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Your search keyword '"Enzinger C"' showing total 3 results
3 results on '"Enzinger C"'

1. Cognitive impairment in relation to MRI metrics in patients with clinically isolated syndrome.

Author

Khalil, M., Enzinger, C., Langkammer, C., Petrovic, K., Loitfelder, M., Tscherner, M., Jehna, M., Bachmaier, G., Wallner-Blazek, M., Ropele, S., Schmidt, R., Fuchs, S., and Fazekas, F.

Subjects
*COGNITION disorders, *MULTIPLE sclerosis, *SYNDROMES, *REGRESSION analysis, *NEUROPSYCHOLOGICAL tests, *ATROPHY, *MAGNETIC resonance imaging
Abstract

Background: Cognitive deficits are frequent in multiple sclerosis (MS) and have been associated with morphologic brain changes. Less information exists on their extent and relation to MRI findings in clinically isolated syndrome (CIS). It is also unclear if structural changes as detected by magnetization transfer (MT) imaging may provide an additional explanation for cognitive dysfunction.Objective: To analyse the extent of cognitive deficits and their relation to MRI metrics including MT imaging in CIS compared to relapsing-remitting MS (RRMS).Methods: Forty-four CIS and 80 RRMS patients underwent the Brief Repeatable Battery of Neuropsychological Tests (BRB-N) and a 3 T MRI scan.Results: BRB-N subtests revealed similar results in CIS and RRMS. Impaired mental processing speed was most prevalent in both groups (CIS 13.6%; RRMS 16.3%) and thus served for correlation with MRI metrics. Using stepwise linear regression analyses, the strongest predictor for decreased mental processing speed was normalized cortex volume (p < 0.001) followed by T2-lesion load (p < 0.05) in RRMS, whereas cortical MT ratio was the only MRI parameter associated with decreased mental processing speed in CIS (p < 0.005).Conclusion: Cognitive dysfunction occurs in CIS in a pattern similar to RRMS, with impaired mental processing speed being most prevalent. Cortical MT-ratio changes may be an early sign for tissue changes related to impaired mental processing speed in CIS while this association shifts to increased signs of cortical atrophy and lesion load in RRMS. [ABSTRACT FROM AUTHOR]

Published
2011
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2. Manual and automated tissue segmentation confirm the impact of thalamus atrophy on cognition in multiple sclerosis: A multicenter study

Author

Burggraaff, Jessica, Liu, Yao, Prieto, Juan C., Simoes, Jorge, de Sitter, Alexandra, Ruggieri, Serena, Brouwer, Iman, Lissenberg-Witte, Birgit I., Rocca, Mara A., Valsasina, Paola, Ropele, Stefan, Gasperini, Claudio, Gallo, Antonio, Pareto, Deborah, Sastre-Garriga, Jaume, Enzinger, Christian, Filippi, Massimo, De Stefano, Nicola, Ciccarelli, Olga, Hulst, Hanneke E., Wattjes, Mike P., Barkhof, Frederik, Uitdehaag, Bernard M. J., Vrenken, Hugo, Guttmann, Charles R. G., Universitat Autònoma de Barcelona, Neurology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Radiology and nuclear medicine, Amsterdam Neuroscience - Brain Imaging, Epidemiology and Data Science, Anatomy and neurosciences, Other Research, APH - Methodology, UCL - (SLuc) Centre du cancer, UCL - (SLuc) Service de chirurgie et transplantation abdominale, UCL - SSS/IREC/CHEX - Pôle de chirgurgie expérimentale et transplantation, Institut Català de la Salut, [Burggraaff J, Simoes J] Department of Neurology, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Liu Y, de Sitter A] Department of Radiology and Nuclear Medicine, MS Center Amsterdam, Amsterdam Neuroscience, Amsterdam UMC, Location VUmc, De Boelelaan 1117, 1118, 1081 HV Amsterdam, The Netherlands. [Prieto JC] Center for Neurological Imaging, Department of Radiology, Brigham and Women’s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA. [Ruggieri S] Department of Human Neurosciences, 'Sapienza' University of Rome, Piazzale Aldo Moro, 5, 00185 Roma RM, Italy. Department of Neurosciences, San Camillo Forlanini Hospital, Circonvallazione Gianicolense, 87, 00152 Roma RM, Italy. [Pareto D] Secció de Neuroradiologia, Unitat de Ressonància Magnètica, Departament de Radiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Sastre-Garriga J] Servei de Neurologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain, Vall d'Hebron Barcelona Hospital Campus, Burggraaff, J., Liu, Y., Prieto, J. C., Simoes, J., de Sitter, A., Ruggieri, S., Brouwer, I., Lissenberg-Witte, B. I., Rocca, M. A., Valsasina, P., Ropele, S., Gasperini, C., Gallo, A., Pareto, D., Sastre-Garriga, J., Enzinger, C., Filippi, M., De Stefano, N., Ciccarelli, O., Hulst, H. E., Wattjes, M. P., Barkhof, F., Uitdehaag, B. M. J., Vrenken, H., and Guttmann, C. R. G.

