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• Bacillus Calmette-Guérin (BCG) could be effective against SARS-CoV-2 based on the concept of trained immunity. • COVID-19 vaccines and BCG can enhance the immune response represented by immunoglobulin G levels. • The cumulative incidence of COVID-19 was smaller in BCG-vaccinated participants. • Immunoglobulin G levels tend to be higher and longer in the group submitted to BCG vaccination. Evatuate if Bacillus Calmette-Guérin (BCG) vaccine could be used as a tool against SARS-CoV-2 based on the concept of trained immunity. A multicenter, double-blinded, randomized clinical trial recruited health care workers (HCWs) in Brazil. The incidence rates of COVID-19, clinical manifestations, absenteeism, and adverse events among HCWs receiving BCG vaccine (Moreau or Moscow strains) or placebo were compared. BCG vaccine-mediated immune response before and after implementing specific vaccines for COVID-19 (CoronaVac or COVISHIELD) was analyzed. Cox proportional hazard and linear mixed effect modeling were used. A total of 264 volunteers were included for analysis (BCG = 134 and placebo = 130). The placebo group presented a COVID-19 cumulative incidence of 0.75% vs 0.52% of BCG. The Moreau strain also presented a higher incidence rate (1.60% × 0.22%). BCG did not show a protective hazard ratio against COVID-19. In addition, the log (immunoglobulin G) level against SARS-CoV-2 presented a higher increase in the BCG group, whether or not participants had COVID-19, but also without statistical significance. Our results suggest that BCG has a tendency of protection against SARS-CoV-2 and higher immunoglobulin G levels than placebo. The clinical trial was registered at https://clinicaltrials.gov/ (NCT04659941). [ABSTRACT FROM AUTHOR]

Abstract: Context: Fatigue is the most common symptom among Hodgkin''s lymphoma survivors. Objectives: To evaluate the psychometric properties of the Brazilian version of the Multidimensional Fatigue Inventory (MFI). Methods: The MFI was translated into Brazilian Portuguese using established forward-backward translation procedures, and the psychometric properties were evaluated in a sample of 200 Hodgkin''s lymphoma survivors. The psychometric properties evaluated included internal consistency and construct validity. The MFI was administered along with the informed consent form. Results: The overall Cronbach''s alpha coefficient for the 20 items was 0.84, ranging from 0.59 to 0.81 for each of the five scales. Correlations between items and scales ranged from 0.32 to 0.72. The factor analysis yielded a five-factor solution that explained 65% of the variance. The first factor merged the original “general fatigue” and “physical fatigue” scales, as has been previously reported. The second factor identified the original “mental fatigue” scale and the fifth factor identified the original “reduced activity” scale. Questions from the original “reduced motivation” scale were represented in both factors three and four. Conclusion: The Brazilian version of the MFI showed satisfactory psychometric properties and can be considered a valid research tool for assessing cancer-related fatigue. [Copyright &y& Elsevier]