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Objectives Artemisinin-resistant Plasmodium falciparum malaria is currently spreading globally, including in Africa. Artemisinin resistance also leads to resistance to partner drugs used in artemisinin-based combination therapies. Sequencing of kelch13 , which is associated with artemisinin resistance, culture-based partner drug susceptibility tests, and ELISA-based growth measurement are conventionally used to monitor resistance; however, their application is challenging in resource-limited settings. Methods An experimental package for field studies with minimum human/material requirements was developed. Results First, qPCR-based SNP assay was applied in artemisinin resistance screening, which can detect mutations within 1 h and facilitate sample selection for subsequent processes. It had 100% sensitivity and specificity compared with DNA sequencing in the detection of the two common artemisinin resistance mutations in Uganda, C469Y and A675V. Moreover, in the partner drug susceptibility test, the cultured samples were dry-preserved on a 96-well filter paper plate and shipped to the central laboratory. Parasite growth was measured by ELISA using redissolved samples. It well reproduced the results of direct ELISA, reducing significant workload in the field (Pearson correlation coefficient: 0.984; 95% CI: 0.975–0.990). Conclusions Large-scale and sustainable monitoring is required urgently to track rapidly spreading drug-resistant malaria. In malaria-endemic areas, where research resources are often limited, simplicity and feasibility of the procedure is especially important. Our approach combines a qPCR-based rapid test, which is also applicable to point-of-care diagnosis of artemisinin resistance and centralized analysis of ex vivo culture. The approach could improve efficiency of field experiments and accelerate global drug resistance surveillance. [ABSTRACT FROM AUTHOR]

The illegal poaching of lions for their body parts poses a severe threat to lion populations across Africa. Poaching accounts for 35% of all human-caused lion deaths, with 51% attributed to retaliatory killings following livestock predation. In nearly half of the retaliatory killings, lion body parts are removed, suggesting that high demand for lion body parts may fuel killings attributed to human-lion conflict. Trafficked items are often confiscated in transit or destination countries far from their country of origin. DNA from lion parts may in some cases be the only available means for examining their geographic origins. In this paper, we present the Lion Localizer, a full-stack software tool that houses a comprehensive database of lion mitochondrial DNA (mtDNA) sequences sourced from previously published studies. The database covers 146 localities from across the African continent and India, providing information on the potential provenance of seized lion body parts. Lion mtDNA sequences of 350 or 1,140 bp corresponding to the cytochrome b region can be generated from lion products and queried against the Lion Localizer database. Using the query sequence, the Lion Localizer generates a listing of exact or partial matches, which are displayed on an interactive map of Africa. This allows for the rapid identification of potential regions and localities where lions have been or are presently being targeted by poachers. By examining the potential provenance of lion samples, the Lion Localizer serves as a valuable resource in the fight against lion poaching. The software is available at https://lionlocalizer.org. [ABSTRACT FROM AUTHOR]

We are honoured to present this special issue of the I Refugee Survey Quarterly i on the contemporary role of the global refugee regime in Africa. THE GLOBAL REFUGEE REGIME IN AFRICA TODAY The global refugee regime remains difficult to define, with no legal or even agreed definition.[2] As a result, it is frequently left undefined in policy discussions and academic articles. Indeed, the papers show how different forms of State marginalisation instrumentalise refugee regime norms, categories and laws to realise broader political goals of African governments. The third theme that arises through the five papers is I resisting the refugee regime. i Supporting previous research on this topic, Hetaba et al. highlight how many forced migrants in Egypt prefer to settle informally due to the perceived barriers in obtaining refugee status through UNHCR and the host State. [Extracted from the article]

Objectives Our paper highlights areas of interest to psychologists studying aging in Africa and what has already been learned about aspects of psychological aging from studies done in the African context. We also considered whether there are issues that are unique about aging in the African context that might challenge how aging is typically considered in psychology research. Methods We reviewed articles recently published in major gerontology journals focusing on African older adults, with the goal of identifying key themes of current geropsychology in Africa. Results We identified a number of dominant themes including: subjective aging, psychosocial impact of widowhood at old age, aging in place, stress and caregiving, cognitive aging, interrelations between HIV and aging, and successful aging. Discussion The themes of psychological aging research identified as especially relevant in Africa provide a starting point for psychological aging researchers in general to engage with the African context. Many African countries may be facing common challenges, but the existing studies are not fully representative of the aging population in the continent. Creating a framework for organizing and coordinating funding will help to address the limited research on geropsychology in Africa. Collaborative research projects/programs, joint classrooms, and fellowships that support African geropsychology scholars will be helpful. Geropsychology will benefit from more engagement with the African context by applying innovative approaches such as the adoption of longitudinal designs, mixed-method research, Experience Sampling Methods, translation of measures into indigenous languages, involvement of rural samples, and implementation science and community-engaged research. [ABSTRACT FROM AUTHOR]

