1. Synthesis, In Silico and In Vitro Antimycobacterial Studies on Substituted Benzofuran Derivatives.
- Author
-
Shelke, D. E., Thorat, B. R., Mali, S. N., and Dhabarde, S. S.
- Subjects
- *
SULFONYL chlorides , *BENZOFURAN , *PROTON magnetic resonance , *MYCOBACTERIUM tuberculosis , *NUCLEAR magnetic resonance , *MASS spectrometry - Abstract
A new series of benzofuran derivatives have been synthesized by the reaction of substituted N-(4-aminophenyl)-1-benzofuran-2-carboxamide with substituted aromatic sulfonyl chlorides in the presence of base with a suitable solvent at 30–100°C temperature and further characterized by Fourier-transform infrared spectroscopy (FT-IR), Proton nuclear magnetic resonance (1H-NMR), elemental analysis and mass spectroscopy studies. All the 26 newly synthesized compounds (Xa–z) were tested for their in-vitro antitubercular (anti-TB) activity against Mycobacterium tuberculosis H37Rv strains. Benzofuran based sulfamides (Xa) and (Xu) were found more potent with the minimum inhibitory concentration (MIC) values 64 µg/mL of each against M. tuberculosis H37Rv; which were then supported by molecular docking studies to gain more insights on the mode of inhibition of M. tuberculosis Polyketide synthase. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF