1. Synthesis of new purine, pteridine, and other pyrimidine derivatives.
- Author
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Abdel-Latif, E., Mustafa, H., Etman, H., and Fadda, A.
- Subjects
- *
PURINES , *URIC acid , *ALLOXURIC substances , *PTERIDINES , *PYRIMIDINES , *HETEROCYCLIC compounds - Abstract
The reaction of malononitrile dimer with phenyl isothiocyanate gave (6-amino-1-phenyl-2-thioxo-1,2,3,4-tetrahydropyrimidin-4-ylidene)malononitrile which was then used as starting material in the synthesis of pharmacologically important fused pyrimidine derivatives, such as 4-dicyanomethylidene-1,5-diphenyl-2-thioxo-1,2,3,4-tetrahydropyrrolo[2,3- d]pyrimidine, 6-cyano-4-dicyanomethylidene-7-methylsulfanyl-5-oxo-1-phenyl-2-thioxo-1,2,3,4,5,8-hexahydropyrido[2,3- d]pyrimidine, 6-dicyanomethylidene-3-phenyl-2-thioxo-1,2,3,6-tetrahydro-9 H-purine, and 6-substituted 4-dicyanomethylidene-7-oxo-1-phenyl-2-thioxo-1,2,3,4,7,8-hexahydropteridines. [ABSTRACT FROM AUTHOR]
- Published
- 2007
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