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Northeast China played an irreplaceable role in population migrations and cultural exchanges in East Asia during the Paleolithic. This paper collected 182 archaeological sites to analyse the characteristics of spatial-temporal variations of Paleolithic human activities in Northeast China, and explored the driving mechanisms behind these variations in combination with the paleoenvironmental and archaeological studies. During the Lower Paleolithic, constrained by the relatively cold-dry climate and blocked by the Songnen paleo-lake basin, the population was sparse and distributed only near 40° N at the southern end of Northeast China. Upon entering the Middle Paleolithic, as humans developed greater tolerance to cold climates and adopted more sophisticated survival strategies with the application of small lithic tools, their numbers increased and geographical distribution expanded northward to 45° N at the central region of Northeast China. The Upper Paleolithic saw a considerable increase in population and expansion across almost all of Northeast China except for the eastern Inner Mongolia Plateau. We speculated that 50 ka and 30 ka BP were two key points, both of which may be associated with a significant increase in the frequency of migrations and communications among humans, and the widespread popularity of highly mobile microblade technology, respectively. In addition, the environmental analysis of archaeological sites revealed a continuous spread of Paleolithic humans to areas with higher elevations, steeper slopes, and lower temperatures. Meanwhile, they were becoming less reliant on water resources and were more widely conducting activities in open-air areas, showing that the environmental adaptability had been continuously improving over time. This study can provide a reference for the reconstruction of the migration history of early humans in East Asia, and is also of great significance for a comprehensive understanding of the evolutionary process of early human-environment interactions. [ABSTRACT FROM AUTHOR]