21 results on '"Wang, Ruoyao"'
Search Results
2. Gut microbiota and serum metabolite signatures along the colorectal adenoma-carcinoma sequence: Implications for early detection and intervention
- Author
-
Guo, Xiaodong, Wang, Ruoyao, Chen, Rui, Zhang, Zhongxiao, Wang, Jingxia, and Liu, Xuan
- Published
- 2024
- Full Text
- View/download PDF
3. Local pH regulation at zinc vanadate cathode by a hierarchical structure for long-life aqueous zinc batteries
- Author
-
He, Tianshun, Wang, Ruoyao, Shi, Hua-Yu, Liu, Xiao-Xia, and Sun, Xiaoqi
- Published
- 2024
- Full Text
- View/download PDF
4. Advancing immunotherapy in triple negative breast Cancer: A novel multimodal theranostic nanoplatform integrating synergetic ferroptosis and photothermal therapy
- Author
-
Cheng, Long, Qiu, Yibo, He, Lingyun, Wang, Haiyang, Zheng, Min, Wang, Ruoyao, Hu, Yaqin, Yu, Huilin, Luo, Wenpei, Xia, Yuanyou, Cao, Yang, Wang, Zhigang, Wang, Yingxiong, Ran, Haitao, and Yang, Lu
- Published
- 2024
- Full Text
- View/download PDF
5. Evaluation of color and stability of ethyl-linked anthocyanin-flavanol pigments in model wine solutions using combined chemical analysis and 3D molecular simulations
- Author
-
Zhao Jian, Guo Min, Wang Ruoyao, Li Lingxi, and Sun Baoshan
- Subjects
red wine ,ethyl-linked anthocyanin-flavanol pigments ,anthocyanins ,color ,stability ,Plant culture ,SB1-1110 - Abstract
Ethyl-linked anthocyanin-flavanol pigments are one of the most important condensation products formed during the red winemaking and ageing period. They have great contribution to the color characteristics and stability of aged red wines. In this study, the color characteristics and stability of ethyl-linked anthocyanin-flavanol pigments and their precursor anthocyanins were evaluated by combined spectrophotometry and 3D molecular simulations. In model wine solutions, the condensation reactions between three anthocyanins and (-)-epicatechin, mediated by acetaldehyde, were conducted to produce ethyl-linked anthocyanin-flavanol pigments. The color was assessed by the CIELab method, and the concentration changes were analyzed by HPLC-DAD. On the other hand, the stability of these pigmented compounds was also calculated by the three 3D molecular simulation methods, that is molecular mechanics, molecular dynamics, and quantum chemistry simulation. The results obtained from CIELab analysis indicated that the formation of ethyl-linked anthocyanin-flavanol pigments resulted in a decrease of L*, a*, b* and C* values, and conversely, a rising of h* value. The 3D molecular simulations revealed that the stability of anthocyanins was as follows: Mv-3-O-glu > Pn-3-O-glu > Cy-3-O-glu. The cis or trans ethyl-linked anthocyanin-flavanol pigments were much more stable than their precursor anthocyanins. Among the pigments, ethyl-linked malvidin-3-O-glucoside-flavanol was more stable than ethyl-linked cyanidin-3-O-glucoside-flavanol and ethyl-linked peonidin-3-O-glucoside-flavanol.
- Published
- 2023
- Full Text
- View/download PDF
6. Integrated serum pharmacochemistry, network pharmacology and pharmacokinetics to explore bioactive components of Gushudan in the treatment of osteoporosis
- Author
-
Ren, Li, Li, Qiuyu, Zhang, Liwei, Wang, Ruoyao, Qin, Feng, Zhao, Longshan, Wei, Xiuyan, and Xiong, Zhili
- Published
- 2023
- Full Text
- View/download PDF
7. Combination of MHI148 Targeted Photodynamic Therapy and STING Activation Inhibits Tumor Metastasis and Recurrence.
- Author
-
Yu, Huilin, Chen, Qiaoqi, Zheng, Min, Wang, Ruoyao, Wang, Haiyang, Cheng, Long, Hu, Yaqin, Dai, Mingyuan, Du, Chier, Luo, Wenpei, Tan, Mixiao, Cao, Yang, Guo, Yuan, and Ran, Haitao
- Published
- 2024
- Full Text
- View/download PDF
8. Self‐Reinforced Bimetallic Mito‐Jammer for Ca2+ Overload‐Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization.
