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Context. Thanks to the Mid-InfraRed Instrument (MIRI) on the James Webb Space Telescope (JWST), our ability to observe the star formation process in the infrared has greatly improved. Due to its unprecedented spatial and spectral resolution and sensitivity in the mid-infrared, JWST/MIRI can see through highly extincted protostellar envelopes and probe the warm inner regions. An abundant molecule in these warm inner regions is SO2, which is a common tracer of both outflow and accretion shocks as well as hot core chemistry. Aims. This paper presents the first mid-infrared detection of gaseous SO2 emission in an embedded low-mass protostellar system rich in complex molecules and aims to determine the physical origin of the SO2 emission. Methods. JWST/MIRI observations taken with the Medium Resolution Spectrometer (MRS) of the low-mass protostellar binary NGC 1333 IRAS 2A in the JWST Observations of Young protoStars (JOYS+) program are presented. The observations reveal emission from the SO2v3 asymmetric stretching mode at 7.35 µm. Using simple slab models and assuming local thermodynamic equilibrium (LTE), we derived the rotational temperature and total number of SO2 molecules. We then compared the results to those derived from high-angular-resolution SO2 data on the same scales (~50–100 au) obtained with the Atacama Large Millimeter/submillimeter Array (ALMA). Results. The SO2 emission from the v3 band is predominantly located on ~50–100 au scales around the mid-infrared continuum peak of the main component of the binary, IRAS 2A1. A rotational temperature of 92 ± 8 K is derived from the v3 lines. This is in good agreement with the rotational temperature derived from pure rotational lines in the vibrational ground state (i.e., v = 0) with ALMA (104 ± 5 K), which are extended over similar scales. However, the emission of the v3 lines in the MIRI-MRS spectrum is not in LTE given that the total number of molecules predicted by a LTE model is found to be a factor of 2 × 104 higher than what is derived for the v = 0 state from the ALMA data. This difference can be explained by a vibrational temperature that is ~100 K higher than the derived rotational temperature of the v = 0 state: Tvib ~ 200 K versus Trot = 104 ± 5 K. The brightness temperature derived from the continuum around the v3 band (~7.35 µm) of SO2 is ~180 K, which confirms that the v3 = 1 level is not collisionally populated but rather infrared-pumped by scattered radiation. This is also consistent with the non-detection of the v2 bending mode at 18–20 µm. The similar rotational temperature derived from the MIRI-MRS and ALMA data implies that they are in fact tracing the same molecular gas. The inferred abundance of SO2 , determined using the LTE fit to the lines of the vibrational ground state in the ALMA data, is 1.0 ± 0.3 × 10−8 with respect to H2, which is on the lower side compared to interstellar and cometary ices (10−8−10−7). Conclusions. Given the rotational temperature, the extent of the emission (~100 au in radius), and the narrow line widths in the ALMA data (~3.5 km s−1), the SO2 in IRAS 2A likely originates from ice sublimation in the central hot core around the protostar rather than from an accretion shock at the disk–envelope boundary. Furthermore, this paper shows the importance of radiative pumping and of combining JWST observations with those from millimeter interferometers such as ALMA to probe the physics on disk scales and to infer molecular abundances. [ABSTRACT FROM AUTHOR]

We present new observations of the Mystic Mountains cloud complex in the Carina Nebula using the ALMA Atacama Compact Array (ACA) to quantify the impact of strong UV radiation on the structure and kinematics of the gas. Our Band 6 observations target CO, 13CO, and C18O; we also detect DCN J=3–2 and 13CS J=5–4. A dendrogram analysis reveals that the Mystic Mountains are a coherent structure, with continuous emission over −10.5 km s−1 < v < −2 km s−1. We perform multiple analyses to isolate non-thermal motions in the Mystic Mountains including computing the turbulent driving parameter, b , which indicates whether compressive or solenoidal modes dominate. Each analysis yields values similar to other pillars in Carina that have been observed in a similar way but are subject to an order of magnitude less intense ionizing radiation. We find no clear correlation between the velocity or turbulent structure of the gas and the incident radiation, in contrast to other studies targeting different regions of Carina. This may reflect differences in the initial densities of regions that go on to collapse into pillars and those that still look like clouds or walls in the present day. Pre-existing over-densities that enable pillar formation may also explain why star formation in the pillars appears more evolved (from the presence of jets) than in other heavily irradiated but non-pillar-like regions. High resolution observations of regions subject to an array of incident radiation are required to test this hypothesis. [ABSTRACT FROM AUTHOR]

