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Perfluorooctanoic acid (PFOA) in environmental matrices is increasingly being studied due to its environmental persistence, global occurrence, bioaccumulation, and associated human health risks. Some indoor environments can significantly impact the health of occupants due to pollutants in indoor air and household dust. To investigate the potential exposure of individuals to PFOA in specific confined environments, this study reports an analytical method and results concerning the determination of PFOA in household dust, used as a passive sampler. To the best of our knowledge, this paper represents one of the first studies concerning PFOA concentrations in indoor dust collected in the south of Italy, within the European region. A total of twenty-three dust samples were collected from two different areas of Sicily (Palermo and Milena), extracted, and analyzed by an UHPLC-QTOF-MS/MS system. Finally, PFOA exposure was estimated using a new index (Indoor PFOA Exposure Index, IPEX) that incorporates the PFOA levels in dust, exposure time, and the correlation between the PFOA in dust and blood. It was then compared across four different exposure groups, revealing that PFOA exposure for people working in chemistry laboratories was evaluated to be ten times higher than the exposure for homemakers. [ABSTRACT FROM AUTHOR]

According to some European Institutions (European Environment Agency, Commission of the European Communities), Environmental Impact Assessment (EIA) could be a better tool to assist natural resource protection in the context of land use planning than when used only for assessing specific projects. Environmental assessment of planning instruments allows the comparison of different alternatives and to scope the analysis and evaluation of relevant impacts when developing projects in the alternatives selected. This paper develops a minimum indicator set useful to evaluate natural resources quality at municipality level as a basis for assessing environmental impacts derived from land use planning instruments and from specific projects in the Valencian region, a representative area of the European Mediterranean Region. Using Principal Component Analysis (PCA), a minimum set of 12 indicators which referred to relevant natural resources (air, water, soil and biodiversity) was defined and used to assess the resources quality of different municipalities of the Valencian region, following a value-function based approach. The results obtained were very similar to those obtained in another study done in the same area that applied a broader set of indicators. These results and the potential reduction in costs estimated show the usefulness of the minimum set of indicators defined in this work for evaluating resources quality. As a demonstration exercise, the indicator set was applied to three municipalities representative of the different land use conflicts and environmental problems of the Valencian region, in order to assess the environmental impacts on natural resources that could be produced from the implementation of a hypothetic urban-industrial expansion plan, a usual land use pattern that has occurred in the European Mediterranean Region in the lasts decades. The results obtained show that coastal municipalities are better alternatives to implement an urban-industrial expansion than inland and intermediate municipalities in terms of environmental impacts although the loss of high productivity soils must be avoided. Given that the environmental issues considered are representative of the European Mediterranean Region, it follows that the approach developed in this work can be useful to predict environmental impacts on natural resources from planning instruments in the whole region. [ABSTRACT FROM AUTHOR]

Biomass production in marginal lands represents one of the most challenging and promising alternatives to sustainably produce biofuels. Native species seem to be the most adequate option to obtain a profitable output when low-input techniques are applied, and biomass is grown in depleted soils and harsh climatic conditions. In this study, a 5-year field trial in the island of Majorca served to investigate different autochthonous and naturalized Mediterranean perennial grasses as novel candidate lignocellulosic bioenergy crops for the semi-arid Mediterranean area and compare them with commercial ones (both Mediterranean and non-Mediterranean). Species and growing season had a significant effect on biomass production, perennialism and biomass quality. Arundo donax (winter crops) and Piptatherum miliaceum (autumn crops) performed better than the commercial species tested (Panicum virgatum for winter crops and Festuca arundinacea for autumn crops) in biomass production and perennialism. In terms of biomass quality, Panicum virgatum was the best species, having high structural content (mainly cellulose and hemicellulose), low non-structural content and the lowest ash. However, Ampelodesmos mauritanicus and Arundo donax rendered similar results, with no significant difference in terms of cellulose production for this latter but with higher lignin content. For the autumn species, Festuca arundinacea was the species with the best biomass quality but with the highest ash production for all the species considered. Hence, both for winter or autumn regimes, native or naturalized plants seem to be better suited than the commercial commonly used for biomass production with energy-producing purposes. Further research must be conducted in terms of seed biology and physiology, seedbed preparation methods, sowing time, seedling density and weed control before they can firmly be proposed as adequate alternatives for energy purposes. [ABSTRACT FROM AUTHOR]

