446 results on '"Pin, Isabelle"'
Search Results
2. Residential greenspace and lung function decline over 20 years in a prospective cohort: The ECRHS study
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Markevych, Iana, Zhao, Tianyu, Fuertes, Elaine, Marcon, Alessandro, Dadvand, Payam, Vienneau, Danielle, Garcia Aymerich, Judith, Nowak, Dennis, de Hoogh, Kees, Jarvis, Deborah, Abramson, Michael J., Accordini, Simone, Amaral, Andre FS, Bentouhami, Hayat, Jacobsen Bertelsen, Randi, Boudier, Anne, Bono, Roberto, Bowatte, Gayan, Casas, Lidia, Dharmage, Shyamali C, Forsberg, Bertil, Gislason, Thorarinn, Gnesi, Marco, Holm, Mathias, Jacquemin, Benedicte, Janson, Christer, Jogi, Rain, Johannessen, Ane, Keidel, Dirk, Leynaert, Benedicte, Maldonado Perez, José Antonio, Marchetti, Pierpaolo, Migliore, Enrica, Martínez-Moratalla, Jesús, Orru, Hans, Pin, Isabelle, Potts, James, Probst-Hensch, Nicole, Ranzi, Andrea, Sánchez-Ramos, José Luis, Siroux, Valerie, Soussan, David, Sunyer, Jordi, Urrutia Landa, Isabel, Villani, Simona, and Heinrich, Joachim
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- 2023
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3. Exposure to a mixture of non-persistent environmental chemicals and neonatal thyroid function in a cohort with improved exposure assessment
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Coiffier, Ophélie, Nakiwala, Dorothy, Rolland, Matthieu, Malatesta, Andres, Lyon-Caen, Sarah, Chovelon, Benoît, Faure, Patrice, Sophie Gauchez, Anne, Guergour, Dorra, Sakhi, Amrit K., Sabaredzovic, Azemira, Thomsen, Cathrine, Pin, Isabelle, Slama, Rémy, Corne, Christelle, and Philippat, Claire
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- 2023
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4. Pre-natal exposure to NO2 and PM2.5 and newborn lung function: An approach based on repeated personal exposure measurements
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Lepeule, Johanna, Pin, Isabelle, Boudier, Anne, Quentin, Joane, Lyon-Caen, Sarah, Supernant, Karine, Seyve, Emie, Chartier, Ryan, Slama, Remy, and Siroux, Valérie
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- 2023
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5. Prenatal exposure to triclosan assessed in multiple urine samples and placental DNA methylation
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Jedynak, Paulina, Broséus, Lucile, Tost, Jörg, Busato, Florence, Gabet, Stephan, Thomsen, Cathrine, Sakhi, Amrit K., Pin, Isabelle, Slama, Rémy, Lepeule, Johanna, and Philippat, Claire
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- 2023
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6. HOMA indices as screening tests for cystic fibrosis-related diabetes
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Toin, Tom, Reynaud, Quitterie, Denis, Angélique, Durieu, Isabelle, Mainguy, Catherine, Llerena, Catherine, Pin, Isabelle, Touzet, Sandrine, and Reix, Philippe
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- 2022
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7. Skewed X-chromosome inactivation drives the proportion of DNAAF6-defective airway motile cilia and variable expressivity in primary ciliary dyskinesia.
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Thomas, Lucie, Cuisset, Laurence, Papon, Jean-Francois, Tamalet, Aline, Pin, Isabelle, Taam, Rola Abou, Faucon, Catherine, Montantin, Guy, Tissier, Sylvie, Duquesnoy, Philippe, Moal, Florence Dastot - Le, Copin, Bruno, Carion, Nathalie, Louis, Bruno, Chantot-Bastaraud, Sandra, Siffroi, Jean-Pierre, Mitri, Rana, Coste, André, Escudier, Estelle, and Thouvenin, Guillaume
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Background Primary ciliary dyskinesia (PCD) is a rare airway disorder caused by defective motile cilia. Only male patients have been reported with pathogenic mutations in X-linked DNAAF6, which result in the absence of ciliary dynein arms, whereas their heterozygous mothers are supposedly healthy. Our objective was to assess the possible clinical and ciliary consequences of X-chromosome inactivation (XCI) in these mothers. Methods XCI patterns of six mothers of male patients with DNAAF6-related PCD were determined by DNA-methylation studies and compared with their clinical phenotype (6/6 mothers), as well as their ciliary phenotype (4/6 mothers), as assessed by immunofluorescence and high-speed videomicroscopy analyses. The mutated X chromosome was tracked to assess the percentage of cells with a normal inactivated DNAAF6 allele. Results The mothers' phenotypes ranged from absence of symptoms to mild/moderate or severe airway phenotypes, closely reflecting their XCI pattern. Analyses of the symptomatic mothers' airway ciliated cells revealed the coexistence of normal cells and cells with immotile cilia lacking dynein arms, whose ratio closely mirrored their XCI pattern. Conclusion This study highlights the importance of searching for heterozygous pathogenic DNAAF6 mutations in all female relatives of male PCD patients with a DNAAF6 defect, as well as in females consulting for mild chronic respiratory symptoms. Our results also demonstrate that about one-third--ranging from 20% to 50%--normal ciliated airway cells sufficed to avoid severe PCD, a result paving the way for gene therapy. [ABSTRACT FROM AUTHOR]
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- 2024
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8. Pre- and early post-natal exposure to phthalates and DINCH in a new type of mother-child cohort relying on within-subject pools of repeated urine samples
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Philippat, Claire, Rolland, Matthieu, Lyon-Caen, Sarah, Pin, Isabelle, Sakhi, Amrit K., Sabaredzovic, Azemira, Thomsen, Cathrine, and Slama, Rémy
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- 2021
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9. Prenatal Exposure to P[M.sub.2.5] Oxidative Potential and Lung Function in Infants and Preschool-Age Children: A Prospective Study
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Marsal, Anouk, Slama, Remy, Lyon-Caen, Sarah, Borlaza, Lucille Joanna S., Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaelle, and Siroux, Valerie
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Redox potential -- Health aspects ,Preschool children -- Health aspects -- Physiological aspects ,Infants -- Health aspects -- Physiological aspects ,Pulmonary ventilation -- Health aspects ,Pediatric research ,Air pollution -- Health aspects ,Particles -- Health aspects -- Physiological aspects ,Prenatal influences -- Environmental aspects -- Health aspects ,Environmental issues ,Health - Abstract
Background: Fine particulate matter (P[M.sub.2.5]) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal P[M.sub.2.5] oxidative potential (OP) on lung function in infants and preschool children. Objectives: We estimated the associations of personal exposure to P[M.sub.2.5] and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. Methods: We used data from 356 mother-child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout ([N.sub.2]MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal P[M.sub.2.5] mass and OP with lung function parameters were estimated using multiple linear regressions. Results: In neonates, an interquartile (IQR) increase in O[P.sup.DTT.sub.v] (0.89 nmol/min/[m.sup.3]) was associated with a decrease in functional residual capacity (FRC) measured by [N.sub.2]MBW [[beta] = -2.26 mL; 95% confidence interval (CI): -4.68, 0.15]. Associations with P[M.sub.2.5] showed similar patterns in comparison with O[P.sup.DTT.sub.v] but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs ([Rrs.sub.7-19]) from AOS tended to be associated with higher O[P.sup.DTT.sub.v] ([beta] = 0.09hPa * s/L; 95% CI: -0.06, 0.24) and O[P.sup.AA.sub.v] (IQR = 1.14nmol/min/[m.sup.3]; [beta] = 0.12hPa * s/L; 95% CI: -0.04, 0.27) but not with P[M.sub.2.5] (IQR = 6.9 [micro]g/[m.sup.3]; [beta] = 0.02hPa * s/L; 95% CI: -0.13, 0.16). Results for FRC and [Rrs.sub.7-19] remained similar in OP models adjusted on P[M.sub.2.5]. Discussion: Prenatal exposure to O[P.sup.DTT.sub.v] was associated with several offspring lung function parameters over time, all related to lung volumes. https://doi.org/10.1289/EHP11155, Introduction Exposure to ambient particulate matter (PM) increases risk of chronic respiratory diseases and triggers asthma and chronic obstructive pulmonary diseases. (1-3) Early life, including pregnancy, is a vulnerable time [...]