- Author
-
Du, Chier, Guo, Xun, Qiu, Xiaoling, Jiang, Weixi, Wang, Xiaoting, An, Hongjin, Wang, Jingxue, Luo, Yuanli, Du, Qianying, Wang, Ruoyao, Cheng, Chen, Guo, Yuan, Teng, Hua, Ran, Haitao, Wang, Zhigang, Li, Pan, Zhou, Zhiyi, and Ren, Jianli
- Subjects
KREBS cycle ,ADENOSINE triphosphate ,REACTIVE oxygen species ,CALCIUM ions ,HYDROGEN peroxide ,MITOCHONDRIA - Abstract
Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria‐mediated cell death. However, the highly adaptive nature and damage‐repair capabilities of malignant tumors strongly limit the efficacy of treatments based on a single treatment mode. To address this challenge, a self‐reinforced bimetallic Mito‐Jammer is developed by incorporating doxorubicin (DOX) and calcium peroxide (CaO2) into hyaluronic acid (HA) ‐modified metal‐organic frameworks (MOF). After cellular, Mito‐Jammer dissociates into CaO2 and Cu2+ in the tumor microenvironment. The exposed CaO2 further yields hydrogen peroxide (H2O2) and Ca2+ in a weakly acidic environment to strengthen the Cu2+‐based Fenton‐like reaction. Furthermore, the combination of chemodynamic therapy and Ca2+ overload exacerbates ROS storms and mitochondrial damage, resulting in the downregulation of intracellular adenosine triphosphate (ATP) levels and blocking of Cu‐ATPase to sensitize cuproptosis. This multilevel interaction strategy also activates robust immunogenic cell death and suppresses tumor metastasis simultaneously. This study presents a multivariate model for revolutionizing mitochondria damage, relying on the continuous retention of bimetallic ions to boost cuproptosis/immunotherapy in cancer. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
9. Nitric oxide nano-reactor DNMF/PLGA enables tumor vascular microenvironment and chemo-hyperthermia synergetic therapy.
- Author
-
Wang, Ruoyao, Cheng, Long, He, Lingyun, Du, Chier, Wang, Haiyang, Peng, Bohao, Yu, Xiaoqing, Liu, Weiwei, Luo, Wenpei, Ran, Haitao, and Yang, Lu
- Subjects
- *
TUMOR microenvironment , *PHOTOTHERMAL effect , *VASCULAR endothelial cells , *TRIPLE-negative breast cancer , *ACOUSTIC imaging , *NITRIC oxide , *DOXORUBICIN - Abstract
Background: Breast cancer ranks first among malignant tumors, of which triple-negative breast cancer (TNBC) is characterized by its highly invasive behavior and the worst prognosis. Timely diagnosis and precise treatment of TNBC are substantially challenging. Abnormal tumor vessels play a crucial role in TNBC progression and treatment. Nitric oxide (NO) regulates angiogenesis and maintains vascular homeostasis, while effective NO delivery can normalize the tumor vasculature. Accordingly, we have proposed here a tumor vascular microenvironment remodeling strategy based on NO-induced vessel normalization and extracellular matrix collagen degradation with multimodality imaging-guided nanoparticles against TNBC called DNMF/PLGA. Results: Nanoparticles were synthesized using a chemotherapeutic agent doxorubicin (DOX), a NO donor L-arginine (L-Arg), ultrasmall spinel ferrites (MnFe2O4), and a poly (lactic-co-glycolic acid) (PLGA) shell. Nanoparticle distribution in the tumor was accurately monitored in real-time through highly enhanced magnetic resonance imaging and photoacoustic imaging. Near-infrared irradiation of tumor cells revealed that MnFe2O4 catalyzes the production of a large amount of reactive oxygen species (ROS) from H2O2, resulting in a cascade catalysis of L-Arg to trigger NO production in the presence of ROS. In addition, DOX activates niacinamide adenine dinucleotide phosphate oxidase to generate and supply H2O2. The generated NO improves the vascular endothelial cell integrity and pericellular contractility to promote vessel normalization and induces the activation of endogenous matrix metalloproteinases (mainly MMP-1 and MMP-2) so as to promote extravascular collagen degradation, thereby providing an auxiliary mechanism for efficient nanoparticle delivery and DOX penetration. Moreover, the chemotherapeutic effect of DOX and the photothermal effect of MnFe2O4 served as a chemo-hyperthermia synergistic therapy against TNBC. Conclusion: The two therapeutic mechanisms, along with an auxiliary mechanism, were perfectly combined to enhance the therapeutic effects. Briefly, multimodality image-guided nanoparticles provide a reliable strategy for the potential application in the fight against TNBC. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