Context. The fragmentation mode of high-mass molecular clumps and the accretion processes that form the most massive stars (M ≳ 8 M⊙) are still not well understood. A growing number of case studies have found massive young stellar objects (MYSOs) to harbour disk-like structures, painting a picture that the formation of high-mass stars may proceed through disk accretion, similar to that of lower-mass stars. However, the properties of such structures have yet to be uniformly and systematically characterised. Aims. The aim of this work is to uniformly study the kinematic properties of a large sample of MYSOs and characterise the stability of possible circumstellar disks against gravitational fragmentation. Methods. We have undertaken a large observational programme (CORE) making use of interferometric observations from the Northern Extended Millimetre Array (NOEMA) for a sample of 20 luminous (L > 104L⊙) protostellar objects in the 1.37 mm wavelength regime in both continuum and spectral line emission, reaching 0.4″ resolution (800 au at 2 kpc). Results. We present the gas kinematics of the full sample and detect dense gas emission surrounding 15 regions within the CORE sample. Using the dense gas tracer CH3CN, we find velocity gradients across 13 cores perpendicular to the directions of bipolar molecular outflows, making them excellent disk candidates. The extent of the CH3CN emission tracing the disk candidates varies from 1800 to 8500 au. Analysing the free-fall to rotational timescales, we find that the sources are rotationally supported. The rotation profiles of some disk candidates are well described by differential rotation while for others the profiles are poorly resolved. Fitting the velocity profiles with a Keplerian model, we find protostellar masses in the range of ~ 10–25 M⊙. Modelling the level population of CH3CN (12K–11K) K = 0–6 lines, we present temperature maps and find median temperature in the range 70–210 K with a diversity in distributions. Radial profiles of the specific angular momentum (j) for the best disk candidates span a range of 1–2 orders of magnitude, on average ~10−3 km s−1 pc, and they follow j ∝ r1.7, which is consistent with a poorly resolved rotating and infalling envelope-disk model. Studying the Toomre stability of the disk candidates, we find almost all (11 out of 13) disk candidates to be prone to fragmentation due to gravitational instabilities at the scales probed by our observations, as a result of their high disk to stellar mass ratio. In particular, disks with masses greater than ~ 10–20% of the mass of their host (proto)stars are Toomre unstable, and more luminous YSOs tend to have disks that are more massive compared to their host star and hence more prone to fragmentation. Conclusions. In this work, we show that most disk structures around high-mass YSOs are prone to disk fragmentation early in their formation due to their high disk to stellar mass ratio. This impacts the accretion evolution of high-mass protostars which will have significant implications for the formation of the most massive stars. [ABSTRACT FROM AUTHOR]

During the commissioning of JWST , the medium-resolution spectrometer (MRS) on the mid-infrared instrument (MIRI) observed the planetary nebula SMP LMC 058 in the Large Magellanic Cloud. The MRS was designed to provide medium resolution (R  = λ/Δλ) 3D spectroscopy in the whole MIRI range. SMP LMC 058 is the only source observed in JWST commissioning that is both spatially and spectrally unresolved by the MRS and is a good test of JWST 's capabilities. The new MRS spectra reveal a wealth of emission lines not previously detected in this planetary nebula. From these lines, the spectral resolving power (λ/Δλ) of the MRS is confirmed to be in the range R  = 4000–1500, depending on the MRS spectral sub-band. In addition, the spectra confirm that the carbon-rich dust emission is from complex hydrocarbons and SiC grains and that there is little to no time evolution of the SiC dust and emission line strengths over a 17-yr epoch. These commissioning data reveal the great potential of the MIRI MRS for the study of circumstellar and interstellar material. [ABSTRACT FROM AUTHOR]

Abstract Background Cholesterol 7-alpha-hydroxylase (CYP7A1) is the rate limiting enzyme for converting cholesterol into bile acids. Genetic variations in the CYP7A1 gene have been associated with metabolic disorders of cholesterol and bile acids, including hypercholesterolemia, hypertriglyceridemia, arteriosclerosis, and gallstone disease. Current genetic studies are focused mainly on analysis of a single nucleotide polymorphism (SNP) at A-278C in the promoter region of the CYP7A1 gene. Here we report a genetic approach for an extensive analysis on linkage disequilibrium (LD) blocks and haplotype structures of the entire CYP7A1 gene and its surrounding sequences in Africans, Caucasians, Asians, Mexican-Americans, and African-Americans. Result The LD patterns and haplotype blocks of CYP7A1 gene were defined in Africans, Caucasians, and Asians using genotyping data downloaded from the HapMap database to select a set of haplotype-tagging SNPs (htSNP). A low cost, microarray-based platform on thin-film biosensor chips was then developed for high-throughput genotyping to study transferability of the HapMap htSNPs to Mexican-American and African-American populations. Comparative LD patterns and haplotype block structure was defined across all test populations. Conclusion A constant genetic structure in CYP7A1 gene and its surrounding sequences was found that may lead to a better design for association studies of genetic variations in CYP7A1 gene with cholesterol and bile acid metabolism.

