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Around the world, the occurrence of landslides has become one of the greatest threats to human life, property, infrastructure, and natural environments. Despite extensive research and discussions on the spatiotemporal dependence of landslide displacements, there is still a lack of understanding concerning the factors that appear to control displacement distribution in landslides because of their significant variations. This paper implements a Graph Convolutional Network (GCN) to predict displacement following the Moio della Civitella landslide in southern Italy and identify factors that may affect the distribution of movement following the landslide. An interferometric technique, known as permanent scatter interferometry (PSI), has been developed based on Synthetic Aperture Radar (SAR) satellite imagery to derive permanent scatter points that can be used to represent the deformation of landslides. This study utilized the GCN regression model applied to PSs points and data reflecting geological and geomorphological factors to extract the interdependency between paired data points, resulting in an adjacency matrix of the interval [0, 0,8). The proposed model outperforms conventional machine learning and deep learning algorithms such as linear regression (LR), K-nearest neighbors (KNN), Support vector regression (SVR), Decision tree, lasso, and artificial neural network (ANN). The absolute error between the actual and predicted deformation is used to evaluate the proposed model, which is less than 2 millimeters for most test set points. [ABSTRACT FROM AUTHOR]

The field of additive manufacturing, particularly 3D printing, has ushered in a significant transformation in the realm of joint arthritis treatment through prosthetic surgery. This innovative technology allows for the creation of bespoke prosthetic devices that are tailored to meet the specific needs of individual patients. These devices are constructed using high-performance materials, including titanium and cobalt-chrome alloys. Nevertheless, the routine physical activities of patients, such as walking, sitting, and running, can induce wear and tear on the materials comprising these prosthetic devices, subsequently diminishing their functionality and durability. In response to this challenge, this research has endeavored to leverage novel techniques. The primary focus of this study lies in the development of an algorithm designed to optimize hip replacement procedures via the mechanical design of the prosthesis. This optimization process exploits the capabilities of machine learning algorithms, multi-body dynamics, and finite element method (FEM) simulations. The paramount innovation in this methodology is the capacity to design a prosthetic system that intricately adapts to the distinctive characteristics of each patient (weight, height, gait cycle). The primary objective of this research is to enhance the performance and longevity of prosthetic devices by improving their fatigue strength. The evaluation of load distribution on the prosthetic device, facilitated by FEM simulations, anticipates a substantial augmentation in the useful life of the prosthetic system. This research holds promise as a notable advancement in prosthetic technology, offering a more efficacious treatment option for patients suffering from joint arthritis. The aim of this research is to make meaningful contributions to the enhancement of patient quality of life and the long-term performance of prosthetic devices. [ABSTRACT FROM AUTHOR]

The knowledge of crop evapotranspiration is crucial for several hydrological processes, including those related to the management of agricultural water sources. In particular, the estimations of actual evapotranspiration fluxes within fields are essential to managing irrigation strategies to save water and preserve water resources. Among the indirect methods to estimate actual evapotranspiration, ET a , the eddy covariance (EC) method allows to acquire continuous measurement of latent heat flux (LE). However, the time series of EC measurements are sometimes characterized by a lack of data due to the sensors' malfunctions. At this aim, Machine Learning (ML) techniques could represent a powerful tool to fill possible gaps in the time series. In this paper, the ML technique was applied using the Gaussian Process Regression (GPR) algorithm to fill gaps in daily actual evapotranspiration. The technique was tested in six different plots, two in Italy, three in the United States of America, and one in Canada, with different crops and climatic conditions in order to consider the suitability of the ML model in various contexts. For each site, the climate variables were not the same, therefore, the performance of the method was investigated on the basis of the available information. Initially, a comparison of ground and reanalysis data, where both databases were available, and between two different satellite products, when both databases were available, have been conducted. Then, the GPR model was tested. The mean and the covariance functions were set by considering a database of climate variables, soil water status measurements, and remotely sensed vegetation indices. Then, five different combinations of variables were analyzed to verify the suitability of the ML approach when limited input data are available or when the weather variables are replaced with reanalysis data. Cross-validation was used to assess the performance of the procedure. The model performances were assessed based on the statistical indicators: Root Mean Square Error (RMSE), coefficient of determination (R2), Mean Absolute Error (MAE), regression coefficient (b), and Nash-Sutcliffe efficiency coefficient (NSE). The quite high Nash Sutcliffe Efficiency (NSE) coefficient, and the root mean square error (RMSE) low values confirm the suitability of the proposed algorithm. • GPR algorithm is suitable to fill gaps in daily ET a time series. • The best m(x) and k(x,x') functions required by the GPR algorithm were identified. • The best results were obtained when the dataset included climate data, SWC and VIs. • The use of ERA5-L data and VIs retrieved by Sentinel 2 or MODIS is a good alternative. • GPR algorithm was tested for different crops in continental and temperate zones. [ABSTRACT FROM AUTHOR]