10. Vacuum bell therapy for pectus excavatum: a retrospective study.
- Author
-
Lei, Weixuan, Shao, Mengqi, Hu, Yan, Cao, Jieming, Han, Wei, Wang, Ruoyao, Fei, Quanming, Zou, Jian, Yi, Junqi, Cheng, Zheyu, and Liu, Wenliang
- Subjects
PECTUS excavatum ,RETROSPECTIVE studies ,CHEST pain ,CASE-control method - Abstract
Background: Pectus excavatum, the most common chest wall deformity, is frequently treated with Nuss procedure. Here we will describe non-invasive procedure and analyze the variables associated vacuum bell therapy for patients with pectus excavatum. Methods: Retrospective case–control study in a single center between July 2018 and February 2022, including patients with pectus excavatum treated with vacuum bell. Follow-up was continued to September 2022. The Haller index and Correction index was calculated before and after treatment to analysis the effectiveness of vacuum bell therapy. Results: There were 98 patients enrolled in the treatment group, with 72 available for analysis, and the follow-up period ranged from 1.1 to 4.4 years (mean 3.3 years). When analyzing with the Haller Index, 18 patients (25.0%) showed excellent correction, 13 patients (18.1%) achieved good correction, and 4 patients (5.6%) had fair correction. The remaining patients had a poor outcome. Characteristics predicting a non-poor prognosis included initial age ≤ 11 years (OR = 3.94, p = 0.013) and patients with use over 24 consecutive months (OR = 3.95, p = 0.013). A total of 9 patients (12.5%) achieved a CI reduction below 10. Patients who started vacuum bell therapy at age > 11 had significantly less change compared to those who started at age ≤ 11 (P < 0.05). Complications included chest pain (5.6%), swollen skin (6.9%), chest tightness (1.4%) and erythema (15.3%). Conclusions: A certain percentage of patients with pectus excavatum can achieve excellent correction when treated with pectus excavatum therapy. Variables predicting better outcome including initial age ≤ 11 years both in HI and CI and vacuum bell use over 24 consecutive months in HI. In summary, pectus excavatum is an emerging non-invasive therapy for pectus excavatum and will be widely performed in a certain group of patients. [ABSTRACT FROM AUTHOR]
- Published
- 2024
- Full Text
- View/download PDF
11. How to use academic and digital fingerprints to catch and eliminate contract cheating during online multiple-choice examinations: a case study.
