1. Comorbidity status of deceased COVID-19 in-patients in Italy.
- Author
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Vetrano, Davide Liborio, Tazzeo, Clare, Palmieri, Luigi, Marengoni, Alessandra, Zucchelli, Alberto, Lo Noce, Cinzia, Onder, Graziano, Italian National Institute of Health Covid-Mortality Group, Andrianou, Xanthi, Barbariol, Pierfrancesco, Bella, Antonino, Bellino, Stefania, Benelli, Eva, Bertinato, Luigi, Boros, Stefano, Brambilla, Gianfranco, Calcagnini, Giovanni, Canevelli, Marco, Castrucci, Maria Rita, and Censi, Federica
- Subjects
MORTALITY risk factors ,OBESITY ,COVID-19 ,STROKE ,CHRONIC diseases ,MYOCARDIAL ischemia ,ATRIAL fibrillation ,RISK assessment ,HOSPITAL mortality ,TYPE 2 diabetes ,OBSTRUCTIVE lung diseases ,DEMENTIA ,STATISTICAL sampling ,LOGISTIC regression analysis ,COMORBIDITY ,HEART failure ,DISEASE complications ,OLD age - Abstract
Background: Most COVID-19-related deaths have occurred in older persons with comorbidities. Specific patterns of comorbidities related to COVID-19 deaths have not been investigated. Methods: A random sample of 6085 individuals in Italy who died in-hospital with confirmed COVID-19 between February and December 2020 were included. Observed to expected (O/E) ratios of disease pairs were computed and logistic regression models were used to determine the association between disease pairs with O/E values ≥ 1.5. Results: Six pairs of diseases exhibited O/E values ≥ 1.5 and statistically significant higher odds of co-occurrence in the crude and adjusted analyses: (1) ischemic heart disease and atrial fibrillation, (2) atrial fibrillation and heart failure, (3) atrial fibrillation and stroke, (4) heart failure and COPD, (5) stroke and dementia, and (6) type 2 diabetes and obesity. Conclusion: In those deceased in-hospital due to COVID-19 in Italy, disease combinations defined by multiple cardio-respiratory, metabolic, and neuropsychiatric diseases occur more frequently than expected. This finding indicates a need to investigate the possible role of these clinical profiles in the chain of events that lead to death in individuals who have contracted SARS-CoV-2. [ABSTRACT FROM AUTHOR]
- Published
- 2021
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