The Mid-Infrared Instrument (MIRI) on the James Webb Space Telescope (JWST), has imaging, four coronagraphs, and both low and medium resolution spectroscopic modes. Being able to simulate MIRI observations will help commissioning of the instrument, as well as get users familiar with representative data. We designed the MIRI instrument simulator (mirisim) to mimic the on-orbit performance of the MIRI imager and spectrometers using the Calibration Data Products (CDPs) developed by the MIRI instrument team. The software incorporates accurate representations of the detectors, slicers, distortions, and noise sources along the light path including the telescope's radiative background and cosmic rays. The software also includes a module that enables users to create astronomical scenes to simulate. mirisim is a publicly available python package that can be run at the command line, or from within python. The outputs of mirisim are detector images in the same uncalibrated data format that will be delivered to MIRI users. These contain the necessary metadata for ingestion by the JWST calibration pipeline. [ABSTRACT FROM AUTHOR]

We have studied the dust density, temperature, and velocity distributions of the archetypal massive young stellar object (MYSO) AFGL 2591. Given its high luminosity (⁠|$L=2\times 10^5\, \mbox{L$_{\odot}$}$|⁠) and distance (d  = 3.3 kpc), AFGL 2591 has one of the highest |$\sqrt{L}/d$| ratio, giving better resolved dust emission than any other MYSO. As such, this paper provides a template on how to use resolved multiwavelength data and radiative transfer to obtain a well-constrained 2D axisymmetric analytic rotating infall model. We show for the first time that the resolved dust continuum emission from Herschel 70-  μ m observations is extended along the outflow direction, whose origin is explained in part from warm dust in the outflow cavity walls. However, the model can only explain the kinematic features from CH3CN observations with unrealistically low stellar masses (<15 M⊙), indicating that additional physical processes may be playing a role in slowing down the envelope rotation. As part of our three-step continuum and line fitting, we have identified model parameters that can be further constrained by specific observations. High-resolution mm visibilities were fitted to obtain the disc mass (6 M⊙) and radius (2200 au). A combination of SED and near-infrared observations were used to estimate the luminosity and envelope mass together with the outflow cavity inclination and opening angles. [ABSTRACT FROM AUTHOR]

Forming high-mass stars have a significant effect on their natal environment. Their feedback pathways, including winds, outflows, and ionizing radiation, shape the evolution of their surroundings which impacts the formation of the next generation of stars. They create or reveal dense pillars of gas and dust towards the edges of the cavities they clear. They are modelled in feedback simulations, and the sizes and shapes of the pillars produced are consistent with those observed. However, these models predict measurably different kinematics which provides testable discriminants. Here we present the first ALMA Compact Array (ACA) survey of 13 pillars in Carina, observed in 12CO, 13CO, and C18O J = 2–1, and the 230 GHz continuum. The pillars in this survey were chosen to cover a wide range in properties relating to the amount and direction of incident radiation, proximity to nearby irradiating clusters and cloud rims, and whether they are detached from the cloud. With these data, we are able to discriminate between models. We generally find pillar velocity dispersions of <1 km s−1 and that the outer few layers of molecular emission in these pillars show no significant offsets from each other, suggesting little bulk internal motions within the pillars. There are instances where the pillars are offset in velocity from their parental cloud rim, and some with no offset, hinting at a stochastic development of these motions. [ABSTRACT FROM AUTHOR]

Scattered light high-resolution imaging of the protoplanetary disc orbiting HD100453 shows two symmetric spiral arms, possibly launched by an external stellar companion. In this paper, we present new, sensitive high-resolution (∼30 mas) Band 7 ALMA observations of this source. This is the first source where we find counterparts in the sub-mm continuum to both scattered light spirals. The CO J  = 3–2 emission line also shows two spiral arms; in this case, they can be traced over a more extended radial range, indicating that the southern spiral arm connects to the companion position. This is clear evidence that the companion is responsible for launching the spirals. The pitch angle of the submillimetre continuum spirals (∼6°) is lower than the one in scattered light (∼16°). We show that hydrodynamical simulations of binary–disc interaction can account for the difference in pitch angle only if one takes into account that the mid-plane is colder than the upper layers of the disc, as expected for the case of externally irradiated discs. [ABSTRACT FROM AUTHOR]

Context. The formation process of high-mass stars (>8 M⊙) is poorly constrained, particularly the effects of clump fragmentation creating multiple systems and the mechanism of mass accretion onto the cores. Aims. We study the fragmentation of dense gas clumps, and trace the circumstellar rotation and outflows by analyzing observations of the high-mass (~500 M⊙) star-forming region IRAS 23033+5951. Methods. Using the Northern Extended Millimeter Array (NOEMA) in three configurations and the IRAM 30 m single-dish telescope at 220 GHz, we probe the gas and dust emission at an angular resolution of ~0.45′′, corresponding to 1900 au. Results. In the millimeter (mm) continuum emission, we identify a protostellar cluster with at least four mm-sources, where three of them show a significantly higher peak intensity well above a signal-to-noise ratio of 100. Hierarchical fragmentation from large to small spatial scales is discussed. Two fragments are embedded in rotating structures and drive molecular outflows, traced by 13CO (2–1) emission. The velocity profiles across two of the cores are similar to Keplerian but are missing the highest-velocity components close to the center of rotation, which is a common phenomena from observations like these, and other rotation scenarios are not excluded entirely. Position–velocity diagrams suggest protostellar masses of ~6 and 19 M⊙. Rotational temperatures from fitting CH3CN (12K− 11K) spectra are used for estimating the gas temperature and thereby also the disk stability against gravitational fragmentation, utilizing Toomre's Q parameter. Assuming that the candidate disk is in Keplerian rotation about the central stellar object and considering different disk inclination angles, we identify only one candidate disk as being unstable against gravitational instability caused by axisymmetric perturbations. Conclusions. The dominant sources cover different evolutionary stages within the same maternal gas clump. The appearance of rotation and outflows of the cores are similar to those found in low-mass star-forming regions. [ABSTRACT FROM AUTHOR]