The African region of the World Health Organization (WHO) recently adopted a strategy aimed at more comprehensive care for noncommunicable diseases (NCDs) in the region. The WHO's World Health Assembly has also newly approved several ambitious disease-specific targets that raise the expectations of chronic care and plans to revise and update the NCD-Global Action Plan. These actions provide a critically needed opportunity for reflection and course correction in the global health response to NCDs. In this paper, we highlight the status of the indicators that are currently used to monitor progress towards global goals for chronic care. We argue that weak health systems and lack of access to basic NCD medicines and technologies have prevented many countries from achieving the level of progress required by the NCD epidemic, and current targets do little to address this reality. We identify gaps in existing metrics and explore opportunities to realign the targets with the pressing priorities facing today's health systems. [ABSTRACT FROM AUTHOR]

Water will be a major limitation to food production in the 21st century, and drought issues already prevail in many parts of the world. Finding solutions to ensure that farmers harvest profitable crops, and secure food supplies for families and feed for animals that will provide for them through to the next season are urgent necessities. The Interdrought community has been addressing this issue for almost 30 years in a series of international conferences, characterized by a multi-disciplinary approach across the domains of molecular biology, physiology, genetics, agronomy, breeding, environmental and social sciences, policy, and systems modeling. This special issue presents papers from the 7th edition of the conference, the first to be held in Africa, that paid special attention to drought in a smallholder context, adding a 'system' dimension to the crop focus from the previous Interdrought events (Varshney et al. , 2018 ; Hammer et al. , 2021). [ABSTRACT FROM AUTHOR]

SUMMARY: Earthquake hazard assessment is the first step towards implementing prevention, preparedness and response or faster recovery actions to reduce the risk of seismic disasters. In this paper, we present a comprehensive study on present-day seismicity in terms of the estimated waiting time and conditional probability in Africa by 2022–2072 using four competing distribution models (Brownian passage time (BPT), gamma, lognormal and Weibull). We also investigate how much Coulomb stress change $\ ({\Delta {\rm CFF}})$ induced by previous earthquakes that occurred in neighbouring active sources should revise the probability of occurrence at the location of the next events. We analyse large earthquakes with moment magnitude, ${M}_{\rm w} \ge 6.0$ , collating data from the Global Centroid Moment Tensor and from several published literature that list fault plane solutions of large African earthquakes since 1900. We assume that the data set is stationary and consists of independent events. First, the model's parameters are estimated and the results of the statistical analysis of the interevent times show clear evidence of quasi-periodic recurrence behaviour for large earthquakes ${M}_{\rm w} \ge $ 6.0 in different seismotectonic regions in Africa. Next, a comparison among the distribution models is performed with the aim of selecting the most suitable one. The results in terms of the maximum likelihood criterion and its extension (Akaike Information Criterion) indicate that, in general, the BPT and Weibull models had similar fits to each other, and performed slightly better than gamma and lognormal models. Then, we use Gaussian random distributions to treat parameter uncertainties (e.g. aperiodicity, maximum expected magnitude, slip rate and mean recurrence time) of the distribution models associated with each seismotectonic region. From repeated Monte Carlo draws, we assess uncertainties of the 50-yr conditional probability values for the next earthquake obtained from two distribution models (BPT and BPT + $\Delta {\rm CFF}$) related to the 50th percentile. The results of the BPT distribution indicate very high chances of future earthquakes in the study region where the conditional probability of a large earthquake reaches 99.5, 95.6, 83.1 and 82.2 per cent for the western branch of the East African Rift System (EARS), northwest Africa, the Afar region, and the eastern branch of EARS, respectively. Taking into account the effect of stress change from interacting sources (BPT + $\Delta {\rm CFF}$), these probabilities are slightly modified to 99.8, 98.4, 89.9 and 87.3 per cent for the western branch of EARS, northwest Africa, the Afar region and the eastern branch of EARS, respectively. These marginal increases suggest that the estimated effect of the earthquake interaction introduced by the coseismic slip of previous earthquakes on neighbouring active sources is minor if compared with the uncertainties affecting the renewal models used for the basic time-dependent conditional probability assessment. [ABSTRACT FROM AUTHOR]

