1. MicroRNA-30c-2-3p targets STRIP2 to suppress malignant progression of gastric cancer cells.
- Author
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Wu, Junfei, Lu, Guochun, Zhou, Shengkun, Jin, Zier, and Fang, Fu
- Subjects
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STOMACH cancer , *CANCER cells , *CANCER invasiveness , *ANTINEOPLASTIC agents , *CELL lines - Abstract
MicroRNA plays a crucial part in genesis and development of gastric cancer (GC). We uncovered that microRNA-30c-2-3p was down-regulated in GC tissue and cell lines. Suppression of microRNA-30c-2-3p promoted progression of GC cells in vitro. STRIP2 was confirmed as a target for microRNA-30c-2-3p. MicroRNA-30c-2-3p overexpression remarkably suppressed cell malignant behaviours, while reintroduction of STRIP2 partially restored the anticancer effect of microRNA-30c-2-3p. Taken together, these findings suggested that microRNA-30c-2-3p acted as a candidate tumour suppressor in GC by directly targeting STRIP2. Therefore, microRNA-30c-2-3p can be used as a towardly GC therapeutic target. [ABSTRACT FROM AUTHOR]
- Published
- 2022
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