We present the highest angular resolution (∼20 × 15 mas–44 × 33 au) Atacama Large Millimeter/sub-millimeter Array (ALMA) observations that are currently possible of the proto-O-star G17.64+0.16 in Band 6. The Cycle 5 observations with baselines out to 16 km probe scales < 50 au and reveal the rotating disc around G17.64+0.16, a massive forming O-type star. The disc has a ring-like enhancement in the dust emission that is especially visible as arc structures to the north and south. The Keplerian kinematics are most prominently seen in the vibrationally excited water line, H2O 55, 0−64, 3 ν2 = 1 (Eu = 3461.9 K). The mass of the central source found by modelling the Keplerian rotation is consistent with 45 ± 10 M⊙. The H30α (231.9 GHz) radio-recombination line and the SiO (5-4) molecular line were detected at up to the ∼10σ level. The estimated disc mass is 0.6 − 2.6 M⊙ under the optically thin assumption. Analysis of the Toomre Q parameter in the optically thin regime indicates that the disc stability is highly dependent on temperature. The disc currently appears stable for temperatures > 150 K; this does not preclude that the substructures formed earlier through disc fragmentation. [ABSTRACT FROM AUTHOR]

Context. This study is part of the CORE project, an IRAM/NOEMA large program consisting of observations of the millimeter continuum and molecular line emission towards 20 selected high-mass star-forming regions. The goal of the program is to search for circumstellar accretion disks, study the fragmentation process of molecular clumps, and investigate the chemical composition of the gas in these regions. Aims. We focus on IRAS 23385+6053, which is believed to be the least-evolved source of the CORE sample. This object is characterized by a compact molecular clump that is IR-dark shortward of 24 μm and is surrounded by a stellar cluster detected in the near-IR. Our aim is to study the structure and velocity field of the clump. Methods. Observations were performed at ~1.4 mm and employed three configurations of NOEMA and additional single-dish maps, merged with the interferometric data to recover the extended emission. Our correlator setup covered a number of lines from well-known hot core tracers and a few outflow tracers. The angular (~0′′.45–0′′.9) and spectral (0.5 km s−1) resolutions were sufficient to resolve the clump in IRAS 23385+6053 and investigate the existence of large-scale motions due to rotation, infall, or expansion. Results. We find that the clump splits into six distinct cores when observed at sub-arcsecond resolution. These are identified through their 1.4 mm continuum and molecular line emission. We produce maps of the velocity, line width, and rotational temperature from the methanol and methyl cyanide lines, which allow us to investigate the cores and reveal a velocity and temperature gradient in the most massive core. We also find evidence of a bipolar outflow, possibly powered by a low-mass star. Conclusions. We present the tentative detection of a circumstellar self-gravitating disk lying in the most massive core and powering a large-scale outflow previously known in the literature. In our scenario, the star powering the flow is responsible for most of the luminosity of IRAS 23385+6053 (~3000 L⊙). The other cores, albeit with masses below the corresponding virial masses, appear to be accreting material from their molecular surroundings and are possibly collapsing or on the verge of collapse. We conclude that we are observing a sample of star-forming cores that is bound to turn into a cluster of massive stars. [ABSTRACT FROM AUTHOR]

Context. Circumstellar discs around massive stars could mediate the accretion onto the star from the infalling envelope, and could minimize the effects of radiation pressure. Despite such a crucial role, only a few convincing candidates have been provided for discs around deeply embedded O-type (proto)stars. Aims. In order to establish whether disc-mediated accretion is the formation mechanism for the most massive stars, we have searched for circumstellar, rotating discs around a limited sample of six luminous (>105 L⊙) young stellar objects. These objects were selected on the basis of their IR and radio properties in order to maximize the likelihood of association with disc+jet systems. Methods. We used ALMA with ~0".2 resolution to observe a large number of molecular lines typical of hot molecular cores. In this paper we limit our analysis to two disc tracers (methyl cyanide, CH3CN, and its isotopologue, 13CH3CN), and an outflow tracer (silicon monoxide, SiO). Results. We reveal many cores, although their number depends dramatically on the target. We focus on the cores that present prominent molecular line emission. In six of these a velocity gradient is seen across the core, three of which show evidence of Keplerian-like rotation. The SiO data reveal clear but poorly collimated bipolar outflow signatures towards two objects only. This can be explained if real jets are rare (perhaps short-lived) in very massive objects and/or if stellar multiplicity significantly affects the outflow structure. For all cores with velocity gradients, the velocity field is analysed through position-velocity plots to establish whether the gas is undergoing rotation with 3rot ∝ R-α, as expected for Keplerian-like discs. Conclusions. Our results suggest that in three objects we are observing rotation in circumstellar discs, with three more tentative cases, and one core where no evidence for rotation is found. In all cases but one, we find that the gas mass is less than the mass of any embedded O-type star, consistent with the (putative) discs undergoing Keplerian-like rotation. With the caveat of low number statistics, we conclude that the disc detection rate could be sensitive to the evolutionary stage of the young stellar object. In young, deeply embedded sources, the evidence for discs could be weak because of confusion with the surrounding envelope, while in the most evolved sources the molecular component of the disc could have already been dispersed. Only in those objects that are at an intermediate stage of the evolution would the molecular disc be sufficiently prominent and relatively less embedded to be detectable by mm/submm observations. [ABSTRACT FROM AUTHOR]