Background: Resilience is defined as the ability to modify thoughts to cope with stressful events. Patients with schizophrenia (SCZ) having higher resilience (HR) levels show less severe symptoms and better real-life functioning. However, the clinical factors contributing to determine resilience levels in patients remain unclear. Thus, based on psychological, historical, clinical and environmental variables, we built a supervised machine learning algorithm to classify patients with HR or lower resilience (LR). Methods: SCZ from the Italian Network for Research on Psychoses (N = 598 in the Discovery sample, N = 298 in the Validation sample) underwent historical, clinical, psychological, environmental and resilience assessments. A Support Vector Machine algorithm (based on 85 variables extracted from the above-mentioned assessments) was built in the Discovery sample, and replicated in the Validation sample, to classify between HR and LR patients, within a nested, Leave-Site-Out Cross-Validation framework. We then investigated whether algorithm decision scores were associated with the cognitive and clinical characteristics of patients. Results: The algorithm classified patients as HR or LR with a Balanced Accuracy of 74.5% (p < 0.0001) in the Discovery sample, and 80.2% in the Validation sample. Higher self-esteem, larger social network and use of adaptive coping strategies were the variables most frequently chosen by the algorithm to generate decisions. Correlations between algorithm decision scores, socio-cognitive abilities, and symptom severity were significant (p FDR < 0.05). Conclusions: We identified an accurate, meaningful and generalizable clinical-psychological signature associated with resilience in SCZ. This study delivers relevant information regarding psychological and clinical factors that non-pharmacological interventions could target in schizophrenia. [ABSTRACT FROM AUTHOR]

A reliable prediction of the spatio-temporal drought variation can lead to a reduction in vulnerability and an improvement in the management of drought-dependent businesses. In this study, three clustering algorithms, K-mean, Hierarchical and Expectation–Maximization, were first used to divide Southern Italy into homogeneous drought regions, based on gridded data of the Standardized Precipitation Evapotranspiration Index forecasting with a 6 months' time scale (SPEI6). The Hierarchical algorithm identified five well-distinct clusters characterized by drought events of different duration and severity, considering the different morphoclimatic characteristics of the study area. Then, the mean SPEI6 time series were evaluated for each cluster and used to assess the evolutionary drought trends. In addition, two Machine Learning (ML) algorithms, M5P and Support Vector Regression (SVR), were also used to develop forecasting models for the SPEI6, without the need for additional exogenous inputs. Moreover, the Stacking ML technique was used to develop a hybrid model based on both individual M5P and SVR algorithms. The clustering-forecasting combination makes it possible to identify the evolutionary trends taking place in the various homogeneous areas in a concise but effective manner. The hybrid M5P-SVR model (R2 up to 0.91, minimum Root Mean Square Error RMSE = 0.38) outperformed both M5P (R2 up to 0.87, minimum RMSE = 0.42) and SVR (R2 up to 0.89, minimum RMSE = 0.39) models, showing to be particularly suitable for drought forecasting in areas with long and severe drought events. [ABSTRACT FROM AUTHOR]