Entomopathogenic fungi (EFs) are widely used as biological control agents. However, some strains of Beauveria bassiana and Metarhizium brunneum can also promote plant growth and increase nutrient uptake. We examined the effects of soil properties on the performance of Triticum durum inoculated by seed dressing with these EFs and grown on 12 agricultural soils. The plants were supplied with all nutrients except P and Zn (essential for yield and the grain quality of wheat). Fungal inoculation increased the grain yield and harvest index significantly with B. bassiana (17% and 14%, respectively) but not with M. brunneum (6% and 6%, respectively). The increase in grain yield was positively and moderately correlated with the soil available phosphorus (POlsen) in plants inoculated with B. bassiana and with the soil content in poorly crystalline Fe oxides with M. brunneum. In addition, the increase in aerial dry matter resulting from inoculation with B. bassiana was negatively correlated with soil available Zn. Furthermore, the observed increase in grain yields due to fungal inoculation resulted in P and Zn grain dilution (grain nutrient concentrations decrease). Inoculation with B. bassiana increased grain Zn uptake and the proportion of Zn in grain relative to that in aerial dry matter. Success in the mutualistic relationship between EF and wheat plants depends on the fungal strain and soil properties. [ABSTRACT FROM AUTHOR]

Perfluorooctanoic acid (PFOA) in environmental matrices is increasingly being studied due to its environmental persistence, global occurrence, bioaccumulation, and associated human health risks. Some indoor environments can significantly impact the health of occupants due to pollutants in indoor air and household dust. To investigate the potential exposure of individuals to PFOA in specific confined environments, this study reports an analytical method and results concerning the determination of PFOA in household dust, used as a passive sampler. To the best of our knowledge, this paper represents one of the first studies concerning PFOA concentrations in indoor dust collected in the south of Italy, within the European region. A total of twenty-three dust samples were collected from two different areas of Sicily (Palermo and Milena), extracted, and analyzed by an UHPLC-QTOF-MS/MS system. Finally, PFOA exposure was estimated using a new index (Indoor PFOA Exposure Index, IPEX) that incorporates the PFOA levels in dust, exposure time, and the correlation between the PFOA in dust and blood. It was then compared across four different exposure groups, revealing that PFOA exposure for people working in chemistry laboratories was evaluated to be ten times higher than the exposure for homemakers.

F12511(S)-2',3',5'-trimethyl-4'-hydroxy-alpha-dodecylthio-alpha-phenylacetanilide (F12511) is a new Acyl-CoA cholesterol acyltransferase (ACAT) inhibitor that not only reduces the plasma cholesterol levels but also has anti-atherosclerotic actions in animals models. The study's aim was to analyze if F12511 may directly modify the ability of tumor necrosis factor--alpha (TNF-alpha)-incubated bovine aortic endothelial cells (BAEC) to express endothelial nitric oxide synthase (eNOS) protein and inflammatory-related proteins such as platelet endothelial cell adhesion molecule (PECAM) and CD40 ligand (CD40L). The addition of increasing concentrations of F12511 (10 to 10 mol/L) failed to modify the level of eNOS protein expressed in control BAEC. TNF-alpha (10 ng/mL) reduced the expression of eNOS protein. In TNF-alpha--incubated BAEC, F12511 protected eNOS expression in a concentration-dependent manner. TNF-alpha stimulated the expression of both CD40L and PECAM in cultured BAEC. F12511 (10 mol/L) failed to modify the expression of CD40L and PECAM in control and TNF-alpha-incubated BAEC. Reverse transcriptase polymerase chain reaction showed a marked expression of the ACAT-2 isoform and absent of expression of the ACAT-1 isoform in BAEC. The presence of ACAT-2 isoform in BAEC was further confirmed by Western blot. F12511 failed to modify the expression of the proinflammatory associated proteins PECAM and CD40L in the endothelium but protected eNOS expression in the endothelial cells exposed to inflammatory conditions.