1. Evaluation of subclinical cardiovascular risk in drug-naive pediatric patients with anxiety disorders.
- Author
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Akıncı, Mehmet Akif, Uzun, Necati, and Alp, Hayrullah
- Subjects
CARDIOVASCULAR diseases risk factors ,ECHOCARDIOGRAPHY ,CAROTID intima-media thickness ,CHILDHOOD obesity ,MULTIVARIATE analysis ,AGE distribution ,TURKS ,REGRESSION analysis ,RISK assessment ,PSYCHOLOGICAL tests ,CORONARY artery disease ,ANALYSIS of covariance ,ANXIETY disorders ,CLASSIFICATION of mental disorders ,BODY mass index ,AORTA ,EPICARDIAL adipose tissue ,DISEASE risk factors ,CHILDREN ,ADOLESCENCE - Abstract
Objective: This study examined subclinical atherosclerosis in drug-naïve children with anxiety disorders using non-invasive measures to investigate the clinical features associated with subclinical atherosclerosis. Method: A total of 37 drug-naive children and adolescents with anxiety disorders and 37 healthy controls were included in the study. The Children's Depression Inventory (CDI) and the State-Trait Anxiety Inventory (STAI-T and STAI-S) were used to assess children's depression and anxiety levels. Carotid artery intima-media (cIMT), epicardial adipose tissue (EAT), and periaortic adipose tissue (PAT) thicknesses, which are indicators of subclinical atherosclerosis, were obtained by echocardiographic measurements. Results: Multivariate analysis of covariance (MANCOVA) revealed a significant main effect on cIMT, EAT thickness, and PAT thickness, independent of confounding factors such as age, sex, body mass index, mean blood pressure, and family income (Pillai's Trace V =.76, F (1, 72) = 35.60, P <.001, ηp
2 =.76). Analysis of covariance (ANCOVA) showed that cIMT, EAT thickness, and PAT thickness values were significantly higher in the anxiety disorder group compared to the the control group (P <.001). In partial correlation analysis, a positive correlation was observed between STAI-T and cIMT and EAT thickness. In linear regression analyses, age and STAI-T were significantly correlated with cIMT and EAT thickness levels. Conclusions: These results suggest that subclinical cardiovascular risk is significantly increased in children and adolescents with anxiety disorders. [ABSTRACT FROM AUTHOR]- Published
- 2024
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