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- 2023
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10. Pregnancy Exposure to Phenols and Anthropometric Measures in Gestation and at Birth
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Jedynak, Paulina, Rolland, Matthieu, Pin, Isabelle, Thomsen, Cathrine, Sakhi, Amrit K., Sabaredzovic, Azemira, Philippat, Claire, and Slama, Rémy
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- 2022
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11. Paediatric long term continuous positive airway pressure and noninvasive ventilation in France: A cross-sectional study
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Fauroux, Brigitte, Khirani, Sonia, Amaddeo, Alessandro, Massenavette, Bruno, Bierme, Priscille, Taytard, Jessica, Stremler, Nathalie, Baravalle-Einaudi, Melisande, Mazenq, Julie, Ioan, Iulia, Schweitzer, Cyril, Lampin, Marie Emilie, Binoche, Alexandra, Mordacq, Clemence, Bergounioux, Jean, Mbieleu, Blaise, Rubinsztajn, Robert, Sigur, Elodie, Labouret, Geraldine, Genevois, Aline, Becourt, Arnaud, Hullo, Eglantine, Pin, Isabelle, Debelleix, Stéphane, Galodé, François, Bui, Stéphanie, Moreau, Johan, Renoux, Marie Catherine, Matecki, Stefan, Lavadera, Marc Lubrano, Heyman, Rachel, Pomedio, Michael, Le Clainche, Laurence, Bokov, Plamen, Masson, Alexandra, Hangard, Pauline, Menetrey, Celine, Jokic, Mikael, Gachelin, Elsa, Perisson, Caroline, Pervillé, Anne, Fina, Agnes, Giovannini-Chami, Lisa, Fleurence, Emmanuelle, Barzic, Audrey, Breining, Audrey, Ollivier, Morgane, Labbé, Guillaume, Coutier, Laurianne, and Aubertin, Guillaume
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- 2021
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12. Factors Associated with Asthma Severity in Children: Data from the French COBRAPed Cohort
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Abou-Taam, Rola, Le Bourgeois, Muriel, Hadchouel-Duvergé, Alice, Drummond, David, Delacourt, Christophe, Alyanakian, Marie-Alexandra, Chatennoud, Lucienne, Thumerelle, Caroline, Mordacq, Clémence, Badiu-Decleyre, Irina, Bonnel, Cécile, Delbecque, Laure, Beghin, Laurent, Mingardi, Graziella, Tournegros, Caroline, Roditis, Léa, Wanin, Stéphanie, Lebras, Marie Noelle, Debelleix, Stéphane, Siao, Valérie, Servat, Marine, Simon, Guillaume, El Boustany, Patricia, Bosdure, Emmanuelle, Mazenq, Julie, Cabon, Isabelle, Ohlmann, Camille, Vrielynck, Stéphanie, Jubin, Virginie, André Gomez, Sylvie-Anne, Werck Gallois, Marie-Christine, Lezmi, Guillaume, Lejeune, Stéphanie, Pin, Isabelle, Blanchon, Sylvain, Bouazza, Naïm, Jolaine, Valérie, Marguet, Christophe, Houdoin, Véronique, Berger, Patrick, Fayon, Michael, Dubus, Jean-Christophe, Reix, Philippe, Pellan, Mathieu, Brouard, Jacques, Chiron, Raphael, Giovannini-Chami, Lisa, Deschildre, Antoine, and de Blic, Jacques
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- 2021
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13. Bronchodilator response and lung function decline: Associations with exhaled nitric oxide with regard to sex and smoking status
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Nerpin, Elisabet, Ferreira, Diogenes Seraphim, Weyler, Joost, Schlunnsen, Vivi, Jogi, Rain, Raherison Semjen, Chantal, Gislasson, Thorainn, Demoly, Pascal, Heinrich, Joachim, Nowak, Dennis, Corsico, Angelo, Accordini, Simone, Marcon, Alessandro, Squillacioti, Giulia, Olivieri, Mario, Nielsen, Rune, Johannessen, Ane, Gómez Real, Francisco, Garcia -Aymerich, Judith, Urrutia, Isabel, Pereira-Vega, Antonio, Gullón, Jose Antonio, Olin, Anna-Carin, Forsberg, Bertil, Emilsson, Össur Ingi, Pin, Isabelle, Jarvis, Deborah, Janson, Christer, and Malinovschi, Andrei
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- 2021
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14. Phenol and Phthalate Effects on Thyroid Hormone Levels during Pregnancy: Relying on In Vitro Assays and Adverse Outcome Pathways to Inform an Epidemiological Analysis
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Nakiwala, Dorothy, Noyes, Pamela D., Faure, Patrice, Chovelon, Benoit, Corne, Christelle, Gauchez, Anne Sophie, Guergour, Dorra, Lyon-Caen, Sarah, Sakhi, Amrit K., Sabaredzovic, Azemira, Thomsen, Cathrine, Pin, Isabelle, Slama, Remy, and Philippat, Claire
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Thyroid hormones -- Health aspects -- Measurement ,Fetal diseases -- Risk factors ,Phenols -- Environmental aspects -- Health aspects ,Thyroid diseases -- Risk factors -- Complications and side effects ,Phthalates -- Environmental aspects -- Health aspects ,Pregnant women -- Health aspects ,Pediatric research ,Environmental issues ,Health - Abstract
Background: Studies characterizing associations between phenols, phthalates and thyroid hormones during pregnancy produce inconsistent results. This divergence may be partly attributable to false positives due to multiple comparison testing of large numbers of chemicals, and measurement error as studies rely on small numbers of biospecimens despite high intra-individual variability in urinary chemical metabolite concentrations. Objectives: This study employs a priori chemical filtering and expanded urinary biomonitoring to evaluate associations between phenol/phthalate exposures and serum thyroid hormones assessed during pregnancy. Methods: A two-tiered approach was implemented: a) In vitro high-throughput screening results from the ToxCast/Tox21 database, as informed by a thyroid Adverse Outcome Pathway network, were evaluated to select phenols/phthalates with activity on known and putative molecular initiating events in the thyroid pathway; and b) Adjusted linear regressions were used to study associations between filtered compounds and serum thyroid hormones measured in 437 pregnant women recruited in Grenoble area (France) between 2014 and 2017. Phenol/phthalate metabolites were measured in repeated spot urine sample pools (median: 21 samples/women). Results: The ToxCast/Tox21 screening reduced the chemical set from 16 to 13 and the associated number of statistical comparisons by 19%. Parabens were negatively associated with free triiodothyronine (T3) and the T3/T4 (total thyroxine) ratio. Monobenzyl phthalate was positively associated with total T4 and negatively with the T3/T4 ratio. Effect modification by iodine status was detected for several compounds (among them ZDEHP and mono-n-butyl phthalate) that were associated with some hormones among women with normal iodine levels. Conclusion: For these chemicals, screening for compounds with an increased likelihood for thyroid-related effects and relying on repeated urine samples to assess exposures improved the overall performance of multichemical analyses of thyroid disruption. This approach may improve future evaluations of human data for the thyroid pathway with implication for fetal health and may serve as a model for evaluating other toxicity outcomes. https://doi.org/10.1289/EHP10239, Introduction During pregnancy, euthyroidism is crucial for normal fetal growth and development. (1) Even subtle alterations of thyroid hormone homeostasis can negatively impact the growing fetus and postnatal health. (2) [...]
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- 2022
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15. Low serum DHEA-S is associated with impaired lung function in women
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Pesce, Giancarlo, Triebner, Kai, van der Plaat, Diana A., Courbon, Dominique, Hustad, Steinar, Sigsgaard, Torben, Nowak, Dennis, Heinrich, Joachim, Anto, Josep M., Dorado-Arenas, Sandra, Martinez-Moratalla, Jesús, Gullon-Blanco, Jose A., Sanchez-Ramos, José L., Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Gislason, Thorarinn, Torén, Kjell, Forsberg, Bertil, Lindberg, Eva, Zemp, Elisabeth, Jogi, Rain, Probst-Hensch, Nicole, Dharmage, Shyamali C., Jarvis, Debbie, Garcia-Aymerich, Judith, Marcon, Alessandro, Gómez-Real, Francisco, and Leynaert, Bénédicte
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- 2020
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16. Atopy Modifies the Association Between Inhaled Corticosteroid Use and Lung Function Decline in Patients with Asthma
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Marcon, Alessandro, Marchetti, Pierpaolo, Antó, Josep M., Cazzoletti, Lucia, Cerveri, Isa, Corsico, Angelo, Ferreira, Diogenes Seraphim, Garcia-Aymerich, Judith, Gislason, David, Heinrich, Joachim, Jõgi, Rain, Johannessen, Ane, Leynaert, Bénédicte, Malinovschi, Andrei, Pin, Isabelle, Probst-Hensch, Nicole, Weyler, Joost, Janson, Christer, Jarvis, Deborah, and Accordini, Simone
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- 2020
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17. Long-term air pollution exposure is associated with increased severity of rhinitis in 2 European cohorts
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Burte, Emilie, Leynaert, Bénédicte, Marcon, Alessandro, Bousquet, Jean, Benmerad, Meriem, Bono, Roberto, Carsin, Anne-Elie, de Hoogh, Kees, Forsberg, Bertil, Gormand, Frederic, Heinrich, Joachim, Just, Jocelyne, Nieuwenhuijsen, Mark, Pin, Isabelle, Stempfelet, Morgane, Sunyer, Jordi, Villani, Simona, Künzli, Nino, Siroux, Valérie, Jarvis, Deborah, Nadif, Rachel, and Jacquemin, Bénédicte
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- 2020
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18. Occupational exposures and incidence of chronic bronchitis and related symptoms over two decades : the European Community Respiratory Health Survey
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Lytras, Theodore, Kogevinas, Manolis, Kromhout, Hans, Carsin, Anne-Elie, Antó, Josep Maria, Bentouhami, Hayat, Weyler, Joost, Heinrich, Joachim, Nowak, Dennis, Urrutia, Isabel, Martínez-Moratalla, Jesús, Gullón, José Antonio, Vega, Antonio Pereira, Semjen, Chantal Raherison, Pin, Isabelle, Demoly, Pascal, Leynaert, Bénédicte, Villani, Simona, Gíslason, Thorarinn, Svanes, Øistein, Holm, Mathias, Forsberg, Bertil, Norbäck, Dan, Mehta, Amar J, Probst-Hensch, Nicole, Benke, Geza, Jogi, Rain, Torén, Kjell, Sigsgaard, Torben, Schlünssen, Vivi, Olivieri, Mario, Blanc, Paul D, Watkins, John, Bono, Roberto, Buist, A. Sonia, Vermeulen, Roel, Jarvis, Deborah, and Zock, Jan-Paul
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- 2019
19. Non-infectious rhinitis is more strongly associated with early—rather than late—onset of COPD: data from the European Community Respiratory Health Survey (ECRHS)
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Bergqvist, Joel, Andersson, Anders, Schiöler, Linus, Olin, Anna-Carin, Murgia, Nicola, Bove, Mogens, Janson, Christer, Abramson, Michael J., Leynaert, Bénédicte, Nowak, Dennis, Franklin, Karl A., PIN, Isabelle, Storaas, Torgeir, Schlünssen, Vivi, Heinrich, Joachim, and Hellgren, Johan
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- 2020
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20. Restrictive spirometry pattern is associated with low physical activity levels. A population based international study
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Carsin, Anne-Elie, Fuertes, Elaine, Schaffner, Emmanuel, Jarvis, Debbie, Antó, Josep M., Heinrich, Joachim, Bellisario, Valeria, Svanes, Cecilie, Keidel, Dirk, Imboden, Medea, Weyler, Joost, Nowak, Dennis, Martinez-Moratalla, Jesus, Gullón, José-Antonio, Sanchez Ramos, José Luis, Caviezel, Seraina, Beckmeyer-Borowko, Anna, Raherison, Chantal, Pin, Isabelle, Demoly, Pascal, Cerveri, Isa, Accordini, Simone, Gislason, Thorarinn, Toren, Kjell, Forsberg, Bertil, Janson, Christer, Jogi, Rain, Emtner, Margareta, Gómez Real, Francisco, Raza, Wasif, Leynaert, Bénédicte, Pascual, Silvia, Guerra, Stefano, Dharmage, Shyamali C., Probst-Hensch, Nicole, and Garcia-Aymerich, Judith
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- 2019
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21. Intra-breath changes in respiratory mechanics are sensitive to history of respiratory illness in preschool children: the SEPAGES cohort.
