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Background: Invasive pneumococcal disease (IPD, Streptococcus pneumoniae) has been a nationally notifiable disease in Canada since 2000. The use of conjugate vaccines has caused a shift in the distribution of serotypes over time. This report is a summary of the demographics, serotypes and antimicrobial resistance of IPD isolates collected in Canada in 2021 and 2022. Methods: The National Microbiology Laboratory (NML) of the Public Health Agency of Canada in Winnipeg, Manitoba collaborates with provincial and territorial public health laboratories to conduct national surveillance of IPD. There were 1,999 isolates reported in 2021 and 3,775 isolates in 2022. Serotype was determined by the Quellung reaction or whole-genome sequencing (WGS). Antimicrobial susceptibilities were determined by WGS methods, broth microdilution, or data shared by collaborators in the Canadian Antimicrobial Resistance Alliance program at the University of Manitoba. Population-based IPD incidence rates were obtained through the Canadian Notifiable Disease Surveillance System. Results: The incidence of IPD in Canada was 5.62 cases per 100,000 population in 2021, decreasing from the peak of 10.86 cases per 100,000 population in 2018. Serotypes with increasing trends (p<0.05) between 2018 and 2022 included: 4 (6.1%–12.4%), 9V (1.0%–5.1%) and 12F (4.8%–5.4%). The overall prevalence of PCV13 serotypes increased over the same period (31.2%−41.5%, p<0.05) while the prevalence of non-vaccine types decreased significantly (27.3%–21.5%, p<0.0001). The highest rates of antimicrobial resistance in 2021 and 2022 were seen with clarithromycin (21%, 2021; 24%, 2022) and erythromycin (22%, 2021; 24%, 2022). Multidrug-resistant IPD continued to increase from 2018 to 2022 (6.7%–12.6%, p<0.05). Conclusion: The number of cases of IPD continued to decrease in 2021 in comparison to previous years, however, 2022 saw a return to pre-COVID-19 levels. Disease due to PCV13 serotypes 3, 4, 9V and 19F, as well as non-PCV13 serotypes 12F and 20, is increasing in prevalence. Surveillance of IPD to monitor changing serotype distribution and antimicrobial resistance is essential. [ABSTRACT FROM AUTHOR]

The use of fiber-reinforced composite materials for the construction and rehabilitation of civil engineering structures is relatively new. Structural members are routinely joined by bolted connections. Bolted connections are relatively easy to assemble and maintain, and are capable of transferring the high loads that typically occur in civil engineering structures. Currently there is a serious lack of knowledge on the behavior and design of bolted connections for fiber-reinforced composites. In light of this, a comprehensive experimental and analytical investigation was conducted at the University of Manitoba to study the behavior of bolted connections in composite materials appropriate for civil engineering applications. A total of 102 single-bolt connections were tested up to failure. The various parameters investigated were the width of the structural member, the edge distance, the thickness, and the direction of the fibers with respect to the applied load. The experimental program also included comprehensive material testing to determine the various in-plane material properties. This paper discusses the experimental program, test results, and various modes of failure as affected by the foregoing parameters. From the test results an analytical model and design procedure were developed as proposed in a companion paper. [ABSTRACT FROM AUTHOR]

Abstract: An extensive research project is currently being carried out at the University of Manitoba, Canada, involving the development of glass fiber-reinforced polymer (GFRP) wind turbine towers. The towers consist of multi-cell segments, each segment constructed from eight filament wound cells jointed together with resin applied over their interface. The present paper mainly addresses the static and dynamic characteristics, such as failure static loads, modes of failure, fundamental frequencies and periods of such segmented composite towers. Both experimental and numerical results are presented. The experimental investigation involved the testing of two jointed scaled towers. These specimens had a total height of 4.88-m (16-ft) and were tested as cantilevers under static and dynamic loading. The testing was conducted at the W.R. McQuade Structural Engineering Laboratory of the University of Manitoba. Finally, finite element models were developed to analyze the structural behavior, static and dynamic, of single and multi-cell composite segments and towers. The results from the finite element models under static loading were validated through comparison with the experimental results. [Copyright &y& Elsevier]