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1,786 results on '"Cheng, Yue"'

12. Hypoxia‐inducible factor‐1α attenuates renal podocyte injury in male rats in a simulated high‐altitude environment by upregulating Krüppel‐like factor 4 expression

Author

Zeng Xiaoshan, Cheng Huan, Gan Zhilin, Mo Liwen, Zeng Yan, and Cheng Yue

Subjects
high‐altitude, hypoxia‐inducible factor‐1α, Krüppel‐like factor 4, podocyte, Physiology, QP1-981
Abstract

Abstract Previous studies have shown that podocyte injury is involved in the development of proteinuria in rats under hypobaric hypoxia conditions. Prolyl hydroxylase inhibitors (PHIs) may reduce proteinuria. This study aimed to further investigate whether the protective effects of hypoxia‐inducible factor 1α (HIF1α) on podocyte injury induced by hypobaric hypoxia are related to Krüppel‐like factor 4 (KLF4). Rats were housed in a low‐pressure oxygen chamber to simulate a high‐altitude environment (5000 m), and a PHI was intraperitoneally injected. Urinary protein electrophoresis was performed and the morphology of the podocytes was observed by electron microscopy. Rat podocytes were cultured under 1% O2, and siRNA was used to interfere with KLF4 expression. The protein expression levels of HIF1α, KLF4, CD2‐associated protein (CD2AP) and nephrin were determined by western blotting. Compared with those in the experimental group, the rats in the intervention group on day 14 had lower urinary protein levels, increased protein expression levels of CD2AP and nephrin, and reduced podocyte injury. The results of in vitro experiments showed that the protein expression levels of KLF4, CD2AP and nephrin were greater in the PHI intervention group and lower in the HIF1α inhibitors group than in the low‐oxygen group. The protein expression of CD2AP and nephrin in the siKLF4‐transfected podocytes treated with PHI and HIF1α inhibitors did not differ significantly from that in the low‐oxygen group. HIF1α may be involved in reducing progressive high‐altitude proteinuria by regulating KLF4 expression and contributing to the repair of podocyte injury induced by hypobaric hypoxia.

Published
2024
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13. Electrical detection of mobile skyrmions with 100% tunneling magnetoresistance in a racetrack-like device

Author

Mengqi Zhao, Aitian Chen, Pei-Yuan Huang, Chen Liu, Laichuan Shen, Jiahao Liu, Le Zhao, Bin Fang, Wen-Cheng Yue, Dongxing Zheng, Ledong Wang, Hao Bai, Ka Shen, Yan Zhou, Shasha Wang, Enlong Liu, Shikun He, Yong-Lei Wang, Xixiang Zhang, and Wanjun Jiang

Subjects
Materials of engineering and construction. Mechanics of materials, TA401-492, Atomic physics. Constitution and properties of matter, QC170-197
Abstract

Abstract Magnetic skyrmions are topological spin textures that are regarded as promising information carriers for next-generation spintronic memory and computing devices. For practical applications, their deterministic generation, manipulation, and efficient detection are the most critical aspects. Although the generation and manipulation of skyrmions have been extensively studied, efficient electrical detection of mobile skyrmions by using techniques that are compatible with modern magnetic memory technology, remains to be adequately addressed. Here, through integrating magnetic multilayers that host nanoscale skyrmions, together with the magnetic tunnel junctions (MTJ), we demonstrate the electrical detection of skyrmions by using the tunneling magnetoresistance (TMR) effect with a TMR ratio that reaches over 100% at room temperature. By building prototype three-terminal racetrack-like devices, we further show the electrical detection of mobile skyrmions by recording the time-dependent TMR ratios. Along with many recent developments, our results could advance the development of skyrmionic memory and logic devices.

Published
2024
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14. Integrated and DC-powered superconducting microcomb

Author

Chen-Guang Wang, Wuyue Xu, Chong Li, Lili Shi, Junliang Jiang, Tingting Guo, Wen-Cheng Yue, Tianyu Li, Ping Zhang, Yang-Yang Lyu, Jiazheng Pan, Xiuhao Deng, Ying Dong, Xuecou Tu, Sining Dong, Chunhai Cao, Labao Zhang, Xiaoqing Jia, Guozhu Sun, Lin Kang, Jian Chen, Yong-Lei Wang, Huabing Wang, and Peiheng Wu