Variations in drug metabolism may alter drug efficacy and cause toxicity; better understanding of the mechanisms and risks shall help to practice precision medicine. At the 21 st International Symposium on Microsomes and Drug Oxidations held in Davis, California, USA, in October 2–6, 2016, a number of speakers reported some new findings and ongoing studies on the regulation mechanisms behind variable drug metabolism and toxicity, and discussed potential implications to personalized medications. A considerably insightful overview was provided on genetic and epigenetic regulation of gene expression involved in drug absorption, distribution, metabolism, and excretion (ADME) and drug response. Altered drug metabolism and disposition as well as molecular mechanisms among diseased and special populations were presented. In addition, the roles of gut microbiota in drug metabolism and toxicology as well as long non-coding RNAs in liver functions and diseases were discussed. These findings may offer new insights into improved understanding of ADME regulatory mechanisms and advance drug metabolism research. [ABSTRACT FROM AUTHOR]

We present an analysis of the effect of feedback from O- and B-type stars with data from the integral field spectrograph Multi Unit Spectroscopic Explorer (MUSE) mounted on the Very Large Telescope of pillar-like structures in the Carina Nebular Complex, one of the most massive star-forming regions in the Galaxy. For the observed pillars, we compute gas electron densities and temperatures maps, produce integrated line and velocity maps of the ionized gas, study the ionization fronts at the pillar tips, analyse the properties of the single regions, and detect two ionized jets originating from two distinct pillar tips. For each pillar tip, we determine the incident ionizing photon flux Q0, pil originating from the nearby massive O- and B-type stars and compute the mass-loss rate ... of the pillar tips due to photoevaporation caused by the incident ionizing radiation. We combine the results of the Carina data set with archival MUSE data of a pillar in NGC 3603 and with previously published MUSE data of the Pillars of Creation in M16, and with a total of 10 analysed pillars, find tight correlations between the ionizing photon flux and the electron density, the electron density and the distance from the ionizing sources, and the ionizing photon flux and the mass-loss rate. The combined MUSE data sets of pillars in regions with different physical conditions and stellar content therefore yield an empirical quantification of the feedback effects of ionizing radiation. In agreement with models, we find that ... ∝ Q0.pil1/2. [ABSTRACT FROM AUTHOR]

The pregnane X receptor (PXR) and constitutive androstane receptor (CAR) are well-known xenobiotic-sensing nuclear receptors with overlapping functions. However, there lacks a quantitative characterization to distinguish between the PXR and CAR target genes and signaling pathways in the liver. The present study performed a transcriptomic comparison of the PXR- and CAR-targets using RNA-Seq in livers of adult wild-type mice that were treated with the prototypical PXR ligand PCN (200 mg/kg, i.p. once daily for 4 days in corn oil) or the prototypical CAR ligand TCPOBOP (3 mg/kg, i.p., once daily for 4 days in corn oil). At the given doses, TCPOBOP differentially regulated many more genes (2125) than PCN (212), and 147 of the same genes were differentially regulated by both chemicals. As expected, the top pathways differentially regulated by both PCN and TCPOBOP were involved in xenobiotic metabolism, and they also up-regulated genes involved in retinoid metabolism, but down-regulated genes involved in inflammation and iron homeostasis. Regarding unique pathways, PXR activation appeared to overlap with the aryl hydrocarbon receptor signaling, whereas CAR activation appeared to overlap with the farnesoid X receptor signaling, acute-phase response, and mitochondrial dysfunction. The mRNAs of differentially regulated drug-processing genes (DPGs) partitioned into three patterns, namely TCPOBOP-induced, PCN-induced, as well as TCPOBOP-suppressed gene clusters. The cumulative mRNAs of the differentially regulated DPGs, phase-I and -II enzymes, as well as efflux transporters were all up-regulated by both PCN and TCPOBOPOP, whereas the cumulative mRNAs of the uptake transporters were down-regulated only by TCPOBOP. The absolute mRNA abundance in control and receptor-activated conditions was examined in each DPG category to predict the contribution of specific DPG genes in the PXR/CAR-mediated pharmacokinetic responses. The preferable differential regulation by TCPOBOP in the entire hepatic transcriptome correlated with a marked change in the expression of many DNA and histone epigenetic modifiers. In conclusion, the present study has revealed known and novel, as well as common and unique targets of PXR and CAR in mouse liver following pharmacological activation using their prototypical ligands. Results from this study will further support the role of these receptors in regulating the homeostasis of xenobiotic and intermediary metabolism in the liver, and aid in distinguishing between PXR and CAR signaling at various physiological and pathophysiological conditions. This article is part of a Special Issue entitled: Xenobiotic nuclear receptors: New Tricks for An Old Dog, edited by Dr. Wen Xie [ABSTRACT FROM AUTHOR]