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Siroux, Valérie, Boudier, Anne, Lyon-Caen, Sarah, Quentin, Joane, Gioria, Yoann, Hantos, Zoltán, Slama, Rémy, Pin, Isabelle, and Bayat, Sam
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PRESCHOOL children ,RESPIRATORY mechanics ,RESPIRATORY obstructions ,BRONCHITIS ,WHEEZE ,RESPIRATORY organ sounds - Abstract
Background: Intra-breath oscillometry has been proposed as a sensitive means of detecting airway obstruction in young children. We aimed to assess the impact of early life wheezing and lower respiratory tract illness on lung function, using both standard and intra-breath oscillometry in 3 year old children. Methods: History of doctor-diagnosed asthma, wheezing, bronchiolitis and bronchitis and hospitalisation for respiratory problems were assessed by questionnaires in 384 population-based children. Association of respiratory history with standard and intra-breath oscillometry parameters, including resistance at 7 Hz (R
7 ), frequency-dependence of resistance (R7 − 19 ), reactance at 7 Hz (X7 ), area of the reactance curve (AX), end-inspiratory and end-expiratory R (ReI , ReE ) and X (XeI , XeE ), and volume-dependence of resistance (ΔR = ReE -ReI ) was estimated by linear regression adjusted on confounders. Results: Among the 320 children who accepted the oscillometry test, 281 (88%) performed 3 technically acceptable and reproducible standard oscillometry measurements and 251 children also performed one intra-breath oscillometry measurement. Asthma was associated with higher ReI , ReE , ΔR and R7 and wheezing was associated with higher ΔR. Bronchiolitis was associated with higher R7 and AX and lower XeI and bronchitis with higher ReI . No statistically significant association was observed for hospitalisation. Conclusions: Our findings confirm the good success rate of oscillometry in 3-year-old children and indicate an association between a history of early-life wheezing and lower respiratory tract illness and lower lung function as assessed by both standard and intra-breath oscillometry. Our study supports the relevance of using intra-breath oscillometry parameters as sensitive outcome measures in preschool children in epidemiological cohorts. [ABSTRACT FROM AUTHOR]- Published
- 2024
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22. Asthma Medication Ratio Phenotypes in Elderly Women
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Chanoine, Sébastien, Pin, Isabelle, Sanchez, Margaux, Temam, Sofia, Pison, Christophe, Le Moual, Nicole, Severi, Gianluca, Boutron-Ruault, Marie-Christine, Fournier, Agnès, Bousquet, Jean, Bedouch, Pierrick, Varraso, Raphaëlle, and Siroux, Valérie
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- 2018
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23. Serum cytokine profiles as predictors of asthma control in adults from the EGEA study
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Akiki, Zeina, Rava, Marta, Diaz Gil, Oscar, Pin, Isabelle, le Moual, Nicole, Siroux, Valérie, Guerra, Stefano, Chamat, Soulaima, Matran, Regis, Fitó, Montserrat, Salameh, Pascale, and Nadif, Rachel
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- 2017
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24. Mechanisms of the Development of Allergy (MeDALL): Introducing novel concepts in allergy phenotypes
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Anto, Josep M., Bousquet, Jean, Akdis, Mubeccel, Auffray, Charles, Keil, Thomas, Momas, Isabelle, Postma, Dirkje S., Valenta, Rudolf, Wickman, Magnus, Cambon-Thomsen, Anne, Haahtela, Tari, Lambrecht, Bart N., Lodrup Carlsen, Karin C., Koppelman, Gerard H., Sunyer, Jordi, Zuberbier, Torsten, Annesi-Maesano, Isabelle, Arno, Albert, Bindslev-Jensen, Carsten, De Carlo, Giuseppe, Forastiere, Francesco, Heinrich, Joachim, Kowalski, Marek L., Maier, Dieter, Melén, Erik, Smit, Henriette A., Standl, Marie, Wright, John, Asarnoj, Anna, Benet, Marta, Ballardini, Natalia, Garcia-Aymerich, Judith, Gehring, Ulrike, Guerra, Stefano, Hohmann, Cynthia, Kull, Inger, Lupinek, Christian, Pinart, Mariona, Skrindo, Ingebjorg, Westman, Marit, Smagghe, Delphine, Akdis, Cezmi, Andersson, Niklas, Bachert, Claus, Ballereau, Stephane, Ballester, Ferran, Basagana, Xavier, Bedbrook, Anna, Bergstrom, Anna, von Berg, Andrea, Brunekreef, Bert, Burte, Emilie, Carlsen, Kai-Hakon, Chatzi, Leda, Coquet, Jonathan M., Curin, Mirela, Demoly, Pascal, Eller, Esben, Fantini, Maria Pia, von Hertzen, Leena, Hovland, Vergard, Jacquemin, Benedicte, Just, Jocelyne, Keller, Theresa, Kiss, Renata, Kogevinas, Manolis, Koletzko, Sibylle, Lau, Susanne, Lehmann, Irina, Lemonnier, Nicolas, Mäkelä, Mika, Mestres, Jordi, Mowinckel, Peter, Nadif, Rachel, Nawijn, Martijn C., Pellet, Johan, Pin, Isabelle, Porta, Daniela, Rancière, Fanny, Rial-Sebbag, Emmanuelle, Saeys, Yvan, Schuijs, Martijn J., Siroux, Valerie, Tischer, Christina G., Torrent, Mathies, Varraso, Raphaelle, Wenzel, Kalus, and Xu, Cheng-Jian
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- 2017
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25. Specific IgE and IgG measured by the MeDALL allergen-chip depend on allergen and route of exposure: The EGEA study
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Siroux, Valérie, Lupinek, Christian, Resch, Yvonne, Curin, Mirela, Just, Jocelyne, Keil, Thomas, Kiss, Renata, Lødrup Carlsen, Karin, Melén, Erik, Nadif, Rachel, Pin, Isabelle, Skrindo, Ingebjørg, Vrtala, Susanne, Wickman, Magnus, Anto, Josep Maria, Valenta, Rudolf, and Bousquet, Jean
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- 2017
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26. Nebulized hypertonic saline 3% for 1 versus 3 days in hospitalized bronchiolitis: a blinded non-inferiority randomized controlled trial
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Beal, Gaëlle, Barbier, Catherine, Thoret, Sophie, Rubio, Amandine, Bonnet, Mathilde, Mazet, Roseline, Ego, Anne, and Pin, Isabelle
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- 2019
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27. Exposure to Disinfectants and Cleaning Products and Respiratory Health of Workers and Children in Daycares: The CRESPI Cohort Protocol
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Le Moual, Nicole, Dumas, Orianne, Bonnet, Pierre, Eworo Nchama, Anastasie, Le Bot, Barbara, Sévin, Etienne, Pin, Isabelle, Siroux, Valérie, Mandin, Corinne, Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Centre Scientifique et Technique du Bâtiment (CSTB), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Laboratoire d'étude et de recherche en environnement et santé (LERES), École des Hautes Études en Santé Publique [EHESP] (EHESP), Département des sciences en santé environnementale (DEESSE), Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Laboratoire d épidémiologie des rayonnements ionisants (IRSN/PSE-SANTE/SESANE/LEPID), Service de recherche sur les effets biologiques et Sanitaires des rayonnements ionisants (IRSN/PSE-SANTE/SESANE), and Institut de Radioprotection et de Sûreté Nucléaire (IRSN)-Institut de Radioprotection et de Sûreté Nucléaire (IRSN)
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[SDV.EE.SANT]Life Sciences [q-bio]/Ecology, environment/Health ,Epidemiology ,Settled dust ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Environmental and occupational exposures ,Indoor air quality ,[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract ,Asthma - Abstract
International audience; Although cleaning tasks are frequently performed in daycare, no study has focused on exposures in daycares in relation to respiratory health. The CRESPI cohort is an epidemiological study among workers (n~320) and children (n~540) attending daycares. The purpose is to examine the impact of daycare exposures to disinfectants and cleaning products (DCP) on the respiratory health of workers and children. A sample of 108 randomly selected daycares in the region of Paris has been visited to collect settled dust to analyze semi-volatile organic compounds and microbiota, as well as sample indoor air to analyze aldehydes and volatile organic compounds. Innovative tools (smartphone applications) are used to scan DCP barcodes in daycare and inform their use; a database then matches the barcodes with the products’ compositions. At baseline, workers/parents completed a standardized questionnaire, collecting information on DCP used at home, respiratory health, and potential confounders. Follow-up regarding children’s respiratory health (monthly report through a smartphone application and biannual questionnaires) is ongoing until the end of 2023. Associations between DCP exposures and the respiratory health of workers/children will be evaluated. By identifying specific environments or DCP substances associated with the adverse respiratory health of workers and children, this longitudinal study will contribute to the improvement of preventive measures.
