11 results on '"Atripaldi, Lidia"'
Search Results
2. Indications and techniques of non-invasive ventilation (NIV) in neuromuscular diseases.
- Author
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Annunziata, Anna, Coppola, Antonietta, Simioli, Francesca, Atripaldi, Lidia, Marotta, Antonella, Esquinas, Antonio, and Fiorentino, Giuseppe
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- 2024
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3. COVID-19 vaccination in adults with congenital heart disease: Real-world data from an Italian tertiary centre
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Fusco, Flavia, Scognamiglio, Giancarlo, Merola, Assunta, Roma, Anna Selvaggia, Nicastro, Carmine, Spatarella, Micaela, D'Abbraccio, Maurizio, Di Mauro, Gabriella, Atripaldi, Umberto, Atripaldi, Lidia, Correra, Anna, Palma, Michela, Barracano, Rosaria, Borrelli, Nunzia, Capuano, Annalisa, and Sarubbi, Berardo
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- 2021
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4. Alpha-1 Antitrypsin PI M Heterozygotes with Rare Variants: Do They Need a Clinical and Functional Follow-Up?
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Annunziata, Anna, Fiorentino, Giuseppe, Balestrino, Marco, Rega, Roberto, Spinelli, Sara, Atripaldi, Lidia, Sola, Alessio, Massaro, Federica, and Calabrese, Cecilia
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GENETIC carriers ,TRYPSIN inhibitors ,GENETIC variation ,PROTEASE inhibitors - Abstract
(1) Background: Few data are available on the risk of airway dysfunction in protease inhibitor (PI*) M heterozygotes carrying rare null or deficient allelic variants of the gene SERPINA-1 (PI*MR). (2) Methods: In this observational study, in a cohort of PI*MR heterozygotes, we evaluated respiratory functional parameters at baseline and at one-year follow-up. Moreover, we compared such parameters with those of the PI*MZ and PI*MS patients. (3) Results: A total of 60 patients were recruited; 35 PI*MR, 11 PI*MZ and 14 PI*MS. At the annual follow-up, the PI*MR and PI*MZ patients demonstrated a significantly higher FEV
1 decline than the PI*MS group (p = 0.04 and p = 0.018, respectively). The PI*MR patients showed a significant increase in DLCO annual decline in comparison with the PI*MS group (p = 0.02). At baseline, the PI*MR smoking patients, compared with nonsmokers, showed statistically significant lower values of FEV1 , FEV1 /FVC and DLCO (p = 0.0004, p < 0.0001, p = 0.007, respectively) and, at the one-year follow-up, they displayed a significantly higher FEV1 and DLCO decline (p = 0.0022, p = 0.011, respectively). PI*MR heterozygotes with COPD showed a significantly higher FEV1 , FEV1 /FVC and DLCO annual decline in comparison with healthy PI*MR (p = 0.0083, p = 0.043, p = 0.041). (4) Conclusions: These results suggest that PI*MR heterozygotes, particularly smokers with COPD, have a greater annual decline in respiratory functional parameters and need to be monitored. [ABSTRACT FROM AUTHOR]- Published
- 2024
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5. New Insights into the Identification of Metabolites and Cytokines Predictive of Outcome for Patients with Severe SARS-CoV-2 Infection Showed Similarity with Cancer.
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Costantini, Susan, Madonna, Gabriele, Di Gennaro, Elena, Capone, Francesca, Bagnara, Palmina, Capone, Mariaelena, Sale, Silvia, Nicastro, Carmine, Atripaldi, Lidia, Fiorentino, Giuseppe, Parrella, Roberto, Montesarchio, Vincenzo, Atripaldi, Luigi, Ascierto, Paolo A., and Budillon, Alfredo
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HEMATOPOIETIC growth factors ,PROTON magnetic resonance ,SARS-CoV-2 ,METABOLITES ,COVID-19 - Abstract
SARS-CoV-2 infection is characterized by several clinical manifestations, ranging from the absence of symptoms to severe forms that necessitate intensive care treatment. It is known that the patients with the highest rate of mortality develop increased levels of proinflammatory cytokines, called the "cytokine storm", which is similar to inflammatory processes that occur in cancer. Additionally, SARS-CoV-2 infection induces modifications in host metabolism leading to metabolic reprogramming, which is closely linked to metabolic changes in cancer. A better understanding of the correlation between perturbed metabolism and inflammatory responses is necessary. We evaluated untargeted plasma metabolomics and cytokine profiling via
1 H-NMR (proton nuclear magnetic resonance) and multiplex Luminex assay, respectively, in a training set of a limited number of patients with severe SARS-CoV-2 infection classified on the basis of their outcome. Univariate analysis and Kaplan–Meier curves related to hospitalization time showed that lower levels of several metabolites and cytokines/growth factors, correlated with a good outcome in these patients and these data were confirmed in a validation set of patients with similar characteristics. However, after the multivariate analysis, only the growth factor HGF, lactate and phenylalanine retained a significant prediction of survival. Finally, the combined analysis of lactate and phenylalanine levels correctly predicted the outcome of 83.3% of patients in both the training and the validation set. We highlighted that the cytokines and metabolites involved in COVID-19 patients' poor outcomes are similar to those responsible for cancer development and progression, suggesting the possibility of targeting them by repurposing anticancer drugs as a therapeutic strategy against severe SARS-CoV-2 infection. [ABSTRACT FROM AUTHOR]- Published
- 2023
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6. An unusual way to improve lung function in congenital myopathies: the power of singing.
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Valentino, Maria Rosaria, Annunziata, Anna, Atripaldi, Lidia, and Fiorentino, Giuseppe
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- 2023
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7. Exploring the Role of Krebs von den Lungen-6 in Severe to Critical COVID-19 Patients.
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D'Agnano, Vito, Scialò, Filippo, Perna, Francesco, Atripaldi, Lidia, Sanduzzi, Stefano, Allocca, Valentino, Vitale, Maria, Pastore, Lucio, Bianco, Andrea, and Perrotta, Fabio
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COVID-19 ,BODY mass index ,MULTIPLE organ failure ,SARS-CoV-2 - Abstract
COVID-19 encompasses a broad spectrum of clinical conditions caused by SARS-CoV-2 infection. More severe cases experience acute respiratory and/or multiorgan failure. KL-6 is a glycoprotein expressed mainly from type II alveolar cells with pro-fibrotic properties. Serum KL-6 concentrations have been found in patients with COVID-19. However, the relevance of KL-6 in patients with severe and critical COVID-19 has not been fully elucidated. Methods: Retrospective data from consecutive severe to critical COVID-19 patients were collected at UOC Clinica Pnuemologica "Vanvitelli", A.O. dei Colli, Naples, Italy. The study included patients with a positive rhinopharyngeal swab for SARS-CoV-2 RNA with severe or critical COVID-19. Results: Among 87 patients, 24 had poor outcomes. The median KL-6 value in survivors was significantly lower when compared with dead or intubated patients (530 U/mL versus 1069 U/mL p < 0.001). KL-6 was correlated with body mass index (BMI) (r: 0.279, p: 0.009), lung ultrasound score (LUS) (r: 0.429, p < 0.001), Chung Score (r: 0.390, p < 0.001). KL-6 was associated with the risk of death or oro-tracheal intubation (IOT) after adjusting for gender, BMI, Charlson Index, Chung Score, and PaO
2 /FIO2 (OR 1.003 95% CI 1.001–1.004, p < 0.001). Serum KL-6 value of 968 has a sensitivity of 79.2%, specificity of 87.1%, PPV 70.4%, NPV 91.5%, AUC: O.85 for risk of death or IOT. Conclusions: The presented research highlights the relevance of serum KL-6 in severe to critical COVID-19 patients in predicting the risk of death or IOT. [ABSTRACT FROM AUTHOR]- Published
- 2022
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8. Evolution of the Clinical Profile and Outcomes of Unvaccinated Patients Affected by Critical COVID-19 Pneumonia from the Pre-Vaccination to the Post-Vaccination Waves in Italy.
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Calabrese, Cecilia, Annunziata, Anna, Mariniello, Domenica Francesca, Coppola, Antonietta, Mirizzi, Angela Irene, Simioli, Francesca, Pelaia, Corrado, Atripaldi, Lidia, Pugliese, Gaia, Guarino, Salvatore, and Fiorentino, Giuseppe
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SARS-CoV-2 ,COVID-19 ,TREATMENT effectiveness ,PNEUMONIA ,RESPIRATORY insufficiency - Abstract
The vaccination campaign and the new SARS-CoV-2 variants may have changed the clinical profile and outcomes of patients admitted to sub-intensive unit care. We conducted a retrospective study aimed to compare the clinical and radiological features of unvaccinated critical COVID-19 patients hospitalized during the last pandemic wave (December 2021–February 2022, No-Vax group) and before starting the vaccination campaign (March–December 2020, Pre-Vax group). The No-Vax group was also compared with vaccinated patients of the same pandemic wave (Vax group). With respect to the Pre-Vax group, the No-Vax group contained a higher percentage of smokers (p = 0.0007) and a lower prevalence of males (p = 0.0003). At admission, the No-Vax patients showed both a higher CT score of pneumonia and a worse severe respiratory failure (p < 0.0001). In the No-Vax group, a higher percentage of deaths occurred, though this was not significant. In comparison with the No-Vax group, the Vax patients were older (p = 0.0097), with a higher Charlson comorbidity index (p < 0.0001) and a significantly lower HRCT score (p = 0.0015). The percentage of deaths was not different between the two groups. The No-Vax patients showed a more severe disease in comparison with the Pre-Vax patients, and were younger and had fewer comorbidities than the Vax patients. [ABSTRACT FROM AUTHOR]
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- 2022
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9. Clinical Outcome Prediction in COVID-19 Patients by Lymphocyte Subsets Analysis and Monocytes' iTNF-α Expression.