- Author
-
Emery-Wetherell, Meaghan and Wang, Ruoyao
- Subjects
- *
HUMAN fingerprints , *MULTIPLE choice examinations , *STUDENT cheating , *STATISTICS education , *CURRICULUM - Abstract
Over four semesters of a large introductory statistics course the authors found students were engaging in contract cheating on Chegg.com during multiple choice examinations. In this paper we describe our methodology for identifying, addressing and eventually eliminating cheating. We successfully identified 23 out of 25 students using a combination of unique academic and digital fingerprints, and identified students who used virtual private networks (VPNs) to protect their online identity. There were two forms of cheating – posting questions and waiting for responses from tutors, and looking for questions that had already been solved. We found that 165 questions from these examinations were posted by 10 different students, but that the most common form of cheating was searching for answers that had already been posted. This paper discusses these patterns of Chegg usage, the consequences of not catching cheating early on, and how students reacted to being caught. Also provided are R and Python code that readers may use to identify cheating students in their own courses. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
12. ByteSized32: A Corpus and Challenge Task for Generating Task-Specific World Models Expressed as Text Games
- Author
-
Wang, Ruoyao, Todd, Graham, Yuan, Eric, Xiao, Ziang, Côté, Marc-Alexandre, and Jansen, Peter
- Subjects
FOS: Computer and information sciences ,Artificial Intelligence (cs.AI) ,Computer Science - Computation and Language ,Computer Science - Artificial Intelligence ,Computation and Language (cs.CL) - Abstract
In this work we examine the ability of language models to generate explicit world models of scientific and common-sense reasoning tasks by framing this as a problem of generating text-based games. To support this, we introduce ByteSized32, a corpus of 32 highly-templated text games written in Python totaling 24k lines of code, each centered around a particular task, and paired with a set of 16 unseen text game specifications for evaluation. We propose a suite of automatic and manual metrics for assessing simulation validity, compliance with task specifications, playability, winnability, and alignment with the physical world. In a single-shot evaluation of GPT-4 on this simulation-as-code-generation task, we find it capable of producing runnable games in 27% of cases, highlighting the difficulty of this challenge task. We discuss areas of future improvement, including GPT-4's apparent capacity to perform well at simulating near canonical task solutions, with performance dropping off as simulations include distractors or deviate from canonical solutions in the action space., 10 pages
- Published
- 2023
13. Non‐Covalent Interactions between Polyvinyl Chloride and Conjugated Polymers Enable Excellent Mechanical Properties and High Stability in Organic Solar Cells.
- Author
-
Guan, Chong, Xiao, Chengyi, Liu, Xin, Hu, Zhijie, Wang, Ruoyao, Wang, Chao, Xie, Chengcheng, Cai, Ziqi, and Li, Weiwei
- Subjects
CONJUGATED polymers ,SOLAR cells ,PHOTOVOLTAIC power systems ,POLYVINYL chloride ,ORGANIC electronics ,FLEXIBLE electronics ,THIN films - Abstract
The incorporation of insulating polymers into conjugated polymers has been widely explored as a strategy to improve mechanical properties of flexible organic electronics. However, phase separation due to the immiscibility of these polymers has limited their effectiveness. In this study, we report the discovery of multiple non‐covalent interactions that enhances the miscibility between insulating and conjugated polymers, resulting in improved mechanical properties. Specifically, we have added polyvinyl chloride (PVC) into the conjugated polymer PM6 and observed a significant increase in solution viscosity, indicative of favorable miscibility between these two polymers. This phenomenon has been rarely observed in other insulating/conjugated polymer composites. Thin films of PM6/PVC exhibit a much‐improved crack‐onset strain of 19.35 %, compared to 10.12 % for pristine PM6 films. Analysis reveal that a "cyclohexyl‐like" structure formed through dipole‐dipole interactions and hydrogen bonding between PVC and PM6 acted as a cross‐linking site in the thin films, leading to improved mechanical properties. Moreover, PM6/PVC blend films have demonstrated excellent thermal and bending stability when applied as an electron donor in organic solar cells. These findings provide new insights into non‐covalent interactions that can be utilized to enhance the properties of conjugated polymers and may have potential applications in flexible organic electronics. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
14. N‑Annulated Perylene Bisimide-Based Double-Cable Polymers with Open-Circuit Voltage Approaching 1.20 V in Single-Component Organic Solar Cells.
- Author
-
Wang, Ruoyao, Xia, Dongdong, Jiang, Xudong, Zhao, Chaowei, Zhou, Shengxi, Fang, Haisheng, Wang, Jing, Tang, Zheng, Xiao, Chengyi, and Li, Weiwei