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- 2023
28. Identification of a new locus at 16q12 associated with time to asthma onset
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Sarnowski, Chloé, Sugier, Pierre-Emmanuel, Granell, Raquel, Jarvis, Debbie, Dizier, Marie-Hélène, Ege, Markus, Imboden, Medea, Laprise, Catherine, Khusnutdinova, Elza K., Freidin, Maxim B., Cookson, William O.C., Moffatt, Miriam, Lathrop, Mark, Siroux, Valérie, Ogorodova, Ludmila M., Karunas, Alexandra S., James, Alan, Probst-Hensch, Nicole M., von Mutius, Erika, Pin, Isabelle, Kogevinas, Manolis, Henderson, A. John, Demenais, Florence, and Bouzigon, Emmanuelle
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- 2016
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29. Women using bleach for home cleaning are at increased risk of non-allergic asthma
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Matulonga, Bobette, Rava, Marta, Siroux, Valérie, Bernard, Alfred, Dumas, Orianne, Pin, Isabelle, Zock, Jan-Paul, Nadif, Rachel, Leynaert, Bénédicte, and Le Moual, Nicole
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- 2016
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30. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis
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Aberer, Werner, Adachi, Mitsuru, Agache, Ioana, Akdis, Cezmi, Akdis, Mubeccel, Annesi-Maesano, Isabella, Ansotegui, Ignacio J., Anto, Josep M., Arshad, S. Hasan, Baiardini, Ilaria, Baigenzhin, Abay K., Barbara, Cristina, Bateman, Eric D., Beghé, Bianca, Bel, Elisabeth H., Ben Kheder, Ali, Bennoor, Kazi S., Benson, Michael, Bernstein, David, Michael, Bewick, Thomas, Bieber, Bindslev-Jensen, Carsten, Bjermer, Leif, Blain, Hubert, Boner, Attilio, Bonini, Matteo, Bonini, Sergio, Bosse, Isabelle, Bouchard, Jacques, Boulet, Louis-Philippe, Bourret, Rodolphe A., Bousquet, Philippe J., Braido, Fulvio, Briggs, Andrew H., Brightling, Christopher E., Buhl, Roland, Burney, Peter, Bush, Andrew, Caballero-Fonseca, Fernando, Caimmi, Davide P., Camargos, Paulo, Camuzat, Thierry, Carlsen, Kai-Hakon, Carr, Warner, Casale, Thomas B., Sarabia, Alfonso Cepeda, Chatzi, Leda, Chen, Yuzhi, Chiron, Raphaël, Chkhartishvili, Ekaterine, Chuchalin, Alexander, Ciprandi, Georgio, Cirule, Ieva, Correia de Sousa, Jaime, Costa, David, Crooks, George, Custovic, Adnan, Dahlen, Sven-Erik, Darsow, Ulf, De Blay, Frédéric, De Manuel Keenoy, Esteban, Dedeu, Tony, Deleanu, Diana, Denburg, Judah, Didier, Alain, Dinh-Xuan, Anh-Tuan, Dokic, Dejan, Douagui, Habib B., Dubakiene, Ruta, Durham, Stephen, Dykewicz, Mark, El-Gamal, Yehia, Emuzyte, Regina, Fink-Wagner, Antje, Fiocchi, Alessandro, Forastiere, Francesco, Gamkrelidze, Amiran, Gemicioğlu, Bilun, Gereda, Jose E., Gerth van Wijk, Roy, Gotua, Maia, Grisle, Ineta, Guzmán, M. Antonieta, Haahtela, Tari, Heinrich, Joachim, Hellquist-Dahl, Birthe, Horak, Friedrich, Howarth, Peter H., Humbert, Marc, Hyland, Michael, Ivancevich, Juan-Carlos, Jares, Edgardo J., Johnston, Sebastian L., Jonquet, Olivier, Joos, Guy, Jung, Ki-Suck, Just, Jocelyne, Jutel, Marek, Kaidashev, Igor P., Khaitov, Musa, Kalayci, Omer, Kalyoncu, Fuat, Keith, Paul, Khaltaev, Nikolai, Kleine-Tebbe, Jorg, Klimek, Ludger, N'Goran, Bernard Koffi, Kolek, Vitezlav, Koppelman, Gerard H., Kowalski, Marek, Kull, Inger, Kvedariene, Violeta, Lambrecht, Bart, Lau, Susanne, Laune, Daniel, Le Thi Tuyet, Lan, Li, Jing, Lieberman, Phillipe, Lipworth, Brian J., Renaud, Louis, Magard, Yves, Magnan, Antoine, Mahboub, Bassam, Majer, Ivan, Makela, Mika, Manning, Peter J., Masjedi, Mohamad R., Maurer, Marcus, Mavale-Manuel, Sandra, Melén, Erik, Melo-Gomes, Elisabete, Mercier, Jacques, Merk, Hans, Miculinic, Neven, Mihaltan, Florin, Milenkovic, Branislava, Mohammad, Yousser, Molimard, Mathieu, Momas, Isabelle, Montilla-Santana, Anna, Morais-Almeida, Mario, Mösges, Ralph, Nadif, Rachel, Namazova-Baranova, Leyla, Neffen, Hugo, Nekam, Kristof, Neou, Angelos, Niggemann, Bodo, Nyembue, Dieudonné, O'Hehir, Robyn, Ohta, Ken, Okamoto, Yoshitaka, Okubo, Kim, Ouedraogo, Solange, Paggiaro, Pier-Luigi, Pali-Schöll, Isabella, Palmer, Stephen, Panzner, Petr, Papi, Alberto, Park, Hae-Sim, Pavord, Ian, Pawankar, Ruby, Pfaar, Oliver, Picard, Robert, Pigearias, Bernard, Pin, Isabelle, Plavec, Davor, Pohl, Wolfgang, Popov, Todor, Postma, Dirkje S., Potter, Paul, Poulsen, Lars K., Rabe, Klaus F., Raciborski, Filip, Pontal, Françoise Radier, Reitamo, Sakari, Repka-Ramirez, Maria-Susana, Robalo-Cordeiro, Carlos, Roberts, Graham, Rodenas, Francisco, Rolland, Christine, Rodriguez, Miguel Roman, Romano, Antonino, Rosado-Pinto, José, Rosario, Nelson A., Rosenwasser, Larry, Rottem, Menachem, Sanchez-Borges, Mario, Sastre-Dominguez, Joaquim, Schmid-Grendelmeier, Peter, Serrano, Eli, Simons, F. Estelle R., Sisul, Juan-Carlos, Skrindo, Ingebjorg, Smit, Henriette A., Solé, Dirceu, Sooronbaev, Talant, Spranger, Otto, Stelmach, Rafael, Strandberg, Timo, Sunyer, Jordi, Thijs, Carel, Todo-Bom, Ana-Maria, Triggiani, Massimo, Valenta, Rudolf, Valero, Antonio L., van Hage, Marianne, Vandenplas, Olivier, Vezzani, Giorgio, Vichyanond, Pakit, Viegi, Giovanni, Wagenmann, Martin, Wahn, Ulrich, De Yun, Wang, Williams, Denis, Wright, John, Yawn, Barbara P., Yiallouros, Panayiotis, Yusuf, Osman M., Zar, Heather J., Zernotti, Mario, Zhang, Luo, Zhong, Nanshan, Zidarn, Mihaela, Bousquet, Jean, Schünemann, Holger J., Hellings, Peter W., Arnavielhe, Sylvie, Bachert, Claus, Bedbrook, Anna, Bergmann, Karl-Christian, Bosnic-Anticevich, Sinthia, Brozek, Jan, Calderon, Moises, Canonica, G. Walter, Chavannes, Niels H., Cox, Linda, Chrystyn, Henry, Cruz, Alvaro A., Dahl, Ronald, De Carlo, Giuseppe, Demoly, Pascal, Devillier, Phillipe, Dray, Gérard, Fletcher, Monica, Fokkens, Wytske J., Fonseca, Joao, Gonzalez-Diaz, Sandra N., Grouse, Lawrence, Keil, Thomas, Kuna, Piotr, Larenas-Linnemann, Désirée, Lodrup Carlsen, Karin C., Meltzer, Eli O., Mullol, Jaoquim, Muraro, Antonella, Naclerio, Robert N., Palkonen, Susanna, Papadopoulos, Nikolaos G., Passalacqua, Giovanni, Price, David, Ryan, Dermot, Samolinski, Boleslaw, Scadding, Glenis K., Sheikh, Aziz, Spertini, François, Valiulis, Arunas, Valovirta, Erkka, Walker, Samantha, Wickman, Magnus, Yorgancioglu, Arzu, and Zuberbier, Torsten
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- 2016
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31. Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study
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de Blic, Jacques, Deschildre, Antoine, Lemanac'h, Gaëlle, Bui, Stéphanie, Marguet, Christophe, Lubrano, Marc, Labbé, André, Petit, Isabelle, Faye, Albert, Lorrot, Mathie, Mahdi, Fouad, Dubus, Jean-Christophe, Bosdure, Emmanuelle, Pin, Isabelle, Llerena, Cathy, Derelle, Jocelyne, Schweitzer, Cyril, Epaud, Ralph, Nathan, Nadia, Reix, Philippe, Wanin, Stéphanie, David, Valérie, de Pontbriand, Ulrika, Brouard, Jacques, Bessière, Aude, Douay, Caroline, Dupont, Claire, Petit, Claire, Richard, Jean-Romain, Toneatti, Christine, Vibet, Marie-Anne, Le Bourgeois, Muriel, Ferroni, Agnès, Leruez-Ville, Marianne, Varon, Emmanuelle, Thumerelle, Caroline, Brémont, François, Fayon, Michael J., Delacourt, Christophe, Ligier, Caroline, Watier, Laurence, and Guillemot, Didier
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- 2016
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32. Forced midexpiratory flow between 25% and 75% of forced vital capacity is associated with long-term persistence of asthma and poor asthma outcomes
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Siroux, Valérie, Boudier, Anne, Dolgopoloff, Maïa, Chanoine, Sébastien, Bousquet, Jean, Gormand, Frederic, Just, Jocelyne, Le Moual, Nicole, Nadif, Rachel, Pison, Christophe, Varraso, Raphaëlle, Matran, Regis, and Pin, Isabelle
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- 2016
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33. Changes in IgE sensitization and total IgE levels over 20 years of follow-up
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Amaral, André F.S., Newson, Roger B., Abramson, Michael J., Antó, Josep M., Bono, Roberto, Corsico, Angelo G., de Marco, Roberto, Demoly, Pascal, Forsberg, Bertil, Gislason, Thorarinn, Heinrich, Joachim, Huerta, Ismael, Janson, Christer, Jõgi, Rain, Kim, Jeong-Lim, Maldonado, José, Martinez-Moratalla Rovira, Jesús, Neukirch, Catherine, Nowak, Dennis, Pin, Isabelle, Probst-Hensch, Nicole, Raherison-Semjen, Chantal, Svanes, Cecilie, Urrutia Landa, Isabel, van Ree, Ronald, Versteeg, Serge A., Weyler, Joost, Zock, Jan-Paul, Burney, Peter G.J., and Jarvis, Deborah L.
