652 results
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2. The conformational landscape of human transthyretin revealed by cryo-EM
3. Propagation of neuronal micronuclei regulates microglial characteristics
4. Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis
5. Tucatinib and trastuzumab in HER2-mutated metastatic breast cancer: a phase 2 basket trial
6. Maternal ELL3 loss-of-function leads to oocyte aneuploidy and early miscarriage
7. Neural mechanisms of relational learning and fast knowledge reassembly in plastic neural networks
8. Molecular basis of neurosteroid and anticonvulsant regulation of TRPM3
9. Multi-omic quantitative trait loci link tandem repeat size variation to gene regulation in human brain
10. Gut microbial-derived phenylacetylglutamine accelerates host cellular senescence
11. Orphanhood and caregiver death among children in the United States by all-cause mortality, 2000–2021
12. Intracerebroventricular anaerobic dopamine in Parkinson’s disease with l-dopa-related complications: a phase 1/2 randomized-controlled trial
13. FUT10 and FUT11 are protein O-fucosyltransferases that modify protein EMI domains
14. Molecular mechanisms of inverse agonism via κ-opioid receptor–G protein complexes
15. Multi-omics-based mapping of decidualization resistance in patients with a history of severe preeclampsia
16. Burdens of type 2 diabetes and cardiovascular disease attributable to sugar-sweetened beverages in 184 countries
17. Molecular basis of human nuclear and mitochondrial tRNA 3′ processing
18. Unequal roles of cities in the intercity healthcare system
19. Impact of doxycycline post-exposure prophylaxis for sexually transmitted infections on the gut microbiome and antimicrobial resistome
20. Exocyst stimulates multiple steps of exocytic SNARE complex assembly and vesicle fusion
21. Menopause-induced 17β-estradiol and progesterone loss increases senescence markers, matrix disassembly and degeneration in mouse cartilage
22. Gene-level alignment of single-cell trajectories
23. Neoadjuvant anti-PD-1 alone or in combination with anti-TIGIT or an oncolytic virus in resectable stage IIIB–D melanoma: a phase 1/2 trial
24. Autogene cevumeran with or without atezolizumab in advanced solid tumors: a phase 1 trial
25. Blood DNA virome associates with autoimmune diseases and COVID-19
26. System vaccinology analysis of predictors and mechanisms of antibody response durability to multiple vaccines in humans
27. An evaluation framework for clinical use of large language models in patient interaction tasks
28. Membrane mechanics dictate axonal pearls-on-a-string morphology and function
29. Super-resolution imaging of fast morphological dynamics of neurons in behaving animals
30. Emergence of a brainstem somatosensory tonotopic map for substrate vibration
31. Deep learning-based models for preimplantation mouse and human embryos based on single-cell RNA sequencing
32. ONIX: a unified open-source platform for multimodal neural recording and perturbation during naturalistic behavior
33. Chronic social stress induces p16-mediated senescent cell accumulation in mice
34. Temporal profiling of human lymphoid tissues reveals coordinated defense against viral challenge
35. Persistent glucose consumption under antibiotic treatment protects bacterial community
36. Inhibition of OSBP blocks retrograde trafficking by inducing partial Golgi degradation
37. Orpinolide disrupts a leukemic dependency on cholesterol transport by inhibiting OSBP
38. Unlocking saponin biosynthesis in soapwort
39. Compact RNA editors with natural miniature Cas13j nucleases
40. Uncoupling histone modification crosstalk by engineering lysine demethylase LSD1
41. Direct inhibition of tumor hypoxia response with synthetic transcriptional repressors
42. Integrating single-cell RNA and T cell/B cell receptor sequencing with mass cytometry reveals dynamic trajectories of human peripheral immune cells from birth to old age
43. T cell immune evasion by SARS-CoV-2 JN.1 escapees targeting two cytotoxic T cell epitope hotspots
44. Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer
45. Variants and vaccines impact nasal immunity over three waves of SARS-CoV-2
46. Differential roles of human CD4+ and CD8+ regulatory T cells in controlling self-reactive immune responses
47. IRE1α–XBP1 safeguards hematopoietic stem and progenitor cells by restricting pro-leukemogenic gene programs
48. Low-avidity T cells drive endogenous tumor immunity in mice and humans
49. β-Glucan reprograms neutrophils to promote disease tolerance against influenza A virus
50. A multi-kinase inhibitor screen identifies inhibitors preserving stem-cell-like chimeric antigen receptor T cells
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