Subjects
WLG, Word List Generation, SPM12, Statistical Parametric Mapping 12, Audiology, Tàlem - Imatgeria, Etiv, estimated total intracranial volume, lcsh:RC346-429, Otros calificadores::Otros calificadores::/complicaciones [Otros calificadores], GIF, Geodesic Information Flows, 0302 clinical medicine, Cognition, Segmentation, Thalamus, CP, cognitively preserved, NBV, Normalized brain volume, Multiple Sclerosi, Other subheadings::/diagnosis [Other subheadings], Neuropsychological assessment, Cognitive decline, Generalized estimating equation, WMV, white matter volume, ICC, intraclass correlation coefficient, medicine.diagnostic_test, 05 social sciences, Nervous System Diseases::Autoimmune Diseases of the Nervous System::Demyelinating Autoimmune Diseases, CNS::Multiple Sclerosis [DISEASES], sistema nervioso::sistema nervioso central::encéfalo::prosencéfalo::diencéfalo::tálamo [ANATOMÍA], Regular Article, Neuropsychological test, HC, healthy control, SDMT, Symbol Digit Modalities Test, Magnetic Resonance Imaging, Neurology, PASAT, Paced Auditory Serial Addition Test, enfermedades del sistema nervioso::enfermedades autoinmunitarias del sistema nervioso::enfermedades autoinmunes desmielinizantes del SNC::esclerosis múltiple [ENFERMEDADES], lcsh:R858-859.7, VolBrain, MRI Brain Volumetry System, SRT, Selective Reminding Test, Human, MRI, Esclerosi múltiple - Complicacions, medicine.medical_specialty, CNR, contrast-to-noise ratio, Multiple Sclerosis, Cognitive Neuroscience, RRMS, Relapsing-Remitting Multiple Sclerosis, Otros calificadores::/diagnóstico [Otros calificadores], Nervous System::Central Nervous System::Brain::Prosencephalon::Diencephalon::Thalamus [ANATOMY], 10/36 SRT, 10/36 Spatial Recall Test, lcsh:Computer applications to medicine. Medical informatics, NGMV, Normalized grey matter volume, 050105 experimental psychology, SD, standard deviations, CII, cognitive impairment index, EDSS, Expanded Disability Status Scale, WCST, Wisconsin Card Sorting Test, 03 medical and health sciences, Atrophy, medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, WM, white matter, lcsh:Neurology. Diseases of the nervous system, Thalamu, CI, cognitively impaired and preserved (CP), BRB-N, Brief Repeatable Battery of Neuropsychological Tests, business.industry, Multiple sclerosis, FSL-FIRST, FMRIB Integrated Registration and Segmentation Tool, eTIV, estimated total intracranial volume, CAT12, Computational Anatomy Toolbox for Statistical Parametric Mapping 12, GM, grey matter, medicine.disease, Deep grey matter, NWMV, Normalized white matter volume, MS, Multiple Sclerosis, GMV, grey matter volume, IPS, information processing speed, Neurology (clinical), business, 030217 neurology & neurosurgery, Other subheadings::Other subheadings::/complications [Other subheadings]
Abstract

Highlights • Thalamus atrophy is associated with cognitive impairment in multiple sclerosis. • This was confirmed by automated and manual segmentations, but effect sizes varied. • The algorithms work in a multi-center setting. • Automated techniques exhibit proportional bias with respect to thalamus size. • Differences between vendors can affect the robustness of these associations., Background and rationale Thalamus atrophy has been linked to cognitive decline in multiple sclerosis (MS) using various segmentation methods. We investigated the consistency of the association between thalamus volume and cognition in MS for two common automated segmentation approaches, as well as fully manual outlining. Methods Standardized neuropsychological assessment and 3-Tesla 3D-T1-weighted brain MRI were collected (multi-center) from 57 MS patients and 17 healthy controls. Thalamus segmentations were generated manually and using five automated methods. Agreement between the algorithms and manual outlines was assessed with Bland-Altman plots; linear regression assessed the presence of proportional bias. The effect of segmentation method on the separation of cognitively impaired (CI) and preserved (CP) patients was investigated through Generalized Estimating Equations; associations with cognitive measures were investigated using linear mixed models, for each method and vendor. Results In smaller thalami, automated methods systematically overestimated volumes compared to manual segmentations [ρ=(-0.42)-(-0.76); p-values

