Juan Campos, Juan José Soler, Juan Melchor, Beatriz Blanco, [Blanco, Beatriz] Univ Granada, Dept Struct Mech, Granada 18071, Spain, [Blanco, Beatriz] Ibs GRANADA, Inst Invest Biosanitaria, Granada 18012, Spain, [Melchor, Juan] Ibs GRANADA, Inst Invest Biosanitaria, Granada 18012, Spain, [Campos, Juan] Univ Granada, Fac Ciencias, Dept Matemat Aplicada, Granada 18071, Spain, [Soler, Juan] Univ Granada, Fac Ciencias, Dept Matemat Aplicada, Granada 18071, Spain, [Campos, Juan] Univ Granada, Res Unit Modelling Nat MNat, Granada 18071, Spain, [Melchor, Juan] Univ Granada, Res Unit Modelling Nat MNat, Granada 18071, Spain, [Soler, Juan] Univ Granada, Res Unit Modelling Nat MNat, Granada 18071, Spain, [Melchor, Juan] Univ Granada, Dept Stat & Operat Res, Granada 18071, Spain, MINECO-Feder (Spain), Junta de Andalucia (Spain), Instituto de Salud Carlos III, Ministry of Science, Innovation and Universities of Spain, Consejeria de Economia, Conocimiento, Empresas y Universidad, European Regional Development Fund (ERDF), [Blanco,B] Department of Structural Mechanics, University of Granada, Granada, Spain. [Blanco,B, Melchor,J] Instituto de Investigación Biosanitaria, ibs.GRANADA, Granada, Spain. [Campos,J, Soler,J] Departamento de Matemática Aplicada, Facultad de Ciencias, Universidad de Granada, Granada, Spain. [Campos,J, Melchor,J, Soler,J] Research Unit 'Modelling Nature' (MNat), Universidad de Granada, Granada, Spain., and This paper has been partially supported by the MINECO-Feder (Spain) research grant num bers RTI2018-098850-B-I00 (J.C., J.S.) & EQC2018-004508-P (B.B., J.M.), the Junta de Andalucía (Spain) Projects PY18-RT-2422 (J.C., J.S.), A-FQM-311-UGR18 (J.C., J.S.) & IE2017-5537 (B.B., J.M.), and by the Instituto de Salud Carlos III, project number DTS17/00087 (J.M., J.S.). This study was also funded by Ministry of Science, Innovation and Universities of Spain, project numbers DPI2017-85359-R (B.B., J.M.) & PID2019-106947RA-C22 (B.B., J.M.) and by Consejería de Economía, Conocimiento, Empresas y Universidad and European Regional Development Fund (ERDF), ref. SOMM17/6109/UGR (J.C., J.M., J.S.). Lastly, B.B. research was granted by Ministry of Science, Innovation and Universities of Spain, FPU2017/01415.
What are the biomechanical implications in the dynamics and evolution of a growing solid tumor? Although the analysis of some of the biochemical aspects related to the signaling pathways involved in the spread of tumors has advanced notably in recent times, their feedback with the mechanical aspects is a crucial challenge for a global understanding of the problem. The aim of this paper is to try to illustrate the role and the interaction between some evolutionary processes (growth, pressure, homeostasis, elasticity, or dispersion by flux-saturated and porous media) that lead to collective cell dynamics and defines a propagation front that is in agreement with the experimental data. The treatment of these topics is approached mainly from the point of view of the modeling and the numerical approach of the resulting system of partial differential equations, which can be placed in the context of the Hele-Shaw-type models. This study proves that local growth terms related to homeostatic pressure give rise to retrograde diffusion phenomena, which compete against migration through flux-saturated dispersion terms., MINECO-Feder (Spain) research grant numbers RTI2018-098850-B-I00 (J.C., J.S.) & EQC2018-004508-P (B.B., J.M.), Junta de Andalucía (Spain) Projects PY18-RT-2422 (J.C., J.S.), A-FQM-311-UGR18 (J.C., J.S.) & IE2017-5537 (B.B., J.M.), Instituto de Salud Carlos III, project number DTS17/00087 (J.M., J.S.), Ministry of Science, Innovation and Universities of Spain, project numbers DPI2017-85359-R (B.B., J.M.) & PID2019-106947RA-C22 (B.B., J.M.), Consejería de Economía, Conocimiento, Empresas y Universidad and European Regional Development Fund (ERDF), ref. SOMM17/6109/UGR (J.C., J.M., J.S.), Ministry of Science, Innovation and Universities of Spain, FPU2017/01415