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Since the first evidence of a global polarization of Λ hyperons in relativistic nuclear collisions in 2017, spin has opened a new window in the field, both at experimental and theoretical level, and an exciting perspective. The current state of the field is reviewed with regard to the theoretical understanding of the data, reporting on the most recent achievements and envisioning possible developments. The intriguing connections of spin physics in relativistic matter with fundamental questions in quantum field theory and applications in the non-relativistic domain are discussed. [ABSTRACT FROM AUTHOR]