- Published
- 2022
- Full Text
- View/download PDF
15. Osimertinib as Neoadjuvant Therapy for Resectable Non-Small Cell Lung Cancer: A Case Series.
- Author
-
Hu, Yan, Ren, Siying, Yang, Lulu, Tong, Zhongyi, Wang, Ruoyao, Han, Wei, Zeng, Chao, Li, Jina, Xiao, Peng, Wang, Li, Yu, Fenglei, and Liu, Wenliang
- Subjects
NON-small-cell lung carcinoma ,NEOADJUVANT chemotherapy ,EPIDERMAL growth factor receptors ,OSIMERTINIB ,PROTEIN-tyrosine kinase inhibitors - Abstract
Background: Evidence of osimertinib as neoadjuvant therapy for resectable non-small cell lung cancer (NSCLC) are currently lacking. This case series study aimed to assess the safety and feasibility of neoadjuvant osimertinib therapy followed by surgery for resectable NSCLC. Materials and methods: Patients with resectable NSCLC with epidermal growth factor receptor (EGFR) mutation who received osimertinib as neoadjuvant therapy followed by surgery at our center were included. Demographic features, radiologic and pathological assessment of response, surgery-related details and complications, toxicity profiles, and prognostic outcomes were extracted. Results: A total of 13 patients were included in this study. The median age at the time of surgical resection was 57 years (interquartile range: 52–64 years), and eight (61.5%) patients were female. The objective response rate (ORR) was 69.2% (9/13), and the complete resection rate was 100%. The rates of pathologic downstaging and lymph node downstaging were 100% (13/13) and 66.7% (6/9), respectively. There were no perioperative deaths and only three (23.1%) patients had postoperative complications. Seven (53.8%) and 13 (100%) patients experienced grade 1 treatment-related adverse reactions and laboratory abnormalities, respectively. No patients experienced drug withdrawal or surgical delays due to the adverse events. No patients showed grade 2 or worse toxicity profiles. One patient was lost to follow-up. The other 12 patients were alive and free of disease recurrence with a median follow-up time of 9.5 months. Conclusion: Neoadjuvant osimertinib therapy seemed to be safe and feasible for resectable EGFR-mutated NSCLC. Future large prospective studies are warranted to confirm whether osimertinib as neoadjuvant therapy outperforms standard tyrosine kinase inhibitors (TKIs) or chemotherapy for resectable EGFR-mutated NSCLC. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
16. Turning industrial waste-flax noil into regenerated cellulose fiber electrodes for eco-friendly supercapacitors.
- Author
-
Zhang, Qian, Wang, Ruoyao, Zou, Yuhang, Mao, Jifu, and Wang, Lu
- Subjects
- *
CELLULOSE fibers , *SUPERCAPACITORS , *CARBON electrodes , *MANUFACTURING processes , *ENERGY storage , *ACTIVATED carbon , *SUPERCAPACITOR electrodes , *POLYACRYLONITRILES - Abstract
Sustainable conversion of wastes into eco-friendly wearable energy storage materials is of uppermost priority when facing the rapid development of human society. Although some attempts have successfully developed wastes into activated carbon electrodes, the high energy consumption of the production process and the powder form greatly restrict their application in eco-friendly wearable supercapacitors. Here, industrial waste-flax noil was conversed into fiber-shaped supercapacitors (FSSCs) via wet spinning and in situ deposition of polypyrrole (PPy). The regenerated cellulose fibers (RCFs) collected from the ethyl alcohol coagulation bath possessed excellent tensile behaviors and multi-groove surfaces, encouraging the subsequent textile processing and ions activities. After PPy deposition, the obtained fiber electrodes yielded high specific capacitance (510.7 F g-1 at 0.5 A g-1) and excellent coulombic efficiency (99.3% at 10 A g-1). More importantly, the assembled FSSCs delivered remarkable electrochemical performances and could power the LED. The green strategy proposed in this work provides a new consideration for converting wastes into practical eco-friendly wearable devices. [Display omitted] • Flax noil was successfully converted into eco-friendly fiber supercapacitors. • ETf@PPy12 electrodes possessed high specific capacitance and coulombic efficiency. • The assembled flexible supercapacitor showed superior electrochemical performance. • The devices in series could power the LED. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