- Author
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Madonna, Gabriele, Sale, Silvia, Capone, Mariaelena, De Falco, Chiara, Santocchio, Valentina, Di Matola, Tiziana, Fiorentino, Giuseppe, Pirozzi, Caterina, D'Antonio, Anna, Sabatino, Rocco, Atripaldi, Lidia, Atripaldi, Umberto, Raffone, Marcello, Curvietto, Marcello, Grimaldi, Antonio Maria, Vanella, Vito, Festino, Lucia, Scarpato, Luigi, Palla, Marco, and Spatarella, Michela
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LYMPHOCYTE count ,COVID-19 ,LYMPHOCYTE subsets ,TREATMENT effectiveness ,REGULATORY T cells ,SARS-CoV-2 ,MONOCYTES - Abstract
Simple Summary: Several studies have explored the role of the inflammatory cells and cytokines involved in the protection or pathogenesis of coronavirus disease 2019. Unfortunately, the results have been controversial, and further studies are needed to better understand not only the roles but also the balance of these parameters, which are crucial data to improve prevention and treatment. As COVID-19 has a well-determined phasic progression and rapidly deteriorates approximately seven days after the onset of symptoms, it is extremely necessary to detect the clinical signs that are predictive of the outcome as early as possible. To this end, in this preliminary study, we evaluated the data relating to the monocyte intracellular TNF-α expression and lymphocyte subpopulations in peripheral blood collected from patients at admission and every day of hospitalization until day 7. Our findings point to a modulation of the different cellular mediators of the immune system, which probably play a key role in the outcome of the coronavirus disease 2019. In December 2019, a novel coronavirus, "SARS-CoV-2", was recognized as the cause of coronavirus disease 2019 (COVID-19). Several studies have explored the changes and the role of inflammatory cells and cytokines in the immunopathogenesis of the disease, but until today, the results have been controversial. Based on these premises, we conducted a retrospective assessment of monocyte intracellular TNF-α expression (iTNF-α) and on the frequencies of lymphocyte sub-populations in twenty-five patients with moderate/severe COVID-19. We found lymphopenia in all COVID-19 infected subjects compared to healthy subjects. On initial observation, in patients with favorable outcomes, we detected a high absolute eosinophil count and a high CD4+/CD8+ T lymphocytes ratio, while in the Exitus Group, we observed high neutrophil and CD8+ T lymphocyte counts. During infection, in patients with favorable outcomes, we observed a rise in the lymphocyte count, in the monocyte and in Treg lymphocyte counts, and in the CD4+ and in CD8+ T lymphocytes count but a reduction in the CD4+/CD8+ T lymphocyte ratio. Instead, in the Exitus Group, we observed a reduction in the Treg lymphocyte counts and a decrease in iTNF-α expression. Our preliminary findings point to a modulation of the different cellular mediators of the immune system, which probably play a key role in the outcomes of COVID-19. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
10. Exploring the Role of Krebs von den Lungen-6 in Severe to Critical COVID-19 Patients
- Author
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Vito D’Agnano, Filippo Scialò, Francesco Perna, Lidia Atripaldi, Stefano Sanduzzi, Valentino Allocca, Maria Vitale, Lucio Pastore, Andrea Bianco, Fabio Perrotta, D'Agnano, Vito, Scialò, Filippo, Perna, Francesco, Atripaldi, Lidia, Sanduzzi, Stefano, Allocca, Valentino, Vitale, Maria, Pastore, Lucio, Bianco, Andrea, Perrotta, Fabio, D'Agnano, V., Scialo, F., Perna, F., Atripaldi, L., Sanduzzi, S., Allocca, V., Vitale, M., Pastore, L., Bianco, A., and Perrotta, F.