Published
2021

3. Structural MRI correlates of cognitive impairment in patients with multiple sclerosis: A Multicenter Study

Author

M Atzori, Massimiliano Copetti, Gianna C Riccitelli, Franz Fazekas, Nicola De Stefano, Maria Laura Stromillo, Deborah Pareto, Massimo Filippi, Elisabetta Pagani, Frederik Barkhof, María Jesús Arévalo, Alvino Bisecco, Antonio Gallo, Hanneke E. Hulst, Tarek A. Yousry, Christian Enzinger, Paolo Preziosa, Maria A. Rocca, Preziosa, Paolo, Rocca, Maria A., Pagani, Elisabetta, Stromillo, Maria Laura, Enzinger, Christian, Gallo, Antonio, Hulst, Hanneke E., Atzori, Matteo, Pareto, Deborah, Riccitelli, Gianna C., Copetti, Massimiliano, De Stefano, Nicola, Fazekas, Franz, Bisecco, Alvino, Barkhof, Frederik, Yousry, Tarek A., Arévalo, Maria J., Filippi, Massimo, Anatomy and neurosciences, Amsterdam Neuroscience - Neuroinfection & -inflammation, Radiology and nuclear medicine, Preziosa, P, Rocca, Ma, Pagani, E, Stromillo, Ml, Enzinger, C, Gallo, A, Hulst, He, Atzori, M, Pareto, D, Riccitelli, Gc, Copetti, M, De Stefano, N, Fazekas, F, Bisecco, A, Barkhof, F, Yousry, Ta, Arévalo, Mj, and Filippi, M

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Neurology, Multiple Sclerosis, Audiology, Neuropsychological Tests, Diffusion tensor MRI, 030218 nuclear medicine & medical imaging, White matter, 03 medical and health sciences, 0302 clinical medicine, Atrophy, Nuclear Medicine and Imaging, medicine, Cognitive impairment, Multicenter, Multiple sclerosis, Voxel-wise analysis, Cognitive Dysfunction, Female, Humans, Middle Aged, Magnetic Resonance Imaging, Neurology (clinical), Anatomy, Radiology, Nuclear Medicine and Imaging, Radiological and Ultrasound Technology, Radiology, Nuclear Medicine and imaging, Neuropsychological assessment, Research Articles, medicine.diagnostic_test, Magnetic resonance imaging, Cognition, medicine.disease, medicine.anatomical_structure, multiple sclerosi, Psychology, Radiology, 030217 neurology & neurosurgery, Diffusion MRI, voxel-wise analysis
Abstract

In a multicenter setting, we applied voxel‐based methods to different structural MR imaging modalities to define the relative contributions of focal lesions, normal‐appearing white matter (NAWM), and gray matter (GM) damage and their regional distribution to cognitive deficits as well as impairment of specific cognitive domains in multiple sclerosis (MS) patients. Approval of the institutional review boards was obtained, together with written informed consent from all participants. Standardized neuropsychological assessment and conventional, diffusion tensor and volumetric brain MRI sequences were collected from 61 relapsing‐remitting MS patients and 61 healthy controls (HC) from seven centers. Patients with ≥2 abnormal tests were considered cognitively impaired (CI). The distribution of focal lesions, GM and WM atrophy, and microstructural WM damage were assessed using voxel‐wise approaches. A random forest analysis identified the best imaging predictors of global cognitive impairment and deficits of specific cognitive domains. Twenty‐three (38%) MS patients were CI. Compared with cognitively preserved (CP), CI MS patients had GM atrophy of the left thalamus, right hippocampus and parietal regions. They also showed atrophy of several WM tracts, mainly located in posterior brain regions and widespread WM diffusivity abnormalities. WM diffusivity abnormalities in cognitive‐relevant WM tracts followed by atrophy of cognitive‐relevant GM regions explained global cognitive impairment. Variable patterns of NAWM and GM damage were associated with deficits in selected cognitive domains. Structural, multiparametric, voxel‐wise MRI approaches are feasible in a multicenter setting. The combination of different imaging modalities is needed to assess and monitor cognitive impairment in MS. Hum Brain Mapp 37:1627‐1644, 2016. © 2016 Wiley Periodicals, Inc.

Published
2016

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