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Your search keyword '"Bauer, Rebecca"' showing total 5 results
5 results on '"Bauer, Rebecca"'

1. Cytokine profile of anti-spike CD4+T cells predicts humoral and CD8+T cell responses after anti-SARS-CoV-2 mRNA vaccination

Author

Benhamouda, Nadine, Besbes, Anissa, Bauer, Rebecca, Mabrouk, Nesrine, Gadouas, Gauthier, Desaint, Corinne, Chevrier, Lucie, Lefebvre, Maeva, Radenne, Anne, Roelens, Marie, Parfait, Béatrice, Weiskopf, Daniela, Sette, Alessandro, Gruel, Nadège, Courbebaisse, Marie, Appay, Victor, Paul, Stephane, Gorochov, Guy, Ropers, Jacques, Lebbah, Said, Lelievre, Jean-Daniel, Johannes, Ludger, Ulmer, Jonathan, Lebeaux, David, Friedlander, Gerard, De Lamballerie, Xavier, Ravel, Patrice, Kieny, Marie Paule, Batteux, Fréderic, Durier, Christine, Launay, Odile, and Tartour, Eric

Published
2024
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2. Incidence of COVID-19 mRNA vaccine symptomatic breakthrough infections during Omicron circulation in adults with or without infection prior to vaccination

Author

Durier, Christine, Ninove, Laetitia, van der Werf, Sylvie, Lefebvre, Maeva, Desaint, Corinne, Bauer, Rebecca, Attia, Mikael, Lecompte, Anne-Sophie, Lachatre, Marie, Maakaroun-Vermesse, Zoha, Nicolas, Jean-François, Verdon, Renaud, Kiladjian, Jean-Jacques, Loubet, Paul, Schmidt-Mutter, Catherine, Corbin, Violaine, Ansart, Séverine, Melica, Giovanna, Resch, Martine, Netzer, Emmanuelle, Kherabi, Yousra, Tardieu, Raphaëlle, Lelièvre, Jean-Daniel, Tartour, Eric, Meyer, Laurence, de Lamballerie, Xavier, and Launay, Odile

Published
2024
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4. Airway tryptase levels inform the lack of clinical efficacy of the tryptase inhibitor MTPS9579A in asthma.

Author

Rhee, Horace, Henderson, Lindsay M., Bauer, Rebecca N., Wong, Kit, Staton, Tracy L., Choy, David F., Banerjee, Prajna, Poon, Victor, Yoshida, Kenta, Chen, Chen, Long, Keyi, Sperinde, Gizette, Laing, Steven T., Jones, Nicholas S., Glickstein, Sara B., Dayal, Parul, Fong, Alice, Dash, Ajit, Pulka, Grazyna, and Leaker, Brian

Subjects
*MAST cells, *TRYPTASE, *ASTHMATICS, *PHARMACOKINETICS, *CLINICAL trials, *ASTHMA
Abstract

Background Methods Results Conclusions Tryptase, a mast cell protease, has been identified as a potential therapeutic target in managing patients with refractory asthma. We assessed the efficacy, safety, pharmacokinetics, and pharmacodynamics of MTPS9579A, an anti‐tryptase antibody, in a phase 2a randomized trial for patients with uncontrolled asthma and a phase 1c trial to understand activity within the lower respiratory tract.Phase 2a patients (n = 134) received 1800 mg MTPS9579A or placebo intravenously every 4 weeks for 48 weeks. The primary endpoint was time to the first composite exacerbation event. Phase 1c patients (n = 27) received one intravenous dose of 300 or 1800 mg MTPS9579A or placebo. Both trials measured MTPS9579A concentrations and effects on tryptase in serum and nasal lining fluid; phase 1c also analyzed bronchial lining fluid.MTPS9579A did not meet the primary endpoint (hazard ratio = 0.90; 95% CI: 0.55–1.47; p = 0.6835); exacerbation rates in the placebo group were low. Serum and nasal MTPS9579A pharmacokinetics and tryptase levels were consistent with data from healthy volunteers. However, in phase 1c patients, compared to nasal levels, MTPS9579A bronchial concentrations were 6.8‐fold lower, and bronchial active and total tryptase levels were higher (119‐fold and 30‐fold, respectively). Pharmacokinetic/pharmacodynamic modeling predicted intravenous doses of 3800 mg every 4 weeks would be necessary to achieve 95% active tryptase inhibition from baseline.The MTPS9579A dose tested in the phase 2a study was insufficient to inhibit tryptase in bronchial lining fluid, likely contributing to the observed lack of efficacy. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Serum and Salivary IgG and IgA Response After COVID-19 Messenger RNA Vaccination.

Author

Gorochov, Guy, Ropers, Jacques, Launay, Odile, Dorgham, Karim, da Mata-Jardin, Omaira, Lebbah, Said, Durier, Christine, Bauer, Rebecca, Radenne, Anne, Desaint, Corinne, Vieillard, Louis-Victorien, Rekacewicz, Claire, Lachatre, Marie, Parfait, Béatrice, Batteux, Frédéric, Hupé, Philippe, Ninove, Läétitia, Lefebvre, Maeva, Conrad, Anne, and Dussol, Bertrand

Published
2024
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