Background: Infertility affects over 50 million couples worldwide and impacts people's social and emotional wellbeing. In low- and middle-income countries, particularly across Africa, the inclusion of fertility care into reproductive health (RH) policies remains fragmented or non-existent.Objective and Rationale: This review aims to provide a framework for understanding the inclusion (or lack thereof) of fertility care in RH policies in African settings. It synthesizes the barriers and facilitators to such inclusion, with a view to uncovering the positioning of fertility care in broader health systems and on the agendas of key stakeholders such as health policymakers and practitioners.Search Methods: A qualitative evidence synthesis was performed, systematically searching papers and grey literature. Searches were conducted in MEDLINE, EMBASE, CINAHL, Web of Science and Scopus between February and April 2020. No date restrictions were applied. Language was limited to publications written in English and French. Two reviewers independently screened titles and abstracts, and extracted data, applying thematic coding. The quality of the included papers was evaluated using The Joanna Briggs Institute Checklist for Text and Opinion Papers.Outcomes: The search identified 744 papers, of which 20 were included. Findings were organized under four cross-cutting categories, namely: perceived importance of infertility; influence of policy context; resource availability and access; and perceived quality of care. Across these categories, key barriers to the inclusion of fertility care in RH policies were limited political commitment, under-recognition of the burden of infertility and high costs associated with ART. Conversely, facilitators comprised specialized training on infertility for healthcare providers, standard procedures for ART safety and guidelines and North-South/South-South collaborations.Wider Implications: The inclusion of fertility care in African RH policies depends upon factors that include the recognition of infertility as a disease, strong political engagement and proactivity and affordability of ART through opportunities for partnership with the private sector, which ease costs on the public health system. Further qualitative and quantitative research, including context-specific analysis and in-depth comparative approaches across diverse African countries, will help to delineate differential impacts of local and global factors on fertility care to address this neglected RH issue. [ABSTRACT FROM AUTHOR]

This paper seeks to position the Scramble for Africa in the context of the continent's transformative, global nineteenth century. While imperial historiography develops apace, Africa-facing analyses of the continent's partition and the processes which led to it are increasingly rare. European expansion into Africa was characterized by an aggressive dynamism, and millions of Africans experienced profound crisis in the process of the establishment of colonial rule. Yet Africa's revolutionary nineteenth century was both driven by, and culminated in, complex processes of co-option on the part of Africans and Europeans. The paper proposes that a more Africa-centered assessment of the Scramble is possible, one which aims to contextualize the partition of the continent as part of an ongoing, endogenously shaped but often exogenously connected, transformation in political, economic, and social organization and behavior. While no single overarching theory can apply to the entire continent, it is possible to identify dynamics and processes for change that recur across Africa, from political and military reform to economic innovation. These point toward possibilities for reframing Africa's development in the late precolonial period, and enable us to challenge the hegemony long enjoyed by scholars of European empires. [ABSTRACT FROM AUTHOR]

While current levels of economic inequality in Africa receive ample attention from academics and policymakers, we know little about the long-run evolution of inequality in the region. Even the new and influential 'global inequality literature' that is associated with scholars like Thomas Piketty, Branko Milanovic, and Walter Scheidel has had little to say about Africa so far. This paper is a first effort to fill that void. Building on recent research in African economic history and utilizing the new theoretical frameworks of the global inequality literature, we chart the long-run patterns and drivers of inequality in Africa from the slave trades to the present. Our analysis dismantles mainstream narratives about the colonial roots of persistent high inequality in post-colonial Africa and shows that existing inequality concepts and theories need further calibration to account, among others, for the role of African slavery in the long-run emergence and vanishing of inequality regimes. [ABSTRACT FROM AUTHOR]

