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Start Over Publication Year Range This year Language english Publisher elsevier b.v.
13,103 results

33. White paper: Understanding, informing and defining the regulatory science of microneedle-based dosage forms that are applied to the skin

Author

Dul, Maria, Alali, Mohammed, Ameri, Mahmoud, Burke, Matthew Douglas, Creelman, Benjamin Paul, Dick, Lisa, Donnelly, Ryan F., Eakins, Michael N., Frivold, Collrane, Forster, Angus Harry, Gilbert, Philippe-Alexandre, Henke, Stefan, Henry, Sebastien, Hunt, Desmond, Lewis, Hayley, Mistilis, Jessica Joyce, Park, Jung-Hwan, Prausnitz, Mark R., Robinson, David Kenneth, Hernandez, Carmen Amelia Rodriguez, Shin, Juyeop, Speaker, Tycho Joseph, Strasinger, Caroline, Taylor, Kevin M.G., Zehrung, Darin, Birchall, James C., Jarrahian, Courtney, and Coulman, Sion A.

Published
2025
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46. Automatized quantitative electrocardiography from digitized paper electrocardiograms: A new avenue for risk stratification in patients with Brugada syndrome.

Author

Laporte, Pierre-Léo, Vaglio, Martino, Denjoy, Isabelle, Maison-Blanche, Pierre, Coquard, Charlène, El Bèze, Nathan, Maury, Philippe, Hermida, Alexis, Klug, Didier, Maltret, Alice, Badilini, Fabio, Leenhardt, Antoine, and Extramiana, Fabrice

Abstract

[Display omitted] • We digitized the electrocardiograms (ECGs) of patients with Brugada syndrome. • We performed multi-parametric ECG quantification to assess risk in such patients. • We identified new ECG parameters independently associated with major events. Arrhythmic risk stratification is a major challenge in Brugada syndrome. Studies have evaluated risk stratification based on manually measured electrocardiogram (ECG) parameters at baseline and/or after drug challenge. To assess the predictive value of multiple ECG parameters measured automatically from digitized paper ECGs. During a prospective, multicentre cohort study that included patients with Brugada syndrome with type 1 ECG (spontaneously or drug-induced), paper ECGs were digitized and analysed. Major events were sudden cardiac death, aborted cardiac arrest and appropriate implantable cardioverter-defibrillator (ICD) therapy in the ventricular fibrillation (VF) zone. The predictive value of clinical and ECG parameters was assessed using univariable and multivariable Cox models. ECGs from 301 patients (74% male, mean age 43.1 ± 13.3 years, mean follow-up 7.1 ± 5.6 years) were analysed. Major events occurred in 6% of patients before diagnosis and 8% during follow-up. Two baseline ECG parameters were independently associated with major events: QRS prolongation in lead V1 > 113 ms (hazard ratio [HR] 3.49, 95% confidence interval [CI] 1.72–7.09; P < 0.001) and S duration on DI > 33.5 ms (HR 3.56, 95% CI 1.52–8.31; P < 0.01). In drug-induced patients, changes in the Tpeak-Tend interval on V2 were associated with major events (HR 4.69, 95% CI 1.21–18.17; P = 0.014). Paper ECG datasets could be used for automatic quantitative ECG measurements. We confirmed the association of previously described parameters with events and identified useful new parameters. Multi-parametric ECG quantification may be used to assess risk in patients with Brugada syndrome. [ABSTRACT FROM AUTHOR]

Published
2025
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47. Promoting Food Security Among Adolescents and Young Adults: A Position Paper of the Society for Adolescent Health and Medicine.

Abstract

Food security exists when all people, at all times, have physical, social, and economic access to sufficient, safe, and nutritious food that meets their dietary needs for an active and healthy life. While there is a lengthy body of literature examining food insecurity among children, food insecurity among adolescents and young adults (AYAs) has been relatively understudied. The literature demonstrates that AYAs experiencing food insecurity have poorer physical, mental, and psychosocial health outcomes than their peers, which may persist into adulthood. As AYAs reach reproductive maturity, those experiencing food insecurity are more likely to have children who are also poorly nourished, perpetuating intergenerational poor nutrition and its associated health and socioeconomic costs. In this position paper, Society for Adolescent Health and Medicine (SAHM) recommends actions that healthcare professionals can take to achieve a goal of universal food security among AYAs. As SAHM strives to promote the optimal health of AYAs around the world, the positions in this paper affirm SAHM's commitment to promoting food security for all AYAs. [ABSTRACT FROM AUTHOR]

Published
2025
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