In recent years, immediate breast reconstruction after mastectomy surgery has steadily increased in the treatment pathway of breast cancer (BC) patients due to its potential impact on both the morpho-functional and aesthetic type of the breast and the quality of life. Although recent studies have demonstrated how recent radiotherapy techniques have allowed a reduction of adverse events related to breast reconstruction, capsular contracture (CC) remains the main complication after post-mastectomy radio-therapy (PMRT). In this study, we evaluated the association of the occurrence of CC with some clinical, histological and therapeutic parameters related to BC patients. We firstly performed bivariate statistical tests and we then evaluated the prognostic predictive power of the collected data by using machine learning techniques. Out of a sample of 59 patients referred to our institute, 28 patients (i.e., 47%) showed contracture after PMRT. As a result, only estrogen receptor status (ER) and molecular subtypes were significantly associated with the occurrence of CC after PMRT. Different machine learning models were trained on a subset of clinical features selected by a feature importance approach. Experimental results have shown that collected features have a non-negligible predictive power. The extreme gradient boosting classifier achieved an area under the curve (AUC) value of 68% and accuracy, sensitivity, and specificity values of 68%, 64%, and 74%, respectively. Such a support tool, after further suitable optimization and validation, would allow clinicians to identify the best therapeutic strategy and reconstructive timing. [ABSTRACT FROM AUTHOR]

With seismic catalogues becoming progressively larger, extracting information becomes challenging and calls upon using sophisticated statistical analysis. Data are typically clustered by machine learning algorithms to find patterns or identify regions of interest that require further exploration. Here, we investigate two density-based clustering algorithms, DBSCAN and OPTICS, for their capability to analyse the spatial distribution of seismicity and their effectiveness in discovering highly active seismic volumes of arbitrary shapes in large data sets. In particular, we study the influence of varying input parameters on the cluster solutions. By exploring the parameter space, we identify a crossover region with optimal solutions in between two phases with opposite behaviours (i.e. only clustered and only unclustered data points). Using a synthetic case with various geometric structures, we find that solutions in the crossover region consistently have the largest clusters and best represent the individual structures. For identifying strong anisotropic structures, we illustrate the usefulness of data rescaling. Applying the clustering algorithms to seismic catalogues of recent earthquake sequences (2016 Central Italy and 2016 Kumamoto) confirms that cluster solutions in the crossover region are the best candidates to identify 3-D features of tectonic structures that were activated in a seismic sequence. Finally, we propose a list of recipes that generalizes our analyses to obtain such solutions for other seismic sequences. [ABSTRACT FROM AUTHOR]

Background: Handwriting is an acquired complex cognitive and motor skill resulting from the activation of a widespread brain network. Handwriting therefore may provide biologically relevant information on health status. Also, handwriting can be collected easily in an ecological scenario, through safe, cheap, and largely available tools. Hence, objective handwriting analysis through artificial intelligence would represent an innovative strategy for telemedicine purposes in healthy subjects and people affected by neurological disorders. Materials and Methods: One-hundred and fifty-six healthy subjects (61 males; 49.6 ± 20.4 years) were enrolled and divided according to age into three subgroups: Younger adults (YA), middle-aged adults (MA), and older adults (OA). Participants performed an ecological handwriting task that was digitalized through smartphones. Data underwent the DBNet algorithm for measuring and comparing the average stroke sizes in the three groups. A convolutional neural network (CNN) was also used to classify handwriting samples. Lastly, receiver operating characteristic (ROC) curves and sensitivity, specificity, positive, negative predictive values (PPV, NPV), accuracy and area under the curve (AUC) were calculated to report the performance of the algorithm. Results: Stroke sizes were significantly smaller in OA than in MA and YA. The CNN classifier objectively discriminated YA vs. OA (sensitivity = 82%, specificity = 80%, PPV = 78%, NPV = 79%, accuracy = 77%, and AUC = 0.84), MA vs. OA (sensitivity = 84%, specificity = 56%, PPV = 78%, NPV = 73%, accuracy = 74%, and AUC = 0.7), and YA vs. MA (sensitivity = 75%, specificity = 82%, PPV = 79%, NPV = 83%, accuracy = 79%, and AUC = 0.83). Discussion: Handwriting progressively declines with human aging. The effect of physiological aging on handwriting abilities can be detected remotely and objectively by using machine learning algorithms. [ABSTRACT FROM AUTHOR]