Outflowing motions, whether a wind launched from the disc, a jet launched from the protostar, or the entrained molecular outflow, appear to be a ubiquitous feature of star formation. These outwards motions have a number of root causes, and how they manifest is intricately linked to their environment as well as the process of star formation itself. Using the Atacama Large Millimeter/submillimeter Array (ALMA) Science Verification data of HL Tau, we investigate the high-velocity molecular gas being removed from the system as a result of the star formation process. We aim to place these motions in context with the optically detected jet, and the disc. With these high-resolution (∼1 arcsec) ALMA observations of CO (J=1-0), we quantify the outwards motions of the molecular gas. We find evidence for a bipolar outwards flow, with an opening angle, as measured in the redshifted lobe, starting off at 90°, and narrowing to 60° further from the disc, likely because of magnetic collimation. Its outwards velocity, corrected for inclination angle is of the order of 2.4 km s-1. [ABSTRACT FROM AUTHOR]

Context. Protostars of intermediate-mass provide a bridge between theories of low- and high-mass star formation. Molecular outflows emerging from such sources can be used to determine the influence of fragmentation and multiplicity on protostellar evolution through the apparent correlation of outflow forces of intermediate-mass protostars with the total luminosity instead of the individual luminosity. Aims. The aim of this paper is to derive outflow forces from outflows of six intermediate-mass protostellar regions and validate the apparent correlation between total luminosity and outflow force seen in earlier work, as well as remove uncertainties caused by different methodologies. Methods. By comparing CO 6–5 observations obtained with APEX with non-LTE radiative transfer model predictions, the optical depths, temperatures and densities of the gas of the molecular outflows are derived. Outflow forces, dynamical timescales, and kinetic luminosities are subsequently calculated. Results. Outflow parameters, including the forces, were derived for all sources. Temperatures in excess of 50 K were found for all flows, in line with recent low-mass results. However, comparison with other studies could not corroborate conclusions from earlier work on intermediate-mass protostars which hypothesized that fragmentation enhances outflow forces in clustered intermediate-mass star formation. Any enhancement in comparison with the classical relation between outflow force and luminosity can be attributed to the use of a higher excitation line and improvement in methods. They are in line with results from low-mass protostars using similar techniques. Conclusions. The role of fragmentation on outflows is an important ingredient to understand clustered star formation and the link between low- and high-mass star formation. However, detailed information on spatial scales of a few 100 AU, covering all individual members is needed to make the necessary progress. [ABSTRACT FROM AUTHOR]

Context. Jets and outflows are key ingredients in the formation of stars across the mass spectrum. In clustered regions, understanding powering sources and outflow components poses a significant problem. Aims. We aim to understand the dynamics in the outflow(s) from a cluster in the process of forming massive stars. Methods. We use new VLA observations of the molecular gas (SiO, CS, OCS, and H2CO) in the massive star forming region IRAS 17233-3606 which contains a number of HII regions. We compare these observations to previously published molecular data for this source in order to get a holistic view of the outflow dynamics. Results. We find that the dynamics of the various species can be explained by a single large scale (~0.15 pc) outflow when compared to the sizes of the HII regions, with the different morphologies of the blue and red outflow components explained with respect to the morphology of the surrounding envelope. We further find that the direction of the velocity gradients seen in OCS and H2CO are suggestive of a combination of rotation and outflow motions in the warm gas surrounding the HII regions near the base of the large scale outflow. Conclusions. Our results show that the massive protostars forming within this region appear to be contributing to a single outflow on large scales. This single large scale outflow is traced by a number of different species as the outflow interacts with its surroundings. On the small scales, there appear to be multiple mechanisms contributing to the dynamics which could be a combination of either a small scale outflow or rotation with the dynamics of the large scale outflow. [ABSTRACT FROM AUTHOR]