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- 2016
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34. Correction to: Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome
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Cheung, Warren A., Shao, Xiaojian, Morin, Andréanne, Siroux, Valérie, Kwan, Tony, Ge, Bing, Aïssi, Dylan, Chen, Lu, Vasquez, Louella, Allum, Fiona, Guénard, Frédéric, Bouzigon, Emmanuelle, Simon, Marie-Michelle, Boulier, Elodie, Redensek, Adriana, Watt, Stephen, Datta, Avik, Clarke, Laura, Flicek, Paul, Mead, Daniel, Paul, Dirk S., Beck, Stephan, Bourque, Guillaume, Lathrop, Mark, Tchernof, André, Vohl, Marie-Claude, Demenais, Florence, Pin, Isabelle, Downes, Kate, Stunnenberg, Hendrick G., Soranzo, Nicole, Pastinen, Tomi, and Grundberg, Elin
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- 2019
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35. Early-Life Exposure to a Mixture of Phenols and Phthalates in Relation to Child Social Behavior: Applying an Evidence-Based Prioritization to a Cohort with Improved Exposure Assessment.
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Mustieles, Vicente, Rolland, Matthieu, Pin, Isabelle, Thomsen, Cathrine, Sakhi, Amrit K., Sabaredzovic, Azemira, Muckle, Gina, Guichardet, Karine, Slama, Rémy, and Philippat, Claire
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PHENOL analysis ,MATERNAL exposure ,AIR pollution ,MOTHERS ,STATISTICS ,PHENOLS ,HIGH performance liquid chromatography ,CONFIDENCE intervals ,THIRD trimester of pregnancy ,CHILD behavior ,HEALTH outcome assessment ,REGRESSION analysis ,PLASTICIZERS ,TRICLOSAN ,T-test (Statistics) ,RESEARCH funding ,URINE collection & preservation ,COMMUNICATION ,QUESTIONNAIRES ,MASS spectrometry ,STATISTICAL hypothesis testing ,SOCIAL skills ,SECOND trimester of pregnancy ,DATA analysis software ,LOGISTIC regression analysis ,SENSITIVITY & specificity (Statistics) ,DATA analysis ,METABOLITES ,PARENTS ,KETONES ,PREGNANCY - Abstract
BACKGROUND: Previous studies aiming at relating exposure to phenols and phthalates with child social behavior characterized exposure using one or a few spot urine samples, resulting in substantial exposure misclassification. Moreover, early infancy exposure was rarely studied. OBJECTIVES: We aimed to examine the associations of phthalates and phenols with child social behavior in a cohort with improved exposure assessment and to a priori identify the chemicals supported by a higher weight of evidence. METHODS: Among 406 mother-child pairs from the French Assessment of Air Pollution exposure during Pregnancy and Effect on Health (SEPAGES) cohort, 25 phenols/phthalate metabolites were measured in within-subject pools of repeated urine samples collected at the second and third pregnancy trimesters (∼21 samples/trimester) and at 2 months and 1-year of age (∼7 samples/period). Social behavior was parent-reported at 3 years of age of the child using the Social Responsiveness Scale (SRS). A structured literature review of the animal and human evidence was performed to prioritize the measured phthalates/phenols based on their likelihood to affect social behavior. Both adjusted linear regression and Bayesian Weighted Quantile Sum (BWQS) regression models were fitted. False discovery rate (FDR) correction was applied only to nonprioritized chemicals. RESULTS: Prioritized compounds included bisphenol A, bisphenol S, triclosan (TCS), diethyl-hexyl phthalate (RDEHP), mono-ethyl phthalate (MEP), mono-n-butyl phthalate (MnBP), and mono-benzyl phthalate (MBzP). With the exception of bisphenols, which showed a mixed pattern of positive and negative associations in pregnant mothers and neonates, few prenatal associations were observed. Most associations were observed with prioritized chemicals measured in 1-y-old infants: Each doubling in urinary TCS (β=0.78; 95% CI: 0.00, 1.55) and MEP (β=0.92; 95% CI: -0.11, 1.96) concentrations were associated with worse total SRS scores, whereas MnBP and RDEHP were associated with worse Social Awareness (β=0.25; 95% CI: 0.01, 0.50) and Social Communication (β=0.43; 95% CI: -0.02, 0.89) scores, respectively. BWQS also suggested worse total SRS [Beta 1=1.38; 95% credible interval (CrI): -0.18, 2.97], Social Awareness (Beta 1=0.37; 95% CrI: 0.06, 0.70), and Social Communication (Beta 1=0.91; 95% CrI: 0.31, 1.53) scores per quartile increase in the mixture of prioritized compounds assessed in 1-y-old infants. The few associations observed with nonprioritized chemicals did not remain after FDR correction, with the exception of benzophenone-3 exposure in 1-y-old infants, which was suggestively associated with worse Social Communication scores (corrected 푝=0.07). DISCUSSION: The literature search allowed us to adapt our statistical analysis according to the weight of evidence and create a corpus of experimental and epidemiological knowledge to better interpret our findings. Early infancy appears to be a sensitive exposure window that should be further investigated. [ABSTRACT FROM AUTHOR]
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- 2023
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36. Early delivery following chronic and acute ambient temperature exposure: a comprehensive survival approach.