17. Perylene bisimides-based molecular dyads with different alkyl linkers for single-component organic solar cells.
- Author
-
Fang, Haisheng, Xia, Dongdong, Zhao, Chaowei, Zhou, Shengxi, Wang, Ruoyao, Zang, Yourui, Xiao, Chengyi, and Li, Weiwei
- Subjects
- *
SOLAR cells , *PERYLENE , *DYADS , *OPEN-circuit voltage , *SHORT-circuit currents , *THIN films - Abstract
Two kinds of small molecular dyads (SMDs) based on trithiophene-benzodithiophene-rhodanine (DR3TBDT) main backbone and PBI termini, named SMD2-C6 and SMD2-C12, were designed with different lengths of alkyl linkers (C 6 H 12 and C 12 H 24). The length effect of alkyl linkers on the photovoltaic performance of the two SMDs have been systematically studied. The results show that the length of alkyl linkers can simutaneously tune the energy levels and phase separation in molecular dyad thin films. As a result, a power conversion efficiency of 1.33% was obtained for SMD2-C12 based single-component organic solar cells (SCOSCs), showing higher open-circuit voltage, short-circuit current density, and fill factor than those of SMD2-C6 based devices. Our findings provide a strategy for designing new SMDs and reveal the importance of alkyl linkers' length on the morphology of SMDs toward improved SCOSC performance. Small molecular dyads based on DR3TBDT backbone and PBI end groups with varying alkyl linker lengths have been developed for application in single-component organic solar cells. [Display omitted] • Two molecular dyads based on a donor backbone and perylene bisimides end groups were developed. • Different alkyl linkers as C 6 H 12 and C 12 H 24 were introduced. • Longer alkyl linkers were found to improve the nanophase separation and provided higher efficiency in single-component organic solar cells. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
18. Self-Reinforced Bimetallic Mito-Jammer for Ca 2+ Overload-Mediated Cascade Mitochondrial Damage for Cancer Cuproptosis Sensitization.
- Author
-
Du C, Guo X, Qiu X, Jiang W, Wang X, An H, Wang J, Luo Y, Du Q, Wang R, Cheng C, Guo Y, Teng H, Ran H, Wang Z, Li P, Zhou Z, and Ren J
- Subjects
- Humans, Reactive Oxygen Species, Adenosine Triphosphate, Cell Death, Mitomycin, Tumor Microenvironment, Hydrogen Peroxide, Neoplasms
- Abstract
Overproduction of reactive oxygen species (ROS), metal ion accumulation, and tricarboxylic acid cycle collapse are crucial factors in mitochondria-mediated cell death. However, the highly adaptive nature and damage-repair capabilities of malignant tumors strongly limit the efficacy of treatments based on a single treatment mode. To address this challenge, a self-reinforced bimetallic Mito-Jammer is developed by incorporating doxorubicin (DOX) and calcium peroxide (CaO
2 ) into hyaluronic acid (HA) -modified metal-organic frameworks (MOF). After cellular, Mito-Jammer dissociates into CaO2 and Cu2+ in the tumor microenvironment. The exposed CaO2 further yields hydrogen peroxide (H2 O2 ) and Ca2+ in a weakly acidic environment to strengthen the Cu2+ -based Fenton-like reaction. Furthermore, the combination of chemodynamic therapy and Ca2+ overload exacerbates ROS storms and mitochondrial damage, resulting in the downregulation of intracellular adenosine triphosphate (ATP) levels and blocking of Cu-ATPase to sensitize cuproptosis. This multilevel interaction strategy also activates robust immunogenic cell death and suppresses tumor metastasis simultaneously. This study presents a multivariate model for revolutionizing mitochondria damage, relying on the continuous retention of bimetallic ions to boost cuproptosis/immunotherapy in cancer., (© 2024 The Authors. Advanced Science published by Wiley‐VCH GmbH.)- Published
- 2024
- Full Text
- View/download PDF
19. Non-Covalent Interactions between Polyvinyl Chloride and Conjugated Polymers Enable Excellent Mechanical Properties and High Stability in Organic Solar Cells.