Herbig Ae/Be stars are intermediate-mass pre-main sequence stars surrounded by circumstellar dust disks. Some are observed to produce jets, whose appearance as a sequence of shock fronts (knots) suggests a past episodic outflow variability. This "jet fossil record" can be used to reconstruct the outflow history. We present the first optical to near-infrared (NIR) spectra of the jet from the Herbig Ae star HD 163296, obtained with VLT/X-shooter. We determine the physical conditions in the knots and also their kinematic "launch epochs". Knots are formed simultaneously on either side of the disk, with a regular interval of ~16 yr. The velocity dispersion versus jet velocity and the energy input are comparable between both lobes. However, the mass-loss rate, velocity, and shock conditions are asymmetric. We find Mjet/ Macc ~ 0:01-0:1, which is consistent with magneto-centrifugal jet launching models. No evidence of any dust is found in the high-velocity jet, suggesting a launch region within the sublimation radius (<0.5 au). The jet inclination measured from proper motions and radial velocities confirms that it is perpendicular to the disk. A tentative relation is found between the structure of the jet and the photometric variability of the central source. Episodes of NIR brightening were previously detected and attributed to a dusty disk wind. We report for the first time significant optical fadings lasting from a few days up to a year, coinciding with the NIR brightenings. These are very likely caused by dust lifted high above the disk plane, and this supports the disk wind scenario. The disk wind is launched at a larger radius than the high-velocity atomic jet, although their outflow variability may have a common origin. No significant relation between outflow and accretion variability could be established. Our findings confirm that this source undergoes periodic ejection events, which may be coupled with dust ejections above the disk plane. [ABSTRACT FROM AUTHOR]

Context. The high spatial resolution and line sensitivity of the Atacama Large Millimeter/submillimeter Array (ALMA) opens the possibility of resolving emission from molecules in large samples of circumstellar disks. With an understanding of the conditions under which these molecules can have high abundance, they can be used as direct tracers of distinct physical regions. In particular, DCO+ is expected to have an enhanced abundance within a few Kelvin of the CO freezeout temperature of 19 K, making it a useful probe of the cold disk midplane. Aims. We aim to use line emission from DCO+ to directly resolve the CO "snowline" - the region at which the gas-phase CO abundance drops due to freezeout - and determine the temperature boundaries of the region of DCO+ emission in the HD 163296 disk. This will serve as a test of deuteration models based on enhanced formation of the parent molecule H2D+ and a direct probe of midplane disk structure and ionization. Methods. We compare ALMA line observations of HD 163296 to a grid of models based on the best fit physical model of Qi et al. (2011, ApJ, 740, 84). We vary the upper- and lower-limit temperatures of the region in which DCO+ is present as well as the abundance of DCO+ in order to fit channel maps of the DCO+ J = 5-4 line. To determine the abundance enhancement compared to the general interstellar medium, we carry out similar fitting to HCO+ J = 4-3 and H13CO+ J = 4-3 observations. Results. ALMA images show centrally peaked extended emission from HCO+ and H13CO+. DCO+ emission lies in a resolved ring from ~110 to 160 AU. The outer radius approximately corresponds to the size of the CO snowline as measured by previous lower resolution observations of CO lines in this disk. The ALMA DCO+ data now resolve and image the CO snowline directly. Conclusions. In the best fitting models, HCO+ exists in a region extending from the 19 K isotherm to the photodissociation layer with an abundance of 3 × 10-10 relative to H2. DCO+ exists within the 19-21 K region of the disk with an abundance ratio [DCO+]/[HCO+] = 0.3. This represents a factor of 104 enhancement of the DCO+ abundance within this narrow region of the HD 163296 disk. Such a high enhancement has only previously been seen in prestellar cores. The inferred abundances provide a lower limit to the ionization fraction in the midplane of the cold outer disk (≳4 × 10-10), and suggest the utility of DCO+ as a tracer of its parent molecule H2D+. [ABSTRACT FROM AUTHOR]

Context. Whether high mass stars continue to accrete material beyond the formation of an HII region is still an open question. Ionized infall and outflow have been seen in some sources, but their ties to the surrounding molecular gas are not well constrained. Aims. We aim to quantify the ionized and molecular gas dynamics in a high mass star forming region (K3-50A) and their interaction. Methods. We present CARMA observations of the 3mm continuum, HCO+ and H41α emission, and VLA continuum observations at 23 GHz and 14.7 GHz to quantify the gas and its dynamics in K3-50A. Results. We find large scale dynamics consistent with previous observations. On small scales, we find evidence for interaction between the ionized and molecular gas that suggests the ionized outflow is entraining the molecular one. This is the first time such an outflow entrained by photo ionized gas has been observed. Conclusions. Accretion may be ongoing in K3-50A because an ionized bipolar outflow is still being powered, which is in turn entraining part of the surrounding molecular gas. This outflow scenario is similar to that predicted by ionization feedback models. [ABSTRACT FROM AUTHOR]