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Hough, Ian, Rolland, Matthieu, Guilbert, Ariane, Seyve, Emie, Heude, Barbara, Slama, Rémy, Lyon-Caen, Sarah, Pin, Isabelle, Chevrier, Cécile, Kloog, Itai, and Lepeule, Johanna
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PREMATURE labor ,WEATHER hazards ,TEMPERATE climate ,TEMPERATURE ,HEALTH policy ,HEAT waves (Meteorology) - Abstract
Background Ambient temperature, particularly heat, is increasingly acknowledged as a trigger for preterm delivery but study designs have been limited and results mixed. We aimed to comprehensively evaluate the association between ambient temperature throughout pregnancy and preterm delivery. Methods We estimated daily temperature throughout pregnancy using a cutting-edge spatiotemporal model for 5347 live singleton births from three prospective cohorts in France, 2002–2018. We performed Cox regression (survival analysis) with distributed lags to evaluate time-varying associations with preterm birth simultaneously controlling for exposure during the first 26 weeks and last 30 days of pregnancy. We examined weekly mean, daytime, night-time and variability of temperature, and heatwaves accounting for adaptation to location and season. Results Preterm birth risk was higher following cold (5th vs 50th percentile of mean temperature) 7–9 weeks after conception [relative risk (RR): 1.3, 95% CI: 1.0–1.6 for 2°C vs 11.6°C] and 10–4 days before delivery (RR: 1.6, 95% CI: 1.1–2.1 for 1.2°C vs 12.1°C). Night-time heat (95th vs 50th percentile of minimum temperature; 15.7°C vs 7.4°C) increased risk when exposure occurred within 5 weeks of conception (RR: 2.0, 95% CI: 1.05–3.8) or 20–26 weeks after conception (RR: 2.9, 95% CI: 1.2–6.8). Overall and daytime heat (high mean and maximum temperature) showed consistent effects. We found no clear associations with temperature variability or heatwave indicators, suggesting they may be less relevant for preterm birth. Conclusions In a temperate climate, night-time heat and chronic and acute cold exposures were associated with increased risk of preterm birth. These results suggest night-time heat as a relevant indicator. In the context of rising temperatures and more frequent weather hazards, these results should inform public health policies to reduce the growing burden of preterm births. [ABSTRACT FROM AUTHOR]
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- 2023
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37. Comparing Mycobacterium massiliense and Mycobacterium abscessus lung infections in cystic fibrosis patients
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Roux, Anne-Laure, Catherinot, Emilie, Soismier, Nathalie, Heym, Beate, Bellis, Gil, Lemonnier, Lydie, Chiron, Raphaël, Fauroux, Brigitte, Le Bourgeois, Muriel, Munck, Anne, Pin, Isabelle, Sermet, Isabelle, Gutierrez, Cristina, Véziris, Nicolas, Jarlier, Vincent, Cambau, Emmanuelle, Herrmann, Jean-Louis, Guillemot, Didier, and Gaillard, Jean-Louis
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- 2015
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38. Central venous thrombosis and thrombophilia in cystic fibrosis: A prospective study
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Munck, Anne, Kheniche, Ahmed, Alberti, Corinne, Hubert, Dominique, Martine, Reynaud-Gaubert, Nove-Josserand, Raphaele, Pin, Isabelle, Bremont, Francois, Chiron, Raphael, Couderc, Laure, Dalphin, Marie Laure, Darviot, Estelle, Delaisi, Bertrand, Dominique, Stéphane, Durieu, Isabelle, Fanton, Annelyse, Fayon, Michael, Gérardin, Michèle, Giniès, Jean-Louis, Giraut, Charlotte, Grenet, Dominique, Guillot, Marcel, Huet, Frédéric, Le bourgeois, Muriel, Murris-Epin, Marlène, Ramel, Sophie, Sardet, Anne, Sermet-Gaudelus, Isabelle, Varaigne, Françoise, Wanin, Stéphanie, Weiss, Laurence, and Hurtaud, Marie-Francoise
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- 2015
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39. Toward the Standardization of Mycological Examination of Sputum Samples in Cystic Fibrosis: Results from a French Multicenter Prospective Study
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Coron, Noémie, Pihet, Marc, Fréalle, Emilie, Lemeille, Yolande, Pinel, Claudine, Pelloux, Hervé, Gargala, Gilles, Favennec, Loic, Accoceberry, Isabelle, Durand-Joly, Isabelle, Dalle, Frédéric, Huet, Frédéric, Fanton, Annlyse, Boldron, Amale, Loeuille, Guy-André, Domblides, Philippe, Coltey, Bérengère, Pin, Isabelle, Llerena, Catherine, Troussier, Françoise, Person, Christine, Marguet, Christophe, Wizla, Nathalie, Thumerelle, Caroline, Turck, Dominique, Bui, Stéphanie, Fayon, Michael, Duhamel, Alain, Prévotat, Anne, Wallaert, Benoit, Leroy, Sylvie, Bouchara, Jean-Philippe, and Delhaes, Laurence
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- 2017
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40. Proceedings of Réanimation 2017, the French Intensive Care Society International Congress
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Bougouin, Wulfran, Marijon, Eloi, Planquette, Benjamin, Karam, Nicole, Dumas, Florence, Celermajer, David, Jost, Daniel, Lamhaut, Lionel, Beganton, Frankie, Cariou, Alain, Meyer, Guy, Jouven, Xavier, Bureau, Côme, Charpentier, Julien, Salem, Omar Ben Hadj, Guillemet, Lucie, Arnaout, Michel, Ferre, Alexis, Geri, Guillaume, Mongardon, Nicolas, Pène, Frédéric, Chiche, Jean-Daniel, Mira, Jean-Paul, Labro, Guylaine, Belon, François, Luu, Vinh-Phuc, Chenet, Julien, Besch, Guillaume, Puyraveau, Marc, Piton, Gaël, Capellier, Gilles, Martin, Maëlle, Lascarrou, Jean-Baptiste, Le Thuaut, Aurélie, Lacherade, Jean-Claude, Martin-Lefèvre, Laurent, Fiancette, Maud, Vinatier, Isabelle, Lebert, Christine, Bachoumas, Konstantinos, Yehia, Aihem, Henry-Laguarrigue, Matthieu, Colin, Gwenhaël, Reignier, Jean, Privat, Elodie, Escutnaire, Joséphine, Dumont, Cyrielle, Baert, Valentine, Vilhelm, Christian, Hubert, Hervé, Robert-Edan, Vincent, Lakhal, Karim, Quartin, Andrew, Hobbs, Brian, Cely, Cynthia, Bell, Cynthia, Pham, Tai, Schein, Roland, Geng, Yimin, Ng, Chaan, Ehrmann, Stephan, Gandonnière, Charlotte Salmon, Boisramé-Helms, Julie, Le Tilly, Olivier, De Bretagne, Isabelle Benz, Mercier, Emmanuelle, Mankikian, Julie, Bretagnol, Anne, Meziani, Ferhat, Halimi, Jean Michel, Le Guellec, Chantal Barin, Gaudry, Stéphane, Hajage, David, Tubach, Florence, Pons, Bertrand, Boulet, Eric, Boyer, Alexandre, Chevrel, Guillaume, Lerolle, Nicolas, Carpentier, Dorothée, de Prost, Nicolas, Lautrette, Alexandre, Mayaux, Julien, Nseir, Saad, Ricard, Jean-Damien, Dreyfuss, Didier, Robert, René, Garzotto, Franscesco, Kipnis, Eric, Tetta, Ciro, Ronco, Claudio, Schnell, David, Aurelie, Bourmaud, Reynaud, Marie, Clec’h, Christophe, Benyamina, Mourad, Vincent, François, Mariat, Christophe, Bornstain, Caroline, Rouleau, Stephane, Leroy, Christophe, Cohen, Yves, Morel, Jerome, Legrand, Matthieu, Terreaux, Jeremy, Darmon, Michaël, Cantier, Marie, Morisot, Adeline, Guérot, Emmanuel, Canet, Emmanuel, De Montmollin, Etienne, Voiriot, Guillaume, Neuville, Mathilde, Timsit, Jean-François, Sonneville, Romain, Fayssoil, Abdallah, Stojkovic, Tania, Behin, Anthony, Ogna, Adam, Lofaso, Frédéric, Laforet, Pascal, Wahbi, Karim, Prigent, Helene, Duboc, Denis, Orlikowski, David, Eymard, Bruno, Annane, Djillali, Le Guennec, Loic, Cholet, Clémentine, Bréchot, Nicolas, Hekimian, Guillaume, Besset, Sébastien, Lebreton, Guillaume, Nieszkowska, Ania, Trouillet, Jean Louis, Leprince, Pascal, Combes, Alain, Luyt, Charles-Edouard, Griton, Marion, Sesay, Musa, De Panthou, Nadia Sibaï, Bienvenu, Thomas, Biais, Matthieu, Nouette-Gaulain, Karine, Fossat, Guillaume, Baudin, Florian, Coulanges, Cécile, Bobet, Sabrine, Dupont, Arnaud, Courtes, Léa, Benzekri, Dalila, Kamel, Toufik, Muller, Grégoire, Bercault, Nicolas, Barbier, François, Runge, Isabelle, Skarzynski, Marie, Mathonnet, Armelle, Boulain, Thierry, Jouan, Youenn, Teixera, Noémie, Hassen-Khodja, Claire, Guillon, Antoine, Gaborit, Christophe, Grammatico-Guillon, 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Meddeb, Khaoula, Khedher, Ahmed, Sma, Nesrine, Ayachi, Jihene, Khelfa, Messaouda, Fraj, Nesrine, Lakhal, Hend Ben, Hammed, Hedia, Boukadida, Raja, Hafsa, Hajer, Chouchene, Imed, Boussarsar, Mohamed, Ben, Braiek Dhouha, Ouanes-Besbes, Lamia, Benatti, Kaoutar, Dafir, A., Aissaoui, W., Elallame, W., Haddad, W., Cherkab, R., Elkettani, C., Barrou, L., Hamou, Zakaria