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This study evaluates the performance of two planetary boundary parameterizations in simulating the mean climate of West Africa using the Regional Climate Model version 5 (RegCM5). These planetary boundary parameterizations are the Holtslag scheme and the University of Washington scheme. Two sets of three one-year simulations were carried out at 25 km horizontal resolution with three different initial conditions. The first set of simulations used the Holtslag scheme (hereafter referred to as Hol), while the second used the University of Washington (UW) scheme (hereafter referred to as UW). The results displayed in this study are an average of the three simulations. During the JJAS rainy season, with respect to GPCP, both models overestimated total rainfall in the orographic regions. The UW experiment represented total rainfall fairly well compared to its counterpart, Hol. Both models reproduced convective rainfall well, with a relatively weak dry bias over the Guinean coast subregion. Globally, UW performed better than Hol in simulating precipitation. The pattern of near-surface temperature in both models was well reproduced with a higher bias with Hol than with UW. Indeed, the UW scheme led to a cooling effect owing to the reduction in eddy heat diffusivity in the lower troposphere contributing to reduce the bias. As a consequence, the height of the planetary boundary layer (PBL) was best simulated using the UW scheme but was underestimated compared to ERA5, while using the Hol scheme failed to capture the height of the PBL. This is coherent with the distribution of total cloud cover, which was better simulated with the UW scheme compared to the Hol scheme. This study shows that use of both planetary boundary parameterizations leads to a good simulation of most of the climatological characteristics of the West African region. Nevertheless, use of the UW scheme contributes to a better performance than use of the Hol scheme, and the differentiation between the two schemes is significant along the Guinea Coast and in orographic regions. In these topographically complex regions, UW appears to be more appropriate than Hol. This study emphasizes the importance of planetary boundary parameterizations for accurately simulating climate variables and for improving climate forecasts and projections in West Africa. [ABSTRACT FROM AUTHOR]