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This study investigates and compares large-scale moisture and heat budgets over the eastern rainy sea area around Dongsha, the western rainless sea area around Xisha, and the northern coastland of the South China Sea. Ten-year (2011–20) surface, balloon-sounding, satellite measurements, and ERA5 reanalysis are merged into the physically consistent data to study annual and vertical variations of the budgets. It shows that the surface and column-integrated heat and moisture budgets have the smallest annual evolution over the coastland. The latent heat as a key heat contributor in summer is mainly offset by total cold advection and partially offset by net radiative cooling. The horizontal moisture advection below 700 hPa presents moistening over the sea whereas drying over the coastland during rainy months, in which the vertical moisture advection presents moistening up to 250 hPa for all three subregions. The horizontal temperature advection is weak throughout the year over the sea but displays strong top warming and bottom cooling in summer and nearly the opposite in winter over the coastland. The diabatic cooling with a peak at ∼700 hPa in winter is largely due to the enhanced radiative cooling and latent cooling. While the diabatic heating with a peak at ∼500 hPa in summer is largely due to the enhanced latent heating. The earliest atmospheric heating and moistening occur in spring over the coastland, inducing the earliest precipitation increase. The enhanced heating and moistening over Xisha have a 1-month lag relative to Dongsha, resulting in lagging precipitation. [ABSTRACT FROM AUTHOR]

Key Clinical Message: Prurigo nodularis is frequently difficult to manage with conventional therapy. Given the pathogenesis and refractory nature, we demonstrate a case in which inhibition of JAK–STAT signaling may significantly improve prurigo nodularis. Based on the results, we would like to draw a conclusion that abrocitinib as an inhibitor of Jak is a promising choice for the treatment of prurigo nodularis. [ABSTRACT FROM AUTHOR]

Sjögren's syndrome (SjS) is a systemic, highly diverse, and chronic autoimmune disease with a significant global prevalence. It is a complex condition that requires careful management and monitoring. Recent research indicates that epigenetic mechanisms contribute to the pathophysiology of SjS by modulating gene expression and genome stability. DNA methylation, a form of epigenetic modification, is the fundamental mechanism that modifies the expression of various genes by modifying the transcriptional availability of regulatory regions within the genome. In general, adding a methyl group to DNA is linked with the inhibition of genes because it changes the chromatin structure. DNA methylation changes the fate of multiple immune cells, such as it leads to the transition of naïve lymphocytes to effector lymphocytes. A lack of central epigenetic enzymes frequently results in abnormal immune activation. Alterations in epigenetic modifications within immune cells or salivary gland epithelial cells are frequently detected during the pathogenesis of SjS, representing a robust association with autoimmune responses. The analysis of genome methylation is a beneficial tool for establishing connections between epigenetic changes within different cell types and their association with SjS. In various studies related to SjS, most differentially methylated regions are in the human leukocyte antigen (HLA) locus. Notably, the demethylation of various sites in the genome is often observed in SjS patients. The most strongly linked differentially methylated regions in SjS patients are found within genes regulated by type I interferon. This demethylation process is partly related to B-cell infiltration and disease progression. In addition, DNA demethylation of the runt-related transcription factor (RUNX1) gene, lymphotoxin-α (LTA), and myxovirus resistance protein A (MxA) is associated with SjS. It may assist the early diagnosis of SjS by serving as a potential biomarker. Therefore, this review offers a detailed insight into the function of DNA methylation in SjS and helps researchers to identify potential biomarkers in diagnosis, prognosis, and therapeutic targets., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Wang, Riaz, Wang, Pu, Liang, Wu, Pan, Song, Yang, Zhang, Wu, Han, Tang and Wang.)

As an important horticultural plant, Rhododendron is often used in urban greening and landscape design. However, factors such as the high rate of genetic recombination, frequent outcrossing in the wild, weak linkage disequilibrium, and the susceptibility of gene expression to environmental factors limit further exploration of functional genes related to important horticultural traits, and make the breeding of new varieties require a longer time. Therefore, we choose bark as the target trait which is not easily affected by environmental factors, but also has ornamental properties. Genome-wide association study (GWAS) of Rhododendron delavayi (30 samples), R. irroratum (30 samples) and their F 1 generation R. agastum (200 samples) was conducted on the roughness of bark phenotypes. Finally, we obtained 2416.31 Gbp of clean data and identified 5 328 800 high-quality SNPs. According to the P -value and the degree of linkage disequilibrium of SNPs, we further identified 4 out of 11 candidate genes that affect bark roughness. The results of gene differential expression analysis further indicated that the expression levels of Rhdel02G0243600 and Rhdel08G0220700 in different bark phenotypes were significantly different. Our study identified functional genes that influence important horticultural traits of Rhododendron , and illustrated the powerful utility and great potential of GWAS in understanding and exploiting wild germplasm genetic resources of Rhododendron ., Competing Interests: The authors have no conflicts of interest to declare., (© The Author(s) 2024. Published by Oxford University Press on behalf of Nanjing Agricultural University.)