- Subjects
Space and Planetary Science ,SARS-CoV-2 ,Paleontology ,COVID-19 ,General Biochemistry, Genetics and Molecular Biology ,Ecology, Evolution, Behavior and Systematics ,Krebs von den Lungen-6 ,lung ultrasound score - Abstract
COVID-19 encompasses a broad spectrum of clinical conditions caused by SARS-CoV-2 infection. More severe cases experience acute respiratory and/or multiorgan failure. KL-6 is a glycoprotein expressed mainly from type II alveolar cells with pro-fibrotic properties. Serum KL-6 concentrations have been found in patients with COVID-19. However, the relevance of KL-6 in patients with severe and critical COVID-19 has not been fully elucidated. Methods: Retrospective data from consecutive severe to critical COVID-19 patients were collected at UOC Clinica Pnuemologica “Vanvitelli”, A.O. dei Colli, Naples, Italy. The study included patients with a positive rhinopharyngeal swab for SARS-CoV-2 RNA with severe or critical COVID-19. Results: Among 87 patients, 24 had poor outcomes. The median KL-6 value in survivors was significantly lower when compared with dead or intubated patients (530 U/mL versus 1069 U/mL p < 0.001). KL-6 was correlated with body mass index (BMI) (r: 0.279, p: 0.009), lung ultrasound score (LUS) (r: 0.429, p < 0.001), Chung Score (r: 0.390, p < 0.001). KL-6 was associated with the risk of death or oro-tracheal intubation (IOT) after adjusting for gender, BMI, Charlson Index, Chung Score, and PaO2/FIO2 (OR 1.003 95% CI 1.001–1.004, p < 0.001). Serum KL-6 value of 968 has a sensitivity of 79.2%, specificity of 87.1%, PPV 70.4%, NPV 91.5%, AUC: O.85 for risk of death or IOT. Conclusions: The presented research highlights the relevance of serum KL-6 in severe to critical COVID-19 patients in predicting the risk of death or IOT.
- Published
- 2022
- Full Text
- View/download PDF
11. Nasal Microbiome in COVID-19: A Potential Role of Corynebacterium in Anosmia.
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Nardelli C, Scaglione GL, Testa D, Setaro M, Russo F, Di Domenico C, Atripaldi L, Zollo M, Corrado F, Salvatore P, Pinchera B, Gentile I, and Capoluongo E
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- Humans, Anosmia, RNA, Ribosomal, 16S genetics, SARS-CoV-2 genetics, Bacteria genetics, Corynebacterium genetics, COVID-19, Microbiota, Actinobacteria genetics
- Abstract
The evolution and the development of the symptoms of Coronavirus disease 19 (COVID-19) are due to different factors, where the microbiome plays a relevant role. The possible relationships between the gut, lung, nasopharyngeal, and oral microbiome with COVID-19 have been investigated. We analyzed the nasal microbiome of both positive and negative SARS-CoV-2 individuals, showing differences in terms of bacterial composition in this niche of respiratory tract. The microbiota solution A (Arrow Diagnostics) was used to cover the hypervariable V1-V3 regions of the bacterial 16S rRNA gene. MicrobAT Suite and MicrobiomeAnalyst program were used to identify the operational taxonomic units (OTUs) and to perform the statistical analysis, respectively. The main taxa identified in nasal microbiome of COVID-19 patients and in Healthy Control subjects belonged to three distinct phyla: Proteobacteria (HC = 14%, Cov19 = 35.8%), Firmicutes (HC = 28.8%, Cov19 = 30.6%), and Actinobacteria (HC = 56.7%, Cov19 = 14.4%) with a relative abundance > 1% in all groups. A significant reduction of Actinobacteria in Cov19 group compared to controls (P < 0.001, FDR = 0.01) was found. The significant reduction of Actinobacteria was identified in all taxonomic levels down to the genus (P < 0.01) using the ANOVA test. Indeed, a significantly reduced relative abundance of Corynebacterium was found in the patients compared to healthy controls (P = 0.001). Reduced abundance of Corynebacterium has been widely associated with anosmia, a common symptom of COVID-19 as suffered from our patients. Contrastingly, the Corynebacterium genus was highly represented in the nasal mucosa of healthy subjects. Further investigations on larger cohorts are necessary to establish functional relationships between nasal microbiota content and clinical features of COVID-19., (© 2022. The Author(s).)
- Published
- 2022
- Full Text
- View/download PDF
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