Subjects
Science
Abstract

Abstract Frequency combs, specialized laser sources emitting multiple equidistant frequency lines, have revolutionized science and technology with unprecedented precision and versatility. Recently, integrated frequency combs are emerging as scalable solutions for on-chip photonics. Here, we demonstrate a fully integrated superconducting microcomb that is easy to manufacture, simple to operate, and consumes ultra-low power. Our turnkey apparatus comprises a basic nonlinear superconducting device, a Josephson junction, directly coupled to a superconducting microstrip resonator. We showcase coherent comb generation through self-started mode-locking. Therefore, comb emission is initiated solely by activating a DC bias source, with power consumption as low as tens of picowatts. The resulting comb spectrum resides in the microwave domain and spans multiple octaves. The linewidths of all comb lines can be narrowed down to 1 Hz through a unique coherent injection-locking technique. Our work represents a critical step towards fully integrated microwave photonics and offers the potential for integrated quantum processors.

Published
2024
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15. Identification of a new species of Gyrodactylus von Nordmann, 1832 (Monogenoidea Gyrodactylidae) isolated from Diptychus maculatus in Yarkand River, Xinjiang, China

Author

Cui-lan Hao, Wen-run Zhang, Kadirden Arken, Jin-pu Wang, Cai-xia Shi, Li Zhang, and Cheng Yue

Subjects
Gyrodactylidae, ITS rDNA, Diptychus maculatus, Phylogenetic analysis, Zoology, QL1-991
Abstract

To investigate Gyrodactylus infection of fish in the river system of Xinjiang (China), Gyrodactylus individuals were isolated from specimens of Diptychus maculatus. Morphological characterization and phylogenetic analysis based on ITS1-5.8S-ITS2 rDNA locus revealed that the gyrodactylids belong to new species. Gyrodactylus diptychi n. sp. differs significantly in the morphology of the haptoral structures from 12 known species of Gyrodactylus found in fishes of the subfamily Schizothoracinae. In particular, G. diptychi n. sp. has a relatively short dorsal bar with thick and large ends, flat and straight hamuli roots, and small ventral bar processes. Furthermore, G. diptychi n. sp. is the only representative of Gyrodactylus found on D. maculatus. Using the BLASTn search of ITS1-5.8S-ITS2 rDNA sequences in GenBank and the Bayesian Information and Maximum Likelihood methods, we constructed phylogenetic trees for G. diptychi n. sp. As a result, our studies clearly identified that G. diptychi n. sp. was the first Gyrodactylus monogenean isolated from D. maculatus and a new species belonged to the subgenus Limnonephrotus.

Published
2024
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31. New species of Gyrodactylus von Nordmann, 1832 (Monogenoidea: Gyrodactylidae) from Gymnodiptychus dybowskii (Kessler, 1874) (Schizothoracinae) in the Kunes River (Yili River basin), China

Author

Wen-Run Zhang, Cui-Lan Hao, Kadirden Arken, Meng-Jie Rong, Sheng-Li Tian, Munira Kadir, and Cheng Yue

Subjects
Gyrodactylus gymnodiptychi n. sp., Gymnodiptychus dybowskii, Monogenea, Phylogenetic analysis, China, Zoology, QL1-991
Abstract

Yili River system hosts a diverse fauna of fishes and parasites. Gymnodiptychus dybowskii is a rare and endangered aboriginal cold-water fish inhabit in the Yili river system. Our research identified a new species Gyrodactylus gymnodiptychi n. sp. isolated from G. dybowskii in the Kunes River (Yili River, China). Morphological comparison revealed identifiable differences between the new species and other parasites, including Gyrodactylus aksuensis, and Gyrodactylus tokobaevi, which are two known parasites living in G. dybowskii inhabit in the Aksu River west of Frunze (Kyrgyzstan), as well as Gyrodactylus montanus living in Shizothorax intermedius inhabited in the Tadzhikistan or Uzbekistan. Especially, the dorsal bar of G. gymnodiptychi n. sp. was raised at both ends with a hollow, and its hamulus roots were curved inward. The BLASTN search of GenBank did not detect any other ITS1-5.8S-ITS2 rDNA sequences same as G. gymnodiptychi's. Using the Bayesian Information and Maximum Likelihood methods to analyze the ITS1-5.8S-ITS2 rDNA gene sequences, we constructed phylogenetic trees for G. gymnodiptychi n. sp. Accordingly, our morphological and molecular research indicated that G. gymnodiptychi n. sp. was not only a new species of parasites but also the first Gyrodactylus member identified in the Yili River in China.