As the United Nations inevitably embarks on the digital transformation of peacekeeping, it raises key questions—'technology' or 'human' first. This paper argues that narrowly focusing on technical solutions may move this world body closer to a modern infrastructure, but misses it opportunities for bigger, more impactful peacekeeping process improvement. Whereas, starting with 'humans' or peacekeepers, their goals and pain points and the context of their interactions, means that solutions are targeting meaningful outcomes, not just new software. Using the value sensitive design approach to technology design, the paper extends its application to peacekeeping by integrating human values and the values instantiated in existing or imagined technical designs. These values were distilled out of a mixed methods study carried out at a peace mission deployed in Africa. Analysis identified four horizontal themes (positive UX, integration, connectivity and privacy) across three use contexts (workplace productivity, personal physical safety and well-being). Core values were being safe, family connection, doing work well and being cared for by their organization. Such human-centred technological interventions will enhance the needed capabilities for the peacekeeping forces to win when they need to and to safely enforce lasting peace in a dominant but non-violent fashion where possible. [ABSTRACT FROM AUTHOR]

Objectives Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation, pain, and cartilage and bone damage. There is currently no cure for RA. It is however managed using nonsteroidal anti-inflammatory drugs, corticosteroids and disease-modifying anti-rheumatic drugs, often with severe side effects. Hidden within Africa's lush vegetation are plants with diverse medicinal properties including anti-RA potentials. This paper reviews the scientific literature for medicinal plants, growing in Africa, with reported anti-RA activities and identifies the most abundant phytochemicals deserving research attention. A search of relevant published scientific literature, using the major search engines, such as Pubmed/Medline, Scopus, Google Scholar, etc. was conducted to identify medicinal plants, growing in Africa, with anti-RA potentials. Key findings Twenty plants belonging to 17 families were identified. The plants are rich in phytochemicals, predominantly quercetin, rutin, catechin, kaempferol, etc. known to affect some pathways relevant in RA initiation and progression, and therefore useful in its management. Summary Targeted research is needed to unlock the potentials of medicinal plants by developing easy-to-use technologies for preparing medicines from them. Research attention should focus on how best to exploit the major phytochemicals identified in this review for the development of anti-RA 'green pharmaceuticals'. [ABSTRACT FROM AUTHOR]

Mapanoioideae are one of two subfamilies of Cyperaceae and consist of 186 species. Molecular phylogenetic relationships in subfamily Cyperoideae have recently been studied well, whereas evolutionary relationships in Mapanioideae remain little known. Subfamily Mapanioideae include two tribes. This study focuses on Hypolytreae, which is represented by three genera in Africa (Hypolytrum , Mapania and Principina). In this paper, we present the first molecular phylogenetic study of African Hypolytreae using a Sanger sequencing approach. We aim to (1) test whether Hypolytrum , Mapania and Principina are reciprocally monophyletic; (2) investigate whether the morphologically based sections in Hypolytrum and Mapania represent monophyletic taxa; (3) resolve species delimitation where multiple accessions could be sequenced and (4) explore the relationships of species occurring in West Tropical Africa vs. Central Africa. Our phylogenetic analyses strongly support Mapania and Hypolytrum as separate genera, but Principina is nested in Hypolytrum. This result is consistent with morphological differences. Mapania spp. are obligate rainforest species, but our results show that species from West Tropical Africa and species from Central Africa do not form separate clades. Dispersal between these regions may have happened during interglacial periods when the rainforest was continuous. [ABSTRACT FROM AUTHOR]

In Bangladesh and West Bengal cholera is seasonal, transmission occurs consistently annually. By contrast, in most African countries, cholera has inconsistent seasonal patterns and long periods without obvious transmission. Transmission patterns in Africa occur during intermittent outbreaks followed by elimination of that genetic lineage. Later another outbreak may occur because of reintroduction of new or evolved lineages from adjacent areas, often by human travelers. These then subsequently undergo subsequent elimination. The frequent elimination and reintroduction has several implications when planning for cholera's elimination including: a) reconsidering concepts of definition of elimination, b) stress on rapid detection and response to outbreaks, c) more effective use of oral cholera vaccine and WASH, d) need to readjust estimates of disease burden for Africa, e) re-examination of water as a reservoir for maintaining endemicity in Africa. This paper reviews major features of cholera's epidemiology in African countries which appear different from the Ganges Delta. [ABSTRACT FROM AUTHOR]

This paper studies the relationship between the position of individual scientists within co-authorship networks and their scientific performance. Using co-authorship data from African scientists in the Health and Medical Sciences within a timespan of 15 years (2000–2015), we characterize the collaboration networks and calculate centrality measures for each scientist to explore how scientific production and impact can be associated with their position within the network. Our findings reveal that authors who occupy a better position within their network and are deemed to actively collaborate with others also have a higher research impact. In this regard, South African scientists do not differ from those in the rest of the world. [ABSTRACT FROM AUTHOR]