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Abstract: The synthesis and X-ray structural characterization of Pd(DMPA)Cl2 complex, where DMPA= N,N-dimethylaminopropylamine, is reported. The complex crystallizes in the space group P21/c, a =8.8923(4), b =10.9050(5), c =11.5006(7) Å, β =120.00(18)°, V =948.25(8) Å3, Z =4. The palladium centre has a typical square-planar geometry with a tetrahedral distortion. Stoichiometry and stability constants of the complexes formed between [Pd(DMPA)(H2O)2]2+ and some selected DNA constituents and cytsteine are investigated at 25°C and at constant 0.1M ionic strength. The concentration distribution diagrams of the various species formed are evaluated. The equilibrium constants for the displacement of coordinated ligands as inosine by cysteine are calculated. The results are expected to contribute to the chemistry of tumour therapy. [Copyright &y& Elsevier]

Abstract: Pd(dmen)Cl2 complex was synthesized and characterized, where dmen=N,N-dimethylethylenediamine. Stoichiometry and stability constants of the complexes formed between [Pd(dmen)(H2O)2]2+ and various biologically relevant ligands such as amino acids, peptides and dicarboxylic acids are investigated at 25°C and at constant 0.1M ionic strength. The concentration distribution diagrams of the various species formed are evaluated. The equilibrium constants for the displacement of coordinated ligands as inosine, glycine or methionine by cysteine are calculated. The results are expected to contribute to the chemistry of tumour therapy. [Copyright &y& Elsevier]

Abstract: Pd(DHP)Cl2 and Pd(DHP)(CBDCA) complexes (DHP=1,3-diamino-2-hydroxopropane and CBDCA=1,1-cyclobutanedicarboxylate), were synthesized and characterized by elemental analysis, IR and NMR spectral measurements. The coordination of [Pd(DHP)(H2O)2]2+ with some selected bio-relevant ligands, containing different functional groups was investigated. The ligands used are amino acids, peptides, DNA constituents and dicarboxylic acids. Stoichiometry and stability constants of the complexes formed are reported at 25°C and 0.1M ionic strength. The results show the formation of 1:1 complexes with amino acids and dicarboxylic acids. DNA constituents form 1:1 and 1:2 complexes. Peptides form both 1:1 complexes and the corresponding deprotonated amide species. The effect of chloride ion concentration and dioxane on the acid dissociation constants of 1,1-cyclobutane dicarboxylic acid (CBDCAH2) and the formation constant of its complex with Pd(DHP)2+ was reported. The equilibrium constants for the displacement of coordinated ligands as uracil, glycine or methionine by cysteine are calculated. The results are expected to contribute to the chemistry of antitumour agents. [Copyright &y& Elsevier]

Abstract: Pd(deen)Cl2 and Pd(deen)(CBDCA) complexes, where deen= N,N-diethylethylenediamine and CBDCA=1,1-cyclobutanedicarboxylate, were synthesized and characterized by elemental analysis and spectroscopic techniques. The stoichiometry and stability of the complexes formed between various biologically relevant ligands (amino acids, peptides, DNA constituents and dicarboxylic acids) and [Pd(deen)(H2O)2]2+ were investigated at 25°C and 0.1M ionic strength. The speciation diagrams of the complexes formed in solutions are evaluated. The mode of coordination of glycylglycine is investigated by spectrophotometric measurements. The equilibrium constants for the displacement of coordinated ligands as inosine, glycine or methionine by mercaptoethylamine are calculated. The results are expected to contribute to the chemistry of antitumour agents. [Copyright &y& Elsevier]