg, prednisone, swallowed fluticasone, fluticasone tablet 1.5 mg daily, OVB low dose, reslizumab 3 mg/kg, reslizumab 1 mg/kg, and reslizumab 2 mg/kg., Conclusions: Network meta-analysis demonstrates histological efficacy of multiple medications for EoE. Because of the heterogeneity and large effect size, we recommend more trials comparing pharmacotherapeutic interventions with each other and placebo. An important limitation of this study is absence of clinical efficacy data due to insufficient data. Other limitations include heterogeneity of operator, population, and outcome analysis., (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
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- 2024
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50. Prevalence of Obesity and Metabolic Syndrome in the High Cardiovascular Risk Setting of Rural Western Honduras.
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Montalvan-Sanchez EE, Rodriguez-Murillo A, Carrasco-Stoval T, Carrera K, Beas R, Giron R, Jerez-Moreno V, Soriano-Turcios RA, Reyes-Guerra O, Torres K, Izquierdo-Veraza D, Torres T, Beran AA, Montalvan-Sanchez D, and Norwood DA
- Subjects
- Humans, Male, Female, Middle Aged, Honduras epidemiology, Aged, Cross-Sectional Studies, Prevalence, Cardiovascular Diseases epidemiology, Risk Factors, Metabolic Syndrome epidemiology, Obesity epidemiology, Rural Population statistics & numerical data
- Abstract
Objective: To determine the prevalence of obesity and metabolic syndrome (MS) in the population older than 45 years in rural Western Honduras and contribute to the limited literature on MS in Central America., Methods: Descriptive cross-sectional study conducted in the District of Copan. The study includes 382 men and women aged 45 to 75 years. With proper consent, anthropometric parameters, blood pressure, blood sugar, and lipid profile were evaluated. MS was diagnosed by using the National Cholesterol Education Program Criteria - Adult Panel Treatment III (NCEP-ATP III). Data were stored in REDCap (Research Electronic Data Capture) and analyzed with STATA14., Results: Data were collected on 382 patients; of these, 38% were male and 62% female. The prevalence of obesity was 24.1% for both sexes. The prevalence of MS was 64.9%. Prevalence in males and females was 54% and 71%, respectively. Notable parameters were elevated triglycerides (71%), low High-density lipoprotein cholesterol (HDL-C) (63.4%), and abdominal obesity (56.8%). In men, the distribution of MS was more homogeneous, with a mean result of 80% amongst all ages., Conclusions: The overall prevalence of obesity and MS is severely underestimated in rural Honduras. The most remarkable parameter for MS was high triglycerides (71%). Sixty-nine percent of the population has above-normal Body Mass Index (BMI). Public health efforts to control comorbidities and tackle risk factors in this population should take utmost priority., Competing Interests: Conflict of Interest: No conflicts of interest reported by authors.
- Published
- 2024
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