Ait, Repessé, Xavier, Charron, Cyril, Aubry, Alix, Paternot, Alexis, Maizel, Julien, Slama, Michel, Vieillard-Baron, Antoine, Trifi, Ahlem, Abdellatif, Sami, Fatnassi, Meriem, Daly, Foued, Nasri, Rochdi, Ismail, Khaoula Ben, Lakhal, Salah Ben, Bazalgette, Florian, Daurat, Aurelien, Roger, Claire, Muller, Laurent, Doyen, Denis, Plattier, Rémi, Robert, Alexandre, Hyvernat, Hervé, Bernardin, Gilles, Jozwiak, Mathieu, Gimenez, Julia, Mercado, Pablo, Depret, François, Tilouch, Najla, Mater, Houda, Habiba, Ben Sik Ali, Jaoued, Oussama, Gharbi, Rim, Hassen, Mohamed Fekih, Elatrous, Souheil, Pasquier, Pierre, Vuillemin, Quentin, Schaal, Jean-Vivien, Martinez, Thibault, Duron, Sandrine, Trousselard, Marion, Schwartzbrod, Pierre-Eric, Baugnon, Thomas, Dupic, Laurent, Gout, Caroline Duracher, De Saint Blanquat, Laure, Séguret, Sylvie, Le Ficher, Gaelle, Orliaguet, Gilles, Hubert, Philippe, Bigé, Naïke, Leblanc, Guillaume, Briand, Raphael, Brousse, Lucas, Brunet, Valentine, Chatelain, Léonard, Prat, Dominique, Jacobs, Frédéric, Demars, Nadège, Hamzaoui, Olfa, Moneger, Guy, Sztrymf, Benjamin, Duburcq-Gury, Emilie, Satre-Buisson, Léa, Duburcq, Thibault, Poissy, Julien, Robriquet, Laurent, Jourdain, Merce, Sécheresse, Thierry, Miquet, Mattéo, Simond, Alexis, Usseglio, Pascal, Hamdaoui, Yamina, Boussarsar, Mohamed, Desailly, Victoire, Brun, Patrick, Iglesias, Pauline, Huet, Jérémie, Masseran, Clémence, Claudon, Antoine, Ebeyer, Clément, Truong, Thomas, Tesnière, Antoine, Mignon, Alexandre, Gaudry, Stéphane, Resiere, Dabor, Valentino, Ruddy, Fabre, Julien, Roze, Benoit, Ferge, Jean-Louis, Charbatier, Cyrille, Marie, 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K., Chlilek, A., Hajji, Ahmed, Louati, Assaad, Khaldi, Ammar, Borgi, Aida, Ghali, Nargess, Bouziri, Asma, Menif, Khaled, Ben, Jaballah Najla, Armel, Anwar, Brochon, Jeanne, Dumitrescu, Mihaela, Thévenot, Sarah, Saulnier, Jean-Pascal, Husseini, Khaled, Laland, Catherine, Cremniter, Julie, Bousseau, Anne, Castel, Olivier, Brémaud-Csizmadia, Cassandra, Diss, Margot, Portefaix, Aurélie, Berthiller, Julien, Gillet, Yves, Aoul, Nabil Tabet, Douah, Ali, Addou, Zakaria, Youbi, Houari, Moussati, Mohamed, Belhabiche, Kamel, Mir, Souad, Abada, Sanaa, Amel, Zerhouni, Aouffen, Nabil, Bouzit, Zina, Grati, Ahmed H., Dhonneur, Gilles F., Boussarsar, Mohamed, Lau, Nicolas, Mezhari, Ilham, Roucaud, Nicolas, Le Meur, Matthieu, Paulet, Rémi, Coudray, Jean-Michel, Ghomari, Wahiba Imène, Boumlik, Reda, Peigne, Vincent, Daban, Jean-Louis, Boutonnet, Mathieu, Lenoir, Bernard, Yassine, Hafiani, Mohamed, Cheikh Chaigar, Khalid, Allali, Ihssan, Moussaid, Said, Elyoussoufi, Said, Salmi, Jazia, Amira Ben, Fatima, Jaziri, Wafa, Skouri, Maha, Bennasr, Khaoula, Ben Abdelghni, Sami, Turki, Abdallah Taeib, B., Medhioub, Fatma Kaaniche, Rollet-Cohen, Virginie, Sachs, Philippe, Merchaoui, Zied, Renolleau, Sylvain, Oualha, Mehdi, Eloi, Maxime, Jean, Sandrine, Demoulin, Maryne, Valentin, Cécile, Guilbert, Julia, Walti, Hervé, Carbajal, Ricardo, Leger, Pierre-Louis, Karaca-Altintas, Yasemin, Botte, Astrid, Labreuche, Julien, Drumez, Elodie, Devos, Patrick, Bour, Franck, Leclerc, Francis, Ahmed, Ayari, khaled, Menif, Louati, Assaad, Aida, Borgi, Ammar, Khaldi, Narjess, Ghali, Ahmed, Hajji, Asma, Bouziri, Jaballah, Nejla Ben, Leger, Pierre-Louis, Pansiot, Julien, Besson, Valérie, Palmier, Bruno, Baud, Olivier, Cauli, Bruno, Charriaut-Marlangue, Christiane, Mansuy, Amélie, Michel, Fabrice, Le Bel, Stéphane, Boubnova, Julia, Ughetto, Fabrice, Ovaert, Caroline, Fouilloux, Virginie, Paut, Olivier, Jacquet-Lagrèze, Matthias, Tiebergien, Nicolas, Hanna, Najib, Evain, Jean-Noël, Baudin, Florent, 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Essafi, Fatma, Benabderrahim, A., Jouffroy, Romain, Resiere, Dabor, Sanchez, Bruno, Inamo, Jocelyn, Megarbane, Bruno, Batouche, Djamila-Djahida, Zerhouni, Amel, Tabeliouna, Kheira, Negadi, Amine, Mentouri, Zahia, Le Gall, Fanny, Hanouz, Jean-Luc, Normand, Hervé, Khoury, Abdo, Sall, Fatimata Seydou, De Luca, Alban, Pugin, Aurore, Pazart, Lionel, Vidal, Chrystelle, Leroux, Franck, Khoury, Abdo, L’Her, Erwan, Marjanovic, Nicolas, Khoury, Abdo, Desmettre, Thibault, Lambert, Christophe, Ragey, Sophie Perinel, Baboi, Loredana, Bazin, Jean-Etienne, Koffel, Catherine, Dhonneur, Gilles, Bouzit, Zina, Bradai, Larbi, Ayed, Issam Ben, Aissa, Fethi, Haouache, Hakim, Marechal, Yoann, Biston, Patrick, Piagnerelli, Michael, Bortolotti, Perrine, Colling, Delphine, Colas, Vincent, Voisin, Benoit, Dewavrin, Florent, Onimus, Thierry, Girardie, Patrick, Saulnier, Fabienne, Urbina, Tomas, Nguyen, Yann, Druoton, Anne-Lise, Soudant, Marc, Barraud, Damien, Conrad, Marie, Cravoisy-Popovic, Aurélie, Nace, 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Andrejak, Claire, Ricome, Sylvie, Dupont, Hervé, Baudin, François, Dureau, Pauline, Tanguy, Audrey, Arbelot, Charlotte, Ben, Hassen Kais, Charfeddine, Ahmed, Granger, Benjamin, Laporte, Lucile, Hermetet, Coralie, Regaieg, Kais, Khemakhem, Rim, Chelly, Hedi, Cheikh, Chaigar Mohammed, Mountij, Hamid, Rghioui, Kawtar, Haddad, Wafae, Cherkab, Rachid, Barrou, Houcine, Naima, Aitmouden, bennani, Othmani M., Regaieg, Kais, Douib, Ahmed, Samet, Amal, Cungi, Pierre-Julien, Nguyen, Cédric, Cotte, Jean, D’aranda, Erwan, Meaudre, Eric, Avaro, Jean-Phillipe, Slaoui, Mohamed Taoufik, Mokline, Amel, Rahmani, Imene, Laajili, Achraf, Amri, Helmi, Gharsallah, Lazheri, Gasri, Bahija, Tlaili, Sofiene, Hammouda, Rym, Messadi, Amen Allah, Sudden Death Expertise Center, AKIKI Study Group, DO-RE-MI-FA Group, ENCEPHALITICA Study Group, for the HYPER2S Investigators and REVA Research Network, for the Purpura Fulminans Study Group, GFRUP RMEF, REVA ECMOnet, REA-RAISIN Study Group, for the EurêClark Study Group, and Groupe Communication et Simulation en Pédiatrie
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41. Prevalence of asthma-like symptoms with ageing
- Author
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Jarvis, Debbie, Newson, Roger, Janson, Christer, Corsico, Angelo, Heinrich, Joachim, Anto, Josep M, Abramson, Michael J, Kirsten, Anne-Marie, Zock, Jan Paul, Bono, Roberto, Demoly, Pascal, Leynaert, Bénédicte, Raherison, Chantal, Pin, Isabelle, Gislason, Thorarinn, Jogi, Rain, Schlunssen, Vivi, Svanes, Cecilie, Watkins, John, Weyler, Joost, Pereira-Vega, Antonio, Urrutia, Isabel, Gullón, Jose A, Forsberg, Bertil, Probst-Hensch, Nicole, Boezen, H Marike, Martinez-Moratalla Rovira, Jesús, Accordini, Simone, de Marco, Roberto, and Burney, Peter
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- 2018
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42. Propofol for sedation during less invasive surfactant administration in preterm infants
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Descamps, Claire Sophie, Chevallier, Marie, Ego, Anne, Pin, Isabelle, Epiard, Chloé, and Debillon, Thierry
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- 2017
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43. Longitudinal associations of household use of cleaning agents and asthma symptoms in women: the EGEA study.
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Pacheco Da Silva, Emilie, Ngutuka, Mélanie, Dumas, Orianne, Orsi, Laurent, Ait-hadad, Wassila, Lemire, Pierre, Quentin, Joane, Pin, Isabelle, Varraso, Raphäelle, Siroux, Valérie, and Le Moual, Nicole
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- 2023
- Full Text
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44. Sweat test practice in pediatric pulmonology after introduction of cystic fibrosis newborn screening
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Grimaldi, Céline, Brémont, François, Berlioz-Baudoin, Michèle, Brouard, Jacques, Corvol, Harriet, Couderc, Laure, Lezmi, Guillaume, Pin, Isabelle, Petit, Isabelle, Reix, Philippe, Remus, Natacha, Schweitzer, Cyril, Thumerelle, Caroline, and Dubus, Jean-Christophe
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- 2015
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45. Air pollution and asthma control in the Epidemiological study on the Genetics and Environment of Asthma
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Epidemiological study on the Genetics and Environment of Asthma (EGEA), Jacquemin, Bénédicte, Kauffmann, Francine, Pin, Isabelle, Le Moual, Nicole, Bousquet, Jean, Gormand, Frédéric, Just, Jocelyne, Nadif, Rachel, Pison, Christophe, Vervloet, Daniel, Künzli, Nino, and Siroux, Valérie
- Published
- 2012
46. Prenatal Exposure to PM2.5 Oxidative Potential and Lung Function in Infants and Preschool- Age Children: A Prospective Study.