Observations of higher-excited transitions of abundant molecules such as CO are important for determining where energy in the form of shocks is fed back into the parental envelope of forming stars. The nearby prototypical and protobinary low-mass hot core, IRAS 16293-2422 (I16293) is ideal for such a study. The source was targeted with ALMA for science verification purposes in band 9, which includes CO J = 6-5 (Eup/kB ∼ 116 K), at an unprecedented spatial resolution (∼0″ 002, 25 AU). I16293 itself is composed of two sources, A and B, with a projected distance of 500. CO J = 6-5 emission is detected throughout the region, particularly in small, arcsecond-sized hotspots, where the outflow interacts with the envelope. The observations only recover a fraction of the emission in the line wings when compared to data from single-dish telescopes, with a higher fraction of emission recovered at higher velocities. The very high angular resolution of these new data reveal that a bow shock from source A coincides, in the plane of the sky, with the position of source B. Source B, on the other hand, does not show current outflow activity. In this region, outflow entrainment takes place over large spatial scales, ≳100 AU, and in small discrete knots. This unique dataset shows that the combination of a high-temperature tracer (e.g., CO J = 6-5) and very high angular resolution observations is crucial for interpreting the structure of the warm inner environment of low-mass protostars. [ABSTRACT FROM AUTHOR]

Context. Many physical parameters change with time in star-forming regions. Here we attempt to correlate changes in the infall and outflow motions in high-mass star-forming regions with evolutionary stage using JCMT observations. Aims. From a sample of 45 high-mass star-forming regions in three phases of evolution, we investigate the presence of established infall and outflow tracers to determine whether there are any trends attributable to the age of the source. Methods. We obtained JCMT observations of HCO+/H13CO+ J = 4-3 to trace large-scale infall, and SiO J = 8-7 to trace recent outflow activity. We compared the infall and outflow detections to the evolutionary stage of the host source (high-mass protostellar objects, hypercompact HII regions, and ultracompact HII regions). Results. We find a surprising lack of SiO detections in the middle stage (hypercompact HII regions), which may be an observational bias. When SiO is detected, we find that the integrated intensity of the line increases with evolutionary stage. The integrated intensity of SiO varies with the full width at half maximum of the H13CO+. All of the sources with infall signatures onto ultracompact HII regions have corresponding outflow signatures as well. [ABSTRACT FROM AUTHOR]

Summary: The association of type 2 diabetes with elevated plasma triglyceride (TG) and very low-density lipoproteins (VLDL), and intrahepatic lipid accumulation represents a pathophysiological enigma and an unmet therapeutic challenge. Here, we uncover a link between insulin action through FoxO1, bile acid (BA) composition, and altered lipid homeostasis that brings new insight to this longstanding conundrum. FoxO1 ablation brings about two signature lipid abnormalities of diabetes and the metabolic syndrome, elevated liver and plasma TG. These changes are associated with deficiency of 12α-hydroxylated BAs and their synthetic enzyme, Cyp8b1, that hinders the TG-lowering effects of the BA receptor, Fxr. Accordingly, pharmacological activation of Fxr with GW4064 overcomes the BA imbalance, restoring hepatic and plasma TG levels of FoxO1-deficient mice to normal levels. We propose that generation of 12α-hydroxylated products of BA metabolism represents a signaling mechanism linking hepatic lipid abnormalities with type 2 diabetes, and a treatment target for this condition. [ABSTRACT FROM AUTHOR]

Purpose: To determine if long head of the biceps (LHB) tenotomy is not inferior to suprapectoral LHB tenodesis when performed in conjunction with arthroscopic repair of small- to medium-sized nontraumatic rotator cuff tears.Methods: This multicenter, randomized, non-inferiority trial recruited 100 participants older than 50 years who had a supraspinatus and/or infraspinatus tear sagittally smaller than 3 cm and arthroscopically confirmed LHB pathology. During arthroscopic rotator cuff repair, we randomized 48 patients to undergo suprapectoral LHB tenodesis and 52 patients to undergo LHB tenotomy. Data were collected preoperatively and at 6 weeks, 3 months, and 1 year postoperatively. The primary outcome was non-inferiority of the Constant-Murley score (CMS) at 1-year follow-up. Secondary outcomes included the Dutch Oxford Shoulder Score; Disabilities of the Arm, Shoulder and Hand questionnaire; Popeye deformity; elbow flexion strength index; arm cramping pain; and quality of life (EQ-5D score). The integrity of the rotator cuff repair was assessed with magnetic resonance imaging. Differences between intervention groups were analyzed by mixed modeling.Results: The mean CMS in the LHB tenotomy group improved from 44 (95% confidence interval [CI], 39-48) to 73 (95% CI, 68-79). In patients with LHB tenodesis, the mean CMS improved from 42 (95% CI, 37-48) to 78 (95% CI, 74-82). The difference between groups at 1-year follow-up was 4.8 (97.5% CI, -∞ to 11.4), with a P value for non-inferiority of .06. The secondary outcomes also improved over time, with no remarkable differences between groups. A Popeye deformity occurred in 33% of tenodesis patients and 47% of tenotomy patients (P = .17). Tenotomy was performed with a shorter operative time (73 minutes vs 82 minutes, P = .03). Magnetic resonance imaging showed a recurrent rotator cuff tear in 20% of all cases.Conclusions: Although statistically "inconclusive" regarding non-inferiority of the CMS at 1-year follow-up, any observed differences between patients with LHB tenotomy and those with LHB tenodesis in all outcome scores were small.Level Of Evidence: Level I, randomized controlled trial and treatment study. [ABSTRACT FROM AUTHOR]