Published
2023
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39. The Impact of Excluding Adverse Neonatal Outcomes on the Creation of Gestational Weight Gain Charts Among Women from Low- and Middle-income Countries with Normal and Overweight BMI

Author

Accrombessi, Manfred, Adu-Afarwuah, Seth, Alves, João Guilherme, Leal de Araújo, Carla Adriane, Arifeen, Shams, Artes, Rinaldo, Ashorn, Per, Ashorn, Ulla, Assefa, Nega, Ayoola, Omolola Olukemi, Azizi, Fereidoun, Bawah, Ahmed Tijani, Behboudi-Gandevani, Samira, Berhane, Yemane, Bernstein, Robin, Bhutta, Zulfiqar, Briand, Valérie, Calvo, Elvira Beatriz, Cardoso, Marly Augusto, Cheng, Yue, Chico-Barba, Gabriela, Clayton, Peter Ellis, Collins, Shalean M, Costello, Anthony M, Cruickshank, John Kennedy, Devakumar, Delanjathan, Dewey, Kathryn G, Dwarkanath, Pratibha, Estrada-Gutierrez, Guadalupe, Fair, Frankie J, Farias, Dayana Rodrigues, Friis, Henrik, Ghosh, Shibani, Girard, Amy Webb, Gomo, Exnevia, Gondwe, Austrida, Hallamaa, Lotta, Hambidge, K Michael, Hussein, Hawawu, Huybregts, Lieven, Iqbal, Romaina, Katz, Joanne, Khatry, Subarna K, Kolsteren, Patrick, Krebs, Nancy F, Kulmala, Teija, Kumar, Pratap, Kurpad, Anura V, Lachat, Carl, Lartey, Anna, Lauer, Jacqueline M, Li, Qian, Lipoeto, Nur Indrawaty, López, Laura Beatriz, Loy, See Ling, Maiya, G Arun, Maleta, Kenneth, Malta, Maíra Barreto, Manandhar, Dharma S, Mangani, Charles, Martínez-Rojano, Hugo, Martin-Prevel, Yves, Martorell, Reynaldo, Matias, Susana L, McClure, Elizabeth M, Melse-Boonstra, Alida, Miller, Joshua D, Mohamad, Marhazlina, Jan Mohamed, Hamid Jan, Moore, Sophie, Mosquera, Paola Soledad, Mridha, Malay Kanti, Munim, Shama, Muñoz-Manrique, Cinthya, Natamba, Barnabas K, Ome-Kaius, Maria, Osrin, David, Perichart-Perera, Otilia, Prentice, Andrew M, Ramachandra, Preetha, Ramakrishnan, Usha, Rivera, Juan, Roberfroid, Dominique, Rodrigues, Patricia Lima, Rodríguez-Cano, Ameyalli, Rogerson, Stephen J, Rondó, Patricia HC, Sámano, Reyna, Saville, Naomi M, Shivalli, Siddharudha, Shrestha, Bhim P, Shrestha, Robin, Roberto da Silva Júnior, José, Soltani, Hora, Soofi, Sajid, Tehrani, Fahimeh Ramezani, Thomas, Tinku, Tielsch, James M, Unger, Holger W, Vaz, Juliana dos Santos, Worku, Alemayehu, Yang, Nianhong, Young, Sera L, Yussif, Adam Bawa, Zeng, Lingxia, Zhong, Chunrong, Zhu, Zhonghai, Rangel Bousquet Carrilho, Thais, Wang, Dongqing, Hutcheon, Jennifer A, Wang, Molin, Fawzi, Wafaie W, and Kac, Gilberto

Published
2024
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42. Identification of hypoxic macrophages in glioblastoma with therapeutic potential for vasculature normalization

Author

Wang, Wenying, Li, Tianran, Cheng, Yue, Li, Fei, Qi, Shuhong, Mao, Min, Wu, Jingjing, Liu, Qing, Zhang, Xiaoning, Li, Xuegang, Zhang, Lu, Qi, Haoyue, Yang, Lan, Yang, Kaidi, He, Zhicheng, Ding, Shuaishuai, Qin, Zhongyi, Yang, Ying, Yang, Xi, Luo, Chunhua, Guo, Ying, Wang, Chao, Liu, Xindong, Zhou, Lei, Liu, Yuqi, Kong, Weikai, Miao, Jingya, Ye, Shuanghui, Luo, Min, An, Lele, Wang, Lujing, Che, Linrong, Niu, Qin, Ma, Qinghua, Zhang, Xia, Zhang, Zhihong, Hu, Rong, Feng, Hua, Ping, Yi-Fang, Bian, Xiu-Wu, and Shi, Yu

Published
2024
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