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Marsal, Anouk, Slama, Rémy, Lyon-Caen, Sarah, S. Borlaza, Lucille Joanna, Jaffrezo, Jean-Luc, Boudier, Anne, Darfeuil, Sophie, Elazzouzi, Rhabira, Gioria, Yoann, Lepeule, Johanna, Chartier, Ryan, Pin, Isabelle, Quentin, Joane, Bayat, Sam, Uzu, Gaëlle, Siroux, Valérie, and the SEPAGES cohort study group
- Subjects
LUNG physiology ,PARTICULATE matter ,MATERNAL exposure ,STATISTICS ,CONFIDENCE intervals ,MULTIPLE regression analysis ,PRENATAL exposure delayed effects ,PULMONARY function tests ,DESCRIPTIVE statistics ,RESEARCH funding ,BIOLOGICAL assay ,BREATH tests ,DATA analysis software ,OXIDATION-reduction reaction ,LONGITUDINAL method ,PREGNANCY - Abstract
BACKGROUND: Fine particulate matter (PM
2.5 ) has been found to be detrimental to respiratory health of children, but few studies have examined the effects of prenatal PM2.5 oxidative potential (OP) on lung function in infants and preschool children. OBJECTIVES: We estimated the associations of personal exposure to PM2.5  and OP during pregnancy on offspring objective lung function parameters and compared the strengths of associations between both exposure metrics. METHODS: We used data from 356 mother–child pairs from the SEPAGES cohort. PM filters collected twice during a week were analyzed for OP, using the dithiothreitol (DTT) and the ascorbic acid (AA) assays, quantifying the exposure of each pregnant woman. Lung function was assessed with tidal breathing analysis (TBFVL) and nitrogen multiple-breath washout (N2 MBW) test, performed at 6 wk, and airwave oscillometry (AOS) performed at 3 y. Associations of prenatal PM2.5  mass and OP with lung function parameters were estimated using multiple linear regressions. RESULTS: In neonates, an interquartile (IQR) increase in OPDTT v (0.89nmol/min/m³) was associated with a decrease in functional residual capacity (FRC) measured by N2 MBW [β = -2.26 mL ; 95% confidence interval (CI): -4.68, 0.15]. Associations with PM2.5 showed similar patterns in comparison with OPDTT v but of smaller magnitude. Lung clearance index (LCI) and TBFVL parameters did not show any clear association with the exposures considered. At 3 y, increased frequency-dependent resistance of the lungs (Rrs7-19 ) from AOS tended to be associated with higher OPDTT v (β = 0.09hPa×s/L ; 95% CI: -0.06, 0.24) and OPAA v (IQR = 1.14nmol/min/m³ ; β = 0.12hPa×s/L ; 95% CI: -0.04, 0.27) but not with PM2.5 (IQR = 6.9µg/m³ ; β = 0.02hPa×s/L ; 95% CI: -0.13, 0.16). Results for FRC and Rrs7-19 remained similar in OP models adjusted on PM2.5 . DISCUSSION: Prenatal exposure to OPDTT v  was associated with several offspring lung function parameters over time, all related to lung volumes. [ABSTRACT FROM AUTHOR]- Published
- 2023
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47. Exposure to Phthalates and Phenols during Pregnancy and Offspring Size at Birth
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Philippat, Claire, Mortamais, Marion, Chevrier, Cécile, Petit, Claire, Calafat, Antonia M., Ye, Xiaoyun, Silva, Manori J., Brambilla, Christian, Pin, Isabelle, Charles, Marie-Aline, Cordier, Sylvaine, and Slama, Rémy
- Published
- 2012
48. Asthma control assessed in the EGEA epidemiological survey and health-related quality of life
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Siroux, Valérie, Boudier, Anne, Bousquet, Jean, Vignoud, Lucile, Gormand, Frédéric, Just, Jocelyne, Le Moual, Nicole, Leynaert, Bénédicte, Nadif, Rachel, Pison, Christophe, Scheinmann, Pierre, Vervloet, Daniel, Anto, Josep Maria, Kauffmann, Francine, and Pin, Isabelle
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- 2012
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49. Functional variation in allelic methylomes underscores a strong genetic contribution and reveals novel epigenetic alterations in the human epigenome
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Cheung, Warren A., Shao, Xiaojian, Morin, Andréanne, Siroux, Valérie, Kwan, Tony, Ge, Bing, Aïssi, Dylan, Chen, Lu, Vasquez, Louella, Allum, Fiona, Guénard, Frédéric, Bouzigon, Emmanuelle, Simon, Marie-Michelle, Boulier, Elodie, Redensek, Adriana, Watt, Stephen, Datta, Avik, Clarke, Laura, Flicek, Paul, Mead, Daniel, Paul, Dirk S., Beck, Stephan, Bourque, Guillaume, Lathrop, Mark, Tchernof, André, Vohl, Marie-Claude, Demenais, Florence, Pin, Isabelle, Downes, Kate, Stunnenberg, Hendrick G., Soranzo, Nicole, Pastinen, Tomi, and Grundberg, Elin
- Published
- 2017
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50. Associations between a mixture of phenols and phthalates and child behaviour in a French mother–child cohort with repeated assessment of exposure
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Guilbert, Ariane, Rolland, Matthieu, Pin, Isabelle, Thomsen, Cathrine, Sakhi, Amrit, Sabaredzovic, Azemira, Slama, Rémy, Guichardet, Karine, Philippat, Claire, Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire [Grenoble] (CHU)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université Grenoble Alpes (UGA), Norwegian Institute of Public Health [Oslo] (NIPH), ANR-19-CE36-0003,EDeN,Exposition précoces aux perturbateurs endocriniens et neurodéveloppement de l'enfant : le rôle de l'axe hypothalamo-hypophysaire(2019), ANR-12-PDOC-0029,ANR-12-PDOC-0029-01,ANR-12-PDOC-0029-01, ANR-14-CE21-0007,SHALCOH,Expositions prénatales aux phénols et santé de l'enfant : analyse longitudinale(2014), ANR-18-CE36-0005,ETAPE,Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire(2018), ANR-15-IDEX-0002,UGA,IDEX UGA(2015), ANR-15-IDEX-0005,ANR-15-IDEX5 ,ANR-15-IDEX5, European Project: 311765,EC:FP7:ERC,ERC-2012-StG_20111109,E-DOHAD(2013), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), ANR-15-IDEX5ANR-15-IDEX5ANR-15-IDEX-0005, ANR-12-PDOC-0029,PAPER,Grossesse, pollution atmospherique, epigenetique, et sante respiratoire(2012), BARBAGALLO, Maïlys, Exposition précoces aux perturbateurs endocriniens et neurodéveloppement de l'enfant : le rôle de l'axe hypothalamo-hypophysaire - - EDeN2019 - ANR-19-CE36-0003 - AAPG2019 - VALID, Retour Post-Doctorant - Grossesse, pollution atmospherique, epigenetique, et sante respiratoire - - PAPER2012 - ANR-12-PDOC-0029 - PDOC - VALID, Appel à projets générique - Expositions prénatales aux phénols et santé de l'enfant : analyse longitudinale - - SHALCOH2014 - ANR-14-CE21-0007 - Appel à projets générique - VALID, APPEL À PROJETS GÉNÉRIQUE 2018 - Exposition prénatale au tabac et à la pollution atmosphérique et effets sur la santé respiratoire et le neurodévelopment de l'enfant: rôle de la méthylation placentaire - - ETAPE2018 - ANR-18-CE36-0005 - AAPG2018 - VALID, IDEX UGA - - UGA2015 - ANR-15-IDEX-0002 - IDEX - VALID, and Environmentally-induced Developmental Origins of Health and Disease - E-DOHAD - - EC:FP7:ERC2013-02-01 - 2018-01-31 - 311765 - VALID
- Subjects
Male ,Weighted quantile sum regression ,Child behavior ,[SDV]Life Sciences [q-bio] ,Phthalic Acids ,[SCCO] Cognitive science ,Environmental Exposure ,Bisphenols ,Mother-Child Relations ,Triclosan ,[SDV] Life Sciences [q-bio] ,Environmental sciences ,[SCCO]Cognitive science ,Phenols ,Phthalates ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,Pregnancy ,Prenatal exposure ,Humans ,Environmental Pollutants ,Female ,GE1-350 ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Child - Abstract
International audience; Background: Synthetic phenols and phthalates can interfere with biological pathways involved in brain development. Despite the high within-subject temporal variability of urinary concentrations observed for their metabolites, studies investigating effects of phenols and phthalates on child behaviour often relied on a limited number of spot biospecimens to assess exposure. Besides, the majority did not consider mixture effects.Objectives: To study the combined effect of prenatal exposure to synthetic phenols and phthalates on child behaviour using repeated exposure measurements.Methods: We assessed concentrations of 12 phenols, 13 phthalate and 2 non-phthalate plasticizer metabolites in within-subject pools of multiple urine samples (median = 21 samples per individual pool) collected at two distinct time points during pregnancy in 416 mother-child pairs from the French SEPAGES cohort. Child behaviour was evaluated at two years using the Child Behaviour Checklist 1.5-5 (CBCL). Associations between a mixture of biomarkers of exposure and externalizing and internalizing behaviour scores were studied using adjusted Weighted Quantile Sum (WQS) regressions with a repeated holdout validation (100 repetitions).Results: The positive WQS indexes were associated with both the externalizing and internalizing behaviour scores in the whole population, indicating greater risk of behavioural problems. Stratification for child sex suggested stronger associations in girls than boys. On average, girls externalizing and internalizing scores increased by 3.67 points (95% CI: 1.24, 6.10) and 2.47 points (95 %CI: 0.60, 4.33) respectively, for an increase of one tertile in the WQS index, compared with 1.70 points (95 %CI: -0.42, 3.81) and 1.17 points (95 %CI: -0.50, 2.84) in boys. Main contributors for the associations observed in girls were bisphenol A (weight of 18%), triclosan (17%) and monoethyl phthalate (MEP, 15%) for the externalizing score and MEP (19%), mono-benzyl phthalate (MBzP, 19%) and mono-n-butyl phthalate (MnBP, 16%) for the internalizing score.Discussion: Our results suggest adverse associations between in utero exposure to a mixture of phenols and phthalates and child behaviour, mainly in girls. Public health consequences may be substantial due to the widespread exposure of the population to these compounds.
- Published
- 2021
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