- Author
-
Guan C, Xiao C, Liu X, Hu Z, Wang R, Wang C, Xie C, Cai Z, and Li W
- Abstract
The incorporation of insulating polymers into conjugated polymers has been widely explored as a strategy to improve mechanical properties of flexible organic electronics. However, phase separation due to the immiscibility of these polymers has limited their effectiveness. In this study, we report the discovery of multiple non-covalent interactions that enhances the miscibility between insulating and conjugated polymers, resulting in improved mechanical properties. Specifically, we have added polyvinyl chloride (PVC) into the conjugated polymer PM6 and observed a significant increase in solution viscosity, indicative of favorable miscibility between these two polymers. This phenomenon has been rarely observed in other insulating/conjugated polymer composites. Thin films of PM6/PVC exhibit a much-improved crack-onset strain of 19.35 %, compared to 10.12 % for pristine PM6 films. Analysis reveal that a "cyclohexyl-like" structure formed through dipole-dipole interactions and hydrogen bonding between PVC and PM6 acted as a cross-linking site in the thin films, leading to improved mechanical properties. Moreover, PM6/PVC blend films have demonstrated excellent thermal and bending stability when applied as an electron donor in organic solar cells. These findings provide new insights into non-covalent interactions that can be utilized to enhance the properties of conjugated polymers and may have potential applications in flexible organic electronics., (© 2023 Wiley-VCH GmbH.)
- Published
- 2023
- Full Text
- View/download PDF
20. The Roles and Targeting of Tumor-Associated Macrophages.
- Author
-
Li Y, Wang R, and Gao Q
- Subjects
- Humans, Tumor-Associated Macrophages, Tumor Microenvironment
- Abstract
Tumor-associated macrophages (TAMs) are the most abundant infiltrating immune cells in the tumor microenvironment (TME) and play an important role in tumor progression. Clinically, the increase of TAMs infiltration is linked to poor prognosis of patients with various cancer types. Multiple studies have demonstrated that reducing or reprogramming TAMs can inhibit the occurrence or development of tumors. Therefore, TAMs have been identified as novel targets for the treatment of cancer therapy. In this review, the origin, polarization, roles, and targeting of TAMs in malignancies, are discussed., Competing Interests: The authors declare no conflict of interest., (© 2023 The Author(s). Published by IMR Press.)
- Published
- 2023
- Full Text
- View/download PDF
21. Case Report: Pathological Complete Response to Neoadjuvant Alectinib in a Patient With Resectable ALK-Positive Non-Small Cell Lung Cancer.
- Author
-
Hu Y, Ren S, Wang R, Han W, Xiao P, Wang L, Yu F, and Liu W
- Abstract
Background: Alectinib, a highly selective inhibitor of ALK, is currently used in the first-line setting of untreated advanced ALK-positive NSCLC and in the second-line setting of crizotinib-resistant ALK-positive NSCLC. Despite promising efficacy and tolerability in the treatment of advanced ALK-positive NSCLC, the activity of alectinib as neoadjuvant therapy in resectable ALK-positive NSCLC remains to be investigated. Case presentation: Herein, we report a case of a 58-year-old female patient presented to our hospital with hemoptysis for 1 month. Contrast-enhanced computerized tomography (CT) of the chest showed an approximately 4.2 × 3.4 cm mass in the right hilum with localized obstructive pneumonia in the right lower lobe and multiple enlarged lymph nodes in the right hilum and mediastinum. Serum oncological markers results showed elevated levels of CA19-9, CEA, CA125, and CA242. Bronchoscopic biopsy of the mass showed poorly differentiated pulmonary adenocarcinoma and immunohistochemical testing results confirmed ALK positivity. Neoadjuvant alectinib was given at a dosage of 600 mg twice per day for two cycles (56 days), achieving a partial response of the disease with 90% shrinkage of the mass at the subsequent whole-body positron emission tomography. Repeat serum oncological markers results showed that only CA125 was elevated, but lower than before therapy. A bilobectomy of the right middle and lower lobes and systemic lymphadectomy under video-assisted thoracoscopic approach was successfully performed 7 days after the last dose of alectinib. Postoperative pathology showed pathological complete response (pCR). The patient experienced an uneventful postoperative course and continued to receive alectinib and did not report any specific discomfort at her 8-month follow-up. Thoracoabdominal CT at 8 months postoperatively showed no recurrence and repeated examination of serum oncological markers were negative. Conclusion: We report a case of resectable ALK-positive NSCLC treated with neoadjuvant aletinib achieving pCR. Our case highlights the feasibility of alectinib as neoadjuvant therapy for the treatment of resectable ALK-positive NSCLC. Undoubtedly, the safety and efficacy of this novel treatment modality needs to be explored in future large clinical trials., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2022 Hu, Ren, Wang, Han, Xiao, Wang, Yu and Liu.)
- Published
- 2022
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.